Kavanaugh, M P, Miller, D G, Zhang, W, Law, W, Kozak, S L, Kabat, D, ...
Cell surface receptors for gibbon ape leukemia virus (Glvr-1) and murine amphotropic retrovirus (Ram-1) are distinct but related proteins having multiple membrane-spanning regions. Distant homology...
Hoatlin, M E, Kozak, S L, Lilly, F, Chakraborti, A, Kozak, C A, Kabat, D
The leukemogenic membrane glycoprotein (gp55) encoded by Friend spleen focus-forming virus appears to bind to erythropoietin receptors (EpoR) sto stimulate erythroblastosis [Li, J.-P., D'Andrea,...
Hoatlin, M E, Ferro, F E, Geib, R W, Fox, M T, Kozak, S L, Kabat, D
Although the Friend virus-encoded membrane glycoprotein (gp55) activates erythropoietin receptors (EpoR) to cause erythroblastosis only in certain inbred strains of mice but not in other species,...
Kozak, S L, Siess, D C, Kavanaugh, M P, Miller, A D, Kabat, D
A rat cDNA (rRam-1), which was cloned on the basis that it enables Chinese hamster ovary (CHO) cells to be infected by amphotropic host range murine retroviruses, was recently found to encode a...
Siess, D C, Kozak, S L, Kabat, D
Chinese hamster ovary (CHO) cells are naturally resistant to infection by amphotropic and ecotropic murine retroviruses, but they become susceptible after expressing corresponding receptors rRAM-1...
Wang, H, Klamo, E, Kuhmann, S E, Kozak, S L, Kavanaugh, M P, Kabat, D
The cell surface receptor for ecotropic host-range (infection limited to mice or rats) murine leukemia viruses (MuLVs) is the widely expressed system y+ transporter for cationic amino acids (CAT-1)....
Kozak, S L, Platt, E J, Madani, N, Ferro, F E, Peden, K, Kabat, D
We have used a focal infectivity method to quantitatively analyze the CD4, CXCR-4, and CCR-5 dependencies for infections by diverse primary patient (PR) and laboratory-adapted (LA) isolates of human...
Platt, E J, Madani, N, Kozak, S L, Kabat, D
Recent evidence suggests that primary patient isolates of T-cell-tropic human immunodeficiency virus type 1 (HIV-1 ) have lower affinities for CD4 than their laboratory-adapted derivatives, that this...
Kuhmann, S E, Platt, E J, Kozak, S L, Kabat, D
CCR5, a receptor for the CC chemokines RANTES, Mip1alpha, and Mip1beta, has been identified as a coreceptor for infections by macrophage-tropic isolates of human immunodeficiency virus type 1...
Kabat, D, Kozak, S L, Wehrly, K, Chesebro, B
CD4 is known to be an important receptor for human immunodeficiency virus type 1 (HIV-1) infection of T lymphocytes and macrophages. However, the limiting steps in CD4-dependent HIV-1 infections in...
A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.
Hoatlin, M E, Ferro, F E, Kozak, S L, Kabat, D
The Pvu delta mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, Pvu delta causes...
Kozak, S L, Hoatlin, M E, Ferro, F E, Majumdar, M K, Geib, R W, Fox, M T, ...
The env gene of Friend spleen focus-forming virus (SFFV) encodes a membrane glycoprotein (gp55) that is inefficiently (3 to 5%) processed from the rough endoplasmic reticulum to form a larger dimeric...
Paul, R, Schuetze, S, Kozak, S L, Kozak, C A, Kabat, D
Previous studies identified a common site (Sfpi-1) for proviral integration in immortalized Friend erythroleukemias. cDNAs corresponding to a 1.5-kb Sfpi-1 mRNA were isolated and sequenced. These...
Retroviral vectors offer major advantages for gene transfer studies but have not been useful for producing proteins in large quantities. This deficiency has resulted in part from interference to...
Paul, R, Schuetze, S, Kozak, S L, Kabat, D
By using a tagged derivative of Friend spleen focus-forming virus, we previously obtained evidence that proviral integration(s) in the host genome can cause erythroblast immortality by abrogating the...
Bestwick, R K, Kozak, S L, Kabat, D
A procedure is described for stably expressing cloned genes at high levels in vertebrate cells and for obtaining these genes in high-titer virus preparations. The process uses retroviral vectors and...
Kavanaugh, M P, Miller, D G, Zhang, W, Law, W, Kozak, S L, Kabat, D, ...
Cell surface receptors for gibbon ape leukemia virus (Glvr-1) and murine amphotropic retrovirus (Ram-1) are distinct but related proteins having multiple membrane-spanning regions. Distant homology...
Hoatlin, M E, Kozak, S L, Lilly, F, Chakraborti, A, Kozak, C A, Kabat, D
The leukemogenic membrane glycoprotein (gp55) encoded by Friend spleen focus-forming virus appears to bind to erythropoietin receptors (EpoR) sto stimulate erythroblastosis [Li, J.-P., D'Andrea,...
Hoatlin, M E, Ferro, F E, Geib, R W, Fox, M T, Kozak, S L, Kabat, D
Although the Friend virus-encoded membrane glycoprotein (gp55) activates erythropoietin receptors (EpoR) to cause erythroblastosis only in certain inbred strains of mice but not in other species,...
Kozak, S L, Siess, D C, Kavanaugh, M P, Miller, A D, Kabat, D
A rat cDNA (rRam-1), which was cloned on the basis that it enables Chinese hamster ovary (CHO) cells to be infected by amphotropic host range murine retroviruses, was recently found to encode a...
Siess, D C, Kozak, S L, Kabat, D
Chinese hamster ovary (CHO) cells are naturally resistant to infection by amphotropic and ecotropic murine retroviruses, but they become susceptible after expressing corresponding receptors rRAM-1...
Wang, H, Klamo, E, Kuhmann, S E, Kozak, S L, Kavanaugh, M P, Kabat, D
The cell surface receptor for ecotropic host-range (infection limited to mice or rats) murine leukemia viruses (MuLVs) is the widely expressed system y+ transporter for cationic amino acids (CAT-1)....
Kozak, S L, Platt, E J, Madani, N, Ferro, F E, Peden, K, Kabat, D
We have used a focal infectivity method to quantitatively analyze the CD4, CXCR-4, and CCR-5 dependencies for infections by diverse primary patient (PR) and laboratory-adapted (LA) isolates of human...
Platt, E J, Madani, N, Kozak, S L, Kabat, D
Recent evidence suggests that primary patient isolates of T-cell-tropic human immunodeficiency virus type 1 (HIV-1 ) have lower affinities for CD4 than their laboratory-adapted derivatives, that this...
Kuhmann, S E, Platt, E J, Kozak, S L, Kabat, D
CCR5, a receptor for the CC chemokines RANTES, Mip1alpha, and Mip1beta, has been identified as a coreceptor for infections by macrophage-tropic isolates of human immunodeficiency virus type 1...
Kabat, D, Kozak, S L, Wehrly, K, Chesebro, B
CD4 is known to be an important receptor for human immunodeficiency virus type 1 (HIV-1) infection of T lymphocytes and macrophages. However, the limiting steps in CD4-dependent HIV-1 infections in...
A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.
Hoatlin, M E, Ferro, F E, Kozak, S L, Kabat, D
The Pvu delta mutant of Friend spleen focus-forming virus encodes the smallest env glycoprotein (apparent M(r), 41,000) known to activate erythropoietin receptors. In vivo, Pvu delta causes...
Kozak, S L, Hoatlin, M E, Ferro, F E, Majumdar, M K, Geib, R W, Fox, M T, ...
The env gene of Friend spleen focus-forming virus (SFFV) encodes a membrane glycoprotein (gp55) that is inefficiently (3 to 5%) processed from the rough endoplasmic reticulum to form a larger dimeric...
Paul, R, Schuetze, S, Kozak, S L, Kozak, C A, Kabat, D
Previous studies identified a common site (Sfpi-1) for proviral integration in immortalized Friend erythroleukemias. cDNAs corresponding to a 1.5-kb Sfpi-1 mRNA were isolated and sequenced. These...
Retroviral vectors offer major advantages for gene transfer studies but have not been useful for producing proteins in large quantities. This deficiency has resulted in part from interference to...
Paul, R, Schuetze, S, Kozak, S L, Kabat, D
By using a tagged derivative of Friend spleen focus-forming virus, we previously obtained evidence that proviral integration(s) in the host genome can cause erythroblast immortality by abrogating the...
Bestwick, R K, Kozak, S L, Kabat, D
A procedure is described for stably expressing cloned genes at high levels in vertebrate cells and for obtaining these genes in high-titer virus preparations. The process uses retroviral vectors and...