METABOLIC STUDIES OF ENERGY DENSE COMPOUNDS FOR AEROSPACE NUTRITION. (2005)
Miller,S. A., Dymsza,H. A., Tannenbaum,S. R., Goldblith,S. A.
The aim of these studies was the development of model compounds with which information useful in understanding energy metabolism might be obtained to aid in development of food for space travel....
Farmer, Peter B., Bartsch, H., Boobis, A., Chipman, K., Gescher, A., Kadlubar, F.F., ...
Correspondence - no abstract available.
Stillwell, W.G., Sinha, R., Tannenbaum, S.R.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic aromatic amine formed in meat products during cooking. The genotoxity of PhIP requires an...
AMINO CARBOXYLIC INHIBITION OF LIPID OXIDATION IN DEHYDRATED FOODS. (1998)
Oxidation of methyl linoleate was studied in a freeze-dried model system based on microcrystalline cellulose in the presence and in the absence of amino acids. The antioxidant activity of some of the...
SUCROSE HYDROLYSIS AT LIMITED WATER CONCENTRATION. (1998)
Schoebel,T., Tannenbaum,S. R., Labuza,T. P.
To enable development of a model describing reaction kinetics in dehydrated foods, sucrose hydrolysis was studied at limited water concentration. Saturated sucrose solutions containing various acids...
Vascularized Tissue Sensors for Generic Toxin and Pathogen Detection (1998)
Griffith, Linda G., Tannenbaum, S. R., Wands, J., Sherley, J., Schaver, D.
We developed three iterative prototypes of a bioreactor system that facilitates micro-perfusion of tissue-like structures formed from primary liver cells, and showed that the bioreactor and detection...
MNNG-induced gastric carcinoma in ferrets infected with Helicobacter mustelae (1993)
Fox, J.G., Wishnok, J.S., Murphy, J.C., Tannenbaum, S.R., Correa, P.
N-Methyl-N-nitro-N'-nitrosoguanidine (MNNG) is a gastric carcinogen in several animal species and has been used in a number of systems to dissect the co-carcinogenic potential of various compounds in...
Prevost, V., Shuker, D.E.G., Bartsch, H., Pastorelli, R., Stillwell, W.G., Trudel, L.J., ...
A mouse monoclonal antibody (Mab) was prepared which showed high specificity for a potential marker of exposure to methylating carcinogens such as 3-methyladenine (3-MeAde). In a low-temperature...
Turesky, R.J., Aeschbacher, H.U., Würzner, H.P., Skipper, P.L., Tannenbaum, S.R.
A metabolite of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) was incorrectly characterized in this paper. The metabolite was thought to be an acetyl conjugate of the 5-hydroxyl-ated...
Turesky, R.J., Aeschbacher, H.U., Würzner, H.P., Skipper, P.L., Tannenbaum, S.R.
The metabolic fate of 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), a carcinogen formed in cooked meat and fish, has been investigated in male Sprague-Dawley rats. Five metabolites were...
Lintas, C., Clark, A., Fox, J., Tannenbaum, S.R., Newberne, P.M.
Formation of N-nitrosodimethylamine (NDMA) from the precursors nitrite and dimethylamine has been studied in the chronically fistulated dog stomach. Measurements have also been made as a function of...
Gal, A, Tamir, S, Tannenbaum, S R, Wogan, G N
SJL mice spontaneously develop pre-B-cell lymphoma that we hypothesized might stimulate macrophages to produce nitric oxide (NO.). Transplantation of an aggressive lymphoma (RcsX) was used to induce...
Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man.
Castillo, L, DeRojas, T C, Chapman, T E, Vogt, J, Burke, J F, Tannenbaum, S R, ...
Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine. We have conducted two experiments, each in four healthy adult men...
Nunoshiba, T, DeRojas-Walker, T, Wishnok, J S, Tannenbaum, S R, Demple, B
Nitric oxide is a free radical (NO) formed biologically through the oxidation of L-arginine by nitric oxide synthases. NO is produced transiently in mammalian cells for intercellular signaling and in...
DNA damage and mutation in human cells exposed to nitric oxide in vitro.
Nguyen, T, Brunson, D, Crespi, C L, Penman, B W, Wishnok, J S, Tannenbaum, S R
Nitric oxide (NO.) is a physiological messenger formed by several cell types. Reaction with O2 forms oxides that nitrosate amines at pH values near 7. We now report experiments in which NO. was added...
Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages.
Nunoshiba, T, DeRojas-Walker, T, Tannenbaum, S R, Demple, B
Nitric oxide (NO.) is produced as a cytotoxic free radical through enzymatic oxidation of L-arginine in activated macrophages. Pure NO. gas was previously found to induce the Escherichia coli soxRS...
Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli.
Ralt, D, Wishnok, J S, Fitts, R, Tannenbaum, S R
We have developed a rapid and sensitive fluorimetric method, based on the formation of a fluorescent product from nitrosation of 2,3-diaminonaphthalene, for measuring the ability of bacteria to...
Production of an Autoinhibitor by a Thermophilic Bacillus
Chou, T. W., Greasham, R., Tannenbaum, S. R., Demain, A. L.
Premature cessation of rapid, exponential growth and a low final cell yield were observed with a thermophilic bacillus in a glucose-mineral salts-vitamin medium. Restricted growth was not due to...
Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.
Bryant, M S, Vineis, P, Skipper, P L, Tannenbaum, S R
Hemoglobin adducts of 15 aromatic amines were determined in nonsmokers and smokers of blond- or black-tobacco cigarettes living in Turin, Italy. The subjects were all males age 55 or less and were...
Green, L C, Wagner, D A, Rand, W, Istfan, N, Young, V R, ...
Nitrate metabolism was investigated in long-term metabolic studies in healthy young men. Under conditions of constant low ingestion of nitrate (less than 180 mumol/day per subject), the amount of...
Characterization of a Heat-Shock Process for Reduction of the Nucleic Acid Content of Candida utilis
Ohta, S., Maul, S., Sinskey, A. J., Tannenbaum, S. R.
A process for reducing the nucleic acid content of Candida utilis NRRL Y900 has been developed. The optimal process consists of heating the cells suspended in spent medium initially at pH 4.0 for...
Castro, A. C., Sinskey, A. J., Tannenbaum, S. R.
Yeast as a source of protein for human consumption is limited by its relatively high nucleic acid content. In this study, we developed an enzymatic method of decreasing the nucleic acid content....
Wagner, D A, Young, V R, Tannenbaum, S R
Incorporation of an oral dose of [15N]ammonium acetate into urinary [15N]nitrate has been demonstrated in the rat. Investigation of the regulation of nitrate synthesis has shown that Escherichia coli...
Nitric oxide production is intensely and persistently increased in tissue by thermal injury.
Carter, E A, Derojas-Walker, T, Tamir, S, Tannenbaum, S R, Yu, Y M, Tompkins, R G
NO is a major messenger molecule which regulates immunity and vascular tone, serves as a neurotransmitter and participates in wound healing. It has also been known to be increased in vivo by thermal...
Nitrate biosynthesis in the rat. Precursor-product relationships with respect to ammonia.
Wagner, D A, Moldawer, L L, Pomposelli, J J, Tannenbaum, S R, Young, V R
The endogenous biosynthesis of nitrate in rats was investigated by using 15NH3 administered as a continuous intravenous infusion for as long as 96 h. A comparison of the enrichment of 15N in urinary...
Elevated blood levels of carcinogens in passive smokers.
Maclure, M, Katz, R B, Bryant, M S, Skipper, P L, Tannenbaum, S R
The hypothesis that involuntary exposure to tobacco smoke--passive smoking--results in greater risk of cancer was assessed by measuring the levels of two known carcinogens in the blood of 57...
Turesky, R J, Gross, G A, Stillwell, W G, Skipper, P L, Tannenbaum, S R
Heterocyclic aromatic amines (HAAs) are animal carcinogens and suspected human carcinogens which are formed in cooked foods at the low parts per billion level. HAAs in cooked meats were purified by...
Molecular dosimetry of aromatic amines in human populations.
Certain aromatic amines carcinogenic for the human urinary bladder, such as 4-aminobiphenyl, undergo hepatic metabolic activation to N-hydroxylamines, which are transported to the bladder. During the...
Characterization of various classes of protein adducts.
Tannenbaum, S R, Skipper, P L, Wishnok, J S, Stillwell, W G, Day, B W, Taghizadeh, K
Analysis of the types of protein adducts formed by chemical carcinogens indicate that adducts may be categorized into various classes according to the nature of the carcinogen as well as the amino...
Urinary markers for exposures to alkylating or nitrosating agents.
Wishnok, J S, Tannenbaum, S R, Stillwell, W G, Glogowski, J A, Leaf, C D
Investigation of urinary markers as indices of endogenous nitrosation and of gastric cancer etiology has been a major focus of our work. As part of this effort, studies have been carried out on a...
Turesky, R J, Stillwell, W G, Skipper, P L, Tannenbaum, S R
Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazol[4,5-f]quinoxaline (MeIQx) and their binding to blood proteins were examined in the rat to develop methods...
Gal, A, Tamir, S, Tannenbaum, S R, Wogan, G N
SJL mice spontaneously develop pre-B-cell lymphoma that we hypothesized might stimulate macrophages to produce nitric oxide (NO.). Transplantation of an aggressive lymphoma (RcsX) was used to induce...
Splanchnic metabolism of dietary arginine in relation to nitric oxide synthesis in normal adult man.
Castillo, L, DeRojas, T C, Chapman, T E, Vogt, J, Burke, J F, Tannenbaum, S R, ...
Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine. We have conducted two experiments, each in four healthy adult men...
Nunoshiba, T, DeRojas-Walker, T, Wishnok, J S, Tannenbaum, S R, Demple, B
Nitric oxide is a free radical (NO) formed biologically through the oxidation of L-arginine by nitric oxide synthases. NO is produced transiently in mammalian cells for intercellular signaling and in...
DNA damage and mutation in human cells exposed to nitric oxide in vitro.
Nguyen, T, Brunson, D, Crespi, C L, Penman, B W, Wishnok, J S, Tannenbaum, S R
Nitric oxide (NO.) is a physiological messenger formed by several cell types. Reaction with O2 forms oxides that nitrosate amines at pH values near 7. We now report experiments in which NO. was added...
Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages.
Nunoshiba, T, DeRojas-Walker, T, Tannenbaum, S R, Demple, B
Nitric oxide (NO.) is produced as a cytotoxic free radical through enzymatic oxidation of L-arginine in activated macrophages. Pure NO. gas was previously found to induce the Escherichia coli soxRS...
Bacterial catalysis of nitrosation: involvement of the nar operon of Escherichia coli.
Ralt, D, Wishnok, J S, Fitts, R, Tannenbaum, S R
We have developed a rapid and sensitive fluorimetric method, based on the formation of a fluorescent product from nitrosation of 2,3-diaminonaphthalene, for measuring the ability of bacteria to...
Production of an Autoinhibitor by a Thermophilic Bacillus
Chou, T. W., Greasham, R., Tannenbaum, S. R., Demain, A. L.
Premature cessation of rapid, exponential growth and a low final cell yield were observed with a thermophilic bacillus in a glucose-mineral salts-vitamin medium. Restricted growth was not due to...
Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.
Bryant, M S, Vineis, P, Skipper, P L, Tannenbaum, S R
Hemoglobin adducts of 15 aromatic amines were determined in nonsmokers and smokers of blond- or black-tobacco cigarettes living in Turin, Italy. The subjects were all males age 55 or less and were...
Green, L C, Wagner, D A, Rand, W, Istfan, N, Young, V R, ...
Nitrate metabolism was investigated in long-term metabolic studies in healthy young men. Under conditions of constant low ingestion of nitrate (less than 180 mumol/day per subject), the amount of...
Characterization of a Heat-Shock Process for Reduction of the Nucleic Acid Content of Candida utilis
Ohta, S., Maul, S., Sinskey, A. J., Tannenbaum, S. R.
A process for reducing the nucleic acid content of Candida utilis NRRL Y900 has been developed. The optimal process consists of heating the cells suspended in spent medium initially at pH 4.0 for...
Castro, A. C., Sinskey, A. J., Tannenbaum, S. R.
Yeast as a source of protein for human consumption is limited by its relatively high nucleic acid content. In this study, we developed an enzymatic method of decreasing the nucleic acid content....
Wagner, D A, Young, V R, Tannenbaum, S R
Incorporation of an oral dose of [15N]ammonium acetate into urinary [15N]nitrate has been demonstrated in the rat. Investigation of the regulation of nitrate synthesis has shown that Escherichia coli...
Nitric oxide production is intensely and persistently increased in tissue by thermal injury.
Carter, E A, Derojas-Walker, T, Tamir, S, Tannenbaum, S R, Yu, Y M, Tompkins, R G
NO is a major messenger molecule which regulates immunity and vascular tone, serves as a neurotransmitter and participates in wound healing. It has also been known to be increased in vivo by thermal...
Nitrate biosynthesis in the rat. Precursor-product relationships with respect to ammonia.
Wagner, D A, Moldawer, L L, Pomposelli, J J, Tannenbaum, S R, Young, V R
The endogenous biosynthesis of nitrate in rats was investigated by using 15NH3 administered as a continuous intravenous infusion for as long as 96 h. A comparison of the enrichment of 15N in urinary...
Elevated blood levels of carcinogens in passive smokers.
Maclure, M, Katz, R B, Bryant, M S, Skipper, P L, Tannenbaum, S R
The hypothesis that involuntary exposure to tobacco smoke--passive smoking--results in greater risk of cancer was assessed by measuring the levels of two known carcinogens in the blood of 57...
Turesky, R J, Gross, G A, Stillwell, W G, Skipper, P L, Tannenbaum, S R
Heterocyclic aromatic amines (HAAs) are animal carcinogens and suspected human carcinogens which are formed in cooked foods at the low parts per billion level. HAAs in cooked meats were purified by...
Molecular dosimetry of aromatic amines in human populations.
Certain aromatic amines carcinogenic for the human urinary bladder, such as 4-aminobiphenyl, undergo hepatic metabolic activation to N-hydroxylamines, which are transported to the bladder. During the...
Characterization of various classes of protein adducts.
Tannenbaum, S R, Skipper, P L, Wishnok, J S, Stillwell, W G, Day, B W, Taghizadeh, K
Analysis of the types of protein adducts formed by chemical carcinogens indicate that adducts may be categorized into various classes according to the nature of the carcinogen as well as the amino...
Urinary markers for exposures to alkylating or nitrosating agents.
Wishnok, J S, Tannenbaum, S R, Stillwell, W G, Glogowski, J A, Leaf, C D
Investigation of urinary markers as indices of endogenous nitrosation and of gastric cancer etiology has been a major focus of our work. As part of this effort, studies have been carried out on a...
Turesky, R J, Stillwell, W G, Skipper, P L, Tannenbaum, S R
Metabolism of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazol[4,5-f]quinoxaline (MeIQx) and their binding to blood proteins were examined in the rat to develop methods...
Erdman, S. E., Rao, V. P., Poutahidis, T., Rogers, A. B., Taylor, C. L., Jackson, E. A., ...
Recombinase-activating gene-2-deficient (Rag2−/−) mice lacking functional lymphocytes provide a useful model of chronic inflammatory bowel disease-emulating events in human colon cancer....
Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variability.
Ronco, G., Vineis, P., Bryant, M. S., Skipper, P. L., Tannenbaum, S. R.
In a previous study we found that aromatic amines, particularly 4-aminobiphenyl, formed haemoglobin adducts at higher concentrations in the blood of smokers compared to non-smokers. We re-analyse...