Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.
Ashany, D, Song, X, Lacy, E, Nikolic-Zugic, J, Friedman, S M, Elkon, K B
The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and...
Functional three-domain single-chain T-cell receptors.
Chung, S, Wucherpfennig, K W, Friedman, S M, Hafler, D A, Strominger, J L
T-cell receptors (TCRs) are membrane anchored heterodimers structurally related to antibody molecules. Single-chain antibodies can be engineered by linking the two variable domains, which fold...
Human T-cell responses to Mycoplasma arthritidis-derived superantigen.
Bhardwaj, N, Hodtsev, A S, Nisanian, A, Kabak, S, Friedman, S M, Cole, B C, ...
When injected into mice, Mycoplasma arthritidis causes a chronic arthritis that resembles rheumatoid arthritis, histologically. The organism produces a superantigen termed Mycoplasma arthritidis...
The apoptosis-1/Fas protein in human systemic lupus erythematosus.
Mysler, E, Bini, P, Drappa, J, Ramos, P, Friedman, S M, Krammer, P H, ...
Three independent mutations involving the apoptosis-1 (APO-1)/Fas receptor or its putative ligand have led to lupuslike diseases associated with lymphadenopathy in different strains of mice. To...
Laurence, J, Friedman, S M, Chartash, E K, Crow, M K, Posnett, D N
HIV selectively inhibited the proliferative response of clonal CD4+ T lymphocytes to alloantigen while other alloantigen-dependent responses were unperturbed. Specifically, impaired blastogenesis...
Chartash, E K, Crow, M K, Friedman, S M
We have utilized CD23 expression as a marker for B cell activation in order to investigate the biochemical basis for synergy between antigen and T helper (Th) cells in the activation of resting human...
Irigoyen, O H, Rizzolo, P V, Thomas, Y, Hemler, M E, Shen, H H, Friedman, S M, ...
A monoclonal antibody, PVR-11, was obtained after hybridization of X63Ag8.653 murine myeloma cells with spleen cells from a mouse immunized with human lymphocytes. It recognizes a 175,000- to...
Li, Y, Sun, G R, Tumang, J R, Crow, M K, Friedman, S M
T lymphocytes reactive with as yet undefined joint-localized foreign or autoantigens may be important in the pathogenesis of RA. Molecular studies demonstrating skewed T cell antigen receptor (TCR)...
High molecular weight antigens present on human T cells.
Judd, W, Poodry, C A, Broder, S, Friedman, S M, Chess, L, Strominger, J L
A series of eight high molecular weight (140,000-220,000) glycoproteins on human peripheral T cells were recognized by radioimmunoprecipitation with a rabbit antiserum. The pattern of antigens...
Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.
Posnett, D N, Wang, C Y, Friedman, S M
Three different murine monoclonal antibodies to the human clonotypic T-cell antigen receptor immunoprecipitate the alpha-beta chain heterodimer; induce comodulation of the clonotypic molecule with...
Friedman, S M, Breard, J M, Humphreys, R E, Strominger, J L, Schlossman, S F, Chess, L
A recently described technique for the polyclonal induction of plaque-forming cells from human bone-marrow derived (B) lymphocytes of peripheral blood has been used to assess the role of a human...
Laurence, J, Kulkosky, J, Friedman, S M, Posnett, D N, Ts'o, P O
Two alloreactive human CD4+ T cell clones, recognizing HLA-DR2 and HLA-DR1 determinants, lost their specific proliferative capacity after infection with HIV. This system was used to explore the...
Friedman, S M, Green, A, Russo, C, Posnett, D N, Diffley, D, Crow, M K
The effect of a cloned allospecific human Th cell, termed 86, on the in vitro generation of altered self-reactive cytolytic T lymphocytes (CTL) was investigated. Utilizing the induction of hapten...
Hepatitis B screening in a New York City obstetrics service.
Friedman, S M, DeSilva, L P, Fox, H E, Bernard, G
A cross-sectional chart review study was performed of hepatitis B virus (HBV) surface antigen screening of 532 women admitted to a New York City hospital obstetrics service from 1984 to 1985....
Rubella in the workplace: the need for employee immunization.
Goodman, A K, Friedman, S M, Beatrice, S T, Bart, S W
From 1983 to 1985, the New York City Department of Health investigated five workplace outbreaks of rubella. Approximately 40 per cent of the 265 cases were detected among women of child-bearing age...
A neonatal hepatitis B surveillance and vaccination program: New York City, 1987 to 1988.
Henning, K J, Pollack, D M, Friedman, S M
From July 1987 to June 1988, 1030 pregnant women with hepatitis B were reported to a New York City surveillance program. Among 832 infants under follow-up, the coverage rates for combined hepatitis B...
Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.
Ashany, D, Song, X, Lacy, E, Nikolic-Zugic, J, Friedman, S M, Elkon, K B
The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and...
Functional three-domain single-chain T-cell receptors.
Chung, S, Wucherpfennig, K W, Friedman, S M, Hafler, D A, Strominger, J L
T-cell receptors (TCRs) are membrane anchored heterodimers structurally related to antibody molecules. Single-chain antibodies can be engineered by linking the two variable domains, which fold...
Human T-cell responses to Mycoplasma arthritidis-derived superantigen.
Bhardwaj, N, Hodtsev, A S, Nisanian, A, Kabak, S, Friedman, S M, Cole, B C, ...
When injected into mice, Mycoplasma arthritidis causes a chronic arthritis that resembles rheumatoid arthritis, histologically. The organism produces a superantigen termed Mycoplasma arthritidis...
The apoptosis-1/Fas protein in human systemic lupus erythematosus.
Mysler, E, Bini, P, Drappa, J, Ramos, P, Friedman, S M, Krammer, P H, ...
Three independent mutations involving the apoptosis-1 (APO-1)/Fas receptor or its putative ligand have led to lupuslike diseases associated with lymphadenopathy in different strains of mice. To...
Laurence, J, Friedman, S M, Chartash, E K, Crow, M K, Posnett, D N
HIV selectively inhibited the proliferative response of clonal CD4+ T lymphocytes to alloantigen while other alloantigen-dependent responses were unperturbed. Specifically, impaired blastogenesis...
Chartash, E K, Crow, M K, Friedman, S M
We have utilized CD23 expression as a marker for B cell activation in order to investigate the biochemical basis for synergy between antigen and T helper (Th) cells in the activation of resting human...
Irigoyen, O H, Rizzolo, P V, Thomas, Y, Hemler, M E, Shen, H H, Friedman, S M, ...
A monoclonal antibody, PVR-11, was obtained after hybridization of X63Ag8.653 murine myeloma cells with spleen cells from a mouse immunized with human lymphocytes. It recognizes a 175,000- to...
Li, Y, Sun, G R, Tumang, J R, Crow, M K, Friedman, S M
T lymphocytes reactive with as yet undefined joint-localized foreign or autoantigens may be important in the pathogenesis of RA. Molecular studies demonstrating skewed T cell antigen receptor (TCR)...
High molecular weight antigens present on human T cells.
Judd, W, Poodry, C A, Broder, S, Friedman, S M, Chess, L, Strominger, J L
A series of eight high molecular weight (140,000-220,000) glycoproteins on human peripheral T cells were recognized by radioimmunoprecipitation with a rabbit antiserum. The pattern of antigens...
Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.
Posnett, D N, Wang, C Y, Friedman, S M
Three different murine monoclonal antibodies to the human clonotypic T-cell antigen receptor immunoprecipitate the alpha-beta chain heterodimer; induce comodulation of the clonotypic molecule with...
Friedman, S M, Breard, J M, Humphreys, R E, Strominger, J L, Schlossman, S F, Chess, L
A recently described technique for the polyclonal induction of plaque-forming cells from human bone-marrow derived (B) lymphocytes of peripheral blood has been used to assess the role of a human...
Laurence, J, Kulkosky, J, Friedman, S M, Posnett, D N, Ts'o, P O
Two alloreactive human CD4+ T cell clones, recognizing HLA-DR2 and HLA-DR1 determinants, lost their specific proliferative capacity after infection with HIV. This system was used to explore the...
Friedman, S M, Green, A, Russo, C, Posnett, D N, Diffley, D, Crow, M K
The effect of a cloned allospecific human Th cell, termed 86, on the in vitro generation of altered self-reactive cytolytic T lymphocytes (CTL) was investigated. Utilizing the induction of hapten...
Hepatitis B screening in a New York City obstetrics service.
Friedman, S M, DeSilva, L P, Fox, H E, Bernard, G
A cross-sectional chart review study was performed of hepatitis B virus (HBV) surface antigen screening of 532 women admitted to a New York City hospital obstetrics service from 1984 to 1985....
Rubella in the workplace: the need for employee immunization.
Goodman, A K, Friedman, S M, Beatrice, S T, Bart, S W
From 1983 to 1985, the New York City Department of Health investigated five workplace outbreaks of rubella. Approximately 40 per cent of the 265 cases were detected among women of child-bearing age...
A neonatal hepatitis B surveillance and vaccination program: New York City, 1987 to 1988.
Henning, K J, Pollack, D M, Friedman, S M
From July 1987 to June 1988, 1030 pregnant women with hepatitis B were reported to a New York City surveillance program. Among 832 infants under follow-up, the coverage rates for combined hepatitis B...