Quantitative assessment of enterprise resource planning software customisation (2009)
One of the main problems faced by the consultants during enterprise resource planning (ERP) implementation is how to align an ERP software package with the business processes of the enterprise...
Quantitative assessment of enterprise resource planning software customisation (2009)
One of the main problems faced by the consultants during enterprise resource planning (ERP) implementation is how to align an ERP software package with the business processes of the enterprise...
G. Buehrer, A. Ghoting, S. Tatikonda, S. Parthasarathy, T. Kurc, J. Saltz
Advances in data collection and storage technologies have given rise to large dynamic data stores. In order to effectively manage and mine such stores on modern and emerging architectures, one must...
Shared State for Client-Server Mining ∗ (2008)
S. Parthasarathy, S. Dwarkadas
For many organizations the explosive growth in data collection techniques and database technology has resulted in large and dynamically growing datasets. These organizations are increasingly turning...
G. Buehrer, A. Ghoting, Xi Zhang, S. Tatikonda, S. Parthasarathy, T. Kurc, ...
Advances in data collection and storage technologies have given rise to large dynamic data stores. In order to effectively manage and mine such stores on modern and emerging architectures, one must...
R. Jin, C. Wang, D. Polshakov, S. Parthasarathy, G. Agrawal
The problem of finding frequent patterns from graph-based datasets is an important one that finds applications in drug discovery, protein structure analysis, XML querying, and social network analysis...
R. Jin, C. Wang, D. Polshakov, S. Parthasarathy, G. Agrawal
The problem of finding frequent patterns from graph-based datasets is an important one that finds applications in drug discovery, protein structure analysis, XML querying, and social network analysis...
A Services Oriented Framework for Next Generation Data Analysis Centers (2008)
H. Wang, A. Ghoting, G. Buehrer, S. Tatikonda, S. Parthasarathy, T. Kurc, ...
Over the past decade, advances in computational and sensor technology have enabled us to dynamically collect vast amounts of data from observations, health screening tests, simulations, and...
Adaptive Polling of Grid Resource Monitors using a Slacker Coherence Model (2008)
R. Sundaresan, M. Lauria, T. Kurc, S. Parthasarathy, Joel Saltz
kurc-1,saltz-1¤ As Data and Computational Grids grow in size and complexity, the crucial task of identifying, monitoring and utilizing available resources in an efficient manner is becoming...
R. C. Rose, S. Parthasarathy, R. C. Rose, S. Parthasarathy, Asr Wireless, Mobile Devices
– Mobile Applications, Devices, and Architectures
Unusual presentation of esophageal tuberculosis mimicking malignancy (2008)
Patnayak, R, Reddy, MK, Parthasarathy, S, Yootla, M, Reddy, V, Jena, A
Unsupervised Discretization, Jee Vang, What Is Discretization, S. Mehta, S. Parthasarathy, H. Yang
– Continuous (aka quantitative) (i.e. weight (lbs): 155.2, 160.2, 199.3) – Categorical (aka quantitative) (i.e. color: red, blue, green, white) • Discretization – Transformation of continuous...
R. Jin, C. Wang, D. Polshakov, S. Parthasarathy, G. Agrawal
The problem of finding frequent patterns from graph-based datasets is an important one that finds applications in drug discovery, protein structure analysis, XML querying, and social network analysis...
Investigating the use of Extrinsic Similarity Measures for Microarray Analysis ∗ ABSTRACT (2008)
D. Ucar, F. Altiparmak, H. Ferhatosmanoglu, S. Parthasarathy
Genes behaving similarly over changing conditions are believed to be part of the same functional module. Identifying functional modules of genes plays an important role in understanding gene...
R. Jothi, S. Parthasarathy, K. Ganesan
Whole genome sequences of the four strains of Streptococcus pneumoniae, encapsulated TIGR4, D39, G54 and nonencapsulated R6 are considered for the comparative study on genome features, whole genome...
Aaron Rosenberg, Julia Hirschberg, Michiel Bacchiani, S Parthasarathy, Philip Isenhour, Larry Stead
SCANMail is a prototype system developed at AT&T Labs for the purpose of providing useful tools for managing and searching through voicemail messages. Content is extracted from voicemail messages...
S. Parthasarathy, M. J. Zaki, M. Ogihara, S. Dwarkadas
The discovery of frequent sequences in temporal databases is an important data mining problem. Most current work assumes that the database is static, and a database update requires rediscovering all...
S. Parthasarathy, M. J. Zaki, M. Ogihara, S. Dwarkadas
The discovery of frequent sequences in temporal databases is an important data mining problem. Most current work assumes that the database is static, and a database update requires rediscovering all...
Shared State for Client-Server Mining (2007)
S. Parthasarathy, S. Dwarkadas
For many organizations the explosive growth in data collection techniques and database technology has resulted in large and dynamically growing datasets. These organizations are increasingly turning...
Analyzing the Software Quality Metrics for Object Oriented Technology (2006)
S. Parthasarathy, N. Anbazhagan
Metrics are units of measurement. Software engineering metrics are units of measurement that are used to characterize the software engineering products and software engineering processes....
Analyzing the Software Quality Metrics for Object Oriented Technology (2006)
S. Parthasarathy, N. Anbazhagan
Metrics are units of measurement. Software engineering metrics are units of measurement that are used to characterize the software engineering products and software engineering processes....
AN EXPLORATORY CASE STUDY ON PERFORMANCE ENHANCEMENT OF ERP PROJECTS 1 (2006)
S. Parthasarathy, N. Anbazhagan, Muthu Ramachandran
Abstract. Business information system is an area of the greatest significance in any business enterprise today. Enterprise Resource Planning [ERP] projects are a growing segment of this vital area....
Design of a next generation sampling service for large scale data analysis applications (2005)
H. Wang, S. Parthasarathy, A. Ghoting, S. Tatikonda, G. Buehrer, T. Kurc, ...
Advances in data collection and storage technologies have resulted in large and dynamically growing data sets at many organizations. Database and data mining researchers often use sampling with great...
Dynamic classification of defect structures in molecular dynamics simulation data (2005)
S. Mehta, S. Barr, T. Choy, H. Yang, S. Parthasarathy, R. Machiraju, ...
In this application paper we explore techniques to classify anomalous structures (defects) in data generated from abinitio Molecular Dynamics (MD) simulations of Silicon (Si) atom systems. These...
The AT&T WATSON speech recognizer (2005)
V. Goffin, C. Allauzen, E. Bocchieri, D. Hakkani-tür, A. Ljolje, S. Parthasarathy, ...
This paper describes the AT&T WATSON real-time speech recognizer, the product of several decades of research at AT&T. The recognizer handles a wide range of vocabulary sizes and is based on...
Organo-phosphate induced delayed neuropathy: Report of two cases (2004)
Singh, S, Ranjit, A, Parthasarathy, S, Sharma, N, Bambery, P
Organo-phosphate induced delayed neuropathy: Report of two cases (2004)
Singh, Surjit, Ranjit, Arun, Parthasarathy, S., Sharma, Navneet, Bambery, Pradeep
none
Organo-phosphate induced delayed neuropathy: Report of two cases (2004)
Singh, Surjit, Ranjit, Arun, Parthasarathy, S., Sharma, Navneet, Bambery, Pradeep
none
Organo-phosphate induced delayed neuropathy: Report of two cases (2004)
Singh, Surjit, Ranjit, Arun, Parthasarathy, S., Sharma, Navneet, Bambery, Pradeep
none
A. Veloso, W. Meira, R. Ferreira, D. Guedes, S. Parthasarathy
Abstract In this paper we propose a novel parallel algorithm for frequent itemset mining. The algorithm is based on the filter-stream programming model, in which the frequent itemset mining process...
A. Veloso, W. Meira Jr., W. Meira, R. Ferreira, D. Guedes, S. Parthasarathy
In this paper we propose a novel parallel algorithm for frequent itemset mining. The algorithm is based on the filter-stream programming model, in which the frequent itemset mining process is...
Towards nic-based intrusion detection (2003)
M. Otey, S. Parthasarathy, A. Ghoting, G. Li, S. Narravula
We present and evaluate a NIC-based network intrusion detection system. Intrusion detection at the NIC makes the system potentially tamper-proof and is naturally extensible to work in a distributed...
Mining Frequent Itemsets in Distributed and Dynamic Databases (2003)
Otey Wang Parthasarathy, M. E. Otey, C. Wang, S. Parthasarathy
Traditional methods for frequent itemset mining typically assume that data is centralized and static. Such methods impose excessive communication overhead when data is distributed, and they waste...
Towards NIC-based Intrusion Detection (2003)
Otey Parthasarathy Ghoting, M. Otey, S. Parthasarathy, A. Ghoting, G. Li, S. Narravula
system. Intrusion detection at the NIC makes the system potentially tamper-proof and is naturally extensible to work in a distributed setting. Simple anomaly detection and signature detection based...
Towards NIC-based Intrusion Detection (2003)
Otey Parthasarathy Ghoting, M. Otey, S. Parthasarathy, A. Ghoting, G. Li, S. Narravula
system. Intrusion detection at the NIC makes the system potentially tamper-proof and is naturally extensible to work in a distributed setting. Simple anomaly detection and signature detection based...
Parthasarathy, S, Balaram, Hemalatha, Balaram, P, Murthy, MRN
The glycolytic enzymes of Plasmodium falciparum (Pf) are attractive drug targets as the parasites lack a functional tricarboxylic cycle and hence depend heavily on glycolysis for their energy...
Triosephosphate isomerase (TIM) has been the subject of many structural and mechanistic studies. At position 96, there is a highly conserved Ser residue, which is proximal to the catalytic site. Thus...
Determination of the structure of the recombinant T = 1 capsid of Sesbania mosaic virus (2002)
Sangita, V, Parthasarathy, S, Toma, S, Lokesh, GL, Gowri, TDS, Satheshkumar, PS, ...
The recombinant coat protein (CP) of Sesbania mosaic virus lacking segments of different lengths from the N-terminus expressed in E. coli was shown to selfassemble into a variety of distinct capsids...
Parthasarathy, S, Balaram, Hemalatha, Balaram, P, Murthy, MRN
The glycolytic enzymes of Plasmodium falciparum (Pf) are attractive drug targets as the parasites lack a functional tricarboxylic cycle and hence depend heavily on glycolysis for their energy...
Triosephosphate isomerase (TIM) has been the subject of many structural and mechanistic studies. At position 96, there is a highly conserved Ser residue, which is proximal to the catalytic site. Thus...
Determination of the structure of the recombinant T = 1 capsid of Sesbania mosaic virus (2002)
Sangita, V, Parthasarathy, S, Toma, S, Lokesh, GL, Gowri, TDS, Satheshkumar, PS, ...
The recombinant coat protein (CP) of Sesbania mosaic virus lacking segments of different lengths from the N-terminus expressed in E. coli was shown to selfassemble into a variety of distinct capsids...
Efficiently mining approximate models of associations in evolving databases (2002)
A. Veloso, B. Gusmão, W. Meira, M. Carvalho, S. Parthasarathy, M. Zaki
Abstract Much of the existing work in machine learning and data mining has relied on devising efficient techniques to build accurate models from the data. Research on how the accuracy of a model...
Efficiently Mining Approximate Models of Associations in Evolving Databases (2002)
A. Veloso, B. Gusmao, W. Meira Jr., M. Carvalho, S. Parthasarathy, M. Zaki
Much of the existing work in machine learning and data mining has relied on devising efficient techniques to build accurate models from the data. Research on how the accuracy...
Efficiently Mining Approximate Models of Associations in Evolving Databases (2002)
A. Veloso, B. Gusmão, W. Meira Jr., W. Meira, M. Carvalho, S. Parthasarathy, ...
Much of the existing work in machine learning and data mining has relied on devising efficient techniques to build accurate models from the data.
Mining Frequent Itemsets in Evolving Databases (2002)
A. A. Veloso, W.Meira Jr., S. Parthasarathy, M.J. Zaki
this paper we present such an approach for a key data mining task: association rule mining
Efficiently mining approximate models of associations in evolving databases (2002)
A. Veloso, B. Gusmão, W. Meira, M. Carvalho, S. Parthasarathy, M. Zaki
Abstract Much of the existing work in machine learning and data mining has relied on devising efficient techniques to build accurate models from the data. Research on how the accuracy of a model...
NIC-based intrusion detection: A feasibility study (2002)
Otey Noronha Li, M. Otey, R. Noronha, G. Li, S. Parthasarathy, D. K. Panda
We present and evaluate a NIC-based network intrusion detection system. Functions such as signature-based and anomaly-based packet classification are performed on the NIC, which has its own processor...
Ajees, Abdul A, Sekar, K, Parthasarathy, S, Schenk, H, Epe, B, Mondon, A
The X-ray crystal structure of the title compound, $(C_{25}H_{28}O_8)$, has been determined. In the structure, both the terminal five-membered rings (A and F) are planar. The fused five-membered...
Using clustering to boost text classification (2001)
Y. C. Fang, S. Parthasarathy, F. Schwartz
In recent years we have seen a tremendous growth in the number of text document collections available on the Internet. Automatic text categorization, the process of assigning unseen documents to...
Using Clustering to Boost Text Classification (2001)
Y. C. Fang, S. Parthasarathy, F. Schwartz
In recent years we have seen a tremendous growth in the number of text document collections available on the Internet. Automatic text categorization, the process of assigning unseen documents to...
On the conditions for synchronization in unidirectionally coupled chaotic oscillators (2000)
Muruganandam, P., Lakshmanan, M., Parthasarathy, S.
The conditions for synchronization in unidirectionally coupled chaotic oscillators are revisited. We demonstrate with typical examples that the conditional Lyapunov exponents (CLEs) play an important...
Comment on ``Intermittent Synchronization in a Pair of Coupled Chaotic Pendula" (2000)
Muruganandam, P., Parthasarathy, S., Lakshmanan, M.
The main aim of this comment is to emphasize that the conditional Lyapunov exponents play an important role in distinguishing between intermittent and persistent synchronization, when the analytic...
Atomic displacement parameters of homologous proteins: Conservation of dynamics (2000)
Lenin, VMS, Parthasarathy, S, Murthy, MRN
Atomic displacement parameters (ADPs) obtained from highresolution refinement of protein structures represent the mean square displacement of protein atoms from their centroid positions. They contain...
Atomic displacement parameters (ADPs) obtained by high resolution X-ray diffraction studies on single crystals of proteins represent the mean square displacement of atoms about their mean position....
Protein thermal stability: insights from atomic displacement parameters (B values) (2000)
The factors contributing to the thermal stability of proteins from thermophilic origins are matters of intense debate and investigation. Thermophilic proteins are thought to possess better packed...
Atomic displacement parameters of homologous proteins: Conservation of dynamics (2000)
Lenin, VMS, Parthasarathy, S, Murthy, MRN
Atomic displacement parameters (ADPs) obtained from highresolution refinement of protein structures represent the mean square displacement of protein atoms from their centroid positions. They contain...
Atomic displacement parameters (ADPs) obtained by high resolution X-ray diffraction studies on single crystals of proteins represent the mean square displacement of atoms about their mean position....
Crystal and Molecular Structure of Desmodin (2000)
Ajees, Abdul A, Sekar, K, Parthasarathy, S, Balakrishna, K
The crystal structure of the title compound has been determined from X-ray diffraction. The compound crystallizes from benzene in the orthorhombic system, space group P212121, with unit cell...
Protein thermal stability: insights from atomic displacement parameters (B values) (2000)
The factors contributing to the thermal stability of proteins from thermophilic origins are matters of intense debate and investigation. Thermophilic proteins are thought to possess better packed...
Crystal and Molecular Structure of Desmodin (2000)
Ajees, Abdul A, Sekar, K, Parthasarathy, S, Balakrishna, K
The crystal structure of the title compound has been determined from X-ray diffraction. The compound crystallizes from benzene in the orthorhombic system, space group P212121, with unit cell...
Protein thermal stability: insights from atomic displacement parameters (B values) (2000)
Parthasarathy, S., Murthy, M.R.N.
The factors contributing to the thermal stability of proteins from thermophilic origins are matters of intense debate and investigation. Thermophilic proteins are thought to possess better packed...
Velanker, SS, Gokhale, RS, Ray, Soumya S, Gopal, B, Parthasarathy, S, Santi, DV, ...
The crystal structure of a covalently cross-linked Lactobacillus casei thymidylate synthase has been determined at 2.8 Å resolution. The sites for mutation to achieve the bis-disulfide linked dimer...
Velanker, SS, Gokhale, RS, Ray, Soumya S, Gopal, B, Parthasarathy, S, Santi, DV, ...
The crystal structure of a covalently cross-linked Lactobacillus casei thymidylate synthase has been determined at 2.8 \AA resolution. The sites for mutation to achieve the bis-disulfide linked dimer...
Correlation coefficients (CCs) between the mean atomic displacement parameters (B values) of the main-chain and the side-chain atoms in selected high-resolution protein structures are distributed...
Velanker, SS, Gokhale, RS, Ray, Soumya S, Gopal, B, Parthasarathy, S, Santi, DV, ...
The crystal structure of a covalently cross-linked Lactobacillus casei thymidylate synthase has been determined at 2.8 Å resolution. The sites for mutation to achieve the bis-disulfide linked dimer...
Correlation coefficients (CCs) between the mean atomic displacement parameters (B values) of the main-chain and the side-chain atoms in selected high-resolution protein structures are distributed...
Velanker, SS, Gokhale, RS, Ray, Soumya S, Gopal, B, Parthasarathy, S, Santi, DV, ...
The crystal structure of a covalently cross-linked Lactobacillus casei thymidylate synthase has been determined at 2.8 \AA resolution. The sites for mutation to achieve the bis-disulfide linked dimer...
Active Mining in a Distributed Setting (1999)
S. Parthasarathy, S. Dwarkadas, M. Ogihara
Most current work in data mining assumes that the data is static, and a database update requires re-mining both the old and new data. In this article, we propose an alternative approach. We outline a...
Detection of target speakers in audio databases (1999)
Ivan Magrin-chagnolleau, Aaron E. Rosenberg, S. Parthasarathy
The problem of speaker detection in audio databases is addressed in this paper. Gaussian mixture modeling is used to build target speaker and background models. A detection algorithm based on a...
Active Mining in a Distributed Setting (1999)
S. Parthasarathy, S. Dwarkadas, M. Ogihara
Most current work in data mining assumes that the data is static, and a database update requires re-mining both the old and new data. In this article, we propose an alternative approach. We outline a...
Incremental and Interactive Sequence Mining (1999)
S. Parthasarathy, M. J. Zaki, M. Ogihara, S. Dwarkadas
The discovery of frequent sequences in temporal databases is an important data mining problem. Most current work assumes that the database is static, and a database update requires rediscovering all...
Detection Of Target Speakers In Audio Databases (1999)
Ivan Magrin-chagnolleau, Aaron E. Rosenberg, S. Parthasarathy
The problem of speaker detection in audio databases is addressed in this paper. Gaussian mixture modeling is used to build target speaker and background models. A detection algorithm based on a...
Incremental and Interactive Sequence Mining (1999)
S. Parthasarathy, M. J. Zaki, M. Ogihara, S. Dwarkadas
The discovery of frequent sequences in temporal databases is an important data mining problem. Most current work assumes that the database is static, and a database update requires rediscovering all...
The domain-server: direct prediction of protein domain-homologies from BLAST search (1999)
Murvai, J, Vlahovicek, K, Barta, E, Parthasarathy, S, Hegyi, H, Pfeiffer, F, ...
Parallel Data Mining for Association Rules on Shared-Memory Multi-Processors. (1998)
Zaki, M. J., Ogihara, M., Parthasarathy, S., Li, W.
Data mining is an emerging research area, whose goal is to extract significant patterns or interesting rules from large databases. High-level inference from large volumes of routine business data can...
Gopal, B, Prasanna, V, Parthasarathy, S, Santi, DV, Balaram, P, Murthy, MRN
Some crystal forms of thymidylate synthase from L. casei exhibit unit sell transformation upon irradiation by X-rays, These forms, all of which occur in the space group P6(1)22, show an elongation in...
Analysis of temperature factor distribution in high-resolution protein structures (1998)
The temperature factors obtained from X-ray refinement of proteins at high resolution show large variations from one structure to another. However, the B-values expressed in units of standard...
Gopal, B, Prasanna, V, Parthasarathy, S, Santi, DV, Balaram, P, Murthy, MRN
Some crystal forms of thymidylate synthase from L. casei exhibit unit sell transformation upon irradiation by X-rays, These forms, all of which occur in the space group P6(1)22, show an elongation in...
Speaker detection in broadcast speech databases (1998)
Aaron E. Rosenberg, Ivan Magrin-chagnolleau, S. Parthasarathy, Qian Huang
Experiments have been carried out to assess the feasibility of detecting target speaker segments in multi-speaker broadcast databases. The experimental database consists of NBC Nightly News...
Analysis of temperature factor distribution in high-resolution protein structures (1997)
The temperature factors obtained from X-ray refinement of proteins at high resolution show large variations from one structure to another. However, the B-values expressed in units of standard...
Custom Memory Placement for Parallel Data Mining (1997)
S. Parthasarathy, M. J. Zaki, W. Li
A lot of data mining tasks, such as Associations, Sequences, and Classification, use complex pointer-based data structures that typically suffer from sub-optimal locality. In the multiprocessor case...
New Algorithms for Fast Discovery of Association Rules (1997)
Zaki Parthasarathy Ogihara, M. J. Zaki, S. Parthasarathy, M. Ogihara, W. Li
Discovery of association rules is an important problem in database mining. In this paper we present new algorithms for fast association mining, which scan the database only once, addressing the open...
New Algorithms for Fast Discovery of Association Rules (1997)
M. J. Zaki, S. Parthasarathy, M. Ogihara, W. Li
Discovery of association rules is an important problem in database mining. In this paper we present new algorithms for fast association mining, which scan the database only once, addressing the open...
S. Parthasarathy, A. E. Rosenberg
We present a design and study the performance of a text-dependent speaker veri�cation system using general phrase passwords. The text of the password utterance and its phone transcription are...
Parallel data mining for association rules on shared-memory multi-processors (1996)
M. J. Zaki, M. Ogihara, S. Parthasarathy, W. Li
Data mining is an emerging research area, whose goal is to extract significant patterns or interesting rules from databases. High-level inference from large volumes of routine business data can...
Parallel Data Mining for Association Rules on Shared-memory Multi-processors (1996)
M. J. Zaki, M. Ogihara, S. Parthasarathy, W. Li
Data mining is an emerging research area, whose goal is to extract significant patterns or interesting rules from databases. High-level inference from large volumes of routine business data can...
Parallel Data Mining for Association Rules on Shared-memory Multi-processors (1996)
M. J. Zaki, M. Ogihara, S. Parthasarathy, W. Li
Data mining is an emerging research area, whose goal is to extract significant patterns or interesting rules from large databases. High-level inference from large volumes of routine business data can...
Parthasarathy, S., Fong, L. G., Quinn, M. T., Steinberg, D.
Macrophage-derived foam cells are hallmarks of early atherosclerotic lesions. Oxidatively modified LDL has been suggested to be a more atherogenic form than native LDL. Oxidized LDL—but not native...
Foam separation of microbial cells (1988)
Parthasarathy, S, Das, TR, Kumar, R, Gopalakrishnan, KS
Batch foam separation has been employed to separate Saccharomyces carlsbergensis cells from their broth without the use of any external surface-active agent. A model has been developed to predict the...
Foam separation of microbial cells (1988)
Parthasarathy, S, Das, TR, Kumar, R, Gopalakrishnan, KS
Batch foam separation has been employed to separate Saccharomyces carlsbergensis cells from their broth without the use of any external surface-active agent. A model has been developed to predict the...
Typescript.
Structure of tert-ButyloxycarbonyI-L-alanyI-L-proline Monohydrate (t-Boc-Ala-Pro) (1982)
Kamwaya, ME, Oster, O, Bradaczek, H, Ponnuswamy, MN, Parthasarathy, S, Nagaraj, R, ...
$C_{13}H_{22}N_2O_5.H_2O$, $M_r$ = 304.37, is orthorhombic, space group ${P2}_12_12_l$, with a = 20.751 (2), b = 13.457 (1), c = 5.875 (1) A, V = 1640.49 $A^3$, $D_o$ = 1.20, $D_c$ = 1.231 Mg...
Structure of tert-ButyloxycarbonyI-L-alanyI-L-proline Monohydrate (t-Boc-Ala-Pro) (1982)
Kamwaya, ME, Oster, O, Bradaczek, H, Ponnuswamy, MN, Parthasarathy, S, Nagaraj, R, ...
$C_{13}H_{22}N_2O_5.H_2O$, $M_r$ = 304.37, is orthorhombic, space group ${P2}_12_12_l$, with a = 20.751 (2), b = 13.457 (1), c = 5.875 (1) A, V = 1640.49 $A^3$, $D_o$ = 1.20, $D_c$ = 1.231 Mg...
Typescript.
Parthasarathy, S., Singh, Harkrishan
Emploi de la méthode thermo-acoustique pour déterminer l'amplitude des vibrations de très haute fréquence d'un quartz plongé dans un liquide. Cette amplitude varie en raison inverse de...
L'absorption des ultrasons par certaines cétones (1958)
Parthasarathy, S., Narasimhan, V.
La célérité des ultrasons et leur coefficient d'absorption ont été mesurés dans plusieurs cétones à différentes températures et les résultats comparés à ceux déjà donnés par divers...
Parthasarathy, S., Singh, Harkrishan
Emploi de la méthode thermo-acoustique pour déterminer l'amplitude des vibrations de très haute fréquence d'un quartz plongé dans un liquide. Cette amplitude varie en raison inverse de...
L'absorption des ultrasons par certaines cétones (1958)
Parthasarathy, S., Narasimhan, V.
La célérité des ultrasons et leur coefficient d'absorption ont été mesurés dans plusieurs cétones à différentes températures et les résultats comparés à ceux déjà donnés par divers...
Parthasarathy, S., Singh, Harkrishan
Emploi de la méthode thermo-acoustique pour déterminer l'amplitude des vibrations de très haute fréquence d'un quartz plongé dans un liquide. Cette amplitude varie en raison inverse de...
L'absorption des ultrasons par certaines cétones (1958)
Parthasarathy, S., Narasimhan, V.
La célérité des ultrasons et leur coefficient d'absorption ont été mesurés dans plusieurs cétones à différentes températures et les résultats comparés à ceux déjà donnés par divers...
Parthasarathy, S., Chari, S.S., Mahendroo, P.P.
L'absorption d'ondes ultrasonores de fréquence 5 Mc/s dans divers composés organiques liquides est étudiée en mesurant le dégagement de chaleur produit à différentes distances de la source par...
Parthasarathy, S., Chari, S.S., Srinivasan, D.
L'absorption d'ondes ultrasonores de 5 MHz est mesurée dans 47 liquides par la méthode des pressions de radiations utilisée par Biquard, puis par Fox et Rock, avec de légères modifications. On...
Parthasarathy, S., Chari, S.S., Mahendroo, P.P.
L'absorption d'ondes ultrasonores de fréquence 5 Mc/s dans divers composés organiques liquides est étudiée en mesurant le dégagement de chaleur produit à différentes distances de la source par...
Parthasarathy, S., Chari, S.S., Srinivasan, D.
L'absorption d'ondes ultrasonores de 5 MHz est mesurée dans 47 liquides par la méthode des pressions de radiations utilisée par Biquard, puis par Fox et Rock, avec de légères modifications. On...
Parthasarathy, S., Chari, S.S., Mahendroo, P.P.
L'absorption d'ondes ultrasonores de fréquence 5 Mc/s dans divers composés organiques liquides est étudiée en mesurant le dégagement de chaleur produit à différentes distances de la source par...
Parthasarathy, S., Chari, S.S., Srinivasan, D.
L'absorption d'ondes ultrasonores de 5 MHz est mesurée dans 47 liquides par la méthode des pressions de radiations utilisée par Biquard, puis par Fox et Rock, avec de légères modifications. On...
Unusual dynamics of extinction in a simple ecological model.
Studies on natural populations and harvesting biological resources have led to the view, commonly held, that (i) populations exhibiting chaotic oscillations run a high risk of extinction; and (ii) a...
Ottnad, E, Parthasarathy, S, Sambrano, G R, Ramprasad, M P, Quehenberger, O, Kondratenko, N, ...
The binding and uptake of oxidatively modified low density lipoprotein (OxLDL) by mouse peritoneal macrophages occurs, in part, via the well characterized acetyl LDL receptor. However, several lines...
Sambrano, G R, Parthasarathy, S, Steinberg, D
Macrophages specifically bind and internalize oxidatively modified low density lipoprotein (LDL) via the acetyl-LDL receptor and possibly one or more additional receptors jointly designated here as...
Wieland, E, Parthasarathy, S, Steinberg, D
Oxidative modification of low density lipoprotein is believed to be an important pathway by which the lipoprotein becomes atherogenic. The in vitro systems for oxidative modification of low density...
Picard, S, Parthasarathy, S, Fruebis, J, Witztum, J L
Aminoguanidine decreases the formation of advanced glycosylation end products that occurs during chronic hyperglycemia. Presumably this occurs because early glycosylation products preferentially bind...
Moulton, K S, Wu, H, Barnett, J, Parthasarathy, S, Glass, C K
The acetylated low density lipoprotein (AcLDL) receptor is expressed on tissue macrophages after their differentiation from monocyte precursors and has been proposed to play a role in the generation...
Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.
Fruebis, J, Parthasarathy, S, Steinberg, D
The events accompanying oxidative modification of low density lipoprotein (LDL) are multiple and complex, and the precise mechanisms remain to be determined. In the present studies, we examined a...
Parthasarathy, S, Khoo, J C, Miller, E, Barnett, J, Witztum, J L, Steinberg, D
Oxidative modification of low density lipoprotein (LDL) enhances its potential atherogenicity in several ways, notably by enhancing its uptake into macrophages. In vivo studies in the rabbit show...
Ylä-Herttuala, S, Rosenfeld, M E, Parthasarathy, S, Glass, C K, Sigal, E, Witztum, J L, ...
Oxidation of low density lipoprotein (LDL) enhances its atherogenicity, and inhibition of such oxidation decreases the rate of progression of atherosclerotic lesions. The mechanism of LDL oxidation...
During oxidative modification of low density lipoprotein (LDL) there is extensive degradation of phosphatidylcholine (PtdCho) to lysophosphatidylcholine (lyso-PtdCho), with the removal of fatty acids...
Quinn, M T, Parthasarathy, S, Steinberg, D
Native low density lipoprotein (LDL) does not affect monocyte/macrophage motility. On the other hand, oxidatively modified LDL inhibits the motility of resident peritoneal macrophages yet acts as a...
A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.
Parthasarathy, S, Wieland, E, Steinberg, D
Oxidative modification of low density lipoprotein (LDL) has been implicated as a factor in the generation of macrophage-derived foam cells in vitro and in vivo. However, the exact mechanism of LDL...
Low density lipoprotein undergoes oxidative modification in vivo.
Palinski, W, Rosenfeld, M E, Ylä-Herttuala, S, Gurtner, G C, Socher, S S, Butler, S W, ...
It has been proposed that low density lipoprotein (LDL) must undergo oxidative modification before it can give rise to foam cells, the key component of the fatty streak lesion of atherosclerosis....
Reaven, P, Parthasarathy, S, Grasse, B J, Miller, E, Steinberg, D, Witztum, J L
We report the results of feeding oleate- or linoleate-enriched diets for 8 wk to mildly hypercholesterolemic subjects and the resulting alterations in composition and functional properties of their...
Antioxidant: a new role for RU-486 and related compounds.
Parthasarathy, S, Morales, A J, Murphy, A A
RU-486 (17 beta-hydroxy-4-dimethylaminophenyl-17-alpha-propenyl estrone 4,9 diene-3-one; mifepristone) is suggested to act by binding to progesterone and glucocorticoid receptors. Based on its...
Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes.
McMurray, H F, Parthasarathy, S, Steinberg, D
Oxidatively modified low density lipoprotein (Ox-LDL) is a known chemoattractant for monocytes. Here we demonstrate, using a modified Boyden chamber assay, that human peripheral blood T lymphocytes,...
Rosenfeld, M E, Khoo, J C, Miller, E, Parthasarathy, S, Palinski, W, Witztum, J L
Pure macrophage-derived foam cells (MFC) were isolated from the aortas of rabbits made atherosclerotic by balloon deendothelialization followed by diet-induced hypercholesterolemia. The MFC were...
Ylä-Herttuala, S, Rosenfeld, M E, Parthasarathy, S, Sigal, E, Särkioja, T, Witztum, J L, ...
Oxidatively modified low density lipoprotein (LDL) exhibits several potentially atherogenic properties, and inhibition of LDL oxidation in rabbits decreases the rate of the development of...
Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases.
Oxidation of LDL by peroxidases has been suggested to be a model for in vivo oxidation. The mechanism might involve the generation of an intermediate radical such as a phenoxy radical. We show that,...
Parthasarathy, S, Fong, L G, Otero, D, Steinberg, D
Macrophages express a specific receptor that recognizes acetylated low density lipoprotein (LDL) and certain other chemically modified forms of LDL but not native LDL. LDL oxidatively modified either...
Quinn, M T, Parthasarathy, S, Fong, L G, Steinberg, D
Previous studies in this laboratory established that low density lipoprotein (LDL) incubated with cultured endothelial cells, smooth muscle cells, or macrophages undergoes free radical-catalyzed...
Ylä-Herttuala, S, Palinski, W, Rosenfeld, M E, Parthasarathy, S, Carew, T E, Butler, S, ...
Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively...
Kamiryo, T, Parthasarathy, S, Numa, S
The cellular content of acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] in Saccharomyces cerevisiae is reduced by the addition of long-chain fatty acids to the...
Steinbrecher, U P, Parthasarathy, S, Leake, D S, Witztum, J L, Steinberg, D
Low density lipoprotein (LDL) incubated with cultured endothelial cells from rabbit aorta or human umbilical vein is altered in several ways (EC-modified): (i) It is degraded by macrophages much...
Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis.
Parthasarathy, S, Kritchevsky, D, Baumann, W J
Clofibric acid (CPIB) and several other systemic hypolipidemic drugs are shown to block phosphatidylcholine synthesis by inhibiting cholinephosphotransferase (ChoPTase; CDPcholine:1,2-diacylglycerol...
Quinn, M T, Parthasarathy, S, Steinberg, D
Cultured rabbit and bovine aortic endothelial cells generated chemotactic activity for mouse resident peritoneal macrophages, demonstrable in the conditioned medium. This chemotactic activity was...
Parthasarathy, S, Steinbrecher, U P, Barnett, J, Witztum, J L, Steinberg, D
Previous studies have established that incubation of low density lipoprotein (LDL) with cultured endothelial cells (EC) converts it to a new form (EC-modified LDL) that is now recognized by a...
Probucol inhibits oxidative modification of low density lipoprotein.
Parthasarathy, S, Young, S G, Witztum, J L, Pittman, R C, Steinberg, D
Previous studies have established that low density lipoprotein (LDL) incubated with endothelial cells (EC) undergoes extensive oxidative modification in structure and that the modified LDL is...
Bird, J E, Milhoan, K, Wilson, C B, Young, S G, Mundy, C A, Parthasarathy, S, ...
The effects of antioxidant therapy with probucol were evaluated in rats subjected to 1 h renal ischemia and to 24 h reperfusion. Probucol exerted significant antioxidant effects in renal cortical...
Oxidative modification of low density lipoprotein (LDL) renders it more atherogenic. Probucol, a highly nonpolar antioxidant, is transported in lipoproteins, including LDL, and inhibits oxidative...
Vascular expression of extracellular superoxide dismutase in atherosclerosis.
Fukai, T, Galis, Z S, Meng, X P, Parthasarathy, S, Harrison, D G
We characterized a novel form of extracellular superoxide dismutase (ecSOD) in atherosclerotic vessels. Specific activity and protein expression of ecSOD was increased two- to threefold in apo...
Why are low-density lipoproteins atherogenic?
Low-density lipoproteins (LDLs) carry most of the cholesterol in human plasma, and high levels of LDL cholesterol clearly cause heart disease. In recent years, many scientists have focused on...
Weisner, C, Mertens, J, Parthasarathy, S, Moore, C, Hunkeler, E M, Hu, T, ...
OBJECTIVE: To compare outcome and cost-effectiveness of the two primary addiction treatment options, day hospitals (DH) and traditional outpatient programs (OP) in a managed care organization, in a...
Unusual dynamics of extinction in a simple ecological model.
Studies on natural populations and harvesting biological resources have led to the view, commonly held, that (i) populations exhibiting chaotic oscillations run a high risk of extinction; and (ii) a...
Ottnad, E, Parthasarathy, S, Sambrano, G R, Ramprasad, M P, Quehenberger, O, Kondratenko, N, ...
The binding and uptake of oxidatively modified low density lipoprotein (OxLDL) by mouse peritoneal macrophages occurs, in part, via the well characterized acetyl LDL receptor. However, several lines...
Sambrano, G R, Parthasarathy, S, Steinberg, D
Macrophages specifically bind and internalize oxidatively modified low density lipoprotein (LDL) via the acetyl-LDL receptor and possibly one or more additional receptors jointly designated here as...
Wieland, E, Parthasarathy, S, Steinberg, D
Oxidative modification of low density lipoprotein is believed to be an important pathway by which the lipoprotein becomes atherogenic. The in vitro systems for oxidative modification of low density...
Picard, S, Parthasarathy, S, Fruebis, J, Witztum, J L
Aminoguanidine decreases the formation of advanced glycosylation end products that occurs during chronic hyperglycemia. Presumably this occurs because early glycosylation products preferentially bind...
Moulton, K S, Wu, H, Barnett, J, Parthasarathy, S, Glass, C K
The acetylated low density lipoprotein (AcLDL) receptor is expressed on tissue macrophages after their differentiation from monocyte precursors and has been proposed to play a role in the generation...
Evidence for a concerted reaction between lipid hydroperoxides and polypeptides.
Fruebis, J, Parthasarathy, S, Steinberg, D
The events accompanying oxidative modification of low density lipoprotein (LDL) are multiple and complex, and the precise mechanisms remain to be determined. In the present studies, we examined a...
Parthasarathy, S, Khoo, J C, Miller, E, Barnett, J, Witztum, J L, Steinberg, D
Oxidative modification of low density lipoprotein (LDL) enhances its potential atherogenicity in several ways, notably by enhancing its uptake into macrophages. In vivo studies in the rabbit show...
Ylä-Herttuala, S, Rosenfeld, M E, Parthasarathy, S, Glass, C K, Sigal, E, Witztum, J L, ...
Oxidation of low density lipoprotein (LDL) enhances its atherogenicity, and inhibition of such oxidation decreases the rate of progression of atherosclerotic lesions. The mechanism of LDL oxidation...
During oxidative modification of low density lipoprotein (LDL) there is extensive degradation of phosphatidylcholine (PtdCho) to lysophosphatidylcholine (lyso-PtdCho), with the removal of fatty acids...
Quinn, M T, Parthasarathy, S, Steinberg, D
Native low density lipoprotein (LDL) does not affect monocyte/macrophage motility. On the other hand, oxidatively modified LDL inhibits the motility of resident peritoneal macrophages yet acts as a...
A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.
Parthasarathy, S, Wieland, E, Steinberg, D
Oxidative modification of low density lipoprotein (LDL) has been implicated as a factor in the generation of macrophage-derived foam cells in vitro and in vivo. However, the exact mechanism of LDL...
Low density lipoprotein undergoes oxidative modification in vivo.
Palinski, W, Rosenfeld, M E, Ylä-Herttuala, S, Gurtner, G C, Socher, S S, Butler, S W, ...
It has been proposed that low density lipoprotein (LDL) must undergo oxidative modification before it can give rise to foam cells, the key component of the fatty streak lesion of atherosclerosis....
Reaven, P, Parthasarathy, S, Grasse, B J, Miller, E, Steinberg, D, Witztum, J L
We report the results of feeding oleate- or linoleate-enriched diets for 8 wk to mildly hypercholesterolemic subjects and the resulting alterations in composition and functional properties of their...
Antioxidant: a new role for RU-486 and related compounds.
Parthasarathy, S, Morales, A J, Murphy, A A
RU-486 (17 beta-hydroxy-4-dimethylaminophenyl-17-alpha-propenyl estrone 4,9 diene-3-one; mifepristone) is suggested to act by binding to progesterone and glucocorticoid receptors. Based on its...
Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes.
McMurray, H F, Parthasarathy, S, Steinberg, D
Oxidatively modified low density lipoprotein (Ox-LDL) is a known chemoattractant for monocytes. Here we demonstrate, using a modified Boyden chamber assay, that human peripheral blood T lymphocytes,...
Rosenfeld, M E, Khoo, J C, Miller, E, Parthasarathy, S, Palinski, W, Witztum, J L
Pure macrophage-derived foam cells (MFC) were isolated from the aortas of rabbits made atherosclerotic by balloon deendothelialization followed by diet-induced hypercholesterolemia. The MFC were...
Ylä-Herttuala, S, Rosenfeld, M E, Parthasarathy, S, Sigal, E, Särkioja, T, Witztum, J L, ...
Oxidatively modified low density lipoprotein (LDL) exhibits several potentially atherogenic properties, and inhibition of LDL oxidation in rabbits decreases the rate of the development of...
Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases.
Oxidation of LDL by peroxidases has been suggested to be a model for in vivo oxidation. The mechanism might involve the generation of an intermediate radical such as a phenoxy radical. We show that,...
Parthasarathy, S, Fong, L G, Otero, D, Steinberg, D
Macrophages express a specific receptor that recognizes acetylated low density lipoprotein (LDL) and certain other chemically modified forms of LDL but not native LDL. LDL oxidatively modified either...
Quinn, M T, Parthasarathy, S, Fong, L G, Steinberg, D
Previous studies in this laboratory established that low density lipoprotein (LDL) incubated with cultured endothelial cells, smooth muscle cells, or macrophages undergoes free radical-catalyzed...
Ylä-Herttuala, S, Palinski, W, Rosenfeld, M E, Parthasarathy, S, Carew, T E, Butler, S, ...
Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively...
Kamiryo, T, Parthasarathy, S, Numa, S
The cellular content of acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] in Saccharomyces cerevisiae is reduced by the addition of long-chain fatty acids to the...
Steinbrecher, U P, Parthasarathy, S, Leake, D S, Witztum, J L, Steinberg, D
Low density lipoprotein (LDL) incubated with cultured endothelial cells from rabbit aorta or human umbilical vein is altered in several ways (EC-modified): (i) It is degraded by macrophages much...
Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis.
Parthasarathy, S, Kritchevsky, D, Baumann, W J
Clofibric acid (CPIB) and several other systemic hypolipidemic drugs are shown to block phosphatidylcholine synthesis by inhibiting cholinephosphotransferase (ChoPTase; CDPcholine:1,2-diacylglycerol...
Quinn, M T, Parthasarathy, S, Steinberg, D
Cultured rabbit and bovine aortic endothelial cells generated chemotactic activity for mouse resident peritoneal macrophages, demonstrable in the conditioned medium. This chemotactic activity was...
Parthasarathy, S, Steinbrecher, U P, Barnett, J, Witztum, J L, Steinberg, D
Previous studies have established that incubation of low density lipoprotein (LDL) with cultured endothelial cells (EC) converts it to a new form (EC-modified LDL) that is now recognized by a...
Probucol inhibits oxidative modification of low density lipoprotein.
Parthasarathy, S, Young, S G, Witztum, J L, Pittman, R C, Steinberg, D
Previous studies have established that low density lipoprotein (LDL) incubated with endothelial cells (EC) undergoes extensive oxidative modification in structure and that the modified LDL is...
Bird, J E, Milhoan, K, Wilson, C B, Young, S G, Mundy, C A, Parthasarathy, S, ...
The effects of antioxidant therapy with probucol were evaluated in rats subjected to 1 h renal ischemia and to 24 h reperfusion. Probucol exerted significant antioxidant effects in renal cortical...
Oxidative modification of low density lipoprotein (LDL) renders it more atherogenic. Probucol, a highly nonpolar antioxidant, is transported in lipoproteins, including LDL, and inhibits oxidative...
Vascular expression of extracellular superoxide dismutase in atherosclerosis.
Fukai, T, Galis, Z S, Meng, X P, Parthasarathy, S, Harrison, D G
We characterized a novel form of extracellular superoxide dismutase (ecSOD) in atherosclerotic vessels. Specific activity and protein expression of ecSOD was increased two- to threefold in apo...
Why are low-density lipoproteins atherogenic?
Low-density lipoproteins (LDLs) carry most of the cholesterol in human plasma, and high levels of LDL cholesterol clearly cause heart disease. In recent years, many scientists have focused on...
Weisner, C, Mertens, J, Parthasarathy, S, Moore, C, Hunkeler, E M, Hu, T, ...
OBJECTIVE: To compare outcome and cost-effectiveness of the two primary addiction treatment options, day hospitals (DH) and traditional outpatient programs (OP) in a managed care organization, in a...
Analysis of temperature factor distribution in high-resolution protein structures.
Parthasarathy, S., Murthy, M. R.
The temperature factors obtained from X-ray refinement of proteins at high resolution show large variations from one structure to another. However, the B-values expressed in units of standard...
Velanker, S. S., Gokhale, R. S., Ray, S. S., Gopal, B., Parthasarathy, S., Santi, D. V., ...
The crystal structure of a covalently cross-linked Lactobacillus casei thymidylate synthase has been determined at 2.8 A resolution. The sites for mutation to achieve the bis-disulfide linked dimer...