Habazaki, H., Ogasawara, T., Fushimi, K., Shimizu, K., Nagata, S., Izumi, T., ...
The present work demonstrates effective inhibition of field crystallization of amorphous anodic niobium oxide by incorporation of silicon species from substrate. The field crystallization,...
Takubo, K., Mizokawa, T., Matsumoto, N., Nagata, S.
We have studied disorder-induced in-gap states and effect of light illumination in the insulating phase of spinel-type CuIr$_2$S$_4$ using ultra-violet photoemission spectroscopy (UPS). The...
Magnetic Landscape of Sun's Polar Region (2008)
Tsuneta, S., Ichimoto, K., Katsukawa, Y., Lites, B. W., Matsuzaki, K., Nagata, S., ...
We present the magnetic landscape of the polar region of the Sun that is unprecedented in terms of high spatial resolution, large field of view, and polarimetric precision. These observations were...
Disintegration of Magnetic Flux in Decaying Sunspots as Observed with the Hinode SOT (2008)
Kubo, M., Lites, B. W., Ichimoto, K., Shimizu, T., Suematsu, Y., Katsukawa, Y., ...
Continuous observations of sunspot penumbrae with the Solar Optical Telescope aboard \textit{Hinode} clearly show that the outer boundary of the penumbra fluctuates around its averaged position. The...
Frequent Occurrence of High-speed Local Mass Downflows on the Solar Surface (2008)
Shimizu, T., Lites, B. W., Katsukawa, Y., Ichimoto, K., Suematsu, Y., Tsuneta, S., ...
We report on new spectro-polarimetric measurements with simultaneous filter imaging observation, revealing the frequent appearance of polarization signals indicating high-speed, probably supersonic,...
Transient horizontal magnetic fields in solar plage regions (2008)
Ishikawa, R., Tsuneta, S., Ichimoto, K., Isobe, H., Katsukawa, Y., Lites, B. W., ...
We report the discovery of isolated, small-scale emerging magnetic fields in a plage region with the Solar Optical Telescope aboard Hinode. Spectro-polarimetric observations were carried out with a...
Physica B 281282 (2000) 631}633 (2008)
Optical Response Of, M. Hayashi, M. Nakayama, T. Nanba, T. Matsumoto, J. Tang, ...
X"S,Se) are ones of ternary metal chalcogen compounds with a thiospinel structure. CuIr undergoes a temperature-induced metal}insulator transition around 226 K. We have measured the temperature...
Coronal transverse magnetohydrodynamic waves in a solar prominence (2008)
Okamoto, T. J., Tsuneta, S., Berger, T. E., Ichimoto, K., Katsukawa, Y., Lites, B. W., ...
Solar prominences are cool 10$^4$ Kelvin plasma clouds supported in the surrounding 10$^6$ Kelvin coronal plasma by as-yet undetermined mechanisms. Observations from \emph{Hinode} show fine-scale...
Status of development of functional materials with perspective on beyond-ITER. (2008)
Shikama, T., Knitter, R., Konys, J., Muroga, T., Tsuchiya, K., Moeslang, A., ...
Fusion Engineering and Design, 83(2008) S.976-82
Formation of porous anodic films on Ti-Si alloys in hot phosphate-glycerol electrolyte (2007)
Habazaki, H., Oikawa, Y., Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., ...
Porous anodic films, with pore size of ~10 nm, have been developed by anodizing of magnetron sputtered Ti-25 at% Si alloy at constant formation voltages in glycerol electrolyte containing dibasic...
Isobe, H., Kubo, M., Minoshima, T., Ichimoto, K., Katsukawa, Y., Tarbell, T. D., ...
The Solar Optical Telescope (SOT) on board Hinode satellite observed an X3.4 class flare on 2006 December 13. Typical two-ribbon structure was observed, not only in the chromospheric CaII H line but...
[62] Jacob Nachmias. Visual Resolution of Two-Bar Patterns and Square-Wave Gratings. Journal (2007)
A. Watanabe, T. Mori, S. Nagata, K. Hiwatashi, H. R. Wilson, ...
[63] J. Rees and J. Botwinick. Detection and decision factors in auditory behaviour of the elderly. Journal of Gerontology, 26:133--136, 1971. [64] D. Regan and K. I. Beverley. Visual Field Described...
A Tale Of Two Spicules: The Impact of Spicules on the Magnetic Chromosphere (2007)
De Pontieu, Bart, McIntosh, Scott W., Hansteen, Viggo H., Carlsson, Mats, Schrijver, C. J., Tarbell, T. D., ...
We use high-resolution observations of the Sun in Ca II H 3968 A from the Solar Optical Telescope on Hinode to show that there are at least two types of spicules that dominate the structure of the...
Quiet Sun internetwork magnetic fields from the inversion of Hinode measurements (2007)
Suarez, D. Orozco, Rubio, L. R. Bellot, Tsuneta, S., Lites, B. W., Ichimoto, K., ...
We analyze Fe I 630 nm observations of the quiet Sun at disk center taken with the spectropolarimeter of the Solar Optical Telescope aboard the Hinode satellite. A significant fraction of the scanned...
Formation Process of a Light Bridge Revealed with the Hinode Solar Optical Telescope (2007)
Katsukawa, Y., Yokoyama, T., Berger, T. E., Ichimoto, K., Kubo, M., Lites, B. W., ...
The Solar Optical Telescope (SOT) aboard HINODE successfully and continuously observed a formation process of a light bridge in a matured sunspot of the NOAA active region 10923 for several days with...
Strategy for the inversion of Hinode spectropolarimetric measurements in the quiet Sun (2007)
Suarez, D. Orozco, Rubio, L. R. Bellot, Tsuneta, S., Lites, B. W., Ichimoto, K., ...
In this paper we propose an inversion strategy for the analysis of spectropolarimetric measurements taken by {\em Hinode} in the quiet Sun. The spectropolarimeter of the Solar Optical Telescope...
Vector spectropolarimetry of dark-cored penumbral filaments with Hinode (2007)
Rubio, L. R. Bellot, Tsuneta, S., Ichimoto, K., Katsukawa, Y., Lites, B. W., Nagata, S., ...
We present spectropolarimetric measurements of dark-cored penumbral filaments taken with Hinode at a resolution of 0.3". Our observations demonstrate that dark-cored filaments are more prominent in...
Emergence of Small-Scale Magnetic Loops in the Quiet Sun Internetwork (2007)
Centeno, R., Socas-Navarro, H., Lites, B., Kubo, M., Frank, Z., Shine, R., ...
We study the emergence of magnetic flux at very small spatial scales (less than 2 arcsec) in the quiet Sun internetwork. To this aim, a time series of spectropolarimetric maps was taken at disk...
Influence of silicon on the growth of barrier-type anodic films on titanium (2007)
Tanvir, M. Tauseef, Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., Thompson, G.E., ...
Amorphous anodic titania, stabilised by incorporation of silicon species, is shown to grow to high voltages on sputter-deposited, single-phase Ti–Si alloys during anodizing at a constant current...
Influence of silicon on the growth of barrier-type anodic films on titanium (2007)
Tanvir, M. Tauseef, Fushimi, K., Shimizu, K., Nagata, S., Skeldon, P., Thompson, G.E., ...
Amorphous anodic titania, stabilised by incorporation of silicon species, is shown to grow to high voltages on sputter-deposited, single-phase Ti–Si alloys during anodizing at a constant current...
Field crystallization of anodic niobia (2007)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Skeldon, P., ...
Influences of electrolyte, pre-thermal treatment and substrate composition have been examined to elucidate the mechanism of field crystallization of anodic niobia formed on magnetron-sputtered...
Field crystallization of anodic niobia (2007)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Skeldon, P., ...
Influences of electrolyte, pre-thermal treatment and substrate composition have been examined to elucidate the mechanism of field crystallization of anodic niobia formed on magnetron-sputtered...
Suppression of Field Crystallization of Anodic Niobia by Oxygen (2006)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Asami, K., ...
Solid-solution Nb–O films containing up to 50 atom % oxygen, prepared by magnetron sputtering, were used to investigate the influence of the oxygen on field crystallization during anodizing at 100...
Suppression of Field Crystallization of Anodic Niobia by Oxygen (2006)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Asami, K., ...
Solid-solution Nb–O films containing up to 50 atom % oxygen, prepared by magnetron sputtering, were used to investigate the influence of the oxygen on field crystallization during anodizing at 100...
Suppression of Field Crystallization of Anodic Niobia by Oxygen (2006)
Habazaki, H., Ogasawara, T., Konno, H., Shimizu, K., Nagata, S., Asami, K., ...
Solid-solution Nb–O films containing up to 50 atom % oxygen, prepared by magnetron sputtering, were used to investigate the influence of the oxygen on field crystallization during anodizing at 100...
Dohgomori, H, Nagata, S, Tanioka, K, Kawanishi, A, Kanai, J, Kanemaru, R
No abstract available.
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death (2005)
KROEMER, G, EL-DEIRY, W, GOLSTEIN, P, PETER, ME, VAUX, D, Vandenabeele, Peter, ...
SEARCHING FOR QUANTUM PHASE TRANSITIONS IN NARROW-BAND METALS (2004)
Grosche, F. M., Moroni-Klementowicz, D., Burrell, R., Fort, D., Awaka, J., Nagata, S., ...
Ionic Ordering in Thiospinel CuIr$_{2}$S$_{4}$ (2002)
Furubayashi, T., Matsumoto, T., Nagata, S.
Crystal structure of spinel compound CuIr$_{2}$S$_{4}$ was examined by powder X-ray diffraction for the insulating phase below the metal-insulator transition at $T_{MI}$ = 230 K. The superstructure...
Exact Treatment of the Pauli Exclusion Operator in Nuclear Matter Calculation (1999)
Suzuki, K., Okamoto, R., Kohno, M., Nagata, S.
Exact expressions of the Pauli exclusion operator Q in the nuclear matter calculation are presented in detail. Exact formulae are also given for the calculations of the single-particle-potential...
Hart, G. L. W., Pickett, W. E., Kurmaev, E. Z., Hartmann, D., Moewes, A., Neumann, M., ...
The electronic structure of spinel-type Cu_(1-x)Ni_xRh_2S_4 (x = 0.0, 0.1, 0.3, 0.5, 1.0) and CuRh_2Se_4 compounds has been studied by means of X-ray photoelectron and fluorescent spectroscopy. Cu...
Just Enough Reality: Comfortable 3-D Viewing via Microstereopsis (1999)
Mel Siegel, S. Nagata, Technology Issues
We address human factors and technology issues for the design of stereoscopic display systems that are natural and comfortable to view. Our title "just enough reality" hints at the contrast...
Induction of cell death by chimeric L-selectin-Fas receptors (1997)
Ishiwatari-Hayasaka, H, Kawashima, H, Osawa, T, Nagata, S, Miyasaka, M
Enhanced and accelerated lymphoproliferation in Fas-null mice.
Adachi, M, Suematsu, S, Suda, T, Watanabe, D, Fukuyama, H, Ogasawara, J, ...
Fas is a 45-kDa membrane protein that transduces an apoptotic signal. The mouse lymphoproliferation (lpr) mutation is a leaky mutation of Fas. In this study, we examined lymphocyte development in...
Ishizaka-Ikeda, E, Fukunaga, R, Wood, W I, Goeddel, D V, Nagata, S
The granulocyte colony-stimulating factor receptor (G-CSF-R) and growth hormone receptor (GH-R) belong to the cytokine receptor family and have some similarity in the cytokine receptor-homologous...
Adachi, M, Watanabe-Fukunaga, R, Nagata, S
The mouse lpr (lymphoproliferation) mutation carries a rearrangement in the chromosomal gene for the Fas antigen, which mediates apoptosis. Isolation and characterization of mouse Fas antigen...
Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.
Fukunaga, R, Seto, Y, Mizushima, S, Nagata, S
Three cDNAs for the human granulocyte colony-stimulating factor (G-CSF) receptor were isolated from the cDNA libraries of human U937 leukemia cells and placenta by using a murine G-CSF receptor cDNA...
Zhang, M., Nagata, S., Miyazawa, K., Kikuchi, H., Esashi, Y.
A competitive enzyme-linked immunosorbent assay (ELISA) was developed to quantify endogenous acetaldehyde-protein adducts (APAs) produced in plant seeds at low acetaldehyde concentrations without...
NADP(+)-dependent D-threonine dehydrogenase from Pseudomonas cruciviae IFO 12047.
Misono, H, Kato, I, Packdibamrung, K, Nagata, S, Nagasaki, S
NADP(+)-dependent D-threonine dehydrogenase (EC 1.1.1.-), which catalyzes the oxidation of the 3-hydroxyl group of D-threonine, was purified to homogeneity from a crude extract of Pseudomonas...
Misono, H, Yonezawa, J, Nagata, S, Nagasaki, S
NAD+-dependent phenylalanine dehydrogenase (EC 1.4.1.) was purified to homogeneity from a crude extract of Rhodococcus maris K-18 isolated from soil. The enzyme had a molecular mass of about 70,000...
Tani, K, Fujii, H, Nagata, S, Miwa, S
Pyruvate kinase (PK) has four isozymes (L, R, M1, M2) that are encoded by two different genes. Among these isozymes, abnormalities of liver (L)-type PK is considered to be associated with hereditary...
Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii.
Thompson, E M, Nagata, S, Tsuji, F I
The marine ostracod Vargula hilgendorfii ejects luciferin and luciferase into seawater to produce a bright luminous cloud. The light is due to the oxidation of luciferin, an imidazopyrazine compound,...
Undermethylation of interferon-gamma gene in human T cell lines and normal T lymphocytes.
Fukunaga, R, Matsuyama, M, Okamura, H, Nagata, K, Nagata, S, Sokawa, Y
The relative levels of DNA methylation at CCGG sequences within and around the interferon-gamma (IFN-gamma) gene in normal human tissues and cell lines were examined by Southern blot analysis using...
Streuli, M, Hall, A, Boll, W, Stewart, W E, Nagata, S, Weissmann, C
Plasmids containing cDNAs for human interferon (IfN) alpha-1, IFN alpha-2, and several hybrids of the two cDNAs, all joined identically to an Escherichia coli lac promoter fragment gave rise, in E....
Itoh, H, Kozasa, T, Nagata, S, Nakamura, S, Katada, T, Ui, M, ...
We have cloned cDNAs encoding alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go and determined their nucleotide sequences. Purified preparations of Gi and Go alpha subunits (Gi...
Granulocyte colony-stimulating factor (G-CSF) plays an essential role in granulopoiesis during bacterial infection. Macrophages produce G-CSF in response to bacterial endotoxins such as...
Two species of human CRK cDNA encode proteins with distinct biological activities.
Matsuda, M, Tanaka, S, Nagata, S, Kojima, A, Kurata, T, Shibuya, M
Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain reaction and by screening of a human placenta cDNA library, respectively....
Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.
Tsuchiya, M, Asano, S, Kaziro, Y, Nagata, S
A cDNA sequence coding for murine granulocyte colony-stimulating factor (G-CSF) has been isolated from a cDNA library prepared with mRNA derived from murine fibrosarcoma NFSA cells, which produce...
Constitutive production of human interferons by mouse cells with bovine papillomavirus as a vector.
Fukunaga, R, Sokawa, Y, Nagata, S
Mouse C127I cells were transformed with a chimeric plasmid consisting of bovine papillomavirus and human interferon (HuIFN) gene (either IFN-gamma or IFN-alpha 5) placed under the control of simian...
Molecular cloning and nucleotide sequence of cDNA for rat ornithine carbamoyltransferase precursor.
Takiguchi, M, Miura, S, Mori, M, Tatibana, M, Nagata, S, Kaziro, Y
Messenger RNA of rat ornithine carbamoyltransferase (EC 2.1.3.3), a mitochondrial matrix enzyme, was enriched by immunoprecipitation of rat liver free polysomes, and recombinant plasmids were...
Nagata, S, Tsunetsugu-Yokota, Y, Naito, A, Kaziro, Y
A 3.1-kilobase Bgl II fragment of Saccharomyces cerevisiae carrying the nuclear gene encoding the mitochondrial polypeptide chain elongation factor (EF) Tu has been cloned on pBR327 to yield a...
Apoptosis by a cytosolic extract from Fas-activated cells.
Fas is a type I membrane protein and its activation by binding of the Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells. In this report we prepared lysates from...
Yoshikawa, A, Murakami, H, Nagata, S
The receptor for granulocyte colony-stimulating factor (G-CSFR) is a hemopoietic growth factor receptor, which mediates proliferation and differentiation signals. The cytoplasmic region of G-CSFR...
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.
Watanabe, D, Suda, T, Hashimoto, H, Nagata, S
Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and splenomegaly and suffer from autoimmune disease. The lpr mice have a defect...
Expression of the functional soluble form of human fas ligand in activated lymphocytes.
Tanaka, M, Suda, T, Takahashi, T, Nagata, S
Fas is a type I membrane protein which mediates apoptosis. Fas ligand (FasL) is a 40 kDa type II membrane protein expressed in cytotoxic T cells upon activation that belongs to the tumor necrosis...
Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.
Suzuki, A, Enari, M, Eguchi, Y, Matsuzawa, A, Nagata, S, Tsujimoto, Y, ...
Fas, also called APO-1, belongs to the tumor necrosis factor/nerve growth factor receptor family and transmits an apoptotic signal within the cell by binding to the Fas ligand. Fas has been...
Molecular cloning and expression of a cDNA encoding the secretin receptor.
Ishihara, T, Nakamura, S, Kaziro, Y, Takahashi, T, Takahashi, K, Nagata, S
Secretin is a 27 amino acid peptide which stimulates the secretion of bicarbonate, enzymes and potassium ion from the pancreas. A complementary DNA encoding the rat secretin receptor was isolated...
Functional domains of the granulocyte colony-stimulating factor receptor.
Fukunaga, R, Ishizaka-Ikeda, E, Pan, C X, Seto, Y, Nagata, S
The granulocyte colony-stimulating factor (G-CSF) receptor has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin...
Redondo, C, Flores, I, Gonzalez, A, Nagata, S, Carrera, A C, Merida, I, ...
Fas is an apoptosis-signaling receptor molecule expressed in vivo on thymocytes, liver, heart, and ovary. In vivo administration of the anti-Fas Jo2 antibody in mice induces severe apoptotic liver...
Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells.
Tsuchiya, M, Nomura, H, Asano, S, Kaziro, Y, Nagata, S
Mouse C127I cells were transformed with a chimeric plasmid consisting of bovine papillomavirus DNA and human granulocyte-colony-stimulating factor (G-CSF) cDNA placed under the control of the SV40...
Arakawa, H, Takiguchi, M, Amaya, Y, Nagata, S, Hayashi, H, Mori, M
The sorting of homologous proteins between two separate intracellular organelles is a major unsolved problem. 3-Oxoacyl-CoA thiolase is localized in mitochondria and peroxisomes, and provides a good...
Nagata, S, Nagashima, K, Tsunetsugu-Yokota, Y, Fujimura, K, Miyazaki, M, Kaziro, Y
Messenger RNA for yeast cytosolic polypeptide chain elongation factor 1 alpha (EF-1 alpha) was partially purified from Saccharomyces cerevisiae. Double-stranded complementary DNA (cDNA) was...
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.
Nagata, S, Tsuchiya, M, Asano, S, Yamamoto, O, Hirata, Y, Kubota, N, ...
Two different cDNAs for human granulocyte colony-stimulating factor (G-CSF) were isolated from a cDNA library constructed with mRNA prepared from human squamous carcinoma cells, which produce G-CSF...
Ihara, S, Nakajima, K, Fukada, T, Hibi, M, Nagata, S, Hirano, T, ...
IL-6 induces differentiation of PC12 cells pretreated with nerve growth factor (NGF). We explored the signals required for neurite outgrowth of PC12 cells by using a series of mutants of a chimeric...
Buchberg, A. M., Brownell, E., Nagata, S., Jenkins, N. A., Copeland, N. G.
Interspecific backcross animals from a cross between C57BL/6J and Mus spretus mice were used to generate a comprehensive linkage map of mouse chromosome 11. The relative map positions of genes...
Enhanced and accelerated lymphoproliferation in Fas-null mice.
Adachi, M, Suematsu, S, Suda, T, Watanabe, D, Fukuyama, H, Ogasawara, J, ...
Fas is a 45-kDa membrane protein that transduces an apoptotic signal. The mouse lymphoproliferation (lpr) mutation is a leaky mutation of Fas. In this study, we examined lymphocyte development in...
Ishizaka-Ikeda, E, Fukunaga, R, Wood, W I, Goeddel, D V, Nagata, S
The granulocyte colony-stimulating factor receptor (G-CSF-R) and growth hormone receptor (GH-R) belong to the cytokine receptor family and have some similarity in the cytokine receptor-homologous...
Adachi, M, Watanabe-Fukunaga, R, Nagata, S
The mouse lpr (lymphoproliferation) mutation carries a rearrangement in the chromosomal gene for the Fas antigen, which mediates apoptosis. Isolation and characterization of mouse Fas antigen...
Three different mRNAs encoding human granulocyte colony-stimulating factor receptor.
Fukunaga, R, Seto, Y, Mizushima, S, Nagata, S
Three cDNAs for the human granulocyte colony-stimulating factor (G-CSF) receptor were isolated from the cDNA libraries of human U937 leukemia cells and placenta by using a murine G-CSF receptor cDNA...
Zhang, M., Nagata, S., Miyazawa, K., Kikuchi, H., Esashi, Y.
A competitive enzyme-linked immunosorbent assay (ELISA) was developed to quantify endogenous acetaldehyde-protein adducts (APAs) produced in plant seeds at low acetaldehyde concentrations without...
NADP(+)-dependent D-threonine dehydrogenase from Pseudomonas cruciviae IFO 12047.
Misono, H, Kato, I, Packdibamrung, K, Nagata, S, Nagasaki, S
NADP(+)-dependent D-threonine dehydrogenase (EC 1.1.1.-), which catalyzes the oxidation of the 3-hydroxyl group of D-threonine, was purified to homogeneity from a crude extract of Pseudomonas...
Misono, H, Yonezawa, J, Nagata, S, Nagasaki, S
NAD+-dependent phenylalanine dehydrogenase (EC 1.4.1.) was purified to homogeneity from a crude extract of Rhodococcus maris K-18 isolated from soil. The enzyme had a molecular mass of about 70,000...
Tani, K, Fujii, H, Nagata, S, Miwa, S
Pyruvate kinase (PK) has four isozymes (L, R, M1, M2) that are encoded by two different genes. Among these isozymes, abnormalities of liver (L)-type PK is considered to be associated with hereditary...
Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii.
Thompson, E M, Nagata, S, Tsuji, F I
The marine ostracod Vargula hilgendorfii ejects luciferin and luciferase into seawater to produce a bright luminous cloud. The light is due to the oxidation of luciferin, an imidazopyrazine compound,...
Undermethylation of interferon-gamma gene in human T cell lines and normal T lymphocytes.
Fukunaga, R, Matsuyama, M, Okamura, H, Nagata, K, Nagata, S, Sokawa, Y
The relative levels of DNA methylation at CCGG sequences within and around the interferon-gamma (IFN-gamma) gene in normal human tissues and cell lines were examined by Southern blot analysis using...
Streuli, M, Hall, A, Boll, W, Stewart, W E, Nagata, S, Weissmann, C
Plasmids containing cDNAs for human interferon (IfN) alpha-1, IFN alpha-2, and several hybrids of the two cDNAs, all joined identically to an Escherichia coli lac promoter fragment gave rise, in E....
Itoh, H, Kozasa, T, Nagata, S, Nakamura, S, Katada, T, Ui, M, ...
We have cloned cDNAs encoding alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go and determined their nucleotide sequences. Purified preparations of Gi and Go alpha subunits (Gi...
Granulocyte colony-stimulating factor (G-CSF) plays an essential role in granulopoiesis during bacterial infection. Macrophages produce G-CSF in response to bacterial endotoxins such as...
Two species of human CRK cDNA encode proteins with distinct biological activities.
Matsuda, M, Tanaka, S, Nagata, S, Kojima, A, Kurata, T, Shibuya, M
Two distinct human CRK cDNAs, designated CRK-I and CRK-II, were isolated from human embryonic lung cells by polymerase chain reaction and by screening of a human placenta cDNA library, respectively....
Isolation and characterization of the cDNA for murine granulocyte colony-stimulating factor.
Tsuchiya, M, Asano, S, Kaziro, Y, Nagata, S
A cDNA sequence coding for murine granulocyte colony-stimulating factor (G-CSF) has been isolated from a cDNA library prepared with mRNA derived from murine fibrosarcoma NFSA cells, which produce...
Constitutive production of human interferons by mouse cells with bovine papillomavirus as a vector.
Fukunaga, R, Sokawa, Y, Nagata, S
Mouse C127I cells were transformed with a chimeric plasmid consisting of bovine papillomavirus and human interferon (HuIFN) gene (either IFN-gamma or IFN-alpha 5) placed under the control of simian...
Molecular cloning and nucleotide sequence of cDNA for rat ornithine carbamoyltransferase precursor.
Takiguchi, M, Miura, S, Mori, M, Tatibana, M, Nagata, S, Kaziro, Y
Messenger RNA of rat ornithine carbamoyltransferase (EC 2.1.3.3), a mitochondrial matrix enzyme, was enriched by immunoprecipitation of rat liver free polysomes, and recombinant plasmids were...
Nagata, S, Tsunetsugu-Yokota, Y, Naito, A, Kaziro, Y
A 3.1-kilobase Bgl II fragment of Saccharomyces cerevisiae carrying the nuclear gene encoding the mitochondrial polypeptide chain elongation factor (EF) Tu has been cloned on pBR327 to yield a...
Apoptosis by a cytosolic extract from Fas-activated cells.
Fas is a type I membrane protein and its activation by binding of the Fas ligand or an agonistic anti-Fas antibody induces apoptosis in Fas-bearing cells. In this report we prepared lysates from...
Yoshikawa, A, Murakami, H, Nagata, S
The receptor for granulocyte colony-stimulating factor (G-CSFR) is a hemopoietic growth factor receptor, which mediates proliferation and differentiation signals. The cytoplasmic region of G-CSFR...
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.
Watanabe, D, Suda, T, Hashimoto, H, Nagata, S
Mice homozygous for lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) develop lymphadenopathy and splenomegaly and suffer from autoimmune disease. The lpr mice have a defect...
Expression of the functional soluble form of human fas ligand in activated lymphocytes.
Tanaka, M, Suda, T, Takahashi, T, Nagata, S
Fas is a type I membrane protein which mediates apoptosis. Fas ligand (FasL) is a 40 kDa type II membrane protein expressed in cytotoxic T cells upon activation that belongs to the tumor necrosis...
Involvement of Fas in regression of vaginal epithelia after ovariectomy and during an estrous cycle.
Suzuki, A, Enari, M, Eguchi, Y, Matsuzawa, A, Nagata, S, Tsujimoto, Y, ...
Fas, also called APO-1, belongs to the tumor necrosis factor/nerve growth factor receptor family and transmits an apoptotic signal within the cell by binding to the Fas ligand. Fas has been...
Molecular cloning and expression of a cDNA encoding the secretin receptor.
Ishihara, T, Nakamura, S, Kaziro, Y, Takahashi, T, Takahashi, K, Nagata, S
Secretin is a 27 amino acid peptide which stimulates the secretion of bicarbonate, enzymes and potassium ion from the pancreas. A complementary DNA encoding the rat secretin receptor was isolated...
Functional domains of the granulocyte colony-stimulating factor receptor.
Fukunaga, R, Ishizaka-Ikeda, E, Pan, C X, Seto, Y, Nagata, S
The granulocyte colony-stimulating factor (G-CSF) receptor has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin...
Redondo, C, Flores, I, Gonzalez, A, Nagata, S, Carrera, A C, Merida, I, ...
Fas is an apoptosis-signaling receptor molecule expressed in vivo on thymocytes, liver, heart, and ovary. In vivo administration of the anti-Fas Jo2 antibody in mice induces severe apoptotic liver...
Characterization of recombinant human granulocyte-colony-stimulating factor produced in mouse cells.
Tsuchiya, M, Nomura, H, Asano, S, Kaziro, Y, Nagata, S
Mouse C127I cells were transformed with a chimeric plasmid consisting of bovine papillomavirus DNA and human granulocyte-colony-stimulating factor (G-CSF) cDNA placed under the control of the SV40...
Arakawa, H, Takiguchi, M, Amaya, Y, Nagata, S, Hayashi, H, Mori, M
The sorting of homologous proteins between two separate intracellular organelles is a major unsolved problem. 3-Oxoacyl-CoA thiolase is localized in mitochondria and peroxisomes, and provides a good...
Nagata, S, Nagashima, K, Tsunetsugu-Yokota, Y, Fujimura, K, Miyazaki, M, Kaziro, Y
Messenger RNA for yeast cytosolic polypeptide chain elongation factor 1 alpha (EF-1 alpha) was partially purified from Saccharomyces cerevisiae. Double-stranded complementary DNA (cDNA) was...
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.
Nagata, S, Tsuchiya, M, Asano, S, Yamamoto, O, Hirata, Y, Kubota, N, ...
Two different cDNAs for human granulocyte colony-stimulating factor (G-CSF) were isolated from a cDNA library constructed with mRNA prepared from human squamous carcinoma cells, which produce G-CSF...
Ihara, S, Nakajima, K, Fukada, T, Hibi, M, Nagata, S, Hirano, T, ...
IL-6 induces differentiation of PC12 cells pretreated with nerve growth factor (NGF). We explored the signals required for neurite outgrowth of PC12 cells by using a series of mutants of a chimeric...
Buchberg, A. M., Brownell, E., Nagata, S., Jenkins, N. A., Copeland, N. G.
Interspecific backcross animals from a cross between C57BL/6J and Mus spretus mice were used to generate a comprehensive linkage map of mouse chromosome 11. The relative map positions of genes...
Senpuku, H, Iizima, T, Yamaguchi, Y, Nagata, S, Ueno, Y, Saito, M, ...
A surface protein antigen (PAc) of Streptococcus mutans, in particular the A-region of the molecule, has been noted as a possible target of effective dental caries vaccine. We have previously shown...
High Fas ligand expression on lymphocytes in lesions of ulcerative colitis
Ueyama, H, Kiyohara, T, Sawada, N, Isozaki, K, Kitamura, S, Kondo, S, ...
a Second Department of Internal Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, Japan, b Department of Cancer Epidemiology, Research Institute, Osaka Medical Center for...
Nagata, S, Nimura, Y, Beppu, S, Park, Y D, Sakakibara, H
The mechanism of systolic anterior motion of the mitral valve and the localisation of the intraventricular pressure gradient were determined in 15 cases of hypertrophic obstructive cardiomyopathy by...
Kinoshita, N, Nimura, Y, Okamoto, M, Miyatake, K, Nagata, S, Sakakibara, H
Mitral regurgitation and its haemodynamic features were investigated non-invasively in cases of hypertrophic cardiomyopathy by means of two dimensional Doppler echocardiography. There were 28...
Echocardiographic features of bioprosthetic valve endocarditis.
Nagata, S, Park, Y D, Nagae, K, Beppu, S, Kawazoe, K, Fujita, T, ...
Abnormal echocardiographic findings in seven cases of bioprosthetic valve endocarditis were confirmed in six at operation. The echocardiograms showed three cases with thickening and increased echo...
Nagata, S, Park, Y D, Nakanishi, N, Beppu, S, Sakakibara, H, Nimura, Y
Abnormalities of the mitral valve in patients with pulmonary stenosis, tetralogy of Fallot, and pulmonary hypertension with right ventricular pressure overload were studied by real time cross...
Miyatake, K, Nimura, Y, Sakakibara, H, Kinoshita, N, Okamoto, M, Nagata, S, ...
Regurgitant flow was analysed in 40 cases of mitral regurgitation, using combined ultrasonic pulsed Doppler technique and two dimensional echocardiography. Abnormal Doppler signals indicative of...
Beppu, S, Nimura, Y, Nagata, S, Tamai, M, Matsuo, H
Twelve cases of endocardial cushion defect were studied before and after operation with ultrasono-cardiotomography (tomography) cross-sectional echocardiography, two-dimensional echocardiography,...
Yamauchi-Takihara, K., Nakajima-Taniguchi, C., Matsui, H., Fujio, Y., Kunisada, K., Nagata, S., ...
OBJECTIVE: The disease-bearing genes for hypertrophic cardiomyopathy (HCM) in HCM families have been identified as the beta-myosin heavy chain, alpha-tropomyosin, and cardiac troponin T genes. Three...
Intracardiac mobile thrombus and D-dimer fragment of fibrin in patients with mitral stenosis.
Yasaka, M, Miyatake, K, Mitani, M, Beppu, S, Nagata, S, Yamaguchi, T, ...
OBJECTIVE--To investigate the relation between intracardiac thrombus and blood coagulability in patients with mitral stenosis. DESIGN--Prospective study. Cross sectional echocardiography and plasma...
Kinoshita, O, Yoshimi, H, Nagata, S, Ishikura, F, Kimura, K, Yamabe, T, ...
OBJECTIVE--To investigate the relation between plasma concentrations of immunoreactive endothelin and haemodynamic variables before and after percutaneous transvenous balloon dilatation of the mitral...
Transient abnormal septal motion after non-surgical closure of the ductus arteriosus.
Beppu, S, Masuda, Y, Sakakibara, H, Izumi, S, Park, Y D, Nagata, S, ...
Abnormal septal motion on M mode echocardiography was seen in eight of 16 patients soon after non-surgical closure of the ductus arteriosus. Ten to twenty-nine months after the procedure the abnormal...
Nishikimi, T., Nagata, S., Sasaki, T., Tomimoto, S., Matsuoka, H., Takishita, S., ...
Objective—To examine the pathophysiological significance of adrenomedullin in the pulmonary circulation by investigating the relation between plasma concentrations of adrenomedullin and central...
Immunological development of preterm infants in early infancy
Zhang, B, Ohtsuka, Y, Fujii, T, Baba, H, Okada, K, Shoji, H, ...
To evaluate the immunological development of preterm infants, especially in early infancy, we examined the serum cytokine levels and the expression of Th2 and Th1 chemokine receptors, CCR4 and CCR5,...
Adenomatoid tumour of the liver
Nagata, S, Aishima, S, Fukuzawa, K, Takagi, H, Yonemasu, H, Iwashita, Y, ...
An unusual primary adenomatoid tumour arising in the normal liver is described. Hepatectomy was performed, and the patient is alive and free of disease 1 year postsurgery. Grossly, the tumour showed...