Kikkawa, T, Suzuki, Y, Makabe, H, Shibata, S, Takahashi, G, Matsumoto, N, ...
No abstract available.
Shouzushima, T, Suzuki, Y, Takahashi, G, Shibata, S, Sato, N, Endo, S
No abstract available.
Shibata, S, Takamiya, K, Ota, Y, Nogawa, N, Ito, Y, Shibata, T, ...
Matsumoto, K, Kubo, H, Murata, H, Uhara, H, Takata, M, Shibata, S, ...
This is a pre-copy-editing, auyhor-produced PDF of an article forpublication in JAPANESE JOURNAL OF CLINICAL ONCOLOGY following peer review. The definitive publisher-authenticated version JAPANESE...
ALL NUMBERS WHOSE POSITIVE DIVISORS HAVE INTEGRAL HARMONIC MEAN UP TO 300 (2008)
Abstract. A positive integer n is said to be harmonic when the harmonic mean H(n) of its positive divisors is an integer. Ore proved that every perfect number is harmonic. No nontrivial odd harmonic...
Matumoto, N, Suzuki, Y, Kikuchi, S, Shioya, N, Shibata, S, Sato, N, ...
No abstract available.
Particle Acceleration and Non-Thermal Emission in Pulsar Outer Magnetospheric Gap (2008)
A two-dimensional electrodynamic model is used to study particle acceleration and non-thermal emission mechanisms in the pulsar magnetospheres. We solve distribution of the accelerating electric...
Ion acceleration and neutral emission mechanisms for 2005 September 7 flare (2008)
Watanabe, K., Murphy, R. J., Share, G. H., Hurford, G. J., Krucker, S., Lin, R. P., ...
Chemical composition of magnetic spherules collected from deep sea sediment (2008)
Sekimoto, S, Kobayashi, T, Takamiya, K, Ebihara, M, Shibata, S
Excitation function for Cu-63(n,p)Ni-63 reaction in neutron energy range up to 15 MeV (2008)
Takamiya, K, Ota, Y, Akamine, M, Shibata, S, Shibata, T, Ito, Y, ...
Takamiya, K, Imanaka, T, Ota, Y, Akamine, M, Shibata, S, Shibata, T, ...
Heated Polar Caps in PSRs 0656+14 and 1055-52 (2007)
C. Greiveldinger, U. Camerini, W. Fry, C. B. Markwardt, H. Ögelman, S. Safi-Harb, ...
We present new ASCA observations covering the 0.5 to 10 keV X-ray range of the cooling neutron star candidates PSR 0656+14 and PSR 1055--52. Previous ROSAT observations had shown that two component...
Target preparation by the precipitation method for nuclear reactions (2007)
Takamiya, K, Ohtsuki, T, Yuki, H, Mitsugashira, T, Sato, N, Suzuki, T, ...
Measurement of Ni-63 produced in Cu samples by the Hiroshima atomic bomb (2007)
Shibata, S., Takamiya, K., Ota, Y., Nogawa, N., Ito, Y., Shibata, T.
Adsorption of fission products onto soils using a fission multitracer (2007)
Takamiya, K., Fukunishi, T., Tsujito, R., Fukutani, S., Takahashi, T., Shibata, S., ...
Discovery of a Featureless X-Ray Spectrum in the Supernova Remnant Shell of G330.2+1.0 (2006)
Torii, K., Uchida, H., Hasuike, K., Tsunemi, H., Yamaguchi, Y., Shibata, S.
We report here on the first pointed X-ray observation of the supernova remnant (SNR) G330.2+1.0. The X-ray morphology is characterized by an extended shell. Its X-ray spectrum is well represented by...
A two-dimensional electrodynamical outer gap model for gamma-ray pulsars: Gamma-ray spectrum (2005)
Takata, J., Shibata, S., Hirotani, K.
A two-dimensional electrodynamical model is used to study particle acceleration in the outer magnetosphere of a pulsar. The charge depletion from the Goldreich-Julian charge density causes a large...
Solar Neutron Events of October-November 2003 (2005)
Watanabe, K., Gros, M., Stoker, P. H., Kudela, K., Lopate, C., Valdes-Galicia, J. F., ...
During the period when the Sun was intensely active on October-November 2003, two remarkable solar neutron events were observed by the ground-based neutron monitors. On October 28, 2003, in...
A pulsar outer gap model with trans-field structure (2004)
Takata, J., Shibata, S., Hirotani, K.
We investigate the electrodynamics of an outer gap in the meridional plane of the aligned-rotator. The charge depletion from the Goldreich-Julian charge density causes a large electric field along...
Spatial Variation of the X-ray spectrum of the Crab Nebula (2004)
Mori, K., Burrows, D. N., Hester, J. J., Pavlov, G. G., Shibata, S., Tsunemi, H.
We present spectral analysis of the Crab Nebula obtained with the {\it Chandra} X-ray observatory. The X-ray spectrum is characterized by a power-law whose index varies across the nebula. The...
Outer-magnetospheric model for Vela-like pulsars: formation of sub-GeV spectrum (2004)
Takata,J., Shibata,S., Hirotani,K.
We investigate the γ -ray emission from an outer-gap accelerator, which is located in the outer magnetosphere of a pulsar. The charge depletion from the GoldreichJulian density causes a large...
Outer-magnetospheric model for Vela-like pulsars: formation of sub-GeV spectrum (2004)
Takata, J., Shibata, S., Hirotani, K.
We investigate the γ -ray emission from an outer-gap accelerator, which is located in the outer magnetosphere of a pulsar. The charge depletion from the GoldreichJulian density causes a large...
Matsumura, H, Aze, T, Oura, Y, Kikunaga, H, Yokoyama, A, Takamiya, K, ...
Feng, Y, Shibata, S, Koshizuka, N, Murakami, M
The irreversibility line and second magnetization peak of heavily overdoped Cu-rich Bi2Sr2CaCu2O8+x (Bi2212) single crystals are studied by accurate magnetization measurements with a field H\parallel...
Outer-magnetospheric model for Vela-like pulsars:formation of sub-GeV spectrum (2003)
Takata, J., Shibata, S., Hirtotani, K.
We investigate the $\gamma$-ray emission from a outer-gap accelerator, which is located in the outer-magnetosphere of a pulsar. The charge depletion from the Goldreich-Julian density causes a large...
Year-scale morphological variation of the X-ray Crab Nebula (2003)
Mori, K., Burrows, D. N., Pavlov, G. G., Hester, J. J., Shibata, S., Tsunemi, H.
We present year-scale morphological variations of the Crab Nebula revealed by Chandra X-ray observatory. Observations have been performed about every 1.7 years over the 3 years from its launch. The...
On the X-ray Image of The Crab Nebula: Comparison with Chandra Observations (2003)
Shibata, S., Tomatsuri, H., Shimanuki, M., Ssito, K., Mori, K.
An axisymmetric model for the Crab Nebula is constructed to examine the flow dynamics in the nebula. The model is based on that of Kennel and Coroniti (1984), although we assume that the...
Photorission of Au-197 and Bi-209 at intermediate energies (2003)
Haba, H, Sakamoto, K, Igarashi, M, Kasaoka, M, Washiyama, K, Matsumura, H, ...
Haba, H, Sakamoto, K, Matsumura, H, Oura, Y, Shibata, S, Furukawa, M, ...
The Crab Nebula: 3-dimensional Modeling (2002)
Shibata, S., Tomatsuri, H., Shimanuki, M., Saito, K., Nakamura, Y., Mori, K.
We construct an axisymmetric model for the Crab Nebula. The flow dyamics is based on the model by Kennel and Coroniti (1984), but we assume that the kinetic-energy-dominant wind is confined in the...
On the Field-Aligned Particle Acceleration in the presence of Electron-Positron Pairs (2002)
Shibata, S., Miyazaki, J., Takahara, F.
We study self-consistency for the pulsar polar cap model. In general, there will remain an unscreened electric field at the pair production front (PPF). We have derived the condition of electric...
On the Electric Field Screening by Electron-Positron Pairs in the Pulsar Magnetosphere II (2002)
Shibata, S., Miyazaki, J., Takahara, F.
We study on the self-consistency of the pulsar polar cap model, i.e., the problem of whether the field-aligned electric field is screened by electron-positron pairs that are injected beyond the pair...
Pulsar Wind Nebulae and Particle Acceleration in the Pulsar Magnetosphere (2002)
Shibata, S., Tomatsuri, M., Shimanuki, M., Saito, K., Nakamura, Y., Mori, K.
This paper deals with the Crab Nebula problem to suggest that particle acceleration takes place not only at the inner shock but also over a larger region in the nebula with disordered magnetic field....
Subaru optical observations of the old pulsar PSR B0950+08 (2002)
Zharikov, S. V., Shibanov, Yu. A., Koptsevich, A. B., Kawai, N., Urata, Y., Komarova, V. N., ...
We report the B band optical observations of an old (17.5 Myr) radiopulsar PSR B0950+08 obtained with the Suprime-Cam at the Subaru telescope. We detected a faint object, B=27.07(16). Within our...
We investigate a stationary pair production cascade in the outer magnetosphere of a spinning neutron star. The charge depletion due to a global current, causes a large electric field along the...
Photofission of Bi-209 at intermediate energies (2002)
Haba, H, Kasaoka, M, Igarashi, M, Washiyama, K, Matsumura, H, Oura, Y, ...
ASCA Detection of Pulsed X-ray Emission from PSR J0631+1036 (2001)
Torii, Ken'ichi, Saito, Y., Nagase, F., Yamagami, T., Kamae, T., Hirayama, M., ...
ASCA's long look at the 288 millisecond radio pulsar, PSR J0631+1036, reveals coherent X-ray pulsation from this source for the first time. The source was first detected in the serendipitous Einstein...
We investigate a stationary pair production cascade in the outer magnetosphere of a spinning neutron star. The charge depletion due to global flows of charged particles, causes a large electric field...
Yamamoto, H., Sato, H., Shibata, S., Murata, M., Fukuda, J., Tanaka, T.
The objective of this study was to elucidate the role of annexin V, an endogenous inhibitor of protein kinase C (PKC), with regard to the antiproliferative effect of gonadotrophin-releasing hormone...
Pulse shape and spectrum of PSR J0218+4232 observed with BeppoSAX (2000)
Mineo, T., Cusumano, G., Kuiper, L., Hermsen, W., Massaro, E., Becker, W., ...
We present the results of a BeppoSAX observation of PSR J0218+4232 which, for the first time, provides detailed information on the pulsar's temporal and spectral emission properties in the broad band...
Haba, H, Matsumura, H, Sakamoto, K, Oura, Y, Shibata, S, Furukawa, M, ...
Matsumura, H, Washiyama, K, Haba, H, Miyamoto, Y, Oura, Y, Sakamoto, K, ...
Crack Arrest by Strong Short Fibers in a Composite. (1998)
Shibata, S., Mori, T., Mura, T.
This paper concerned mmc in some important way and contained information about, utilized, or discussed these subjects: basic topics:, analytical, composite materials materials and material types:,...
Recoil properties in ($\gamma$,n) reaction measured by catcher foil method (1996)
Shibata, S, Fujiwara, I, Nakamura, T, Yamadera, A, Uno, Y, Hodozuka, M, ...
Shibata, S, Shibata, T, Imamura, M, Ohkubo, T, Satoh, S, Uwamino, Y, ...
A method to estimate the fast-neutron fluence for the Hiroshima atomic bomb (1995)
Shibata, T, Imamura, M, Shibata, S, Uwamino, Y, Ohkubo, T, Satoh, S, ...
Hiromi, K., Ohnishi, M., Shibata, S.
J. Bimhem., Vol. 74, p. 399 (1973) FOR TABLE I. Prediction of changes in ko values induced by chemical modification at various subsites of Taka-amylase A.
SERUM ENDOGENOUS THYROXINE LEVELS IN MAN DURING ANAESTHESIA AND SURGERY (1969)
OYAMA, TSUTOMU, SHIBATA, S., MATSUKI, A., KUDO, T.
Determinations of serum thyroxine concentrations were made before induction of anaesthesia, after 20 minutes and 40 minutes of anaesthesia before operation, during operation, and after the end of...
Nagayama, K, Bi, Z, Oguchi, T, Takarada, Y, Shibata, S, Honda, T
An alkaline phosphatase-conjugated 29-base oligonucleotide probe was developed to detect the gene encoding the bundle-forming pilus of enteropathogenic Escherichia coli. The sensitivity and...
Rikihisa, Y, Kawahara, M, Wen, B, Kociba, G, Fuerst, P, Kawamori, F, ...
Infectious agents were isolated from the spleens of three wild mice (Apodemus argenteus) by intraperitoneal inoculation of the spleen homogenate into laboratory mice. The laboratory mice developed...
Shibata, S, Kyuwa, S, Lee, S K, Toyoda, Y, Goto, N
Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy....
Characterization of a temperature-sensitive influenza B virus mutant defective in neuraminidase.
Shibata, S, Yamamoto-Goshima, F, Maeno, K, Hanaichi, T, Fujita, Y, Nakajima, K, ...
ts5, a temperature-sensitive mutant of influenza B virus, belongs to one of seven recombination groups. When the mutant infected MDCK cells at the nonpermissive temperature (37.5 degrees C),...
Shibata, S, Muryoi, T, Saitoh, Y, Brumeanu, T D, Bona, C A, Kasturi, K N
Autoantibodies against nuclear proteins like RNA polymerase I (RNA pol I) are produced in a number of rheumatic autoimmune diseases. Production of antibodies specific for the 190-kD subunit of RNA...
Harata, N, Sasaki, T, Osaki, H, Saito, T, Shibata, S, Muryoi, T, ...
-81 and NE-1 idiotypes (Id) of human nephritogenic anti-DNA antibodies are interspecies Id expressed also in NZB/W F1 mice. We tried to manipulate the synthesis of spontaneously occurring anti-DNA...
Maddox, D E, Shibata, S, Goldstein, I J
This paper presents data on reactions of murine macrophages with a variety of lectins, with special focus on Griffonia simplicifolia I-B4 isolectin, the only lectin we tried that distinguishes...
Nakamura, T, Izumi, J, Takagaki, K, Shibata, S, Kojima, K, Kato, I, ...
Human skin fibroblasts were cultured in the presence of 4-methylumbelliferyl-beta-D-xyloside (Xyl-MU) using a mass-culture system with a microcarrier. The structures of Xyl-MU-induced sugars purified...
Kodama, I, Kondo, N, Shibata, S
Okadaic acid is a monocarboxylic acid with a unique molecular structure of C44H66O13. Okadaic acid, at concentrations above 10(-5) M, caused a dose-dependent increase of contractile force in...
1. In the isolated guinea-pig taenia, application of X537A to the muscle caused a relaxation, while A23187 caused a sustained contraction. 2. Treatment with adrenergic blocking agents and...
Shibata, S, Fukada, K, Imai, H, Abe, T, Yamashita, Y
We investigated the expression pattern of versican, aggrecan, link protein and hyaluronan in the developing limb bud cartilage of the fetal mouse using in situ hybridization and/or...
Nagayama, K, Bi, Z, Oguchi, T, Takarada, Y, Shibata, S, Honda, T
An alkaline phosphatase-conjugated 29-base oligonucleotide probe was developed to detect the gene encoding the bundle-forming pilus of enteropathogenic Escherichia coli. The sensitivity and...
Rikihisa, Y, Kawahara, M, Wen, B, Kociba, G, Fuerst, P, Kawamori, F, ...
Infectious agents were isolated from the spleens of three wild mice (Apodemus argenteus) by intraperitoneal inoculation of the spleen homogenate into laboratory mice. The laboratory mice developed...
Shibata, S, Kyuwa, S, Lee, S K, Toyoda, Y, Goto, N
Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy....
Characterization of a temperature-sensitive influenza B virus mutant defective in neuraminidase.
Shibata, S, Yamamoto-Goshima, F, Maeno, K, Hanaichi, T, Fujita, Y, Nakajima, K, ...
ts5, a temperature-sensitive mutant of influenza B virus, belongs to one of seven recombination groups. When the mutant infected MDCK cells at the nonpermissive temperature (37.5 degrees C),...
Shibata, S, Muryoi, T, Saitoh, Y, Brumeanu, T D, Bona, C A, Kasturi, K N
Autoantibodies against nuclear proteins like RNA polymerase I (RNA pol I) are produced in a number of rheumatic autoimmune diseases. Production of antibodies specific for the 190-kD subunit of RNA...
Harata, N, Sasaki, T, Osaki, H, Saito, T, Shibata, S, Muryoi, T, ...
-81 and NE-1 idiotypes (Id) of human nephritogenic anti-DNA antibodies are interspecies Id expressed also in NZB/W F1 mice. We tried to manipulate the synthesis of spontaneously occurring anti-DNA...
Maddox, D E, Shibata, S, Goldstein, I J
This paper presents data on reactions of murine macrophages with a variety of lectins, with special focus on Griffonia simplicifolia I-B4 isolectin, the only lectin we tried that distinguishes...
Nakamura, T, Izumi, J, Takagaki, K, Shibata, S, Kojima, K, Kato, I, ...
Human skin fibroblasts were cultured in the presence of 4-methylumbelliferyl-beta-D-xyloside (Xyl-MU) using a mass-culture system with a microcarrier. The structures of Xyl-MU-induced sugars purified...
Kodama, I, Kondo, N, Shibata, S
Okadaic acid is a monocarboxylic acid with a unique molecular structure of C44H66O13. Okadaic acid, at concentrations above 10(-5) M, caused a dose-dependent increase of contractile force in...
1. In the isolated guinea-pig taenia, application of X537A to the muscle caused a relaxation, while A23187 caused a sustained contraction. 2. Treatment with adrenergic blocking agents and...
Shibata, S, Fukada, K, Imai, H, Abe, T, Yamashita, Y
We investigated the expression pattern of versican, aggrecan, link protein and hyaluronan in the developing limb bud cartilage of the fetal mouse using in situ hybridization and/or...
Shibata, S, Asano, T, Noguchi, A, Naito, M, Ogura, A, Doi, K
To elucidate the mechanism of human cell elimination from severe combined immunodeficient (SCID) mice transplanted with human peripheral blood lymphocytes (hu-PBL-SCID mice), we explored the...
Nephrotoxic antibody-inducing antigen was extracted in a water-soluble form with adequate ultrasonic treatment of rat glomeruli.
Rats given a single injection in the hind footpads of homologous, water-soluble, organ glycoprotein and Freund's incomplete adjuvant developed proliferative glomerulonephritis.
In rats given a single injection (500 μg) in the hind footpads of heterologous (water-soluble) renal glycoprotein and Freund's incomplete adjuvant, proliferative glomerulonephritis with...
Shibata, S, Sasaki, T, Hirabayashi, Y, Seino, J, Okamura, K, Yoshinaga, K, ...
Fetal wastage is still high in the pregnancies of patients with systemic lupus erythematosus (SLE). We examined retrospectively the cases of 38 patients with inactive SLE in whom pregnancy was either...
Rheumatoid arthritis after human parvovirus B19 infection
MURAI, C., MUNAKATA, Y., TAKAHASHI, Y., ISHII, T., SHIBATA, S., MURYOI, T., ...
Natorio, Y., Hayakawa, I., Shibata, S.
Injection of antibodies to renal tubular membrane (Fx1A) into Lewis rats induces granular deposits of IgG in glomeruli and proteinuria (passive Heymann nephritis, PHN), and similar lesions are also...
An enzyme linked immunosorbent assay (ELISA) was introduced for the detection of nephritogenic glycopeptide, nephritogenoside and Heymann's antigen. In the fraction of crude nephritogenoside which...
Sasaki, T, Shibata, S, Hirabayashi, Y, Sekiguchi, Y, Yoshinaga, K
Depletion of monocytes from peripheral blood mononuclear cells of patients with systemic lupus erythematosus (SLE) resulted in a decreased anti-DNA antibody synthesis in vitro. The addition of...
Natori, Y, Hayakawa, I, Shibata, S
Our previous paper showed that the glycoprotein of Mr 108,000 (gp108) is one of the major components of rat renal tubular brush border antigens and that an injection of anti-gp108 antiserum in rats...
Natori, Y, Hayakawa, I, Shibata, S
An injection of human renal tubular fraction, Fx1A, with Freund's complete adjuvant in rats induces Heymann nephritis (HN) with clinical and morphological features similar to rat Fx1A-induced HN. The...
The detection and characterization of renal brush border antigen (gp108) in various rat tissues.
Natori, Y, Hayakawa, I, Shibata, S
We recently reported that an injection of antibody raised against renal brush border glycoprotein, gp108, in rats induced passive Heymann nephritis with acute and severe proteinuria. In this study,...
Differential expression of a lamininlike substance by high- and low-metastatic tumor cells.
Varani, J., Lovett, E. J., McCoy, J. P., Shibata, S., Maddox, D. E., Goldstein, I. J., ...
High-metastatic murine fibrosarcoma cells readily attached to Type IV (basement membrane) collagen, whereas low-metastatic cells isolated from the same tumor did not. The addition of laminin--a...
Satake, K, Takagi, K, Kodama, I, Honjo, H, Toyama, J, Shibata, S
Mechanisms underlying the bronchorelaxant action of NKH477, a newly developed water-soluble forskolin derivative, were investigated in guinea-pig isolated tracheal smooth muscle.In muscles...
Moriya, T, Yoshinobu, Y, Ikeda, M, Yokota, S, Akiyama, M, Shibata, S
Serotonergic projections from the midbrain raphe nuclei to the suprachiasmatic nuclei (SCN) are known to regulate the photic entrainment of circadian clocks. However, it is not known which...
In vitro effect of 6-hydroxydopamine on isolated rat atria
In vitro treatment with 6-hydroxydopamine (6-OHDA), but not with oxidized 6-hydroxydopamine, caused transient, positive inotropic and chronotropic responses in the isolated rat atria. In the presence...
1. Pretreatment of rabbit aortic strips with bretylium potentiated the contractor response to potassium and tyramine but not to noradrenaline. On the other hand, such pretreatment inhibited the...
The effect of cold storage on the adrenergic mechanisms of intestinal smooth muscle
Hattori, K., Kurahashi, K., Mori, J., Shibata, S.
1. In the guinea-pig taenia caecum, fluorescent adrenergic fibres terminate in both muscle layers. The density of these fibres is greater in the taenia than in the underlying circular muscle layer....
Honda, F, Katsuki, S, Miyahara, J T, Shibata, S
1. Cold storage treatment of the guinea-pig taenia caecum had a greater inhibitory effect on the isoprenaline-induced relaxation than that induced by phenylephrine. Prolonged cold storage (12-14...
β-Adrenoceptor stimulating properties of para-dimethylaminobenzaldehyde
1. Studies on the various isolated tissues indicate that para-dimethylaminobenzaldehyde (DMAB) is a β-adrenoceptor stimulant. DMAB is antagonized by the β-adrenoceptor blocking agent, MJ 1999, but...
Kuchii, M., Miyahara, J. T., Shibata, S.
1. The release of [3H]-noradrenaline and adenine nucleotide evoked by electrical field stimulation (20-60 V, 30 Hz), perivascular nerve stimulation (20-80 V, 60 Hz) and nicotine (10, 100 μM) was...
Kuchii, M., Miyahara, J. T., Shibata, S.
1. Cold storage (2° C) treatment progressively reduced noradrenaline uptake by the taenia caecum of the guinea-pig. After 15 days of cold treatment, [3H]-noradrenaline uptake by tissue was reduced...
Kuchii, M., Miyahara, J.T., Shibata, S.
1 The effects of pretreatment of guinea-pigs with 6-hydroxydopamine (6-OHDA) on the release of [3H]-noradrenaline and [3H]-adenine nucleotide following electrical field, nicotine and perivascular...
Palytoxin-induced contraction and release of endogenous noradrenaline in rat tail artery.
Karaki, H., Nagase, H., Ohizumi, Y., Satake, N., Shibata, S.
1. The mechanism of the contractile effect of a potent marine toxin, palytoxin (PTX) on the rat isolated tail artery was examined. 2. PTX (10(-7) M) induced a contraction in the tail artery which was...
Modulation by glycyrrhetinic acid derivatives of TPA-induced mouse ear oedema.
Inoue, H., Mori, T., Shibata, S., Koshihara, Y.
1. The anti-inflammatory effects of glycyrrhetinic acid and its derivatives on TPA (12-O-tetradecanoylphorbol-13-acetate)-induced mouse ear oedema were studied. The mechanisms of TPA-induced ear...
Karaki, H., Mitsui, M., Nagase, H., Ozaki, H., Shibata, S., Uemura, D.
1. Effects of okadaic acid, a toxin isolated from marine sponges, on smooth muscle contraction and platelet activation were examined. 2. Contractions in rabbit aorta induced by high concentrations of...
Satake, N., Kiyoto, S., Shibata, S., Gandhi, V., Jones, D. J., Morikawa, M.
1. In the rabbit isolated aorta, atropine (3 x 10(-6) M-10(-4) M) inhibited contractile response to noradrenaline without affecting contraction to KCl. 2. In the presence of contraction to...
Satake, N., Shibata, M., Shibata, S.
1. In rat aortic rings contracted by phenylephrine, the relaxation induced by isoprenaline was partly inhibited by iberiotoxin, (ibTX), tetraethylammonium, 4-aminopyridine (4-AP) and...
Hester, R. K., Satake, N., Shibata, S., Ueda, S., Yamahara, J.
In rabbit aorta, pretreatment with 2-aminoisoquinoline, 1.3 (2H.4H)-dione (AQ, 10(-5) M and 10(-4) M) shifted the concentration-response relationship to noradrenaline (NA, 10(-9) M to 10(-4) M) in a...
Mechanism of barium-induced contraction in the vascular smooth muscle of rabbit aorta.
Karaki, H., Satake, N., Shibata, S.
In a solution containing 1.5 mM Ca2+, cumulative application of 0.3-10.0 mM Ba2+ induced a concentration-dependent contraction of the rabbit aorta. This contraction was reduced by the Ca2+ channel...
Anno, T., Kodama, I., Shibata, S., Toyama, J., Yamada, K.
Effects of hypoxia on atrioventricular conduction were investigated in the Langendorff-perfused isolated heart of the rabbit with various extracellular calcium concentrations ([Ca2+]) as well as in...
Electrical effects of okadaic acid extracted from black sponge on rabbit sinus node.
Kondo, N., Kodama, I., Kotake, H., Shibata, S.
1. Effects of okadaic acid on electrical responses and spontaneous activity in the dominant pacemaker cells of rabbit sinus node were investigated by use of microelectrode techniques. 2. Okadaic acid...
Negative inotropic effects of disopyramide on guinea-pig papillary muscles.
Kondo, N., Mizukami, M., Shibata, S.
1. The inhibitory effects of disopyramide on electromechanical responses were investigated in guinea-pig papillary muscles driven by electrical stimuli. Disopyramide up to 10(-5) M did not cause a...
Phentolamine-induced rhythmic contractions in bladder detrusor muscle of guinea-pig.
Satake, N., Shibata, S., Ueda, S.
Phentolamine caused a rhythmic contraction concentration-dependently without affecting resting tone in the detrusor muscle. Prazosin, yohimbine, propranolol, noradrenaline, clonidine or isoprenaline...
The frog spinal cord was used to determine the characteristics of the actions of caroverine and diltiazem, two organic Ca2+-antagonists, on synaptic responses and L-glutamate-induced depolarization....
Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent.
Ishida, Y., Ozaki, H., Shibata, S.
1 Caroverine fumarate, 1-(2-diethylaminoethyl)-3-(p-methoxy-benzyl)-1,2-dihydro-2-quinoxalinone fumarate, caused a greater inhibition of the pressor response to KCl (8 x 10(-2) M) than that to...
Ho, W. K., Nakao, K., Shibata, S.
1. Two arginine derivatives that were developed as thrombin inhibitors (TI-189 and TI-233) selectively inhibited the 5-hydroxytryptamine (5-HT)-induced contraction of rabbit aortic strips in a...
Characteristics contractile response to the calcium ionophore, A23187, in guinea-pig vas deferens.
1. In the guinea-pig isolated vas deferens, the calcium ionophore, A23187, initially caused a phasic contraction followed by rhythmic activity. 2. Treatment with atropine, phentolamine, tetrodotoxin...
1. The effects of palytoxin (PTX) isolated from Palythoa tubercurosa were tested on the isolated intra-arterially perfused spinal cord of the frog. The resting and evoked potentials were recorded by...
Effects of amrinone on the transmembrane action potential of rabbit sinus node pacemaker cells.
Kodama, I., Kondo, N., Shibata, S.
Effects of amrinone on the membrane action potential and spontaneous activity were investigated in sinus node pacemaker cells of rabbit heart by use of microelectrode techniques. Amrinone (1 X 10(-4)...
1 Anthopleurin-B (AP-B), a newly isolated polypeptide from a sea anemone (Anthopleura xanthogrammica) caused relaxation of the guinea-pig isolated ileum following a transient contraction at...
Norton, T. R., Ohizumi, Y., Shibata, S.
1 Anthopleurin-B (AP-B, greater than 3 x 10(-9) M), a newly isolated polypeptide from sea anemone (Anthopleura xanthogrammica), caused powerful rhythmic contractions in the guinea-pig isolated vas...
Predictors of long-term outcome following high-dose chemotherapy in high-risk primary breast cancer
Somlo, G, Simpson, J F, Frankel, P, Chow, W, Leong, L, Margolin, K, ...
We report on a predictive model of long-term outcome in 114 high-risk breast cancer patients treated with high-dose chemotherapy between 1989 and 1994. Paraffin-blocks from 90 of the 114 primaries...