Saadou Issifou

Haplotype specific-sequencing reveals MBL2association with asymptomatic Plasmodium falciparuminfection (2009)

Boldt, Angelica BW, Messias-Reason, Iara J, Lell, Bertrand, Issifou, Saadou, Pedroso, Maria, Kremsner, Peter G, ...

Abstract Background Mannose binding lectin (MBL) has an important role in the activation of the complement system and opsonization of pathogenic microorganisms. Frequent polymorphisms found in the...

Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparummalaria (2008)

Dietmann, Anelia, Lackner, Peter, Helbok, Raimund, Spora, Katharina, Issifou, Saadou, Lell, Bertrand, ...

Abstract Background Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria (SM), are not yet fully understood. Both endothelin-1 (ET-1) and C-type natriuretic...

Therapeutic and prophylactic effect of intermittent preventive anti-malarial treatment in infants (IPTi) from Ghana and Gabon (2008)

May, Jürgen, Adjei, Samuel, Busch, Wibke, Gabor, Julian J, Issifou, Saadou, Kobbe, Robin, ...

Abstract Background Intermittent preventive treatment in infants (IPTi) with sulphadoxine-pyrimethamine (SP) reduces the incidence of malaria episodes in young children. The exact mechanism by which...

Antipyretic effect of ibuprofen in Gabonese children with uncomplicated falciparum malaria: a randomized, double-blind, placebo-controlled trial (2008)

Matsiégui, Pierre-Blaise, Missinou, Michel A, Necek, Magdalena, Mavoungou, Elie, Issifou, Saadou, Lell, Bertrand, ...

Abstract Background Antipyretic drugs are widely used in children with fever, though there is a controversy about the benefit of reducing fever in children with malaria. In order to assess the effect...

Socio-economic status is inversely related to bed net use in Gabon (2008)

Goesch, Julia N, Schwarz, Norbert G, Decker, Marie-Luise, Oyakhirome, Sunny, Borchert, Lea B, Kombila, Ulrich D, ...

Abstract Background Insecticide-treated bed nets (ITNs) range among the most effective measures of malaria prophylaxis, yet their implementation level in sub-Saharan Africa is still low. The goal of...

Pharmacokinetics of two paediatric artesunate mefloquine drug formulations in the treatment of uncomplicated falciparum malaria in Gabon (2007)

Ramharter, Michael, Kurth, Florian M., Bélard, Sabine, Bouyou-Akotet, Marielle K., Mamfoumbi, Modeste Mabika, Agnandji, Selidji T., ...

Objectives Paediatric drug formulations of artemisinin combination therapies and pharmacokinetic data supporting their use in African children are urgently needed for the effective treatment of young...

Short-Course Artesunate Treatment of Uncomplicated Plasmodium falciparum Malaria in Gabon

Borrmann, Steffen, Adegnika, Ayola A., Missinou, Michel A., Binder, Ronald K., Issifou, Saadou, Schindler, Andreas, ...

Artesunate is one of the most important antimalarial agents available, since it is effective against parasites that have developed resistance to conventional antimalarials in sub-Saharan Africa....

Antibodies to Plasmodium falciparum Rifin Proteins Are Associated with Rapid Parasite Clearance and Asymptomatic Infections

Abdel-Latif, Mohamed S., Dietz, Klaus, Issifou, Saadou, Kremsner, Peter G., Klinkert, Mo-Quen

Plasmodium falciparum rifin proteins, belonging to the largest known family of variable infected-erythrocyte surface-expressed proteins encoded by rif genes, were recently shown to be capable of...

Short-Course Regimens of Artesunate-Fosmidomycin in Treatment of Uncomplicated Plasmodium falciparum Malaria

Borrmann, Steffen, Adegnika, Ayola A., Moussavou, Félicien, Oyakhirome, Sunny, Esser, Gilbert, Matsiegui, Pierre-Blaise, ...

Fosmidomycin is effective against malaria, but it needs to be given for ≥4 days when used alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and...

Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with Plasmodium falciparum Malaria

Borrmann, Steffen, Lundgren, Ingrid, Oyakhirome, Sunny, Impouma, Bénido, Matsiegui, Pierre-Blaise, Adegnika, Ayola A., ...

Fosmidomycin plus clindamycin was shown to be efficacious in the treatment of uncomplicated Plasmodium falciparum malaria in a small cohort of pediatric patients aged 7 to 14 years, but more data,...

Short-Course Artesunate Treatment of Uncomplicated Plasmodium falciparum Malaria in Gabon

Borrmann, Steffen, Adegnika, Ayola A., Missinou, Michel A., Binder, Ronald K., Issifou, Saadou, Schindler, Andreas, ...

Artesunate is one of the most important antimalarial agents available, since it is effective against parasites that have developed resistance to conventional antimalarials in sub-Saharan Africa....

Antibodies to Plasmodium falciparum Rifin Proteins Are Associated with Rapid Parasite Clearance and Asymptomatic Infections

Abdel-Latif, Mohamed S., Dietz, Klaus, Issifou, Saadou, Kremsner, Peter G., Klinkert, Mo-Quen

Plasmodium falciparum rifin proteins, belonging to the largest known family of variable infected-erythrocyte surface-expressed proteins encoded by rif genes, were recently shown to be capable of...

Short-Course Regimens of Artesunate-Fosmidomycin in Treatment of Uncomplicated Plasmodium falciparum Malaria

Borrmann, Steffen, Adegnika, Ayola A., Moussavou, Félicien, Oyakhirome, Sunny, Esser, Gilbert, Matsiegui, Pierre-Blaise, ...

Fosmidomycin is effective against malaria, but it needs to be given for ≥4 days when used alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and...

Fosmidomycin plus Clindamycin for Treatment of Pediatric Patients Aged 1 to 14 Years with Plasmodium falciparum Malaria

Borrmann, Steffen, Lundgren, Ingrid, Oyakhirome, Sunny, Impouma, Bénido, Matsiegui, Pierre-Blaise, Adegnika, Ayola A., ...

Fosmidomycin plus clindamycin was shown to be efficacious in the treatment of uncomplicated Plasmodium falciparum malaria in a small cohort of pediatric patients aged 7 to 14 years, but more data,...

Randomized Controlled Trial of Fosmidomycin-Clindamycin versus Sulfadoxine-Pyrimethamine in the Treatment of Plasmodium falciparum Malaria▿ †

Oyakhirome, Sunny, Issifou, Saadou, Pongratz, Peter, Barondi, Fortune, Ramharter, Michael, Kun, Jürgen F., ...

Fosmidomycin-clindamycin therapy given every 12 h for 3 days was compared with a standard single oral dose of sulfadoxine-pyrimethamine. The two treatments showed comparably good tolerabilities and...