S. L. Ackerman

Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation (2005)

Van Empel, V. P., Bertrand, A. T., Kostin, S., Doevendans, P. A., Crijns, H. J., ...

Apoptosis-inducing factor (AIF), or programmed cell death 8 (Pdcd8), is a highly conserved, ubiquitous flavoprotein localized in the mitochondrial intermembrane space. In vivo, AIF provides...

Downregulation of apoptosis-inducing factor in harlequin mutant mice sensitizes the myocardium to oxidative stress-related cell death and pressure overload-induced decompensation (2005)

Van Empel, V. P., Bertrand, A. T., Kostin, S., Doevendans, P. A., Crijns, H. J., ...

Apoptosis-inducing factor (AIF), or programmed cell death 8 (Pdcd8), is a highly conserved, ubiquitous flavoprotein localized in the mitochondrial intermembrane space. In vivo, AIF provides...

Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells (2001)

Barclay, J., Mione, M., Ackerman, S.L., Letts, V.A., Brodbeck, J., Canti, C., ...

The mouse mutant ducky, a model for absence epilepsy, is characterized by spike-wave seizures and ataxia. The ducky gene was mapped previously to distal mouse chromosome 9. High-resolution genetic...

Preparation and screening of an arrayed human genomic library generated with the P1 cloning system.

Shepherd, N S, Pfrogner, B D, Coulby, J N, Ackerman, S L, Vaidyanathan, G, Sauer, R H, ...

We describe here the construction and initial characterization of a 3-fold coverage genomic library of the human haploid genome that was prepared using the bacteriophage P1 cloning system. The cloned...

The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry.

Ackerman, S L, Minden, A G, Yeung, C Y

The murine adenosine deaminase gene has a structurally archetypal TATAA-box-deficient G+C-rich promoter. The three Sp1 binding sites of the promoter are neither necessary nor sufficient for promoter...

Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

Ackerman, S L, Minden, A G, Williams, G T, Bobonis, C, Yeung, C Y

The murine adenosine deaminase (ADA) gene has a (G + C)-rich promoter that can support diverse tissue-specific gene expression. By using deletion and mutation analyses, we have identified a...

Preparation and screening of an arrayed human genomic library generated with the P1 cloning system.

Shepherd, N S, Pfrogner, B D, Coulby, J N, Ackerman, S L, Vaidyanathan, G, Sauer, R H, ...

We describe here the construction and initial characterization of a 3-fold coverage genomic library of the human haploid genome that was prepared using the bacteriophage P1 cloning system. The cloned...

The minimal self-sufficient element in a murine G+C-rich promoter is a large element with imperfect dyad symmetry.

Ackerman, S L, Minden, A G, Yeung, C Y

The murine adenosine deaminase gene has a structurally archetypal TATAA-box-deficient G+C-rich promoter. The three Sp1 binding sites of the promoter are neither necessary nor sufficient for promoter...

Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

Ackerman, S L, Minden, A G, Williams, G T, Bobonis, C, Yeung, C Y

The murine adenosine deaminase (ADA) gene has a (G + C)-rich promoter that can support diverse tissue-specific gene expression. By using deletion and mutation analyses, we have identified a...