Sabine Yerly

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach (2009)

Paraskevis, Dimitrios, Pybus, Oliver, Magiorkinis, Gkikas, Hatzakis, Angelos, Wensing, Annemarie MJ, Van De Vijver, David A, ...

Abstract Background The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial...

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach (2009)

Pybus, Oliver, Magiorkinis, Gkikas, Hatzakis, Angelos, Wensing, Annemarie, Van De Vijver, David, ...

ABSTRACT: BACKGROUND: The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the...

HIV-1-infected patients from the French National Observatory experiencing virological failure while receiving enfuvirtide (2008)

Descamps, Diane, Assoumou, Lambert, Masquelier, Bernard, Marcelin, Anne-Geneviève, Saidi, Souhila, Tamalet, Catherine, ...

Objectives We studied gp41 mutations associated with failing enfuvirtide salvage therapy. Methods This multicentre study involved patients with HIV-1 plasma viral load (pVL) > 5000 copies/mL after...

Assessment of Recent HIV-1 Infection by a Line Immunoassay for HIV-1/2 Confirmation (2007)

Jörg Schüpbach, Martin D. Gebhardt, Zuzana Tomasik, Christoph Niederhauser, Sabine Yerly, Philippe Bürgisser, ...

BackgroundKnowledge of the number of recent HIV infections is important for epidemiologic surveillance. Over the past decade approaches have been developed to estimate this number by testing...

The calculated genetic barrier for antiretroviral drug resistance substitutions is largely similar for different HIV-1 subtypes (2006)

Wensing, Annemarie M J, Angarano, Gioacchino, Asjö, Birgitta, Balotta, Claudia, Boeri, Enzo, ...

BACKGROUND: The genetic barrier, defined as the number of mutations required to overcome drug-selective pressure, is an important factor for the development of HIV drug resistance. Because of high...

Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management (2005)

Van De Vijver, David A, Angarano, Gioacchino, Asjö, Birgitta, Balotta, Claudia, Boeri, Enzo, ...

BACKGROUND: Infection with drug-resistant human immunodeficiency virus type 1 (HIV-1) can impair the response to combination therapy. Widespread transmission of drug-resistant variants has the...

Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues

Van Vaerenbergh, Kristien, Van Laethem, Kristel, Albert, Jan, Boucher, Charles A. B., Clotet, Bonaventura, Floridia, Marco, ...

The prevalence and the genotypic and phenotypic characteristics of multinucleoside-resistant (MNR) human immunodeficiency virus type 1 (HIV-1) variants in Europe were investigated in a multicenter...

Detection of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Pools of Sera Negative for Antibodies to HIV-1 and HIV-2

Morandi, Pierre-Alain, Schockmel, Gérard A., Yerly, Sabine, Burgisser, Philippe, Erb, Peter, Matter, Lukas, ...

A total of 234 pools were prepared from 10,692 consecutive serum samples negative for antibodies to human immunodeficiency virus type 1 (HIV-1) and HIV-2 collected at five virological laboratories...

Switch to Unusual Amino Acids at Codon 215 of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene in Seroconvertors Infected with Zidovudine-Resistant Variants

Yerly, Sabine, Rakik, Abdelrahim, Kinloch De Loes, Sabine, Hirschel, Bernard, Descamps, Diane, Brun-Vézinet, Françoise, ...

Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting...

Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein

Peters, Solange, Muñoz, Miguel, Yerly, Sabine, Sanchez-Merino, Victor, Lopez-Galindez, Cecilio, Perrin, Luc, ...

Resistance of human immunodeficiency virus type 1 (HIV-1) to antiretroviral agents results from target gene mutation within the pol gene, which encodes the viral protease, reverse transcriptase (RT),...

Amplicon Sequencing and Improved Detection of Human Rhinovirus in Respiratory Samples

Deffernez, Christelle, Wunderli, Werner, Thomas, Yves, Yerly, Sabine, Perrin, Luc, Kaiser, Laurent

Improved knowledge of the genotypic characteristics of human rhinovirus (HRV) is required, as are nucleic detection assays with the capacity to overcome both the similarities between members of the...

Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues

Van Vaerenbergh, Kristien, Van Laethem, Kristel, Albert, Jan, Boucher, Charles A. B., Clotet, Bonaventura, Floridia, Marco, ...

The prevalence and the genotypic and phenotypic characteristics of multinucleoside-resistant (MNR) human immunodeficiency virus type 1 (HIV-1) variants in Europe were investigated in a multicenter...

Detection of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in Pools of Sera Negative for Antibodies to HIV-1 and HIV-2

Morandi, Pierre-Alain, Schockmel, Gérard A., Yerly, Sabine, Burgisser, Philippe, Erb, Peter, Matter, Lukas, ...

A total of 234 pools were prepared from 10,692 consecutive serum samples negative for antibodies to human immunodeficiency virus type 1 (HIV-1) and HIV-2 collected at five virological laboratories...

Switch to Unusual Amino Acids at Codon 215 of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene in Seroconvertors Infected with Zidovudine-Resistant Variants

Yerly, Sabine, Rakik, Abdelrahim, Kinloch De Loes, Sabine, Hirschel, Bernard, Descamps, Diane, Brun-Vézinet, Françoise, ...

Sequences of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) domain were determined by direct sequencing of HIV-1 RNA in successive plasma samples from eight seroconverting...

Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein

Peters, Solange, Muñoz, Miguel, Yerly, Sabine, Sanchez-Merino, Victor, Lopez-Galindez, Cecilio, Perrin, Luc, ...

Resistance of human immunodeficiency virus type 1 (HIV-1) to antiretroviral agents results from target gene mutation within the pol gene, which encodes the viral protease, reverse transcriptase (RT),...

Amplicon Sequencing and Improved Detection of Human Rhinovirus in Respiratory Samples

Deffernez, Christelle, Wunderli, Werner, Thomas, Yves, Yerly, Sabine, Perrin, Luc, Kaiser, Laurent

Improved knowledge of the genotypic characteristics of human rhinovirus (HRV) is required, as are nucleic detection assays with the capacity to overcome both the similarities between members of the...

Assessment of Recent HIV-1 Infection by a Line Immunoassay for HIV-1/2 Confirmation

Schüpbach, Jörg, Gebhardt, Martin D, Tomasik, Zuzana, Niederhauser, Christoph, Yerly, Sabine, Bürgisser, Philippe, ...

Jörg Schüpbach and colleagues show that a second-generation Western blot antibody test used to confirm HIV infection can also be used to determine rates of recent HIV infection.

Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen

Sachsenberg, Nicolas, Perelson, Alan S., Yerly, Sabine, Schockmel, Gérard A., Leduc, Dominique, Hirschel, Bernard, ...

We investigated CD4+ and CD8+ T cell turnover in both healthy and HIV-1–infected adults by measuring the nuclear antigen Ki-67 specific for cell proliferation. The mean growth fraction,...