Thesis (Ph. D.)--Leeds Metropolitan University, 1994.
Pyogenic Liver Abscess in the Elderly (1990)
SRIDHARAN, G. V., WILKINSON, S.P., PRIMROSE, W. R.
Seventeen patients over the age of 60 years, admitted to the Aberdeen Teaching Hospitals between 1980 and mid-1988, were diagnosed as having pyogenic liver abscess. Eleven were women and the mean age...
WILKINSON, S. P., STEWART, W. K., PARHAM, D. M., GUTHRIE, W.
Medial calciflcation of arteries is common in chronic renal failure. We report on a patient with extensive calciflcation of the arterial media who development symmetrical acral gangrene and severe...
Inhibitory antimicrobial concentrations against Campylobacter pylori in gastric mucosa (1988)
McNulty, Cliodna A. M., Dent, J. C., Ford, G. A., Wilkinson, S. P.
Gastric mucosal concentrations of erythromycin, amoxycillin, ampicillin and ciprofloxacin were determined in patients at upper gastrointestinal endoscopy 38–480 min after a 500 mg dose of...
Clinical Course of Chronic Lobular Hepatitis: REPORT OF FIVE CASES (1978)
WILKINSON, S. P., PORTMANN, B., COCHRANE, A. M. G., TEE, D. E. H., WILLIAMS, ROGER
The clinical course, and biochemical, immunological, and liver histological changes in five patients with chronic lobular hepatitis are described. All were male (ages 17 to 44 years) and presented...
Wilkinson, S P, Moodie, H, Arroyo, V A, Williams, R
In an analysis of 160 patients with fulminant hepatic failure, the frequency of renal failure in the patiens who had taken an overdose of paracetamol was not significantly higher than in those with...
New spiral bacterium in gastric mucosa.
McNulty, C A, Dent, J C, Curry, A, Uff, J S, Ford, G A, Gear, M W, ...
A new spiral bacterium, distinct from Campylobacter pylori, was found in the gastric mucosa of six patients with gastrointestinal symptoms. All patients had chronic active type B gastritis and four...
Wilkinson, S P, Hirst, D, Day, D W, Williams, R
Measurements of urinary lysozyme were used to evaluate renal tubular integrity in 34 patients with cirrhosis or fulminant hepatic failure who had developed renal impairment. In 18 of the patients the...
Long-term follow up of patients with gastritis associated with Helicobacter pylori infection.
Barnes, R J, Uff, J S, Dent, J C, Gear, M W, Wilkinson, S P
The aim of this study was to evaluate the long-term prognosis for patients suffering from gastritis associated with Helicobacter pylori infection, and in particular the proportion of cases...
Sigmoidoscopy/proctoscopy service with open access to general practitioners.
Donald, I P, FitzGerald Frazer, J S, Wilkinson, S P
Many hospitals now offer barium enema examinations to general practitioners on an open access basis, so bypassing the traditional sequence of first carrying out a sigmoidoscopy. An open access...
Evidence for a circulating sodium transport inhibitor in essential hypertension.
Poston, L, Sewell, R B, Wilkinson, S P, Richardson, P J, Williams, R, Clarkson, E M, ...
The active sodium transport of white cells and red cells obtained from patients with essential hypertension was impaired. Incubating white cells from normotensive subjects in serum obtained from...
De novo acute infection and reactivation of hepatitis B virus in established cirrhosis.
Theodossi, A, Wilkinson, S P, Portmann, B, White, Y, Eddleston, A L, Williams, R, ...
Five patients with cirrhosis proved by biopsy had clinical, biochemical, and serological evidence of an acute hepatitis B infection. In two the illness was fulminant and led to death. Only one...
Renal failure in otherwise uncomplicated acute viral hepatitis.
Wilkinson, S P, Davies, M H, Portmann, B, Williams, R
Twelve patients with otherwise uncomplicated acute viral hepatitis (two were HBsAg-positive) developed renal failure. Apart from dehydration due to repeated vomiting in one patient, no factor...
Frequency and Type of Renal and Electrolyte Disorders in Fulminant Hepatic Failure
Wilkinson, S. P., Blendis, L. M., Williams, Roger
Of 48 patients with fulminant hepatic failure who progressed to grade III or IV encephalopathy 38 showed evidence of renal impairment. In 32 of these patients the underlying cause could be placed...
Arsine toxicity aboard the Asiafreighter.
Wilkinson, S P, McHugh, P, Horsley, S, Tubbs, H, Lewis, M, Thould, A, ...
Eight sailors on board the Asiafreighter were exposed to arsine that had escaped from a cylinder in the cargo hold. Four suffered severe toxicity and within a few hours had developed fever, weakness,...
Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.
Wilkinson, S P, Moodie, H, Stamatakis, J D, Kakkar, V V, Williams, R
An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with...
Wilkinson, S P, Moodie, H, Arroyo, V A, Williams, R
In an analysis of 160 patients with fulminant hepatic failure, the frequency of renal failure in the patiens who had taken an overdose of paracetamol was not significantly higher than in those with...
New spiral bacterium in gastric mucosa.
McNulty, C A, Dent, J C, Curry, A, Uff, J S, Ford, G A, Gear, M W, ...
A new spiral bacterium, distinct from Campylobacter pylori, was found in the gastric mucosa of six patients with gastrointestinal symptoms. All patients had chronic active type B gastritis and four...
Wilkinson, S P, Hirst, D, Day, D W, Williams, R
Measurements of urinary lysozyme were used to evaluate renal tubular integrity in 34 patients with cirrhosis or fulminant hepatic failure who had developed renal impairment. In 18 of the patients the...
Long-term follow up of patients with gastritis associated with Helicobacter pylori infection.
Barnes, R J, Uff, J S, Dent, J C, Gear, M W, Wilkinson, S P
The aim of this study was to evaluate the long-term prognosis for patients suffering from gastritis associated with Helicobacter pylori infection, and in particular the proportion of cases...
Sigmoidoscopy/proctoscopy service with open access to general practitioners.
Donald, I P, FitzGerald Frazer, J S, Wilkinson, S P
Many hospitals now offer barium enema examinations to general practitioners on an open access basis, so bypassing the traditional sequence of first carrying out a sigmoidoscopy. An open access...
Evidence for a circulating sodium transport inhibitor in essential hypertension.
Poston, L, Sewell, R B, Wilkinson, S P, Richardson, P J, Williams, R, Clarkson, E M, ...
The active sodium transport of white cells and red cells obtained from patients with essential hypertension was impaired. Incubating white cells from normotensive subjects in serum obtained from...
De novo acute infection and reactivation of hepatitis B virus in established cirrhosis.
Theodossi, A, Wilkinson, S P, Portmann, B, White, Y, Eddleston, A L, Williams, R, ...
Five patients with cirrhosis proved by biopsy had clinical, biochemical, and serological evidence of an acute hepatitis B infection. In two the illness was fulminant and led to death. Only one...
Renal failure in otherwise uncomplicated acute viral hepatitis.
Wilkinson, S P, Davies, M H, Portmann, B, Williams, R
Twelve patients with otherwise uncomplicated acute viral hepatitis (two were HBsAg-positive) developed renal failure. Apart from dehydration due to repeated vomiting in one patient, no factor...
Frequency and Type of Renal and Electrolyte Disorders in Fulminant Hepatic Failure
Wilkinson, S. P., Blendis, L. M., Williams, Roger
Of 48 patients with fulminant hepatic failure who progressed to grade III or IV encephalopathy 38 showed evidence of renal impairment. In 32 of these patients the underlying cause could be placed...
Arsine toxicity aboard the Asiafreighter.
Wilkinson, S P, McHugh, P, Horsley, S, Tubbs, H, Lewis, M, Thould, A, ...
Eight sailors on board the Asiafreighter were exposed to arsine that had escaped from a cylinder in the cargo hold. Four suffered severe toxicity and within a few hours had developed fever, weakness,...
Endotoxaemia and renal failure in cirrhosis and obstructive jaundice.
Wilkinson, S P, Moodie, H, Stamatakis, J D, Kakkar, V V, Williams, R
An investigation into the possible role of endotoxins in the pathogenesis of renal failure in cirrhosis and obstructive jaundice showed the two to be closely related. None of the patients with...
Shepherd, N A, Healey, C J, Warren, B F, Richman, P I, Thomson, W H, Wilkinson, S P
The mucosa of the pelvic ileal reservoir undergoes adaptive changes--inflammatory, architectural, and metaplastic--on exposure to the faecal stream. Twenty three quadruple loop ileal pouches...
Histological assessment of the Sydney classification of endoscopic gastritis.
Khakoo, S I, Lobo, A J, Shepherd, N A, Wilkinson, S P
To determine the significance of the endoscopic classification of gastritis proposed by a working party at the World Congress of Gastroenterology in Sydney 1990, 167 patients undergoing upper...
Bate, C M, Keeling, P W, O'Morain, C, Wilkinson, S P, Foster, D N, Mountford, R A, ...
Symptomatic patients with endoscopically verified reflux oesophagitis were randomised to a double blind trial in which they received either omeprazole (20 mg once daily) or cimetidine (400 mg four...
Wilkinson, S P, Arroyo, V A, Moodie, H, Blendis, L M, Williams, R
Renal function was evaluated in 40 patients with fulminant hepatic failure, They were divided into two groups on the basis of glomerular filtration rates greater than 40 ml/min or less than 25...
Stern, R B, Wilkinson, S P, Howorth, P J, Williams, R
In view of promising, but uncontrolled, reports of the use of D-penicillamine in active chronic hepatitis, a randomised, prospective, controlled trial of this drug against prednisone was carried out....
Potassium and magnesium depletion in patients with cirrhosis on maintenance diuretic regimens.
Wheeler, P G, Smith, T, Golindano, C, Alam, A N, Wilkinson, S P, Edmonds, C J, ...
Total body potassium (40K) and leucocyte potassium measurements were carried out on 19 patients with stable but decompensated cirrhosis maintained on diuretics for previous ascites. Of 13 patients...
Changes in the electrolyte content of leucocytes at different clinical stages of cirrhosis.
Alam, A N, Wheeler, P, Wilkinson, S P, Poston, L, Golindano, C, Williamss, R
The intracellular sodium, potassium, and water content of isolated leucocytes was estimated in 47 patients with cirrhosis. The values for sodium showed a wide scatter. In patients without ascites the...
Hepatitis from dantrolene sodium.
Wilkinson, S P, Portmann, B, Williams, R
The clinical course and histological changes in the liver during a presumed adverse reaction to the drug dantrolene sodium are described in four patients. After a typical prodrome one developed a...
Renin-angiotensin-aldosterone system in cirrhosis.
According to traditional concepts, ascites formation and portal hypertension in cirrhosis lead to a deficit in the 'effective' extracellular fluid (ECF) and blood volumes respectively. The...
Reticuloendothelial system and hepatocytic function in fulminant hepatic failure.
Canalese, J, Gove, C D, Gimson, A E, Wilkinson, S P, Wardle, E N, Williams, R
Kupffer cell and hepatocyte function were studied in 36 patients with fulminant hepatic failure by measurement of clearance of 125I microaggregated albumin (125IMAA) and galactose, respectively. Both...
Detection of Campylobacter pylori by the biopsy urease test: an assessment in 1445 patients.
McNulty, C A, Dent, J C, Uff, J S, Gear, M W, Wilkinson, S P
The presence of C pylori infection was determined in 1445 patients undergoing upper gastrointestinal endoscopy over a 12 month period. The presence of C pylori was detected in gastric mucosal biopsy...
Bate, C M, Wilkinson, S P, Bradby, G V, Bateson, M C, Hislop, W S, Crowe, J P, ...
In a randomised, double blind, parallel group study in patients with symptomatic gastric ulcer (94% greater than or equal to 5 mm diameter), 102 received omeprazole 20 mg om and 87 cimetidine 400 mg...
Necrotizing 'sarcoidal' angiitis and granulomatosis of the lung.
Stephen, J G, Braimbridge, M V, Corrin, B, Wilkinson, S P, Day, D, Whimster, W F
A case of necrotizing sarcoid angiitis and granulomatosis (NSG) presenting as a peripheral lung 'tumour' in a 63-year-old man is recorded, and the clinical and pathological features are compared with...
Ford, G. A., Oliver, P. S., Prior, J. S., Butland, R. J., Wilkinson, S. P.
Eleven adult patients with nocturnal asthma, and gastro-oesophageal reflux documented by endoscopy or ambulatory oesophageal pH monitoring completed a double-blind cross-over study (4 week treatment,...
Use of the SeHCAT test in the investigation of diarrhoea.
Ford, G. A., Preece, J. D., Davies, I. H., Wilkinson, S. P.
The SeHCAT test was used to investigate possible bile acid malabsorption in 166 patients presenting to a district general hospital with chronic diarrhoea of uncertain cause. Eighty-four (51%)...
Donald, I. P., Wilkinson, S. P.
The use of sulphasalazine in inflammatory bowel disease is often limited by intolerance or allergy. In previous studies 5-aminosalicylic acid (5ASA), the active ingredient of sulphasalazine, coated...
Wilkinson, S. P., Bernardi, M., Wheeler, P. G., Smith, I. K., Williams, R.
In 4 patients with cirrhosis and ascites, diuretic therapy resulted in an impairment of renal function that was associated with a rise in plasma renin activity (PRA). In 3, this occurred in the...
A fatal case of Epstein-Barr virus infection with jaundice and renal failure.
Davies, M. H., Morgan-Capner, P., Portmann, B., Wilkinson, S. P., Williams, R.
A fatal case of Epstein-Barr virus infection in a 17-year-old male is described. The patient presented with an illness clinically typical of infectious mononucleosis but death followed development of...
Donald, I. P., Gear, M. W., Wilkinson, S. P.
Recurrent attacks of life-threatening dyspnoea and choking occurred in a patient with tetraplegia. Conventional investigations for gastro-oesophageal reflux were normal, but 24-hour oesophageal pH...
Protracted systemic illness and interstitial nephritis due to minocycline.
Wilkinson, S. P., Stewart, W. K., Spiers, E. M., Pears, J.
A severe hypersensitivity-like illness with acute renal failure, lymphadenopathy and skin rash is reported following minocycline treatment in a 16 year old male. Following haemodialysis and steroid...
Duodenal ulceration into the cystic artery.
Ford, G. A., Simpson, A. H., Gear, M. W., Wilkinson, S. P.
We report two cases of massive gastrointestinal bleeding due to anterior duodenal ulceration into the cystic artery, with gallbladder infarction as a complication. These cases indicate the potential...
Ascites reinfusion using the Rhodiascit apparatus—clinical experience and coagulation abnormalities
Wilkinson, S. P., Henderson, J., Davidson, A. R., Williams, Roger
The results of twenty-four ascitic reinfusions in twenty patients, using the Rhodiascit procedure, are reported. The procedure was of no value in the management of patients with spontaneous...
Pathogenesis of renal failure in cirrhosis and fulminant hepatic failure
Wilkinson, S. P., Hurst, D., Portmann, B., Williams, Roger
Acute renal failure in cirrhosis and fulminant hepatic failure represents a spectrum with ‘functional renal failure’ at one end and acute tubular necrosis at the other. In fulminant hepatic...
Renal retention of sodium in cirrhosis and fulminant hepatic failure
Wilkinson, S. P., Alam, A., Moodie, Helen, Williams, Roger
Abnormal renal retention of sodium is a characteristic finding in both cirrhosis and fulminant hepatic failure. In cirrhosis the pathogenesis varies according to the level of renal perfusion. When...
Consequences of acute renal failure relevant to hepatic failure
Weston, M. J., Wilkinson, S. P.
The onset of renal failure in patients with liver failure complicates an already deranged metabolic picture and may increase the retention of many potentially toxic substances. The risk to the...
Use of dialysis in the treatment of renal failure in liver disease
Parsons, Victor, Wilkinson, S. P., Weston, M. J.
Early and thorough peritoneal and haemodialysis has a part to play in the management of selected patients with hepato-renal failure. Patients with advanced irreversible hepatic damage due to...
Keating, J. J., Johnson, P. J., Cochrane, A. M., Gazzard, B. G., Krasner, N., Smith, P. M., ...
In a prospective controlled clinical trial, 108 patients with pancreatic adenocarcinoma were randomly allocated to receive tamoxifen 20 mg b.d., cyproteron acetate 100 mg t.d.s. or no active...