Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Li, L Y, Shoemaker, N B, Wang, G R, Cole, S P, Hashimoto, M K, Wang, J, ...
Bacteroides conjugative transposons can act in trans to excise, circularize, and transfer unlinked integrated elements called NBUs (for nonreplicating Bacteroides units). Previously, we localized and...
Site-directed mutations in the relaxase operon of RP4.
Cole, S P, Lanka, E, Guiney, D G
Mutations were constructed by site-directed mutagenesis in the relaxase operon of the broad-host-range plasmid RP4. The mutations were constructed in smaller plasmids, recombined into the 60-kb RP4...
Perego, M, Cole, S P, Burbulys, D, Trach, K, Hoch, J A
The kinA (spoIIJ) locus contains a single gene which codes for a protein of 69,170 daltons showing strong homology to the transmitter kinases of two component regulatory systems. The purified kinase...
Lohoff, M, Prechtl, S, Sommer, F, Roellinghoff, M, Schmitt, E, Gradehandt, G, ...
A transmembrane pump for organic anions was identified in resting murine T helper (Th) 2, but not Th1 lymphocyte cell clones, as revealed by extrusion of a fluorescent dye. Dye extrusion inhibition...
Leier, I, Jedlitschky, G, Buchholz, U, Center, M, Cole, S P, Deeley, R G, ...
We have previously shown that the multidrug resistance protein (MRP) mediates the ATP-dependent membrane transport of the endogenous glutathione conjugate leukotriene C4 (LTC4) and of structurally...
Cole, S P, Cirillo, D, Kagnoff, M F, Guiney, D G, Eckmann, L
Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic...
Li, L Y, Shoemaker, N B, Wang, G R, Cole, S P, Hashimoto, M K, Wang, J, ...
Bacteroides conjugative transposons can act in trans to excise, circularize, and transfer unlinked integrated elements called NBUs (for nonreplicating Bacteroides units). Previously, we localized and...
Site-directed mutations in the relaxase operon of RP4.
Cole, S P, Lanka, E, Guiney, D G
Mutations were constructed by site-directed mutagenesis in the relaxase operon of the broad-host-range plasmid RP4. The mutations were constructed in smaller plasmids, recombined into the 60-kb RP4...
Perego, M, Cole, S P, Burbulys, D, Trach, K, Hoch, J A
The kinA (spoIIJ) locus contains a single gene which codes for a protein of 69,170 daltons showing strong homology to the transmitter kinases of two component regulatory systems. The purified kinase...
Lohoff, M, Prechtl, S, Sommer, F, Roellinghoff, M, Schmitt, E, Gradehandt, G, ...
A transmembrane pump for organic anions was identified in resting murine T helper (Th) 2, but not Th1 lymphocyte cell clones, as revealed by extrusion of a fluorescent dye. Dye extrusion inhibition...
Leier, I, Jedlitschky, G, Buchholz, U, Center, M, Cole, S P, Deeley, R G, ...
We have previously shown that the multidrug resistance protein (MRP) mediates the ATP-dependent membrane transport of the endogenous glutathione conjugate leukotriene C4 (LTC4) and of structurally...
Campling, B. G., Baer, K., Baker, H. M., Lam, Y. M., Cole, S. P.
Small cell lung cancer (SCLC) is treated primarily with combination chemotherapy. Despite high initial response rates, most patients eventually die with drug resistant disease. In some tumours,...
Chemosensitivity testing of small cell lung cancer using the MTT assay.
Campling, B. G., Pym, J., Baker, H. M., Cole, S. P., Lam, Y. M.
A simple colorimetric test, the MTT assay, has been adapted for chemosensitivity testing of human small cell lung cancer cell lines, and fresh tumour samples. Optimal conditions for clinical...
A monoclonal antibody detecting cell surface epitope on some drug resistant human tumour cell lines.
Multidrug resistance-associated antigens on drug-sensitive and -resistant human tumour cell lines.
In this paper the biochemical properties of the antigens detected by six murine monoclonal antibodies (MAbs) are described. These MAbs react selectively with the multidrug-resistant small cell lung...
Cole, S. P., Pinkoski, M. J., Bhardwaj, G., Deeley, R. G.
The doxorubicin-selected multidrug resistant small cell lung cancer cell line, H69AR, is cross-resistant to the Vinca alkaloids and epipodophyllotoxins, but does not overexpress P-glycoprotein, a 170...
Hasegawa, S., Abe, T., Naito, S., Kotoh, S., Kumazawa, J., Hipfner, D. R., ...
The acquisition of the multidrug resistance phenotype in human tumours is associated with an overexpression of the 170 kDa P-glycoprotein encoded by the multidrug resistance 1 (MDR1) gene, and also...
Hipfner, D. R., Gao, M., Scheffer, G., Scheper, R. J., Deeley, R. G., Cole, S. P.
Inherent or acquired resistance to multiple natural product drugs in human tumour cells is often associated with increased expression of multidrug resistance protein (MRP), a 190-kDa integral...
Cole, S. P., Downes, H. F., Slovak, M. L.
We have examined the ability of eight compounds to enhance adriamycin (ADM) sensitivity of two human tumour cell lines (a small cell lung cancer cell line, NCI-H69, and a fibrosarcoma cell line,...