Inactivation of {beta}-lactamases from Enterobacter cloacae by monophosphams (1988)
Bush, Karen, Smith, S. A., Tanaka, S. K., Bonner, D. P.
Amongst the monocyclic β-lactam antibiotics, selected monophosphams were potent mechanism-based inactivators of the P99 and E2 cephalosporinases of Enterobacter cloacae. Inhibition of these enzymes...
Shawar, Ribhi M., MacLeod, David L., Garber, Richard L., Burns, Jane L., Stapp, Jenny R., Clausen, Carla R., ...
The in vitro activity of tobramycin was compared with those of six other antimicrobial agents against 1,240 Pseudomonas aeruginosa isolates collected from 508 patients with cystic fibrosis during...
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor.
Flamm, R K, Vojtko, C, Chu, D T, Li, Q, Beyer, J, Hensey, D, ...
ABT-719 (A-86719.1) is the first compound of a new class of novel DNA gyrase inhibitors, the 2-pyridones, with potent antibacterial activity against gram-positive, gram-negative, and anaerobic...
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.
Versalovic, J, Shortridge, D, Kibler, K, Griffy, M V, Beyer, J, Flamm, R K, ...
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of...
Stone, G G, Shortridge, D, Versalovic, J, Beyer, J, Flamm, R K, Graham, D Y, ...
We have developed a rapid PCR-oligonucleotide ligation assay that can discriminate single base substitutions that are associated with clarithromycin resistance in Helicobacter pylori. Susceptible...
In vitro evaluation of tigemonam, a novel oral monobactam.
Tanaka, S K, Summerill, R A, Minassian, B F, Bush, K, Visnic, D A, Bonner, D P, ...
Tigemonam, a novel, orally administered monobactam, exhibited potent and specific activity in vitro against members of the family Enterobacteriaceae, Haemophilus influenzae, and Neisseria...
Bush, K, Smith, S A, Ohringer, S, Tanaka, S K, Bonner, D P
Tigemonam and temocillin, but not aztreonam, bound to penicillin-binding proteins (PBPs) 1a and 3 of Escherichia coli with apparent improved affinity when challenged with benzylpenicillin at lowered...
Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.
Bush, K, Tanaka, S K, Bonner, D P, Sykes, R B
Strains of Enterobacter cloacae were selected on the basis of resistance to aztreonam, ceftazidime, moxalactam, or imipenem. All strains produced the same E2 beta-lactamase, with an isoelectric point...
In vitro and in vivo evaluations of A-80556, a new fluoroquinolone.
Clement, J J, Tanaka, S K, Alder, J, Vojtko, C, Beyer, J, Hensey, D, ...
A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin,...
Shortridge, V D, Stone, G G, Flamm, R K, Beyer, J, Versalovic, J, Graham, D W, ...
The molecular typing of 81 pretreatment Helicobacter pylori isolates and the comparison of 18 pretreatment-posttreatment pairs is described by restriction fragment length polymorphism (RFLP) of the...
Nilius, A M, Beyer, J M, Flamm, R K, Tanaka, S K
The National Committee for Clinical Laboratory Standards (NCCLS) methods for susceptibility testing of Haemophilus influenzae in Haemophilus test medium allow a pH range of 7.2 to 7.4. However, it is...
Shawar, Ribhi M., MacLeod, David L., Garber, Richard L., Burns, Jane L., Stapp, Jenny R., Clausen, Carla R., ...
The in vitro activity of tobramycin was compared with those of six other antimicrobial agents against 1,240 Pseudomonas aeruginosa isolates collected from 508 patients with cystic fibrosis during...
In vitro evaluation of ABT-719, a novel DNA gyrase inhibitor.
Flamm, R K, Vojtko, C, Chu, D T, Li, Q, Beyer, J, Hensey, D, ...
ABT-719 (A-86719.1) is the first compound of a new class of novel DNA gyrase inhibitors, the 2-pyridones, with potent antibacterial activity against gram-positive, gram-negative, and anaerobic...
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.
Versalovic, J, Shortridge, D, Kibler, K, Griffy, M V, Beyer, J, Flamm, R K, ...
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of...
Stone, G G, Shortridge, D, Versalovic, J, Beyer, J, Flamm, R K, Graham, D Y, ...
We have developed a rapid PCR-oligonucleotide ligation assay that can discriminate single base substitutions that are associated with clarithromycin resistance in Helicobacter pylori. Susceptible...
In vitro evaluation of tigemonam, a novel oral monobactam.
Tanaka, S K, Summerill, R A, Minassian, B F, Bush, K, Visnic, D A, Bonner, D P, ...
Tigemonam, a novel, orally administered monobactam, exhibited potent and specific activity in vitro against members of the family Enterobacteriaceae, Haemophilus influenzae, and Neisseria...
Bush, K, Smith, S A, Ohringer, S, Tanaka, S K, Bonner, D P
Tigemonam and temocillin, but not aztreonam, bound to penicillin-binding proteins (PBPs) 1a and 3 of Escherichia coli with apparent improved affinity when challenged with benzylpenicillin at lowered...
Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.
Bush, K, Tanaka, S K, Bonner, D P, Sykes, R B
Strains of Enterobacter cloacae were selected on the basis of resistance to aztreonam, ceftazidime, moxalactam, or imipenem. All strains produced the same E2 beta-lactamase, with an isoelectric point...
In vitro and in vivo evaluations of A-80556, a new fluoroquinolone.
Clement, J J, Tanaka, S K, Alder, J, Vojtko, C, Beyer, J, Hensey, D, ...
A-80556 is a novel fluoroquinolone with potent antibacterial activity against gram-positive, gram-negative, and anaerobic organisms. A-80556 was more active than ciprofloxacin, ofloxacin,...
Shortridge, V D, Stone, G G, Flamm, R K, Beyer, J, Versalovic, J, Graham, D W, ...
The molecular typing of 81 pretreatment Helicobacter pylori isolates and the comparison of 18 pretreatment-posttreatment pairs is described by restriction fragment length polymorphism (RFLP) of the...
Nilius, A M, Beyer, J M, Flamm, R K, Tanaka, S K
The National Committee for Clinical Laboratory Standards (NCCLS) methods for susceptibility testing of Haemophilus influenzae in Haemophilus test medium allow a pH range of 7.2 to 7.4. However, it is...