DECIPHER : Database of chromosomal imbalance and phenotype in humans using ensembl resources (2009)
Richards, S.M, Bevan, A.P, Clayton, S, Corpas, M, Rajan, D, ...
Moorman, A.V., Richards, S.M., Hancock, J.P., Mitchell, C.D., Vora, A.J., Harrison, C.J., ...
Although both MRD and karyotype are powerful determinants of outcome in childhood ALL, few studies have examined the kinetics of MRD clearance by cytogenetics. In ALL2003, patients are stratified by...
Extrapolation in the context of criteria setting and risk assessment (2008)
Solomon, K.R., Brock, T.C.M., Dyer, S.D., Posthuma, L., Richards, S.M., ...
Extrapolation practice for ecotoxicological effect characterization of chemicals (2008)
Solomon, K.R., Brock, T.C.M., Dyer, S.D., Posthuma, L., Richards, S.M., ...
Extrapolation practice for ecotoxicological effect characterization of chemicals (2008)
Solomon, K.R., Brock, T.C.M., Dyer, S.D., Posthuma, L., Richards, S.M., ...
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukaemia (2007)
Moorman, A.V., Harrison, CJ., Buck, G.A.N., Richards, S.M., Secker-Walker, L.M., Martineau, M., ...
Moorman, A.V., Richards, S.M., Robinson, H.M., Strefford, J.C., Gibson, B.E.S., Kinsey, S.E., ...
Patients with acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21) comprise a novel and distinct biological subgroup. We prospectively screened 1630...
Fielding, A.K., Richards, S.M., Chopra, R., Lazarus, H.M., Litzow, M.R., Buck, G., ...
Most adults with acute lymphoblastic leukemia (ALL) who achieve complete remission (CR) will relapse. We examined the outcome of 609 adults with recurring ALL, all of whom were previously treated on...
Rowe, J.M., Buck, G., Burnett, A.K., Chopra, R., Wiernik, P.H., Richards, S.M., ...
The international acute lymphoblastic leukemia (ALL) study was designed to prospectively define the optimal therapy for adults 60 years of age or younger with newly diagnosed ALL. All patients...
ETV6/AML1 fusion by FISH in adult acute lymphoblastic leukemia (2002)
Martineau, M., Bennett, C.F., Franklin, I.M., Goldstone, A.H., Harewood, L., ...
Dual-color interphase fluorescence in situ hybridization (FISH) with ETV6 and AML1 probes was used for the first time on a series of 159 adult patients with acute lymphoblastic leukemia (ALL), for...
Chessells, J. M., Harrison, C. J., Watson, S. L., Vora, A. J., Richards, S. M.
One hundred and twenty-six infants with acute lymphoblastic leukaemia (ALL) were treated on two consecutive protocols, Infant 87 (n = 40) and Infant 92 (n = 86), in an attempt to improve the poor...
Subauste, M C, Jacoby, D B, Richards, S M, Proud, D
Rhinovirus infections cause over one third of all colds and are a contributing factor to exacerbations of asthma. To gain insights into the early biochemical events that occur in infected epithelial...
Does ovarian sex cord tumour with annular tubules produce progesterone?
Dolan, J, Al-Timimi, A H, Richards, S M, Jeffs, J B, Mason, G C, Smith, D B, ...
Probable progesterone production was identified by an immunoperoxidase assay in a case of an ovarian sex cord tumour with annular tubules. The tumour was associated with a serous cystadenofibroma in...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Britton, J A, Anderson, L M, Richards, S M, Bailey, C C, Chessells, J M
AIMS--To assess the prevalence and degree of periodic acid Schiff (PAS) positivity in blast cells from children with lymphoblastic leukaemia (ALL); its association with other disease characteristics;...
Zabner, J, Ramsey, B W, Meeker, D P, Aitken, M L, Balfour, R P, Gibson, R L, ...
Cystic fibrosis (CF) is a common autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator gene. Recombinant adenoviruses have shown promise as vectors for...
Clark, M G, Richards, S M, Hettiarachchi, M, Ye, J M, Appleby, G J, Rattigan, S, ...
Uric acid and uracil were released at constant rates (0.95 and 0.4 nmol/min per g respectively) by the perfused rat hindlimb. Noradrenaline, vasopressin or angiotensin II further increased the...
Incidence of self poisoning in patients prescribed psychotropic drugs.
Skegg, K, Skegg, D C, Richards, S M
The drugs most commonly used in self poisoning are the psychotropics, but the proportion of patients given these drugs who take overdoses is unknown. In a prospective study of 43117 people in...
Minor tranquillisers and road accidents.
Skegg, D C, Richards, S M, Doll, R
In a prospective study of 43,117 people, prescriptions issued by general practitioners over two years were linked with records of hospital admissions and deaths. For 57 people injured or killed while...
Subauste, M C, Jacoby, D B, Richards, S M, Proud, D
Rhinovirus infections cause over one third of all colds and are a contributing factor to exacerbations of asthma. To gain insights into the early biochemical events that occur in infected epithelial...
Does ovarian sex cord tumour with annular tubules produce progesterone?
Dolan, J, Al-Timimi, A H, Richards, S M, Jeffs, J B, Mason, G C, Smith, D B, ...
Probable progesterone production was identified by an immunoperoxidase assay in a case of an ovarian sex cord tumour with annular tubules. The tumour was associated with a serous cystadenofibroma in...
Lilleyman, J S, Hann, I M, Stevens, R F, Eden, O B, Richards, S M
As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel...
Lilleyman, J S, Britton, J A, Anderson, L M, Richards, S M, Bailey, C C, Chessells, J M
AIMS--To assess the prevalence and degree of periodic acid Schiff (PAS) positivity in blast cells from children with lymphoblastic leukaemia (ALL); its association with other disease characteristics;...
Zabner, J, Ramsey, B W, Meeker, D P, Aitken, M L, Balfour, R P, Gibson, R L, ...
Cystic fibrosis (CF) is a common autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator gene. Recombinant adenoviruses have shown promise as vectors for...
Clark, M G, Richards, S M, Hettiarachchi, M, Ye, J M, Appleby, G J, Rattigan, S, ...
Uric acid and uracil were released at constant rates (0.95 and 0.4 nmol/min per g respectively) by the perfused rat hindlimb. Noradrenaline, vasopressin or angiotensin II further increased the...
Incidence of self poisoning in patients prescribed psychotropic drugs.
Skegg, K, Skegg, D C, Richards, S M
The drugs most commonly used in self poisoning are the psychotropics, but the proportion of patients given these drugs who take overdoses is unknown. In a prospective study of 43117 people in...
Minor tranquillisers and road accidents.
Skegg, D C, Richards, S M, Doll, R
In a prospective study of 43,117 people, prescriptions issued by general practitioners over two years were linked with records of hospital admissions and deaths. For 57 people injured or killed while...
GARMAN, R D, MUNROE, K, RICHARDS, S M
Therapeutic enzymes are often recognized as foreign by the immune system of patients undergoing enzyme replacement therapy. The antibodies that develop may alter pharmacokinetics and biodistribution...
Remission death in acute lymphoblastic leukaemia: a changing pattern.
Atra, A, Richards, S M, Chessells, J M
The pattern of remission deaths was examined in 842 children with acute lymphoblastic leukaemia (ALL) treated at a single centre over 18 years. The mortality rate from leukaemia fell significantly...
Assessment of the "E' book as a tool for drug monitoring.
Skegg, D C, Richards, S M, Doll, R
For two years, the following records were linked for 10 453 people: (1) basic attributes; (2) details of prescriptions; and (3) information about illnesses recorded by general practitioners (GPs) in...
Wheeler, K, Chessells, J M, Bailey, C C, Richards, S M
The benefits of achieving a long term event free survival of 60-70% by using increasingly intense treatment regimens must be weighed against the increased risk of treatment toxicity. From 1985 to...
Dolan, G, Lilleyman, J S, Richards, S M
Children from the UKALL V trial were studied to assess the clinical importance of myelosuppression during uninterrupted 'maintenance' treatment of 'standard risk' lymphoblastic leukaemia. Those...