In vitro and in vivo antibacterial activities of CS-834, a novel oral carbapenem.
Fukuoka, T, Ohya, S, Utsui, Y, Domon, H, Takenouchi, T, Koga, T, ...
CS-834 is a novel oral carbapenem antibiotic. This compound is an ester-type prodrug of the active metabolite R-95867. The antibacterial activity of R-95867 was tested against 1,323 clinical isolates...
In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic.
Kamimura, T, Kojo, H, Matsumoto, Y, Mine, Y, Goto, S, Kuwahara, S
FK 027 was more active than cefaclor, cephalexin, and amoxicillin against stock strains of a wide variety of gram-negative bacteria, including such opportunistic pathogens as Citrobacter and...
Hendrix, C W, Flexner, C, Szebeni, J, Kuwahara, S, Pennypacker, S, Weinstein, J N, ...
Zidovudine delays the progression of infection and prolongs the survival of human immunodeficiency virus (HIV)-infected patients, but these benefits are limited by dose-related toxicity and the cost...
Yokota, Y, Wakai, Y, Mine, Y, Goto, S, Nishida, M, Kuwahara, S
The host defense against respiratory tract infection with Klebsiella pneumoniae was much weaker in 60-week-old mice than in 4-week-old mice, but the resistance against systemic infection by...
Ito, T, Kuwahara, S, Yokota, T
Automated and manual latex agglutination methods were employed to measure cholera toxin (CT), heat-labile enterotoxin (LT) of Escherichia coli, and their subunits A and B. Dow polystyrene latex...
Nozawa, R T, Yokota, T, Kuwahara, S
As Chinese hamster ovary (CHO) cells on plastic proliferate, many cells float off into the medium instead of piling up after they form a monolayer. Fewer cells were floating in the medium when CHO...
Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities.
Kamimura, T, Matsumoto, Y, Okada, N, Mine, Y, Nishida, M, Goto, S, ...
FK 749 is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and...
Kojo, H, Nishida, M, Goto, S, Kuwahara, S
Antibacterial activity of FK 749 against ampicillin-resistant clinical isolates of Escherichia coli was compared with those of other newly developed cephalosporins. FK 749 was the most active against...
Nonoyama, S, Kojo, H, Mine, Y, Nishida, M, Goto, S, Kuwahara, S
A clinically isolated strain of polymorphonuclear leukocyte (PMN)-resistant Pseudomonas was found to produce an extracellular substance (PMN inhibitor) that inhibits the phagocytic and killing...
Nonoyama, S, Kojo, H, Mine, Y, Nishida, M, Goto, S, Kuwahara, S
The polymorphonuclear leukocyte (PMN) inhibitor isolated from a strain of Pseudomonas aeruginosa which is resistant to the phagocytic and killing activities of rabbit PMN inhibited migration of PMN...
Increased adhesion of Chinese hamster ovary cells to substratum by cholera enterotoxin.
Nozawa, R, Kon, F, Yokota, T, Ohashi, M, Kuwahara, S
A new, simple assay method using Chinese hamster ovary cells was devised for cholera enterotoxin. The effect of the cholera toxin was measured by an increase in cell adhesion to the substratum. The...
Kamimura, T, Mine, Y, Nonoyama, S, Nishida, M, Goto, S, Kuwahara, S
Polymorphonuclear leukocyte (PMN)-resistant strains of Pseudomonas aeruginosa had the ability to interfere with phagocytosis of Escherichia coli, whereas PMN-sensitive strains of P. aeruginosa did...
In vitro and in vivo antibacterial activities of CS-834, a novel oral carbapenem.
Fukuoka, T, Ohya, S, Utsui, Y, Domon, H, Takenouchi, T, Koga, T, ...
CS-834 is a novel oral carbapenem antibiotic. This compound is an ester-type prodrug of the active metabolite R-95867. The antibacterial activity of R-95867 was tested against 1,323 clinical isolates...
In vitro and in vivo antibacterial properties of FK 027, a new orally active cephem antibiotic.
Kamimura, T, Kojo, H, Matsumoto, Y, Mine, Y, Goto, S, Kuwahara, S
FK 027 was more active than cefaclor, cephalexin, and amoxicillin against stock strains of a wide variety of gram-negative bacteria, including such opportunistic pathogens as Citrobacter and...
Hendrix, C W, Flexner, C, Szebeni, J, Kuwahara, S, Pennypacker, S, Weinstein, J N, ...
Zidovudine delays the progression of infection and prolongs the survival of human immunodeficiency virus (HIV)-infected patients, but these benefits are limited by dose-related toxicity and the cost...
Yokota, Y, Wakai, Y, Mine, Y, Goto, S, Nishida, M, Kuwahara, S
The host defense against respiratory tract infection with Klebsiella pneumoniae was much weaker in 60-week-old mice than in 4-week-old mice, but the resistance against systemic infection by...
Ito, T, Kuwahara, S, Yokota, T
Automated and manual latex agglutination methods were employed to measure cholera toxin (CT), heat-labile enterotoxin (LT) of Escherichia coli, and their subunits A and B. Dow polystyrene latex...
Nozawa, R T, Yokota, T, Kuwahara, S
As Chinese hamster ovary (CHO) cells on plastic proliferate, many cells float off into the medium instead of piling up after they form a monolayer. Fewer cells were floating in the medium when CHO...
Ceftizoxime (FK 749), a new parenteral cephalosporin: in vitro and in vivo antibacterial activities.
Kamimura, T, Matsumoto, Y, Okada, N, Mine, Y, Nishida, M, Goto, S, ...
FK 749 is a new parenteral cephalosporin derivative which is more active against various gram-negative bacilli, including the opportunistic pathogens such as Enterobacter, Citrobacter species, and...
Kojo, H, Nishida, M, Goto, S, Kuwahara, S
Antibacterial activity of FK 749 against ampicillin-resistant clinical isolates of Escherichia coli was compared with those of other newly developed cephalosporins. FK 749 was the most active against...
Nonoyama, S, Kojo, H, Mine, Y, Nishida, M, Goto, S, Kuwahara, S
A clinically isolated strain of polymorphonuclear leukocyte (PMN)-resistant Pseudomonas was found to produce an extracellular substance (PMN inhibitor) that inhibits the phagocytic and killing...
Nonoyama, S, Kojo, H, Mine, Y, Nishida, M, Goto, S, Kuwahara, S
The polymorphonuclear leukocyte (PMN) inhibitor isolated from a strain of Pseudomonas aeruginosa which is resistant to the phagocytic and killing activities of rabbit PMN inhibited migration of PMN...
Increased adhesion of Chinese hamster ovary cells to substratum by cholera enterotoxin.
Nozawa, R, Kon, F, Yokota, T, Ohashi, M, Kuwahara, S
A new, simple assay method using Chinese hamster ovary cells was devised for cholera enterotoxin. The effect of the cholera toxin was measured by an increase in cell adhesion to the substratum. The...
Kamimura, T, Mine, Y, Nonoyama, S, Nishida, M, Goto, S, Kuwahara, S
Polymorphonuclear leukocyte (PMN)-resistant strains of Pseudomonas aeruginosa had the ability to interfere with phagocytosis of Escherichia coli, whereas PMN-sensitive strains of P. aeruginosa did...