In Situ TEM Investigation of the Oxidation of Titanium Aluminide Alloys. (1998)
Welsch, G., Friedman, S. L., Kahveci, A. I.
Oxide nucleation and growth on Ti3Al, Ti3Al/Nb and TiAl were studied using TEM during in-situ oxidation at 600-700 C. Dislocations, grain boundaries and second phases, which are the preferential...
Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.
Rockey, D C, Housset, C N, Friedman, S L
Hepatic lipocytes are perisinusoidal cells that have been thought to be analogous to tissue pericytes, a cell type with purported vasoregulatory properties. However, we and others have recently...
Wong, L, Yamasaki, G, Johnson, R J, Friedman, S L
A consistent response to liver injury is the activation of resident mesenchymal cells known as lipocytes (Ito, fat-storing cells) into a proliferating cell type. In cultured lipocytes,...
Maher, J J, Bissell, D M, Friedman, S L, Roll, F J
The cellular origin of hepatic collagen is under active investigation. Several recent studies using cells in primary culture suggest that hepatocytes are the source of much of the collagen in normal...
Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type. We have studied the...
Arthur, M J, Friedman, S L, Roll, F J, Bissell, D M
We report a proteinase that degrades basement-membrane (type IV) collagen and is produced by the liver. Its cellular source is lipocytes (fat-storing or Ito cells). Lipocytes were isolated from...
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S L, Roll, F J, Boyles, J, Bissell, D M
Hepatic lipocytes were isolated from normal rat liver and established in culture. A virtually pure isolate was obtained by fractionating enzymatically digested liver on a discontinuous gradient of...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Lee, S J, Friedman, S L, Whalen, R, Boyer, T D
Hepatocytes in vivo express Alpha and Mu but not Pi forms of glutathione S-transferase (GST). GST P (a fetal Pi form) appears in rat hepatocytes after 2 days in primary culture, which suggests that...
Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.
Rockey, D C, Housset, C N, Friedman, S L
Hepatic lipocytes are perisinusoidal cells that have been thought to be analogous to tissue pericytes, a cell type with purported vasoregulatory properties. However, we and others have recently...
Wong, L, Yamasaki, G, Johnson, R J, Friedman, S L
A consistent response to liver injury is the activation of resident mesenchymal cells known as lipocytes (Ito, fat-storing cells) into a proliferating cell type. In cultured lipocytes,...
Maher, J J, Bissell, D M, Friedman, S L, Roll, F J
The cellular origin of hepatic collagen is under active investigation. Several recent studies using cells in primary culture suggest that hepatocytes are the source of much of the collagen in normal...
Hepatic lipocytes appear to be central to the pathogenesis of hepatic fibrosis, undergoing activation during inflammation to a matrix-producing, proliferative cell type. We have studied the...
Arthur, M J, Friedman, S L, Roll, F J, Bissell, D M
We report a proteinase that degrades basement-membrane (type IV) collagen and is produced by the liver. Its cellular source is lipocytes (fat-storing or Ito cells). Lipocytes were isolated from...
Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.
Friedman, S L, Roll, F J, Boyles, J, Bissell, D M
Hepatic lipocytes were isolated from normal rat liver and established in culture. A virtually pure isolate was obtained by fractionating enzymatically digested liver on a discontinuous gradient of...
Iredale, J P, Murphy, G, Hembry, R M, Friedman, S L, Arthur, M J
Hepatic lipocytes play a central role in the pathogenesis of liver fibrosis, both via production of extracellular matrix proteins and through secretion of matrix metalloproteinases. In this study, we...
Arthur, M J, Stanley, A, Iredale, J P, Rafferty, J A, Hembry, R M, Friedman, S L
The matrix metalloproteinases play an important role in matrix degradation, but there is limited information about this family of enzymes in either normal or diseased human liver. In this study, we...
Lee, S J, Friedman, S L, Whalen, R, Boyer, T D
Hepatocytes in vivo express Alpha and Mu but not Pi forms of glutathione S-transferase (GST). GST P (a fetal Pi form) appears in rat hepatocytes after 2 days in primary culture, which suggests that...
Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis
Xu, L, Hui, A Y, Albanis, E, Arthur, M J, O’Byrne, S M, Blaner, W S, ...
Background: Hepatic stellate cells (HSCs) are a major fibrogenic cell type that contributes to collagen accumulation during chronic liver disease. With increasing interest in developing antifibrotic...