S. Nagpal

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

Nagpal, S, Zelent, A, Chambon, P

An isoform of retinoic acid receptor beta, RAR-beta 4, has been identified. RAR-beta 4 is expressed under the control of the same retinoic acid-responsive promoter as RAR-beta 2. RAR-beta 4, which is...

Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma.

Nagpal, S, Cai, J, Zheng, T, Patel, S, Masood, R, Lin, G Y, ...

All-trans-retinoic acid (RA) is active in the treatment of Kaposi's sarcoma (KS), and retinoids inhibit KS cell growth in vitro. To understand the mechanism of retinoid action in KS, we studied the...

Characterization of a potent varicella-zoster virus-encoded trans-repressor.

Nagpal, S, Ostrove, J M

Using a transient expression assay in Vero cells, we have shown that the protein product from gene 61 of varicella-zoster virus (VZV) can repress the function of the VZV encoded trans-activators on...

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

Nagpal, S, Friant, S, Nakshatri, H, Chambon, P

We have previously reported that the AB regions of retinoic acid receptors (RARs and RXRs) contain a transcriptional activation function capable of modulating the activity of the ligand-dependent...

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

Nicholson, R C, Mader, S, Nagpal, S, Leid, M, Rochette-Egly, C, Chambon, P

Stromelysin is a member of the metalloproteinase family which plays an important role in extracellular matrix remodelling during many normal and disease processes. We show here that in...

Ligand-induced receptor dimerization may be critical for signal transduction by choriogonadotropin.

Grewal, N, Nagpal, S, Chavali, G B, Majumdar, S S, Pal, R, Salunke, D M

A mechanism of signal transduction by human choriogonadotropin (hCG) has been proposed. Competitive inhibition of the binding of hCG to its receptor by the serine protease inhibitors led to the...

Studies on glutathione S-transferases important for sperm function: evidence of catalytic activity-independent functions.

Gopalakrishnan, B, Aravinda, S, Pawshe, C H, Totey, S M, Nagpal, S, Salunke, D M, ...

Our earlier studies reported the identification of a rat testicular protein of 24 kDa with significant similarity at the N-terminus with Mu class glutathione S-transferases (GSTs). Treatment of goat...

Secretion of glutathione S-transferase isoforms in the seminiferous tubular fluid, tissue distribution and sex steroid binding by rat GSTM1.

Mukherjee, S B, Aravinda, S, Gopalakrishnan, B, Nagpal, S, Salunke, D M, Shaha, C

The seminiferous tubular fluid (STF) provides the microenvironment necessary for spermatogenesis in the adluminal compartment of the seminiferous tubule (ST), primarily through secretions of the...

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

Nagpal, S, Zelent, A, Chambon, P

An isoform of retinoic acid receptor beta, RAR-beta 4, has been identified. RAR-beta 4 is expressed under the control of the same retinoic acid-responsive promoter as RAR-beta 2. RAR-beta 4, which is...

Retinoid antagonism of NF-IL6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma.

Nagpal, S, Cai, J, Zheng, T, Patel, S, Masood, R, Lin, G Y, ...

All-trans-retinoic acid (RA) is active in the treatment of Kaposi's sarcoma (KS), and retinoids inhibit KS cell growth in vitro. To understand the mechanism of retinoid action in KS, we studied the...

Characterization of a potent varicella-zoster virus-encoded trans-repressor.

Nagpal, S, Ostrove, J M

Using a transient expression assay in Vero cells, we have shown that the protein product from gene 61 of varicella-zoster virus (VZV) can repress the function of the VZV encoded trans-activators on...

RARs and RXRs: evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo.

Nagpal, S, Friant, S, Nakshatri, H, Chambon, P

We have previously reported that the AB regions of retinoic acid receptors (RARs and RXRs) contain a transcriptional activation function capable of modulating the activity of the ligand-dependent...

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

Nicholson, R C, Mader, S, Nagpal, S, Leid, M, Rochette-Egly, C, Chambon, P

Stromelysin is a member of the metalloproteinase family which plays an important role in extracellular matrix remodelling during many normal and disease processes. We show here that in...

Ligand-induced receptor dimerization may be critical for signal transduction by choriogonadotropin.

Grewal, N, Nagpal, S, Chavali, G B, Majumdar, S S, Pal, R, Salunke, D M

A mechanism of signal transduction by human choriogonadotropin (hCG) has been proposed. Competitive inhibition of the binding of hCG to its receptor by the serine protease inhibitors led to the...

Studies on glutathione S-transferases important for sperm function: evidence of catalytic activity-independent functions.

Gopalakrishnan, B, Aravinda, S, Pawshe, C H, Totey, S M, Nagpal, S, Salunke, D M, ...

Our earlier studies reported the identification of a rat testicular protein of 24 kDa with significant similarity at the N-terminus with Mu class glutathione S-transferases (GSTs). Treatment of goat...

Secretion of glutathione S-transferase isoforms in the seminiferous tubular fluid, tissue distribution and sex steroid binding by rat GSTM1.

Mukherjee, S B, Aravinda, S, Gopalakrishnan, B, Nagpal, S, Salunke, D M, Shaha, C

The seminiferous tubular fluid (STF) provides the microenvironment necessary for spermatogenesis in the adluminal compartment of the seminiferous tubule (ST), primarily through secretions of the...

Humoral hyporesponsiveness to a conjugate contraceptive vaccine and its bypass by diverse carriers using permissible adjuvant

Mandokhot, A, Pal, R, Nagpal, S, Chauhan, V S, Ahlawat, S, Singh, Om

A contraceptive vaccine directed against human chorionic gonadotropin (hCG) has previously undergone clinical testing that demonstrated the feasibility of the approach in preventing pregnancy in...