Greaves, L.C., Preston, S.L., Tadrous, P.J., Taylor, R.W., Barron, M.J., Oukrif, D., ...
The understanding of the fixation of mutations within human tissues and their subsequent clonal expansion is a considerable problem, of which little is known. We have previously shown that...
Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...
The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...
A Population Pharmacokinetic Analysis of the Penetration of the Prostate by Levofloxacin
Drusano, G. L., Preston, S. L., Van Guilder, M., North, D., Gombert, M., Oefelein, M., ...
Prostatitis has remained a pathological entity that is difficult to treat. Part of the difficulty revolves about the putative offending pathogens. For acute prostatitis, members of the...
Drusano, G. L., Preston, S. L., Hardalo, C., Hare, R., Banfield, C., Andes, D., ...
One of the most challenging issues in the design of phase II/III clinical trials of antimicrobial agents is dose selection. The choice is often based on preclinical data from pharmacokinetic (PK)...
Drusano, G. L., Preston, S. L., Smee, D., Bush, K., Bailey, K., Sidwell, R. W.
We examined RWJ-270201 in a lethal model of influenza in BALB/c mice. The aim was to delineate the pharmacodynamically linked variable for the drug. Challenge was performed with influenza virus...
Drusano, G. L., Preston, S. L., Gotfried, M. H., Danziger, L. H., Rodvold, K. A.
Levofloxacin was administered orally to steady state to volunteers randomly in doses of 500 and 750 mg. Plasma and epithelial lining fluid (ELF) samples were obtained at 4, 12, and 24 h after the...
The new stem cell biology: something for everyone
Preston, S L, Alison, M R, Forbes, S J, Direkze, N C, Poulsom, R, Wright, N A
The ability of multipotential adult stem cells to cross lineage boundaries (transdifferentiate) is currently causing heated debate in the scientific press. The proponents see adult stem cells as an...
Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., ...
The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and...
A Population Pharmacokinetic Analysis of the Penetration of the Prostate by Levofloxacin
Drusano, G. L., Preston, S. L., Van Guilder, M., North, D., Gombert, M., Oefelein, M., ...
Prostatitis has remained a pathological entity that is difficult to treat. Part of the difficulty revolves about the putative offending pathogens. For acute prostatitis, members of the...
Drusano, G. L., Preston, S. L., Hardalo, C., Hare, R., Banfield, C., Andes, D., ...
One of the most challenging issues in the design of phase II/III clinical trials of antimicrobial agents is dose selection. The choice is often based on preclinical data from pharmacokinetic (PK)...
Drusano, G. L., Preston, S. L., Smee, D., Bush, K., Bailey, K., Sidwell, R. W.
We examined RWJ-270201 in a lethal model of influenza in BALB/c mice. The aim was to delineate the pharmacodynamically linked variable for the drug. Challenge was performed with influenza virus...
Drusano, G. L., Preston, S. L., Gotfried, M. H., Danziger, L. H., Rodvold, K. A.
Levofloxacin was administered orally to steady state to volunteers randomly in doses of 500 and 750 mg. Plasma and epithelial lining fluid (ELF) samples were obtained at 4, 12, and 24 h after the...
The new stem cell biology: something for everyone
Preston, S L, Alison, M R, Forbes, S J, Direkze, N C, Poulsom, R, Wright, N A
The ability of multipotential adult stem cells to cross lineage boundaries (transdifferentiate) is currently causing heated debate in the scientific press. The proponents see adult stem cells as an...
Recipes for adult stem cell plasticity: fusion cuisine or readymade?
Alison, M R, Poulsom, R, Otto, W R, Vig, P, Brittan, M, Direkze, N C, ...
A large body of evidence supports the idea that certain adult stem cells, particularly those of bone marrow origin, can engraft at alternative locations, particularly when the recipient organ is...