Halothane and sevoflurane inhibit Na/Ca exchange current in rat ventricular myocytes (2005)
Bru-Mercier, G., Hopkins, P. M., Harrison, S. M.
Background. The electrogenic Na+/Ca2+ exchanger (NCX) represents the main extrusion pathway for Ca2+ in ventricular muscle and therefore plays an important role in the regulation...
Graham, M. D., Bru-Mercier, G., Hopkins, P. M., Harrison, S. M.
Background. The volatile anaesthetics isoflurane and sevoflurane induce both negative and positive inotropic effects in ventricular myocytes, the mechanisms of which are not fully understood....
Halothane and sevoflurane inhibit Na/Ca exchange current in rat ventricular myocytes (2005)
Bru-Mercier, G., Hopkins, P. M., Harrison, S. M.
Background. The electrogenic Na+/Ca2+ exchanger (NCX) represents the main extrusion pathway for Ca2+ in ventricular muscle and therefore plays an important role in the regulation of cytosolic Ca2+...
Graham, M. D., Bru-Mercier, G., Hopkins, P. M., Harrison, S. M.
Background. The volatile anaesthetics isoflurane and sevoflurane induce both negative and positive inotropic effects in ventricular myocytes, the mechanisms of which are not fully understood....
Rithalia, A., Qureshi, M. A., Howarth, F. C., Harrison, S. M.
Background. Some of the cellular targets affected by volatile anaesthetics (e.g. halothane) which contribute to the negative inotropic effects of these agents are also affected during the progression...
Graham, M. D., Bru-Mercier, G., Hopkins, P. M., Harrison, S. M.
Background. The volatile anaesthetics isoflurane and sevoflurane induce both negative and positive inotropic effects in ventricular myocytes, the mechanisms of which are not fully understood....
Climate change and Arctic ecosystems I: Vegetation changes north of 55 (2003)
Bigelow, N.H., Brubaker, L.B., Edwards, M.E., Harrison, S.M., Prentice, I.C., Andreson, P.M., ...
Rithalia, A., Hopkins, P. M., Harrison, S. M.
Background. Halothane shortens ventricular action potential duration (APD), as a consequence of its inhibitory effects on a variety of membrane currents, an effect that is greater in...
A. J. Natali, L. A. Wilson, M. Peckham, D. L. Turner, S. M. Harrison, E. White
electrical
Mechanisms underlying the inotropic action of halothane on intact rat ventricular myocytes (1999)
Harrison, S. M., Robinson, M., Davies, L. A., Hopkins, P. M., Boyett, M. R.
Harrison, S.M., Gearing, K.L., Kingsman, A.J, Kingsman, S.M.
A 1.0 kb region of the BPV-1 genome (the long control region, LCR), contains controls for transcription and the origin of replication. Transcription directed by the LCR is activated by the viral...
Thermodynamic control of benzyl alcohol diffusion through human skin. (1983)
Thesis (Ph. D.)--University of Bradford, 1983.
Lee, B Y, Chatterjee, D, Bozic, C M, Brennan, P J, Cohn, D L, Bales, J D, ...
An enzyme-linked immunosorbent assay was constructed by using as antigens the type-specific immunodominant glycopeptidolipids of selected serotypes of Mycobacterium avium. This assay system was used...
Multiple cis-active elements in the long control region of bovine papillomavirus type 1 (BPV-1).
Harrison, S M, Gearing, K L, Kim, S Y, Kingsman, A J, Kingsman, S M
A 1.0 kb region of the BPV-1 genome (the long control region, LCR), contains controls for transcription and the origin of replication. Transcription directed by the LCR is activated by the viral...
1. The intracellular sodium activity (alpha Na1), contraction and membrane current were recorded simultaneously in voltage-clamped guinea-pig ventricular myocytes. 2. Increasing the frequency (from...
The role of inward Na(+)-Ca2+ exchange current in the ferret ventricular action potential.
Janvier, N C, Harrison, S M, Boyett, M R
1. Inward Na(+)-Ca2+ exchange current (iNaCa) was either blocked in ferret ventricular cells by replacing extracellular Na+ with Li+ or substantially reduced by the almost complete elimination of the...
The role of Na(+)-Ca2+ exchange current in electrical restitution in ferret ventricular cells.
Janvier, N C, McMorn, S O, Harrison, S M, Taggart, P, Boyett, M R
1. The mechanisms underlying electrical restitution (recovery of action potential duration after a preceding beat) were investigated in ferret ventricular cells. The time to 80% recovery (t80) of...
Harrison, S M, McCall, E, Boyett, M R
1. The contraction, measured optically, and the intracellular Na+ activity (aNai), measured with the Na(+)-sensitive fluorescent dye SBFI, have been recorded simultaneously in rat and guinea-pig...
Harrison, S M, Lamont, C, Miller, D J
1. The relationship between pCa (-log10[Ca2+]) and steady-state isometric tension has been investigated in saponin- or Triton-treated (chemically 'skinned') cardiac muscle of rat. 2. Hysteresis...
Lee, B Y, Chatterjee, D, Bozic, C M, Brennan, P J, Cohn, D L, Bales, J D, ...
An enzyme-linked immunosorbent assay was constructed by using as antigens the type-specific immunodominant glycopeptidolipids of selected serotypes of Mycobacterium avium. This assay system was used...
Multiple cis-active elements in the long control region of bovine papillomavirus type 1 (BPV-1).
Harrison, S M, Gearing, K L, Kim, S Y, Kingsman, A J, Kingsman, S M
A 1.0 kb region of the BPV-1 genome (the long control region, LCR), contains controls for transcription and the origin of replication. Transcription directed by the LCR is activated by the viral...
1. The intracellular sodium activity (alpha Na1), contraction and membrane current were recorded simultaneously in voltage-clamped guinea-pig ventricular myocytes. 2. Increasing the frequency (from...
The role of inward Na(+)-Ca2+ exchange current in the ferret ventricular action potential.
Janvier, N C, Harrison, S M, Boyett, M R
1. Inward Na(+)-Ca2+ exchange current (iNaCa) was either blocked in ferret ventricular cells by replacing extracellular Na+ with Li+ or substantially reduced by the almost complete elimination of the...
The role of Na(+)-Ca2+ exchange current in electrical restitution in ferret ventricular cells.
Janvier, N C, McMorn, S O, Harrison, S M, Taggart, P, Boyett, M R
1. The mechanisms underlying electrical restitution (recovery of action potential duration after a preceding beat) were investigated in ferret ventricular cells. The time to 80% recovery (t80) of...
Harrison, S M, McCall, E, Boyett, M R
1. The contraction, measured optically, and the intracellular Na+ activity (aNai), measured with the Na(+)-sensitive fluorescent dye SBFI, have been recorded simultaneously in rat and guinea-pig...
Harrison, S M, Lamont, C, Miller, D J
1. The relationship between pCa (-log10[Ca2+]) and steady-state isometric tension has been investigated in saponin- or Triton-treated (chemically 'skinned') cardiac muscle of rat. 2. Hysteresis...
Transmural variations in gene expression of stretch-modulated proteins in the rat left ventricle
Stones, R., Calaghan, S. C., Billeter, R., Harrison, S. M., White, E.
The properties of left ventricular cardiac myocytes vary transmurally. This may be related to the gradients of stress and strain experienced in vivo across the ventricular wall. We tested the...
Rogers, H., Birch, P. J., Harrison, S. M., Palmer, E., Manchee, G. R., Judd, D. B., ...
1. The pharmacological profile of GR94839, a kappa-opioid agonist with limited access to the central nervous system, has been investigated. Its antinociceptive activity has been compared with that of...
Birch, P. J., Harrison, S. M., Hayes, A. G., Rogers, H., Tyers, M. B.
The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, has been evaluated for antinociceptive activity in two well-characterized inflammatory pain models in the rat. (+/-)-CP-96,345 abolished...
Oral amoxycillin, an alternative treatment for neurosyphilis.
Morrison, R E, Harrison, S M, Tramont, E C
A serum amoxycillin concentration of 0.11 g/l was established as being treponemicidal in a rabbit model with orchitis. Seventeen patients treated with amoxycillin 2 g by mouth three times a day plus...
Natali, A J, Wilson, L A, Peckham, M, Turner, D L, Harrison, S M, White, E
Short-term (6 weeks) voluntary wheel running exercise in young female rats that were in an active growth phase resulted in whole-heart hypertrophy and myocyte concentric hypertrophy, when compared to...