S. Okamoto

Publication List Details

Period

1954 - 2009

Number

91

Co-Authors

Continuous metal-insulator transition of the antiferromagnetic perovskite NaOsO3 (2009)

Shi, Y. G., Guo, Y. F., Yu, S., Arai, M., Belik, A. A., Sato, A., ...

Newly synthesized perovskite NaOsO3 shows Curie-Weiss metallic nature at high temperature and suddenly goes into an antiferromagnetically insulating state at 410 K on cooling. Electronic specific...

PDP47 Field Trial of Signaling Interworking of Multi-carrier ASON/GMPLS Network Domains (2008)

A. Nagata, S. Seno, D. Ishii, S. Okamoto, N. Arai, H. Otsuki

Abstract: A seamless end-to-end call set up over multi-carrier ASON and GMPLS network domains was successfully achieved. Interworking of two ASON network domains and five GMPLS network domains was...

Charge transfer in heterostructures of strongly correlated materials (2008)

Gonzalez, I., Okamoto, S., Yunoki, S., Moreo, A., Dagotto, E.

In this manuscript, recent theoretical investigations by the authors in the area of oxide multilayers are briefly reviewed. The calculations were carried out using model Hamiltonians and a variety of...

Magnetization behavior of nanomagnets for patterned media application (2008)

Okamoto, S., Kikuchi, N., Kato, T., Kitakami, O., Mitsuzuka, K., Shimatsu, T., ...

Bit patterned media (BPM) which utilize each magnetic nanostructured dot as one recorded bit has attracted much interest as a promising candidate for future high-density magnetic recording. In this...

NaV2O4: a Quasi-1D Metallic Antiferromagnet with Half-Metallic Chains (2007)

Yamaura, K., Arai, M., Sato, A., Karki, A. B., Young, D. P., Movshovich, R., ...

NaV2O4 crystals were grown under high pressure using a NaCl flux, and the crystals were characterized with X-ray diffraction, electrical resistivity, heat capacity, and magnetization. The structure...

Electron Doping of Cuprates via Interfaces with Manganites (2007)

Yunoki, S., Moreo, A., Dagotto, E., Okamoto, S., Kancharla, S. S., Fujimori, A.

The electron doping of undoped high-$T_c$ cuprates via the transfer of charge from manganites (or other oxides) using heterostructure geometries is here theoretically discussed. This possibility is...

Band insulator to Mott insulator transition in a bilayer Hubbard model (2007)

Kancharla, S. S., Okamoto, S.

The ground state phase diagram of the half-filled repulsive Hubbard model in a bilayer is investigated using cluster dynamical mean field theory. For weak to intermediate values of Coulomb repulsion...

Photoemission from buried interfaces in SrTiO3/LaTiO3 superlattices (2006)

Takizawa, M., Wadati, H., Tanaka, K., Hashimoto, M., Yoshida, T., Fujimori, A., ...

We have measured photoemission spectra of SrTiO3/LaTiO3 superlattices with a topmost SrTiO3 layer of variable thickness. Finite coherent spectral weight with a clear Fermi cut-off was observed at...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

S. Okamoto, G. Kimura, S. Takizawa, H. Yamaguchi

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

Okamoto, S., Kimura, G., Takizawa, S., Yamaguchi, H.

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

Okamoto, S., Kimura, G., Takizawa, S., Yamaguchi, H.

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

Okamoto, S., Kimura, G., Takizawa, S., Yamaguchi, H.

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

Okamoto, S., Kimura, G., Takizawa, S., Yamaguchi, H.

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Earthquake fault rock indicating a coupled lubrication mechanism (2006)

S. Okamoto, G. Kimura, S. Takizawa, H. Yamaguchi

A pseudotachylyte bounded by a carbonate-matrix implosion breccia was found at a fossilized out-of-sequence thrust in the Shimanto accretionary complex, Japan. This occurrence resulted from the...

Theory of orbital state and spin interactions in ferromagnetic titanates (2005)

Khaliullin, G., Okamoto, S.

A spin-orbital superexchange Hamiltonian in a Mott insulator with $t_{2g}$ orbital degeneracy is investigated. More specifically, we focus on a spin ferromagnetic state of the model and study a...

Conflicts in teamwork: Hybrids to the rescue (2005)

M. Tambe, E. Bowring, H. Jung, G. Kaminka, R. Maheswaran, J. Marecki, ...

Today within the AAMAS community, we see at least four competing approaches to building multiagent systems: beliefdesire -intention (BDI), distributed constraint optimization (DCOP), distributed...

Conflicts in teamwork: Hybrids to the rescue (2005)

M. Tambe, E. Bowring, H. Jung, G. Kaminka, R. Maheswaran, J. Marecki, ...

Today within the AAMAS community, we see at least four competing approaches to building multiagent systems: beliefdesire-intention (BDI), distributed constraint optimization (DCOP), distributed...

Ferromagnetic insulating phase in Pr{1-x}Ca{x}MnO3 (2003)

Kajimoto, R., Mochizuki, H., Yoshizawa, H., Okamoto, S., Ishihara, S.

A ferromagnetic insulating (FM-I) state in Pr0.75Ca0.25MnO3 has been studied by neutron scattering experiment and theoretical calculation. The insulating behavior is robust against an external...

Fictive Impurity Models: an Alternative Formulation of the Cluster Dynamical Mean Field Method (2003)

Okamoto, S., Millis, A. J., Monien, H., Fuhrmann, A.

"Cluster" extensions of the dynamical mean field method to include longer range correlations are discussed. It is argued that the clusters arising in these methods are naturally interpreted not as...

Magnetic Order and Dynamics in an Orbitally Degenerate Ferromagnetic Insulator (2002)

Ulrich, C., Khaliullin, G., Okamoto, S., Reehuis, M., Ivanov, A., He, H., ...

Neutron scattering was used to determine the spin structure and the magnon spectrum of the Mott--Hubbard insulator YTiO$_3$. The magnetic structure is complex, comprising substantial G-type and...

Quantum Behavior of Orbitals in Ferromagnetic Titanates: Novel Orderings and Excitations (2002)

Khaliullin, G., Okamoto, S.

We investigate the collective behavior of orbital angular momentum in the spin ferromagnetic state of a Mott insulator with t(2g) orbital degeneracy. The frustrated nature of the interactions leads...

Magnetic Order and Dynamics in an Orbitally Degenerate Ferromagnetic Insulator (2002)

Ulrich, C., Khaliullin, G., Okamoto, S., Reehuis, M., Ivanov, A., He, H., ...

Neutron scattering was used to determine the spin structure and the magnon spectrum of the Mott-Hubbard insulator YTiO3. The magnetic structure is complex, comprising substantial G-type and A-type...

Theory of Raman Scattering from Orbital Excitations in Manganese Oxides (2001)

Okamoto, S., Ishihara, S., Maekawa, S.

We present a theory of the Raman scattering from the orbital wave excitations in manganese oxides. Two excitation processes of the Raman scattering are proposed. The Raman scattering cross section is...

Orbital Structure and Magnetic Ordering in Layered Manganites: Universal Correlation and Its Mechanism (2000)

Okamoto, S., Ishihara, S., Maekawa, S.

Correlation between orbital structure and magnetic ordering in bilayered manganites is examined. A level separation between the $3d_{3z^2-r^2}$ and $3d_{x^2-y^2}$ orbitals in a Mn ion is calculated...

Phase Transition in Perovskite Manganites with Orbital Degree of Freedom (1999)

Okamoto, S., Ishihara, S., Maekawa, S.

Roles of orbital degree of freedom of Mn ions in phase transition as a function of temperature and hole concentration in perovskite manganites are studied. It is shown that the orbital order-disorder...

Orbital Degree of Freedom and Phase Separation in Ferromagnetic Manganites at Finite Temperatures (1999)

Okamoto, S., Ishihara, S., Maekawa, S.

The spin and orbital phase diagram for perovskite manganites are investigated as a function of temperature and hole concentration. The superexchange and double exchange interactions dominate the...

Transition between two ferromagnetic states driven by orbital ordering in La_{0.88}Sr_{0.12}MnO_3 (1999)

Endoh, Y., Hirota, K., Ishihara, S., Okamoto, S., Murakami, Y., Nishizawa, A., ...

A lightly doped perovskite mangantite La_{0.88}Sr_{0.12}MnO_3 exhibits a phase transition at T_{OO}=145 K from a ferromagnetic metal (T_C=172 K) to a novel ferromagnetic insulator.We identify that...

Field Induced Transition from Metal to Insulator in the CMR Manganites (1998)

Endoh, Y., Nojiri, H., Kaneko, K., Hirota, K., Fukuda, T., Kimura, H., ...

The gigantic reduction of the electric resistivity under the applied magnetic field, CMR effect, is now widely accepted to appear in the vicinity of the insulator to metal transition of the...

Two Ferromagnetic States in Magnetoresistive Manganites - First Order Transition Driven by Orbitals - (1998)

Maekawa, S., Ishihara, S., Okamoto, S.

A systematic study of the electronic structure in perovskite manganites is presented. The effective Hamiltonian is derived by taking into account the degeneracy of $e_g$ orbitals and strong electron...

The Stress Corrosion Cracking of Sensitized Austenitic Stainless Steels in High Temperature Water. (1998)

Tsuruta, T., Okamoto, S.

The stress corrosion cracking (SCC) susceptibility of sensitized austenitic stainless steels, mainly Type 304 SS, was investigated in oxygenated high purity water and borated water below 240 C;...

Stress Corrosion Cracking of Sensitized Austenitic Stainless Steels in High-Temperature Water. (1998)

Tsuruta, T., Okamoto, S.

Stress corrosion cracking (SCC) susceptibility of sensitized austenitic stainless steels, mainly type 304 SS, was investigated in oxygenated high-purity water and borated water below 240 deg.C;...

POLYARTHRITIS ASSOCIATED WITH HEPATITIS C VIRUS INFECTION (1994)

UENO, Y., KINOSHITA, R., KISHIMOTO, I., OKAMOTO, S.

Two cases of polyarthritis associated with hepatitis C infection are reported. In Patient 1, stiffness and polyarthritis occurred during the acute stage of hepatitis. The arthritic symptoms lasted...

MAGNETIC PROPERTIES OF AMORPHOUS FERRIC HYDROXIDE GELS (1979)

Okamoto, S., Sekizawa, H.

Magnetic properties of amorphous ferric hydroxide gels prepared in different conditions are investigated with the aid of Mössbauer spectroscopy. It was revealed that when the ageing proceeded, the...

MAGNETIC PROPERTIES OF AMORPHOUS FERRIC HYDROXIDE GELS (1979)

Okamoto, S., Sekizawa, H.

Magnetic properties of amorphous ferric hydroxide gels prepared in different conditions are investigated with the aid of Mössbauer spectroscopy. It was revealed that when the ageing proceeded, the...

MAGNETIC PROPERTIES OF AMORPHOUS FERRIC HYDROXIDE GELS (1979)

Okamoto, S., Sekizawa, H.

Magnetic properties of amorphous ferric hydroxide gels prepared in different conditions are investigated with the aid of Mössbauer spectroscopy. It was revealed that when the ageing proceeded, the...

MÖSSBAUER EFFECT OF 61Ni IN SPINEL TYPE MAGNETIC OXIDES (1971)

Sekizawa, H., Okada, T., Okamoto, S., Ambe, F.

The Mössbauer spectroscopy of 61Ni was effectively utilized to investigate the internal magnetic fields in Ni-containing oxides with spinel or distorted spinel structure. The internal magnetic...

MÖSSBAUER EFFECT OF 61Ni IN SPINEL TYPE MAGNETIC OXIDES (1971)

Sekizawa, H., Okada, T., Okamoto, S., Ambe, F.

The Mössbauer spectroscopy of 61Ni was effectively utilized to investigate the internal magnetic fields in Ni-containing oxides with spinel or distorted spinel structure. The internal magnetic...

MÖSSBAUER EFFECT OF 61Ni IN SPINEL TYPE MAGNETIC OXIDES (1971)

Sekizawa, H., Okada, T., Okamoto, S., Ambe, F.

The Mössbauer spectroscopy of 61Ni was effectively utilized to investigate the internal magnetic fields in Ni-containing oxides with spinel or distorted spinel structure. The internal magnetic...

Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells.

Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...

Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...

In vitro and in vivo antibacterial activities of T-2588, a new oral cephalosporin, compared with those of other oral beta-lactam antibiotics.

Okamoto, S, Hamana, Y, Inoue, M, Mitsuhashi, S

T-2588, the pivaloyloxymethyl ester of T-2525, [6R, 7R]-7-[(z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetoamido] -3- [(5-methyl-2H-tetrazol-2-yl)methyl]-3-cephem-4-carboxylic acid, is a new oral...

Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes.

Weintraub, B C, Eckmann, L, Okamoto, S, Hense, M, Hedrick, S M, Fierer, J

Salmonella spp. are facultative intracellular bacteria which enter the body through the intestinal tract. We studied the roles of T cells expressing either the alpha and beta chains or the gamma and...

Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).

Shima, J, Hesketh, A, Okamoto, S, Kawamoto, S, Ochi, K

A strain of Streptomyces lividans, TK24, was found to produce a pigmented antibiotic, actinorhodin, although S. lividans normally does not produce this antibiotic. Genetic analyses revealed that a...

Molecular cloning and characterization of the obg gene of Streptomyces griseus in relation to the onset of morphological differentiation.

Okamoto, S, Itoh, M, Ochi, K

Morphological differentiation in microorganisms is usually accompanied by a decrease in intracellular GTP pool size, as has been demonstrated in bacillaceae, streptomycetaceae, and yeasts. The obg...

Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae.

Kinoshita, H, Ipposhi, H, Okamoto, S, Nakano, H, Nihira, T, Yamada, Y

BarA of Streptomyces virginiae is a specific receptor protein for virginiae butanolides (VBs), a member of the butyrolactone autoregulators of Streptomyces species. Sequencing around the barA gene...

Cloning of alpha- and beta-galactosidase genes from an extreme thermophile, Thermus strain T2, and their expression in Thermus thermophilus HB27.

Koyama, Y, Okamoto, S, Furukawa, K

The genes encoding thermostable alpha- and beta-galactosidases from an extremely thermophilic bacterium, Thermus strain T2, were cloned in Escherichia coli. The alpha-galactosidase gene was located...

In vitro antibacterial activities of tosufloxacin against and uptake of tosufloxacin by outer membrane mutants of Escherichia coli, Proteus mirabilis, and Salmonella typhimurium.

Mitsuyama, J, Itoh, Y, Takahata, M, Okamoto, S, Yasuda, T

The antibacterial activities of tosufloxacin and other quinolones against and apparent uptakes of tosufloxacin and other quinolones by outer membrane mutants of Escherichia coli, Proteus mirabilis,...

Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus.

Okuda, J, Okamoto, S, Takahata, M, Nishino, T

The activities of new quinolones against 140 strains of methicillin-resistant Staphylococcus aureus were determined. From the relationship between the MICs of sparfloxacin and ciprofloxacin,...

Specificity of the complement resistance and cell association phenotypes encoded by the outer membrane protein genes rck from Salmonella typhimurium and ail from Yersinia enterocolitica.

Heffernan, E J, Wu, L, Louie, J, Okamoto, S, Fierer, J, Guiney, D G

Virulence-associated phenotypes of an outer membrane protein gene family of members of the family Enterobacteriaceae were compared by means of pBR322 constructs transformed into Escherichia coli...

The interaction of RepC initiator with iterons in the replication of the broad host-range plasmid RSF1010.

Miao, D M, Sakai, H, Okamoto, S, Tanaka, K, Okuda, M, Honda, Y, ...

The replication origin of the broad host-range plasmid RSF1010 contains 3.5 copies of a 20mer iteron sequence that bind specifically to the plasmid-encoded initiator, RepC. Here we demonstrated that...

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

Shimizu, H, Mitomo, K, Watanabe, T, Okamoto, S, Yamamoto, K

Interleukin-6 (IL-6) is one of the major mediators of inflammation, and its expression is inducible by the other inflammatory lymphokines, interleukin-1 (IL-1) and tumor necrosis factor alpha...

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.

Nakayama, K, Shimizu, H, Mitomo, K, Watanabe, T, Okamoto, S, Yamamoto, K

The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B. We show here that c-Rel binds to...

Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

Kurachi, H, Okamoto, S, Oka, T

The submandibular gland is a rich source of epidermal growth factor (EGF) in mice. The concentration of EGF in the gland of virgin female mice of C3H/HeN strain increased as much as 9-fold from the...

Evidence for physiological function of epidermal growth factor: pregestational sialoadenectomy of mice decreases milk production and increases offspring mortality during lactation period.

Okamoto, S, Oka, T

Female virgin mice, whose submandibular glands were removed, underwent normal pregnancy and delivery. During the nursing period, however, a substantial number of pups born to and nursed by...

Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.

Kitamura, T, Kimura, K, Jung, B D, Makondo, K, Okamoto, S, Cañas, X, ...

It has been demonstrated that proinsulin C-peptide possesses several biological activities and that its specific binding sites are present on the surface of cell membranes. However, the molecular and...

Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells.

Chen, C Y, Eckmann, L, Libby, S J, Fang, F C, Okamoto, S, Kagnoff, M F, ...

Adaptation to the intracellular environment of host cells is crucial for the pathogenesis of Salmonella infections. The alternative sigma factor RpoS is a global regulator of gene expression during...

In vitro and in vivo antibacterial activities of T-2588, a new oral cephalosporin, compared with those of other oral beta-lactam antibiotics.

Okamoto, S, Hamana, Y, Inoue, M, Mitsuhashi, S

T-2588, the pivaloyloxymethyl ester of T-2525, [6R, 7R]-7-[(z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetoamido] -3- [(5-methyl-2H-tetrazol-2-yl)methyl]-3-cephem-4-carboxylic acid, is a new oral...

Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes.

Weintraub, B C, Eckmann, L, Okamoto, S, Hense, M, Hedrick, S M, Fierer, J

Salmonella spp. are facultative intracellular bacteria which enter the body through the intestinal tract. We studied the roles of T cells expressing either the alpha and beta chains or the gamma and...

Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).

Shima, J, Hesketh, A, Okamoto, S, Kawamoto, S, Ochi, K

A strain of Streptomyces lividans, TK24, was found to produce a pigmented antibiotic, actinorhodin, although S. lividans normally does not produce this antibiotic. Genetic analyses revealed that a...

Molecular cloning and characterization of the obg gene of Streptomyces griseus in relation to the onset of morphological differentiation.

Okamoto, S, Itoh, M, Ochi, K

Morphological differentiation in microorganisms is usually accompanied by a decrease in intracellular GTP pool size, as has been demonstrated in bacillaceae, streptomycetaceae, and yeasts. The obg...

Butyrolactone autoregulator receptor protein (BarA) as a transcriptional regulator in Streptomyces virginiae.

Kinoshita, H, Ipposhi, H, Okamoto, S, Nakano, H, Nihira, T, Yamada, Y

BarA of Streptomyces virginiae is a specific receptor protein for virginiae butanolides (VBs), a member of the butyrolactone autoregulators of Streptomyces species. Sequencing around the barA gene...

Cloning of alpha- and beta-galactosidase genes from an extreme thermophile, Thermus strain T2, and their expression in Thermus thermophilus HB27.

Koyama, Y, Okamoto, S, Furukawa, K

The genes encoding thermostable alpha- and beta-galactosidases from an extremely thermophilic bacterium, Thermus strain T2, were cloned in Escherichia coli. The alpha-galactosidase gene was located...

In vitro antibacterial activities of tosufloxacin against and uptake of tosufloxacin by outer membrane mutants of Escherichia coli, Proteus mirabilis, and Salmonella typhimurium.

Mitsuyama, J, Itoh, Y, Takahata, M, Okamoto, S, Yasuda, T

The antibacterial activities of tosufloxacin and other quinolones against and apparent uptakes of tosufloxacin and other quinolones by outer membrane mutants of Escherichia coli, Proteus mirabilis,...

Inhibitory effects of ciprofloxacin and sparfloxacin on DNA gyrase purified from fluoroquinolone-resistant strains of methicillin-resistant Staphylococcus aureus.

Okuda, J, Okamoto, S, Takahata, M, Nishino, T

The activities of new quinolones against 140 strains of methicillin-resistant Staphylococcus aureus were determined. From the relationship between the MICs of sparfloxacin and ciprofloxacin,...

Specificity of the complement resistance and cell association phenotypes encoded by the outer membrane protein genes rck from Salmonella typhimurium and ail from Yersinia enterocolitica.

Heffernan, E J, Wu, L, Louie, J, Okamoto, S, Fierer, J, Guiney, D G

Virulence-associated phenotypes of an outer membrane protein gene family of members of the family Enterobacteriaceae were compared by means of pBR322 constructs transformed into Escherichia coli...

The interaction of RepC initiator with iterons in the replication of the broad host-range plasmid RSF1010.

Miao, D M, Sakai, H, Okamoto, S, Tanaka, K, Okuda, M, Honda, Y, ...

The replication origin of the broad host-range plasmid RSF1010 contains 3.5 copies of a 20mer iteron sequence that bind specifically to the plasmid-encoded initiator, RepC. Here we demonstrated that...

Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.

Shimizu, H, Mitomo, K, Watanabe, T, Okamoto, S, Yamamoto, K

Interleukin-6 (IL-6) is one of the major mediators of inflammation, and its expression is inducible by the other inflammatory lymphokines, interleukin-1 (IL-1) and tumor necrosis factor alpha...

A lymphoid cell-specific nuclear factor containing c-Rel-like proteins preferentially interacts with interleukin-6 kappa B-related motifs whose activities are repressed in lymphoid cells.

Nakayama, K, Shimizu, H, Mitomo, K, Watanabe, T, Okamoto, S, Yamamoto, K

The proto-oncoprotein c-Rel is a member of the nuclear factor kappa B transcription factor family, which includes the p50 and p65 subunits of nuclear factor kappa B. We show here that c-Rel binds to...

Evidence for the involvement of the submandibular gland epidermal growth factor in mouse mammary tumorigenesis.

Kurachi, H, Okamoto, S, Oka, T

The submandibular gland is a rich source of epidermal growth factor (EGF) in mice. The concentration of EGF in the gland of virgin female mice of C3H/HeN strain increased as much as 9-fold from the...

Evidence for physiological function of epidermal growth factor: pregestational sialoadenectomy of mice decreases milk production and increases offspring mortality during lactation period.

Okamoto, S, Oka, T

Female virgin mice, whose submandibular glands were removed, underwent normal pregnancy and delivery. During the nursing period, however, a substantial number of pups born to and nursed by...

Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein.

Kitamura, T, Kimura, K, Jung, B D, Makondo, K, Okamoto, S, Cañas, X, ...

It has been demonstrated that proinsulin C-peptide possesses several biological activities and that its specific binding sites are present on the surface of cell membranes. However, the molecular and...

Superantigenicity of helper T-cell mitogen (SPM-2) isolated from culture supernatants of Streptococcus pyogenes.

Rikiishi, H, Okamoto, S, Sugawara, S, Tamura, K, Liu, Z X, Kumagai, K

A superantigen (Streptococcus pyogenes mitogen-2; SPM-2) that stimulates human helper T cells bearing unique types of variable domains of T-cell receptor beta-chain (TCR V beta) was isolated from the...

Dry eye after haematopoietic stem cell transplantation

Ogawa, Y., Okamoto, S., Wakui, M., Watanabe, R., Yamada, M., Yoshino, M., ...

AIMS—To determine the incidence, natural course, and severity of dry eye occurring or worsening after haematopoietic stem cell transplantation (SCT).
METHODS—At a tertiary care hospital,...

Thymus lymphocytes in uraemic rats and the effect of thymosin fraction 5 in vivo.

Ikemoto, S, Kamizuru, M, Hayahara, N, Okamoto, S, Wada, S, Kishimoto, T, ...

Thymus lymphocyte subsets in uraemic rats were studied using monoclonal antibodies. Severe and moderate uraemia was induced in rats, and sham-operated and normal rats were used as the controls. As a...

High expression of interleukin-1β in the corneal epithelium of MRL/lpr mice is under the control of their genetic background

OKAMOTO, M, TAKAGI, M, KUTSUNA, M, HARA, Y, NISHIHARA, M, ZHANG, M C, ...

MRL/Mp mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop polyarthritis, sialoadenitis and dacryoadenitis, resembling rheumatoid arthritis (RA), and also corneal...

T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn’s disease

Matsuoka, K, Inoue, N, Sato, T, Okamoto, S, Hisamatsu, T, Kishi, Y, ...

Background and aims: Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn’s disease (CD). Recently, a novel transcription factor T-box expressed in T...

The renal, cardiovascular and hormonal actions of human atrial natriuretic peptide in man; effects of indomethacin.

Miyamori, I, Ikeda, M, Matsubara, T, Okamoto, S, Koshida, H, Yasuhara, S, ...

The renal, cardiovascular and hormonal effects of intravenous infusion of alpha-human atrial natriuretic polypeptides (alpha-hANP) at the concentrations of 0.0125, 0.025, 0.05, 0.1 microgram kg-1...

Tenascin in cerebrospinal fluid is a useful biomarker for the diagnosis of brain tumour.

Yoshida, J, Wakabayashi, T, Okamoto, S, Kimura, S, Washizu, K, Kiyosawa, K, ...

Tenascin, an extracellular matrix glycoprotein, has been reported to be expressed predominantly on glioma tissue in the CNS, both in a cell associated and an excreted form. Recently, a highly...

Osteopontin/Eta-1 upregulated in Crohn’s disease regulates the Th1 immune response

Sato, T, Nakai, T, Tamura, N, Okamoto, S, Matsuoka, K, Sakuraba, A, ...

Background and aims: The pathogenesis of Crohn’s disease (CD), a chronic inflammatory bowel disease characterised by a Th1 immune response, remains unclear. Osteopontin (OPN) is a phosphoprotein...

Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor.

Okamoto, S., Yoshikawa, K., Obata, Y., Shibuya, M., Aoki, S., Yoshida, J., ...

A mouse monoclonal antibody (IgG2b), 3C10, was produced against the truncated epidermal growth factor receptor (EGFR), encoded by the (type III) in-frame deletion mutation of 801 nucleotides of EGFR...

Intracellular localisation of a subunit of human DNA polymerase alpha affecting primase activity recognised by monoclonal antibody (HDR-854-E4) and its application to distinction between proliferative and non-proliferative lesions.

Sugawara, I., Uchino, K., Morishita, Y., Yagura, T., Okamoto, S., Mori, S.

We have successfully established one murine hybridoma that secretes a monoclonal antibody specific for the 77,000 subunit of human DNA polymerase alpha. The results of immunochemical studies, using...