Safety and pharmacokinetics of rimantadine small-particle aerosol.
Atmar, R L, Greenberg, S B, Quarles, J M, Wilson, S Z, Tyler, B, Feldman, S, ...
The safety and pharmacokinetics of rimantadine administered by small-particle aerosol were assessed in healthy adults and adults with acute influenza virus infection. Aerosolized rimantadine...
Activity against rhinoviruses, toxicity, and delivery in aerosol of enviroxime in liposomes.
Wyde, P R, Six, H R, Wilson, S Z, Gilbert, B E, Knight, V
Enviroxime has been shown to inhibit the replication of rhinoviruses and other enteroviruses in concentrations as low as nanograms per milliliter in in vitro assays but is markedly less effective in...
Wyde, P R, Sun, C S, Wilson, S Z, Knight, V
Mice were exposed for 8 h to continuous small-particle aerosols containing natural mouse alpha interferon (estimated dosage 100 U per mouse) or one of two concentrations of hybrid recombinant alpha...
Gilbert, B E, Wilson, S Z, Knight, V, Couch, R B, Quarles, J M, Dure, L, ...
In a double-blind study of influenza in a population of college students in 1984, ribavirin small-particle aerosol treatment of 38 patients (18 treated, 20 control) infected with a new antigenic...
Wyde, P R, Wilson, S Z, Sun, C S, Knight, V
Mice were inoculated intranasally with vesicular stomatitis virus 16 to 22 h after being exposed to small-particle aerosols of saline, natural mouse alpha interferon, recombinant human alpha...
Wyde, P R, Wilson, S Z, Gilbert, B E, Smith, R H
An aerosol generated from a reservoir containing 60 mg of ribavirin per ml given for 2 h twice daily for 4 days afforded the same high level of protection against lethal influenza virus infection of...
Pulmonary deposition and clearance of aerosolized interferon.
Wyde, P R, Wilson, S Z, Kramer, M J, Sun, C S, Knight, V
Small particle aerosols of a hybrid DNA recombinant human alpha interferon, A/D bgl, and a related DNA recombinant leukocyte interferon, A, were generated and delivered to mice for 23.5 h a day for 4...
Gilbert, B E, Wyde, P R, Wilson, S Z
Cryptococcus infections of the lung and central nervous system have become major problems in immuno-compromised patients, leading to the need for additional treatment protocols. We have utilized a...
Gilbert, B E, Wyde, P R, Wilson, S Z, Robins, R K
Ribavirin is active in vitro but not in vivo against a number of viruses capable of causing encephalitis. Ribavirin triacetate (RTA), a lipophilic derivative, has been reported to be more effective...
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.
Wilson, S Z, Knight, V, Wyde, P R, Drake, S, Couch, R B
Ribavirin, amantadine, and the two drugs in combination given in small-particle aerosol were highly effective in the treatment of influenza A infection in mice. Treatment was started 72, 96, and 120...
Treatment of influenza A (H1N1) virus infection with ribavirin aerosol.
Wilson, S Z, Gilbert, B E, Quarles, J M, Knight, V, McClung, H W, Moore, R V, ...
In a randomized, controlled study of ribavirin aerosol treatment of influenza A(H1N1) virus infection among college students, treated patients had a significantly shorter duration of fever than...
Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice.
Gilbert, B E, Wyde, P R, Lopez-Berestein, G, Wilson, S Z
Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight...
Knight, V, Bloom, K, Wilson, S Z, Wilson, R K
Seven well volunteers and three patients with a naturally occurring influenza A/USSR/77 (H1N1)-like infection were given amantadine by small-particle aerosol with a Collison generator modified for...
Safety and pharmacokinetics of rimantadine small-particle aerosol.
Atmar, R L, Greenberg, S B, Quarles, J M, Wilson, S Z, Tyler, B, Feldman, S, ...
The safety and pharmacokinetics of rimantadine administered by small-particle aerosol were assessed in healthy adults and adults with acute influenza virus infection. Aerosolized rimantadine...
Activity against rhinoviruses, toxicity, and delivery in aerosol of enviroxime in liposomes.
Wyde, P R, Six, H R, Wilson, S Z, Gilbert, B E, Knight, V
Enviroxime has been shown to inhibit the replication of rhinoviruses and other enteroviruses in concentrations as low as nanograms per milliliter in in vitro assays but is markedly less effective in...
Wyde, P R, Sun, C S, Wilson, S Z, Knight, V
Mice were exposed for 8 h to continuous small-particle aerosols containing natural mouse alpha interferon (estimated dosage 100 U per mouse) or one of two concentrations of hybrid recombinant alpha...
Gilbert, B E, Wilson, S Z, Knight, V, Couch, R B, Quarles, J M, Dure, L, ...
In a double-blind study of influenza in a population of college students in 1984, ribavirin small-particle aerosol treatment of 38 patients (18 treated, 20 control) infected with a new antigenic...
Wyde, P R, Wilson, S Z, Sun, C S, Knight, V
Mice were inoculated intranasally with vesicular stomatitis virus 16 to 22 h after being exposed to small-particle aerosols of saline, natural mouse alpha interferon, recombinant human alpha...
Wyde, P R, Wilson, S Z, Gilbert, B E, Smith, R H
An aerosol generated from a reservoir containing 60 mg of ribavirin per ml given for 2 h twice daily for 4 days afforded the same high level of protection against lethal influenza virus infection of...
Pulmonary deposition and clearance of aerosolized interferon.
Wyde, P R, Wilson, S Z, Kramer, M J, Sun, C S, Knight, V
Small particle aerosols of a hybrid DNA recombinant human alpha interferon, A/D bgl, and a related DNA recombinant leukocyte interferon, A, were generated and delivered to mice for 23.5 h a day for 4...
Gilbert, B E, Wyde, P R, Wilson, S Z
Cryptococcus infections of the lung and central nervous system have become major problems in immuno-compromised patients, leading to the need for additional treatment protocols. We have utilized a...
Gilbert, B E, Wyde, P R, Wilson, S Z, Robins, R K
Ribavirin is active in vitro but not in vivo against a number of viruses capable of causing encephalitis. Ribavirin triacetate (RTA), a lipophilic derivative, has been reported to be more effective...
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.
Wilson, S Z, Knight, V, Wyde, P R, Drake, S, Couch, R B
Ribavirin, amantadine, and the two drugs in combination given in small-particle aerosol were highly effective in the treatment of influenza A infection in mice. Treatment was started 72, 96, and 120...
Treatment of influenza A (H1N1) virus infection with ribavirin aerosol.
Wilson, S Z, Gilbert, B E, Quarles, J M, Knight, V, McClung, H W, Moore, R V, ...
In a randomized, controlled study of ribavirin aerosol treatment of influenza A(H1N1) virus infection among college students, treated patients had a significantly shorter duration of fever than...
Aerosolized amphotericin B-liposomes for treatment of systemic Candida infections in mice.
Gilbert, B E, Wyde, P R, Lopez-Berestein, G, Wilson, S Z
Mice lethally infected with Candida albicans were exposed to small-particle aerosols containing amphotericin B-liposomes. The drug, when administered twice daily for 2 h (0.58 mg/kg of body weight...
Knight, V, Bloom, K, Wilson, S Z, Wilson, R K
Seven well volunteers and three patients with a naturally occurring influenza A/USSR/77 (H1N1)-like infection were given amantadine by small-particle aerosol with a Collison generator modified for...