Swaminathan, S., Padmapriyadarsini, C., Ponnuraja, C., Sumathi, C.H., Rajasekaran, S., Amerandran, V.A., ...
Background: An increase in tuberculosis (TB) incidence has been associated with human immunodeficiency virus (HIV). Aims: To describe the clinical characteristics and treatment outcome of patients...
A System for Discovering Bioengineered Threats by Knowledge Base Driven Mining of Toxin Data (2007)
This project was funded to establish a Toxin Knowledge Base (TKB) which will encompass information about bacterial toxins in general and toxins relevant to biodefense, in particular. The overall goal...
The 3D Structure of Staphylococcal Enterotoxins (2006)
Sax, Martin, Pletcher, J., Swaminathan, S.
The purpose of this research is to determine the crystal structure of the staphylococcal enterotoxins (SEs) by x-ray diffraction and protein modeling techniques and to correlate the 3D structures...
Modelling Lymphatic Filariasis: Transmission and Control (2004)
Lymphatic filariasis (LF) is a mosquito borne parasitic disease of the tropics. Of the three species of parasites causing the disease, W. bancrofti transmitted by Culex quinquefasciatus is the most...
Nocardia bacteraemia in an HIV positive patient - A case report (2003)
Ramchandran, R, Swaminathan, S, Sulochana, S, Paramasivan, C
An Adaptive Value-based Scheduler and (2003)
In dynamic real-time systems, value-based scheduling aims to achieve graceful degradation during overloads, in addition to maintaining a high schedulability during normal and underloads. The...
Nucleocytoplasmic transport: More than the usual suspects (2002)
A paper in the August 9 issue of Cell describes a novel role for the nucleoporin Npap60/Nup5O as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. These findings add a new...
In this paper, we present a novel and comprehensive resource management solution for the autonomous hot-spot convergence system (AHSCS) that uses sensor web. This solution is in response to a call...
Feedback Control for Real-time Scheduling I (2002)
Deepak R. Sahoo, S. Swaminathan, R. A-omari, Murti V. Salapaka, G. Manimaran, Arun K. Somani
Most of real-time scheduling algorithms are open-loop algorithms as the scheduling decisions are based on the worst-case estimates of task parameters. They do not continuously observe the performance...
A Reliability-aware Value-based Scheduler for Dynamic Multiprocessor Real-time Systems (2002)
The growing needs for building complex real-time applications coupled with advancements in computing technology signify the importance of developing efficient algorithms for dynamic real-time...
Nucleocytoplasmic transport: More than the usual suspects (2002)
A paper in the August 9 issue of Cell describes a novel role for the nucleoporin Npap60/Nup5O as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. These findings add a new...
W. Burleson, R. Tessier, D. Goeckel, S. Swaminathan, P. Jain, J. Euh, ...
Signal processing algorithms and architectures can use dynamic reconfiguration to exploit variations in signal statistics with the objectives of improved performance and reduced power consumption....
W. Burleson, R. Tessier, D. Goeckel, S. Swaminathan, P. Jain, J. Euh, ...
Signal processing algorithms and architectures can use dynamic reconfiguration to exploit variations in signal statistics with the objectives of improved performance and reduced power consumption....
Al-Mg alloys were infiltrated into porous alumina preforms at temperatures greater than 950°C where significant amount of nitride forms in the matrix. The present work aims to obtain a process...
Al-Mg alloys were infiltrated into porous alumina preforms at temperatures greater than 950°C where significant amount of nitride forms in the matrix. The present work aims to obtain a process...
Al-Mg alloys were infiltrated into porous alumina preforms at temperatures greater than 950°C where significant amount of nitride forms in the matrix. The present work aims to obtain a process...
X-Ray Crystallography of Botulinum Neurotoxins (2000)
Sax, Martin, Furey, W., Swaminathan, S.
Botulinum Neurotoxin type E was purchased, and the protein was crystallized. The best diffracting crystals were obtained when the toxin was crystallized in the presence of a peptide from SNAP-25. An...
Dynamic probabilistic risk assessment using event sequence diagrams /--by S. Swaminathan. (1999)
Thesis research directed by Dept. of Materials and Nuclear Engineering.
Parabolized Navier-Stokes Predictions for Three-Dimensional Viscous Supersonic Flows, (1998)
Swaminathan,S., Kim,M. D., Thompson,R. A., Lewis,C. H.
A parabolized Navier-Stokes Code (HYTAC) is used to predict the supersonic, laminar or turbulent viscous flow about arbitrary geometries at moderate angles of attack, and the results are compared...
Brown, H. C., Ramachandran, P. V., Weissman, S. A., Swaminathan, S.
B-Iso-2-ethylapopinocampheyl-9-borabicyclo(3.3.1)nonane (Eapine-Borane), and B-Iso-2-n-propylapopinocampheyl-9-borabicyclo(3.3.1)nonane (Prapine-Borane), prepared via the hydroboration of...
The 3-D Structure of Staphylococcal Enterotoxins. (1998)
Sax, M., Pletcher, J., Swaminathan, S.
The aim of this research is to determine the crystal structures of staphylococcal enterotoxins. As was predicted from the first structure of this family of proteins to have been determined and from...
X-Ray Crystallography of Botulinum Neurotoxin Type E and Its Functional Subunits (1998)
Furey, William, Sax, Martin, Swaminathan, S.
Botulinum Neurotoxin type E was crystallized and an electron density map was analyzed at 3 alpha resolution. A new crystal form was also obtained, and may be helpful in improving the phasing....
Experimental Determination of Low Order Structure Factors in the Intermetallic Compound TiAl. (1998)
Swaminathan, S., Jones, I. P., Zaluzec, N. J., Maher, D. M., Fraser, H. L.
Rocking curves from several low order reflections in TiAl were recorded in digitized form using energy-filtered convergent beam electron diffraction in a transmission electron microscope. The low...
Atypical papillon-lefevre syndrome. (1997)
Swaminathan, S, Jayaraman, M, Sampathkumar, K, Janaki, V, Boopalraj, J
Improvements to discrete dynamic methodologies / (1996)
Thesis (M.S.)--University of Maryland at College Park, 1996.
Protein metanolism in lenses
Thesis (Ph. D.)--University of Warwick, 1985.
Experimental heat transfer analysis of general purpose heat sources / (1981)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1981.
Theoretical studies of water and dilute aqueous solutions / (1978)
"A dissertation submitted to the Graduate Faculty in Chemistry ..."
Swaminathan, S, Tomkinson, B, Kieff, E
Strains of Epstein-Barr virus (EBV) with deletions of the small RNA (EBER) genes were made by homologous recombination using the EBV P3HR-1 strain, which has undergone deletion of the essential...
Ghadge, G D, Swaminathan, S, Katze, M G, Thimmapaya, B
In human cells infected with adenovirus, the virus-associated RNA VAI blocks the activation of the interferon-induced double-stranded-RNA-dependent 68-kDa protein kinase (p68) and maintains normal...
Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.
Harte, W E, Swaminathan, S, Mansuri, M M, Martin, J C, Rosenberg, I E, Beveridge, D L
A dynamical model for the structure of the human immunodeficiency virus 1 (HIV-1) protease dimer in aqueous solution has been developed on the basis of molecular dynamics simulation. The model...
Kumaran, D., Eswaramoorthy, S., Luft, B.J., Koide, S., Dunn, J.J., Lawson, C.L., ...
Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been...
A novel translational regulation function for the simian virus 40 large-T antigen gene.
Rajan, P, Swaminathan, S, Zhu, J, Cole, C N, Barber, G, Tevethia, M J, ...
Cells use the interferon-induced, double-stranded-RNA-dependent protein kinase PKR as a defense against virus infections. Upon activation, PKR phosphorylates and thereby inactivates the protein...
Molecular genetic analysis of Epstein-Barr virus Cp promoter function.
Evans, T J, Farrell, P J, Swaminathan, S
The Cp promoter of Epstein-Barr virus (EBV) directs most transcription of the EBNA genes in lymphoblastoid cell lines. The functions of two control regions in the Cp promoter have been studied by...
DeMarini, D J, Papa, F R, Swaminathan, S, Ursic, D, Rasmussen, T P, Culbertson, M R, ...
The yeast Sen1 protein was discovered by virtue of its role in tRNA splicing in vitro. To help determine the role of Sen1 in vivo, we attempted to overexpress the protein in yeast cells. However,...
Epstein-Barr virus recombinants with specifically mutated BCRF1 genes.
Swaminathan, S, Hesselton, R, Sullivan, J, Kieff, E
Epstein-Barr virus (EBV) recombinants with specifically mutated BCRF1 genes were constructed and compared with wild-type BCRF1 recombinants derived in parallel for the ability to initiate and...
Effects of virally expressed interleukin-10 on vaccinia virus infection in mice.
Kurilla, M G, Swaminathan, S, Welsh, R M, Kieff, E, Brutkiewicz, R R
To investigate the in vivo role of interleukin-10 (IL-10) in viral infection, we compared infections with a recombinant vaccinia virus (VV) expressing IL-10 (VV-IL10) under control of the VV P7.5...
Swaminathan, S, Huneycutt, B S, Reiss, C S, Kieff, E
The recent derivation of otherwise isogenic Epstein-Barr virus (EBV) recombinants carrying or lacking the EBV small RNA (EBER) genes enabled us to test whether EBERs are similar to adenovirus VA RNAs...
Jaiswal, Smita, Khanna, Navin, Swaminathan, S.
A recombinant replication-defective adenovirus vector that can overexpress the ectodomain of the envelope protein of dengue virus type 2 (NGC strain) has been constructed. This virus was immunogenic...
Wang, K Y, Gerena, L, Swaminathan, S, Bolton, P H
The paramagnetic metal ion Mn2+ has been used to probe the electrostatic potentials of a DNA quadruplex that has two quartets with an overall fold of the chair type. A quadruplex with a basket type...
Swaminathan, S, Malhotra, P, Manohar, C F, Dhar, R, Thimmapaya, B
The role of TATA elements in the expression of a mammalian promoter was investigated in the fission yeast Schizosaccharomyces pombe, by studying the human adenovirus E2-early promoter. This is a...
White, Kirsten L., Chen, James M., Margot, Nicolas A., Wrin, Terri, Petropoulos, Christos J., Naeger, Lisa K., ...
Two amino acids inserted between residues 69 and 70 of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) are rare mutations that may develop in viruses containing multiple...
Gashler, A L, Swaminathan, S, Sukhatme, V P
Egr-1 is an immediate-early response gene induced transiently and ubiquitously by mitogenic stimuli and also regulated in response to signals that initiate differentiation. The Egr-1 gene product, a...
Frattini, M G, Hurst, S D, Lim, H B, Swaminathan, S, Laimins, L A
Human papillomavirus (HPV) E2 and E1 proteins are required for the replication of viral genomes in vivo. We have examined the effects of increasing the level of E2 on viral and cellular replication...
Amerik AYu, Swaminathan, S, Krantz, B A, Wilkinson, K D, Hochstrasser, M
Degradation of many eukaryotic proteins requires their prior ligation to polyubiquitin chains, which target substrates to the 26S proteasome, an abundant cellular protease. We describe a yeast...
Wilson, M R, Takov, R, Friendship, R M, Martin, S W, McMillan, I, Hacker, R R, ...
The prevalence and extent of respiratory tract lesions were measured in 1425 pigs from 27 randomly selected herds in the summer of 1982 and winter of 1983. About 75% of pigs had lesions of enzootic...
Molecular dynamics of myoglobin at 298 degrees K. Results from a 300-ps computer simulation.
Levy, R M, Sheridan, R P, Keepers, J W, Dubey, G S, Swaminathan, S, Karplus, M
We have carried out a very long (300 ps) molecular dynamics simulation of the protein myoglobin. This trajectory is approximately three times longer than the longest previous molecular dynamics...
Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.
1. ADH secretion was studied in trained, preoperated conscious monkeys undergoing water diuresis after administration of isosmolar hypertonic solutions of different substances into any one of the...
Search for a natriuretic mechanism sensitive to sodium in the brain of the monkey.
1. The effects of hypertonic saline infusion into the third ventricle were investigated in ten monkeys which were pre-operated, trained, and used in the conscious state under controlled conditions....
Swaminathan, S, Tomkinson, B, Kieff, E
Strains of Epstein-Barr virus (EBV) with deletions of the small RNA (EBER) genes were made by homologous recombination using the EBV P3HR-1 strain, which has undergone deletion of the essential...
Ghadge, G D, Swaminathan, S, Katze, M G, Thimmapaya, B
In human cells infected with adenovirus, the virus-associated RNA VAI blocks the activation of the interferon-induced double-stranded-RNA-dependent 68-kDa protein kinase (p68) and maintains normal...
Domain communication in the dynamical structure of human immunodeficiency virus 1 protease.
Harte, W E, Swaminathan, S, Mansuri, M M, Martin, J C, Rosenberg, I E, Beveridge, D L
A dynamical model for the structure of the human immunodeficiency virus 1 (HIV-1) protease dimer in aqueous solution has been developed on the basis of molecular dynamics simulation. The model...
Kumaran, D., Eswaramoorthy, S., Luft, B.J., Koide, S., Dunn, J.J., Lawson, C.L., ...
Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been...
A novel translational regulation function for the simian virus 40 large-T antigen gene.
Rajan, P, Swaminathan, S, Zhu, J, Cole, C N, Barber, G, Tevethia, M J, ...
Cells use the interferon-induced, double-stranded-RNA-dependent protein kinase PKR as a defense against virus infections. Upon activation, PKR phosphorylates and thereby inactivates the protein...
Molecular genetic analysis of Epstein-Barr virus Cp promoter function.
Evans, T J, Farrell, P J, Swaminathan, S
The Cp promoter of Epstein-Barr virus (EBV) directs most transcription of the EBNA genes in lymphoblastoid cell lines. The functions of two control regions in the Cp promoter have been studied by...
DeMarini, D J, Papa, F R, Swaminathan, S, Ursic, D, Rasmussen, T P, Culbertson, M R, ...
The yeast Sen1 protein was discovered by virtue of its role in tRNA splicing in vitro. To help determine the role of Sen1 in vivo, we attempted to overexpress the protein in yeast cells. However,...