Ayisi, N K, De Clercq, E, Wall, R A, Hughes, H, Sacks, S L
(E)-5-(2-Bromovinyl)-2'-deoxyuridine is a potent antiherpes compound with far better activity against herpes simplex virus type 1 than type 2. To understand the role of drug metabolism in this...
Sacks, S L, Scullard, G H, Pollard, R B, Gregory, P B, Robinson, W S, Merigan, T C
In an uncontrolled trial, 29 patients with chronic hepatitis B virus infection were treated with 93 courses of adenine arabinoside at doses ranging from 2.5 to 15 mg/kg per day. Most patients were...
We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
Sasadeusz, J J, Tufaro, F, Safrin, S, Schubert, K, Hubinette, M M, Cheung, P K, ...
In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant...
Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.
Sacks, S L, Merigan, T C, Kaminska, J, Fox, I H
To assess for possible inhibition of cellular transmethylation during adenine arabinoside (ara-A) therapy, S-adenosylhomocysteine hydrolase activity was analyzed in 10 patients with chronic hepatitis...
Neurotoxic effects during vidarabine therapy for herpes zoster.
Burdge, D R, Chow, A W, Sacks, S L
Two cases of neurotoxic effects resulting from therapy with vidarabine are described. Both patients were undergoing treatment for cutaneously disseminated herpes zoster complicating therapy for solid...
The role of oral acyclovir in the management of genital herpes simplex.
Oral acyclovir is an antiviral nucleoside analogue that has recently been released in Canada for use in selected patients with genital infections by the herpes simplex virus. First episodes of...
Ayisi, N K, De Clercq, E, Wall, R A, Hughes, H, Sacks, S L
(E)-5-(2-Bromovinyl)-2'-deoxyuridine is a potent antiherpes compound with far better activity against herpes simplex virus type 1 than type 2. To understand the role of drug metabolism in this...
Sacks, S L, Scullard, G H, Pollard, R B, Gregory, P B, Robinson, W S, Merigan, T C
In an uncontrolled trial, 29 patients with chronic hepatitis B virus infection were treated with 93 courses of adenine arabinoside at doses ranging from 2.5 to 15 mg/kg per day. Most patients were...
We examined the in vitro susceptibilities of three reference strains and 41 recent clinical isolates of herpes simplex virus types 1 and 2 to 5-ethyl-2'-deoxyuridine. This thymidine analog exerts a...
Gribble, M J, Chow, A W, Naiman, S C, Smith, J A, Bowie, W R, Sacks, S L, ...
Piperacillin as a single agent was compared in a prospective randomized trial with carboxypenicillin-aminoglycoside combinations in empirical therapy of serious bacterial infections. The difference...
Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
Sasadeusz, J J, Tufaro, F, Safrin, S, Schubert, K, Hubinette, M M, Cheung, P K, ...
In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant...
Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.
Sacks, S L, Merigan, T C, Kaminska, J, Fox, I H
To assess for possible inhibition of cellular transmethylation during adenine arabinoside (ara-A) therapy, S-adenosylhomocysteine hydrolase activity was analyzed in 10 patients with chronic hepatitis...
Neurotoxic effects during vidarabine therapy for herpes zoster.
Burdge, D R, Chow, A W, Sacks, S L
Two cases of neurotoxic effects resulting from therapy with vidarabine are described. Both patients were undergoing treatment for cutaneously disseminated herpes zoster complicating therapy for solid...
The role of oral acyclovir in the management of genital herpes simplex.
Oral acyclovir is an antiviral nucleoside analogue that has recently been released in Canada for use in selected patients with genital infections by the herpes simplex virus. First episodes of...
Drug resistance in malaria: three cases and a review.
Isaac-Renton, J. L., Koon, A. L., Chan, R. M., Chow, A. W., Sacks, S. L.
Drug resistance has been well documented in two species of malarial parasites. Of greatest concern are the rapid developments in the resistance of Plasmodium falciparum to commonly used therapeutic...