Nef, H. M., Mollmann, H., Troidl, C., Kostin, S., Bottger, T., Voss, S., ...
Tako-Tsubo cardiomyopathy (TTC) is characterized by a transient contractile dysfunction, but its specific pathomechanism remains unknown. Thus, we performed a systematic expression profiling of genes...
Atrial extracellular matrix remodeling in patients with atrial fibrillation (2008)
Polyakova, V., Miyagawa, S., Szalay, Z., Risteli, J., Kostin, S.
Background: Atrial fibrillation (AF) is the most frequent clinical arrhythmia. Atrial fibrosis is an important factor in initiating and maintaining AF. However, the collagen turnover and its...
Inflammatory cardiomyopathy and premature aging in Sirt7 devicient mice. (2008)
Vahkrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Böttger, T., Kubin, T., ...
Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., Kubin, T., ...
Sirt7 is a member of the mammalian sirtuin family consisting of 7 genes, Sirt1 to Sirt7, which all share a homology to the founding family member, the yeast Sir2 gene. Most sirtuins are supposed to...
Ebelt, H., Jungblut, M., Zhang, Y., Kubin, T., Kostin, S., Technau, A., ...
A growing number of studies are reporting beneficial effects of the transplantation of alleged cardiac stem cells into diseased hearts after myocardial infarction. However, the mechanisms by which...
Ebelt, H., Jungblut, M., Zhang, Y., Kubin, T., Kostin, S., Technau, A., ...
A growing number of studies are reporting beneficial effects of the transplantation of alleged cardiac stem cells into diseased hearts after myocardial infarction. However, the mechanisms by which...
Mees, B., Wagner, S., Ninci, E., Tribulova, S., Martin, S., Van Haperen, R., ...
OBJECTIVE: Arteriogenesis is the major mechanism of vascular growth, which is able to compensate for blood flow deficiency after arterial occlusion. Endothelial nitric oxide synthase (eNOS) activity...
Fischer, S., Gerriets, T., Wessels, C., Walberer, M., Kostin, S., Stolz, E., ...
Cell injury leads to exposure of intracellular material and is associated with increased permeability of vessels in the vicinity of the damage. Here, we demonstrate that natural extracellular RNA as...
Nef, H. M., Mollmann, H., Hilpert, P., Masseli, F., Kostin, S., Troidl, C., ...
Tako-Tsubo cardiomyopathy (TTC) which is usually precipitated by profound emotional stress has been widely reported in the past. Recently, several co-morbidities have been found to be associated with...
Nef, H. M., Mollmann, H., Kostin, S., Troidl, C., Voss, S., Weber, M., ...
AIMS: To gain more insight into the phenomenon of Tako-Tsubo cardiomyopathy (TTC), the purpose of the present study was to investigate the myocardial structure in the acute phase of TTC and after...
Schneider, M., Kostin, S., Strom, C. C., Aplin, M., Lyngbaek, S., Theilade, J., ...
OBJECTIVE: The multifunctional Ca2+-binding protein S100A4 (also known as Mts1 and Fsp1) is involved in fibrosis and tissue remodeling in several diseases including cancer, kidney fibrosis, central...
Kumar, S., Kasseckert, S., Kostin, S., Abdallah, Y., Schafer, C., Kaminski, A., ...
OBJECTIVE: Myocardial ischemia has been shown to induce apoptosis of endothelial cells (EC). However, the mechanism of this endothelial injury is still poorly understood. To analyse the signaling...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
Bone marrow-derived cells contribute to infarct remodelling (2006)
Mollmann, H., Nef, H. M., Kostin, S., Von Kalle, C., Pilz, I., Weber, M., ...
OBJECTIVE: The paradigm that cardiac myocytes are non-proliferating and terminally differentiated cells has recently been challenged by several studies reporting the ability of bone marrow-derived...
Nef, H. M., Mollmann, H., Skwara, W., Bolck, B., Schwinger, R. H., Hamm, Ch, ...
Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity...
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B. R., Schaper, J.
In this study we tested our previous hypothesis that ischemia is a multifactorial injurious event involving all components of the myocyte simultaneously. This hypothesis was based on ultrastructural...
Pathways of myocyte death: implications for development of clinical laboratory biomarkers (2005)
The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death in the...
Schwarz, E. R., Gupta, R., Diep, T. P., Nowak, B., Kostin, S., Grohmann, B., ...
BACKGROUND: We tested the hypothesis of whether carvedilol delays morphologic degeneration and improves functional outcome compared with metoprolol tartrate in patients with hibernating myocardium...
Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes (2005)
Zeevi-Levin, N., Barac, Y. D., Reisner, Y., Reiter, I., Yaniv, G., Meiry, G., ...
OBJECTIVES: Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Van Empel, V. P., Bertrand, A. T., Van Der Nagel, R., Kostin, S., Doevendans, P. A., Crijns, H. J., ...
Apoptosis-inducing factor (AIF), or programmed cell death 8 (Pdcd8), is a highly conserved, ubiquitous flavoprotein localized in the mitochondrial intermembrane space. In vivo, AIF provides...
Van Empel, V. P., Bertrand, A. T., Van Der Nagel, R., Kostin, S., Doevendans, P. A., Crijns, H. J., ...
Apoptosis-inducing factor (AIF), or programmed cell death 8 (Pdcd8), is a highly conserved, ubiquitous flavoprotein localized in the mitochondrial intermembrane space. In vivo, AIF provides...
Kubin, T., Tomars, M., Fach, C., Hein, S., Bramlage, P., Shim, G. J., ...
We have observed increased levels of transforming growth factor-beta1 (TGF-beta1) in human hibernating myocardium (HM). Impaired ventricular function in HM is known to be restored to normal following...
Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes (2005)
Zeevi-Levin, N., Barac, Y. D., Reisner, Y., Reiter, I., Yaniv, G., Meiry, G., ...
OBJECTIVES: Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested...
Schwarz, E. R., Gupta, R., Diep, T. P., Nowak, B., Kostin, S., Grohmann, B., ...
BACKGROUND: We tested the hypothesis of whether carvedilol delays morphologic degeneration and improves functional outcome compared with metoprolol tartrate in patients with hibernating myocardium...
Pathways of myocyte death: implications for development of clinical laboratory biomarkers (2005)
The recognition that cardiac myocytes die by multiple mechanisms and thus substantially affect ventricular remodeling in diseased human hearts supports the concept of ongoing myocyte death in the...
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B. R., Schaper, J.
In this study we tested our previous hypothesis that ischemia is a multifactorial injurious event involving all components of the myocyte simultaneously. This hypothesis was based on ultrastructural...
Ischemia depletes dystrophin and inhibits protein synthesis in the canine heart (2005)
Rodriguez, M., Cai, W. J., Kostin, S., Lucchesi, B.R., Schaper, J.
Bone marrow-derived cells do not incorporate into the adult growing vasculature (2004)
Ziegelhoeffer, T., Fernandez, B., Kostin, S., Heil, M., Voswinckel, R., Helisch, A., ...
Bone marrow-Derived cells have been proposed to form new vessels or at least incorporate into growing vessels in adult organisms under certain physiological and pathological conditions. We...
Toyo-Oka, T., Kawada, T., Nakata, J., Xie, H., Urabe, M., Masui, F., ...
Human hibernating myocardium is jeopardized by apoptotic and autophagic cell death (2004)
Elsaesser, A., Vogt AM, Nef, H.M., Kostin, S., Mollmann, H., Skwara, W., ...
Polyakova, V., Hein, S., Kostin, S., Ziegelhoeffer, T., Schaper, J.
OBJECTIVES: We studied the role of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in fibrosis formation in the transition from hypertrophy to heart failure (HF) as well as the...
Fibroblast growth factors in arteriogenesis (2004)
Zimmermann, R., Fernandez, B., Bühler, A., Martire, A., Kostin, S., Strohm, C., ...
Toyo-Oka, T., Kawada, T., Nakata, J., Xie, H., Urabe, M., Masui, F., ...
Remodeling of the adventitia during coronary arteriogenesis (2003)
Cai, W. J., Koltai, S., Kocsis, E., Scholz, D., Kostin, S., Luo, X., ...
We studied the role of the adventitia in adaptive arteriogenesis during the phase of active growth of coronary collateral vessels (CV) induced by chronic occlusion of the left circumflex coronary...
Hein, S., Arnon, E., Kostin, S., Schonburg, M., Elsasser, A., Polyakova, V., ...
BACKGROUND: The progression of compensated hypertrophy to heart failure (HF) is still debated. We investigated patients with isolated valvular aortic stenosis and differing degrees of left...
Myocytes die by multiple mechanisms in failing human hearts (2003)
Kostin, S., Pool, L., Elsasser, A., Hein, S., Drexler, H. C., Arnon, E., ...
We tested the hypothesis that myocyte loss in failing human hearts occurs by different mechanisms: apoptosis, oncosis, and autophagic cell death. Explanted hearts from 19 patients with idiopathic...
Gap junction remodeling and altered connexin43 expression in the failing human heart (2003)
Kostin, S., Rieger, M., Dammer, S., Hein, S., Richter, M., Klovekorn, W. P., ...
Gap junctions (GJ) are important determinants of cardiac conduction and the evidence has recently emerged that altered distribution of these junctions and changes in the expression of their...
Circulating vascular progenitor cells do not contribute to compensatory lung growth. (2003)
Voswinckel, R., Ziegelhoeffer, T., Heil, M., Kostin, S., Breier, G., Mehling, T., ...
Tissue engineering of a differentiated cardiac muscle construct (2002)
Zimmermann, W.-H., Schneiderbanger, K., Schubert, P., Didié, M., Münzel, F., Heubach, J.F., ...
Blood monocyte concentration is critical for enhancement o collateral artery growth (2002)
Heil, M., Ziegelhoeffer, T., Pipp, F., Kostin, S., Martin, S., Clauss, M., ...
Blood monocyte concentration is critical for enhancement of collateral artery growth (2002)
Heil, M., Ziegelhoeffer, T., Pipp, F., Kostin, S., Martin, S., Clauss, M., ...
0.1152/ajpheart. 01098.2001.-Arteriogenesis has been associated with the presence of monocytes/macrophages within the collateral vessel wall. We tested the hypothesis that arteriogenesis is...
Functional disturbances due to structural remodelling in the failing human heart (2002)
Hein, S., Elsässer, A., Kostin, S., Zimmermann, R., Schaper, J.
Structural correlate of atrial fibrillation in human patients (2002)
Kostin, S., Klein, G., Szalay, Z., Hein, S., Bauer, E.P., Schaper, J.
Structural remodelling in heart failure (2002)
Schaper, J., Kostin, S., Hein, S., Elsässer, A., Arnon, E., Zimmermann, R.
Zonula occludens-1 and connexin 43 expression in the failing human heart
Focal disorganization of gap junctional distribution and down-regulation of the major gap junctional protein connexin 43 are typical features of myocardial remodelling in the failing human heart....
Importance of bicarbonate transport for ischaemia-induced apoptosis of coronary endothelial cells
Kumar, S., Kasseckert, S., Kostin, S., Abdallah, Y., Piper, H. M., Steinhoff, G., ...
Bicarbonate transport (BT) has been previously shown to participate in apoptosis induced by various stress factors. However, the precise role of BT in ischaemia-induced apoptosis is still unknown. To...