Marshall-Clarke, S, Owen, G, Tasker, L
Ligation of surface immunoglobulin (sIg) on certain murine B-lymphoma lines has been shown to initiate a programme leading to growth arrest and death of the cells by apoptosis. The cell lines WEHI...
Activation of normal murine B cells by Echinococcus granulosus.
Cox, D A, Marshall-Clarke, S, Dixon, J B
Echinococcus granulosus protoscolex (PSC) infection of BALB/c mice led, after 4 days, to raised numbers of cells forming plaques with trinitrophenyl-treated sheep red cells and bromelain-treated...
Greenwood, M R, Tasker, L, Cobbold, P H, Marshall-Clarke, S
Cross-linking of surface-immunoglobulin (sIg) has been associated with IP3 production and a rise in cytoplasmic-free calcium ([Ca2+]i) in studies of populations of normal and transformed B cells. We...
Cross-reactions between erythrocytes at the T-cell level
Playfair, J. H. L., Marshall-Clarke, S.
The response of bone marrow (B) cells to sheep red blood cells (SRBC) was measured in the presence of thymus-derived (T) cells that had been stimulated by SRBC or RBC from other species. It was found...
Age-dependent changes in the relative affinity of anti-dinitrophenyl antibodies in mice.
Marshall-Clarke, S, Playfair, J H
The affinity of anti-DNP antibodies produced by mice of various ages has been studied at the cellular level by the plaque inhibition technique. The affinity of PFC produced shortly after a single...
Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T-cell clone.
Champion, B R, Hutchings, P, Davies, S, Marshall-Clarke, S, Cooke, A, Roitt, I M
An autoreactive T-cell clone, MTg9B3, specific for mouse thyroglobulin, has been characterized. This clone has properties consistent with it an being autoreactive T helper cell. It is I-A restricted,...
Carron, J A, Marshall-Clarke, S
Several cloned, non-leukaemic mouse haemopoietic cell lines are believed to be uniquely dependent on interleukin-3 (IL-3) for their survival. All of these lines require the addition of WEHI-3B...
Higham, A D, Sells, R A, Marshall-Clarke, S
The effect of cyclosporin A (CyA) on the response of murine splenocytes to B-cell mitogens, TI-1 and TI-2 antigens was investigated. The proliferative response to LPS was found to be four- to...
Suppression of induced erythrocyte autoantibodies is dependent on Lyt 1 cells.
Hutchings, P, Marshall-Clarke, S, Cooke, A
When normal mice are immunized with rat RBC, autoantibodies to mouse red cells and antigen-specific suppressor cells are generated. Suppressor cell activity is found in T-enriched populations and...
Cox, D A, Dixon, J B, Marshall-Clarke, S
Transformation induced by Echinococcus granulosus in unprimed murine spleen cells in vitro was not prevented by rigorous T- or B-cell depletion. When naïve T- or B-cell populations were further...
Marshall-Clarke, S, Keeler, K D, Parkhouse, M E
Cells separated by the fluorescence activated cell sorter on the basis of their surface IgD (sIgD) phenotype have been examined for responsiveness to thymus-dependent and thymus-independent antigens....
Dissociation of murine B-cell proliferation and differentiation by monoclonal antibody, NIM R2.
Marshall-Clarke, S, Harrison, J, Parkhouse, R M
The rat monoclonal antibody NIM-R2 has been shown to be directed towards a cell surface differentiation antigen of murine B lymphocytes which is expressed to a greater or lesser extent at different...
Ontogeny of murine-B-lymphocytes. Avidity of antigen binding cells in neonatal and adult mice.
Marshall-Clarke, S, Playfair, J H
The heterogeneity of avidity of DNP-binding (rosetting) cells has been studied in mice of various ages, in an attempt to learn more about the development of antibody diversity. The results indicate...
Differential tolerance of thymus-independent and thymus-dependent antibody responses.
Tite, J P, Marshall-Clarke, S, Playfair, J H
The effect of pre-immunization with soluble haptenated serum proteins or haptenated carbohydrates on the subsequent responses to the hapten in thymus-dependent or thymus-independent form was...
Lack of autoantigen-specific splenic suppressor cells in mice with an X-linked B-lymphocyte defect.
Cooke, A, Hutchings, P, Marshall-Clarke, S
Male and female progeny of a cross between CBA/N female and BALB/c male mice were tested for their ability to generate autoantigen-specific suppressor cells as a result of stimulation with...
Functional responses of human neonatal B lymphocytes to antigen receptor cross-linking and CpG DNA
Human neonates are immunologically immature and consequently are highly susceptible to infection. The cellular basis for the dysfunctional immune responses of neonates is not clear, but is likely to...
Marshall-Clarke, S, Tasker, L, Parkhouse, R M E
Mature B lymphocytes respond to antigen receptor ligation by phenotypic changes, including upregulation of major histocompatibility complex class II molecules and expression of B7.2, which are...
Antigen receptor signalling in apoptosis-resistant mutants of WEHI 231 cells
Ligation of membrane immunoglobulin M (mIgM) induces cell cycle arrest and apoptosis in the WEHI 231 B-lymphoma cell line. The molecular mechanisms which link receptor ligation and the nuclear events...