S. Laal

Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T-cell responses across the leprosy spectrum.

Laal, S, Sharma, Y D, Prasad, H K, Murtaza, A, Singh, S, Tangri, S, ...

Pooled polyvalent sera from lepromatous leprosy patients were used to screen a lambda gt11 recombinant DNA expression library of Mycobacterium leprae in order to identify the relevant antigens...

Serodiagnostic Potential of Culture Filtrate Antigens of Mycobacterium tuberculosis

Samanich, K. M., Keen, M. A., Vissa, V. D., Harder, J. D., Spencer, J. S., Belisle, J. T., ...

Our studies of the humoral responses of tuberculosis (TB) patients have defined the repertoire of culture filtrate antigens of Mycobacterium tuberculosis that are recognized by antibodies from...

Antigens of Mycobacterium tuberculosis Expressed during Preclinical Tuberculosis: Serological Immunodominance of Proteins with Repetitive Amino Acid Sequences

Singh, K. K., Zhang, X., Patibandla, A. S., Chien, P., Laal, S.

Four antigens of Mycobacterium tuberculosis that are expressed in vivo after aerosol infection but prior to the development of clinical tuberculosis (TB) in rabbits were identified by immunoscreening...

Homogeneity of Antibody Responses in Tuberculosis Patients

Samanich, K., Belisle, J. T., Laal, S.

The goals of the present study were twofold: (i) to compare the repertoires of antigens in culture filtrates of in vitro-grown Mycobacterium tuberculosis that are recognized by antibodies from...

Human humoral responses to antigens of Mycobacterium tuberculosis: immunodominance of high-molecular-mass antigens.

Laal, S, Samanich, K M, Sonnenberg, M G, Zolla-Pazner, S, Phadtare, J M, Belisle, J T

The selection of antigens of Mycobacterium tuberculosis for most studies of humoral responses in tuberculosis patients has been restricted to molecules that were either immunodominant in immunized...

Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions.

Bastiani, L, Laal, S, Kim, M, Zolla-Pazner, S

In addition to gp41 and gp120, an array of cell adhesion molecules is present on the envelope of human immunodeficiency virus type 1 (HIV-1). To examine the role of the host cell in the acquisition...

Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies.

Laal, S, Burda, S, Gorny, M K, Karwowska, S, Buchbinder, A, Zolla-Pazner, S

The ability of antibodies to the V3 region and the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) to act in synergy to neutralize HIV has been demonstrated previously....

Isolation and serological characterization of a Plasmodium vivax recombinant antigen.

Sharma, Y D, Sharma, V P, Ray, P, Laal, S, Sawant, S D, Verma, S

A genomic library for Plasmodium vivax was constructed in lambda gt11 and immunologically screened with pooled serum samples from vivax patients. Six seroreactive clones were isolated, and one clone,...

Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum.

Laal, S, Bhutani, L K, Nath, I

Fifteen lepromatous leprosy (LL) patients undergoing erythema nodosum leprosum (ENL) reactions were compared with 13 stable, uncomplicated, anergic individuals of the same leprosy background. ENL...

Influence of delayed immune reactions on human epidermal keratinocytes.

Kaplan, G, Witmer, M D, Nath, I, Steinman, R M, Laal, S, Prasad, H K, ...

The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous...

Recombinant fusion protein identified by lepromatous sera mimics native Mycobacterium leprae in T-cell responses across the leprosy spectrum.

Laal, S, Sharma, Y D, Prasad, H K, Murtaza, A, Singh, S, Tangri, S, ...

Pooled polyvalent sera from lepromatous leprosy patients were used to screen a lambda gt11 recombinant DNA expression library of Mycobacterium leprae in order to identify the relevant antigens...

Serodiagnostic Potential of Culture Filtrate Antigens of Mycobacterium tuberculosis

Samanich, K. M., Keen, M. A., Vissa, V. D., Harder, J. D., Spencer, J. S., Belisle, J. T., ...

Our studies of the humoral responses of tuberculosis (TB) patients have defined the repertoire of culture filtrate antigens of Mycobacterium tuberculosis that are recognized by antibodies from...

Antigens of Mycobacterium tuberculosis Expressed during Preclinical Tuberculosis: Serological Immunodominance of Proteins with Repetitive Amino Acid Sequences

Singh, K. K., Zhang, X., Patibandla, A. S., Chien, P., Laal, S.

Four antigens of Mycobacterium tuberculosis that are expressed in vivo after aerosol infection but prior to the development of clinical tuberculosis (TB) in rabbits were identified by immunoscreening...

Homogeneity of Antibody Responses in Tuberculosis Patients

Samanich, K., Belisle, J. T., Laal, S.

The goals of the present study were twofold: (i) to compare the repertoires of antigens in culture filtrates of in vitro-grown Mycobacterium tuberculosis that are recognized by antibodies from...

Human humoral responses to antigens of Mycobacterium tuberculosis: immunodominance of high-molecular-mass antigens.

Laal, S, Samanich, K M, Sonnenberg, M G, Zolla-Pazner, S, Phadtare, J M, Belisle, J T

The selection of antigens of Mycobacterium tuberculosis for most studies of humoral responses in tuberculosis patients has been restricted to molecules that were either immunodominant in immunized...

Host cell-dependent alterations in envelope components of human immunodeficiency virus type 1 virions.

Bastiani, L, Laal, S, Kim, M, Zolla-Pazner, S

In addition to gp41 and gp120, an array of cell adhesion molecules is present on the envelope of human immunodeficiency virus type 1 (HIV-1). To examine the role of the host cell in the acquisition...

Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies.

Laal, S, Burda, S, Gorny, M K, Karwowska, S, Buchbinder, A, Zolla-Pazner, S

The ability of antibodies to the V3 region and the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) to act in synergy to neutralize HIV has been demonstrated previously....

Isolation and serological characterization of a Plasmodium vivax recombinant antigen.

Sharma, Y D, Sharma, V P, Ray, P, Laal, S, Sawant, S D, Verma, S

A genomic library for Plasmodium vivax was constructed in lambda gt11 and immunologically screened with pooled serum samples from vivax patients. Six seroreactive clones were isolated, and one clone,...

Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum.

Laal, S, Bhutani, L K, Nath, I

Fifteen lepromatous leprosy (LL) patients undergoing erythema nodosum leprosum (ENL) reactions were compared with 13 stable, uncomplicated, anergic individuals of the same leprosy background. ENL...

Influence of delayed immune reactions on human epidermal keratinocytes.

Kaplan, G, Witmer, M D, Nath, I, Steinman, R M, Laal, S, Prasad, H K, ...

The epidermal changes that occur in human cutaneous immune responses have been investigated in the tuberculin reaction and in the lesions of tuberculoid and lepromatous leprosy and cutaneous...

Differences in predominant T cell phenotypes and distribution pattern in reactional lesions of tuberculoid and lepromatous leprosy.

Narayanan, R B, Laal, S, Sharma, A K, Bhutani, L K, Nath, I

The nature and histological pattern of the cutaneous infiltrates of 17 leprosy patients in reversal reactions (Type I) and erythema nodosum leprosum (Type II, ENL) were compared with tissues from 18...