Cloning and initial characterization of the human cardiac sodium channel (SCN5A) promoter (2004)
Yang, Ping, Kupershmidt, Sabina, Roden, Dan M.
Objective: Despite the primacy of the sodium current in cardiac electrophysiology and evidence that decreased sodium current is arrhythmogenic in humans, little is known about transcriptional...
Cardiac-enriched LIM domain protein fhl2 is required to generate IKs in a heterologous system (2002)
Kupershmidt, Sabina, Yang, Iris C.-H., Sutherland, Margaret, Wells, K.Sam, Yang, Tao, Yang, Ping, ...
Objective: Co-expression of the KvLQT1 and minK potassium channel subunits is required to recapitulate IKs, the slow component of the cardiac delayed rectifier current, and mutations in either gene...
Divergent expression of delayed rectifier K+ channel subunits during mouse heart development (2001)
Franco, Diego, Demolombe, Sophie, Kupershmidt, Sabina, Dumaine, Robert, Dominguez, Jorge N, Roden, Dan, ...
The repolarization phase of the cardiac action potential is dependent on transmembrane K+ currents. The slow (IKs) and fast (IKr) components of the delayed-rectifier cardiac K+ current are generated...
From genes to channels: normal mechanisms (1999)
Roden, Dan M., Kupershmidt, Sabina
Electrophysiologic remodeling is a process whereby heart disease alters the electrophysiologic properties of cardiac tissue. These alterations, in turn, can cause or exacerbate disease-related...
Typescript (photocopy).
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
Jay, Patrick Y., Harris, Brett S., Maguire, Colin T., Buerger, Antje, Wakimoto, Hiroko, Tanaka, Makoto, ...
Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiac...
Zhai, Peiyong, Yamamoto, Mitsutaka, Galeotti, Jonathan, Liu, Jing, Masurekar, Malthi, Thaisz, Jill, ...
Ang II type 1 (AT1) receptors activate both conventional heterotrimeric G protein–dependent and unconventional G protein–independent mechanisms. We investigated how these different mechanisms...
Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
Jay, Patrick Y., Harris, Brett S., Maguire, Colin T., Buerger, Antje, Wakimoto, Hiroko, Tanaka, Makoto, ...
Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiac...
Zhai, Peiyong, Yamamoto, Mitsutaka, Galeotti, Jonathan, Liu, Jing, Masurekar, Malthi, Thaisz, Jill, ...
Ang II type 1 (AT1) receptors activate both conventional heterotrimeric G protein–dependent and unconventional G protein–independent mechanisms. We investigated how these different mechanisms...
Zhang, Min, Houamed, Khaled, Kupershmidt, Sabina, Roden, Dan, Satin, Leslie S.
The pharmacological properties of slow Ca2+-activated K+ current (Kslow) were investigated in mouse pancreatic β-cells and islets to understand how Kslow contributes to the control of islet...