Scientific Commons: S. Kliewer

Retinoic acid is a negative regulator of AP-1-responsive genes.

Schüle, R, Rangarajan, P, Yang, N, Kliewer, S, Ransone, L J, Bolado, J, ...

We present evidence that retinoic acid can down-regulate transcriptional activation by the nuclear protooncogene c-jun. All three members of the retinoic acid receptor (RAR) subfamily (RAR alpha, RAR...

Loss of a phosphorylated form of transcription factor CREB/ATF in poliovirus-infected cells.

Kliewer, S, Muchardt, C, Gaynor, R, Dasgupta, A

Host cell RNA synthesis is inhibited by poliovirus infection. We have studied the mechanism of poliovirus-induced inhibition of RNA polymerase II-mediated transcription by using the adenovirus early...

Adenovirus early region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation of CREB/ATF and AP1.

Kornuc, M, Kliewer, S, Garcia, J, Harrich, D, Li, C, Gaynor, R

Transcription of the adenovirus early region 3 promoter is strongly induced by the adenovirus E1A protein. Previous DNase I footprinting has indicated that four regions in this promoter serve as...

Multiple transcriptional regulatory domains in the human immunodeficiency virus type 1 long terminal repeat are involved in basal and E1A/E1B-induced promoter activity.

Kliewer, S, Garcia, J, Pearson, L, Soultanakis, E, Dasgupta, A, Gaynor, R

The human immunodeficiency virus (HIV) type 1 long terminal repeat (LTR) is the site of activation of the HIV tat protein. However, additional transactivators, such as the adenovirus E1A and...

An RNA polymerase II transcription factor inactivated in poliovirus-infected cells copurifies with transcription factor TFIID.

Kliewer, S, Dasgupta, A

Inhibition of host cell RNA polymerase II-mediated transcription by poliovirus infection was studied in vitro. Whole-cell extracts prepared from poliovirus-infected HeLa cells at 3 h postinfection...