Harrington, Carl R, Lucchini, Sacha, Ridgway, Karyn P, Wegmann, Udo, Eaton, Tracy J, Hinton, Jay CD, ...
Abstract Background The human gastrointestinal (GI) tract contains a diverse collection of bacteria, most of which are unculturable by conventional microbiological methods. Increasingly molecular...
Sittka, Alexandra, Lucchini, Sacha, Papenfort, Kai, Sharma, Cynthia M., Rolle, Katarzyna, Binnewies, Tim T., ...
Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a thorough analysis of RNA bound to cellular proteins, and, therefore, of post-transcriptional regulons. We used HTPS to...
Papenfort, Kai, Pfeiffer, Verena, Lucchini, Sacha, Sonawane, Avinash, Hinton, Jay C. D., Vogel, Jörg
BMC Microbiology BioMed Central Methodology article (2008)
Carl R Harrington, Sacha Lucchini, Karyn P Ridgway, Udo Wegmann, Tracy J Eaton, Jay Cd Hinton, ...
A short-oligonucleotide microarray that allows improved detection of gastrointestinal tract microbial communities
Garzoni, Christian, Francois, Patrice, Huyghe, Antoine, Couzinet, Sabine, Tapparel, Caroline, Charbonnier, Yvan, ...
Abstract Background Staphylococcus aureus , a leading cause of chronic or acute infections, is traditionally considered an extracellular pathogen despite repeated reports of S. aureus internalization...
Correction: H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria (2007)
Sacha Lucchini, Gary Rowley, Martin D. Goldberg, Douglas Hurd, Marcus Harrison
H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria (2006)
Sacha Lucchini, Gary Rowley, Martin D. Goldberg, Douglas Hurd, Marcus Harrison
Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding sites of H-NS and...
ArrayOme: a program for estimating the sizes of microarray-visualized bacterial genomes (2005)
Ou, Hong-Yu, Smith, Rebecca J., Lucchini, Sacha, Hinton, Jay, Chaudhuri, Roy R., Pallen, Mark, ...
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for...
ArrayOme: a program for estimating the sizes of microarray-visualized bacterial genomes (2005)
Ou, Hong-Yu, Smith, Rebecca, Lucchini, Sacha, Hinton, Jay, Chaudhuri, Roy R., Pallen, Mark, ...
ArrayOme is a new program that calculates the size of genomes represented by microarray-based probes and facilitates recognition of key bacterial strains carrying large numbers of novel genes....
Thesis (doctoral)--Swiss Federal Institute of Technology Zurich, 1999.
Comparative Genomics of Streptococcus thermophilus Phage Species Supports a Modular Evolution Theory
Lucchini, Sacha, Desiere, Frank, Brüssow, Harald
The comparative analysis of five completely sequenced Streptococcus thermophilus bacteriophage genomes demonstrated that their diversification was achieved by a combination of DNA recombination...
Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, ...
For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide...
Comparative Genomic Indexing Reveals the Phylogenomics of Escherichia coli Pathogens
Anjum, Muna F., Lucchini, Sacha, Thompson, Arthur, Hinton, Jay C. D., Woodward, Martin J.
The Escherichia coli O26 serogroup includes important food-borne pathogens associated with human and animal diarrheal disease. Current typing methods have revealed great genetic heterogeneity within...
Lucchini, Sacha, Liu, Hong, Jin, Qi, Hinton, Jay C. D., Yu, Jun
Shigella flexneri, the etiologic agent of bacillary dysentery, invades epithelial cells as well as macrophages and dendritic cells and escapes into the cytosol soon after invasion. Dissection of the...
ArrayOme: a program for estimating the sizes of microarray-visualized bacterial genomes
Ou, Hong-Yu, Smith, Rebecca, Lucchini, Sacha, Hinton, Jay, Chaudhuri, Roy R., Pallen, Mark, ...
ArrayOme is a new program that calculates the size of genomes represented by microarray-based probes and facilitates recognition of key bacterial strains carrying large numbers of novel genes....
H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria
Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D
Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding sites of H-NS and...
Comparative Genomics of Streptococcus thermophilus Phage Species Supports a Modular Evolution Theory
Lucchini, Sacha, Desiere, Frank, Brüssow, Harald
The comparative analysis of five completely sequenced Streptococcus thermophilus bacteriophage genomes demonstrated that their diversification was achieved by a combination of DNA recombination...
Clements, Mark O., Eriksson, Sofia, Thompson, Arthur, Lucchini, Sacha, Hinton, Jay C. D., Normark, Staffan, ...
For many pathogens, the ability to regulate their replication in host cells is a key element in establishing persistency. Here, we identified a single point mutation in the gene for polynucleotide...
Comparative Genomic Indexing Reveals the Phylogenomics of Escherichia coli Pathogens
Anjum, Muna F., Lucchini, Sacha, Thompson, Arthur, Hinton, Jay C. D., Woodward, Martin J.
The Escherichia coli O26 serogroup includes important food-borne pathogens associated with human and animal diarrheal disease. Current typing methods have revealed great genetic heterogeneity within...
Lucchini, Sacha, Liu, Hong, Jin, Qi, Hinton, Jay C. D., Yu, Jun
Shigella flexneri, the etiologic agent of bacillary dysentery, invades epithelial cells as well as macrophages and dendritic cells and escapes into the cytosol soon after invasion. Dissection of the...
ArrayOme: a program for estimating the sizes of microarray-visualized bacterial genomes
Ou, Hong-Yu, Smith, Rebecca, Lucchini, Sacha, Hinton, Jay, Chaudhuri, Roy R., Pallen, Mark, ...
ArrayOme is a new program that calculates the size of genomes represented by microarray-based probes and facilitates recognition of key bacterial strains carrying large numbers of novel genes....
H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria
Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D
Histone-like nucleoid structuring protein (H-NS) is a modular protein that is associated with the bacterial nucleoid. We used chromatin immunoprecipitation to determine the binding sites of H-NS and...
Papenfort, Kai, Pfeiffer, Verena, Mika, Franziska, Lucchini, Sacha, Hinton, Jay C D, Vogel, Jörg
The bacterial envelope stress response (ESR) is triggered by the accumulation of misfolded outer membrane proteins (OMPs) upon envelope damage or excessive OMP synthesis, and is mediated by the...
Correction: H-NS Mediates the Silencing of Laterally Acquired Genes in Bacteria
Lucchini, Sacha, Rowley, Gary, Goldberg, Martin D, Hurd, Douglas, Harrison, Marcus, Hinton, Jay C. D
Balbontín, Roberto, Rowley, Gary, Pucciarelli, M. Graciela, López-Garrido, Javier, Wormstone, Yvette, Lucchini, Sacha, ...
Transcriptomic analyses during growth in Luria-Bertani medium were performed in strain SL1344 of Salmonella enterica serovar Typhimurium and in two isogenic derivatives lacking Dam methylase. More...
Garzoni, Christian, Francois, Patrice, Huyghe, Antoine, Couzinet, Sabine, Tapparel, Caroline, Charbonnier, Yvan, ...
McFarland, Kirsty A., Lucchini, Sacha, Hinton, Jay C. D., Dorman, Charles J.
The fim operon of Salmonella enterica serovar Typhimurium encodes type 1 fimbriae. The expression of fim is controlled in response to environmental signals through a complex regulatory cascade...
Sittka, Alexandra, Lucchini, Sacha, Papenfort, Kai, Sharma, Cynthia M., Rolle, Katarzyna, Binnewies, Tim T., ...
Recent advances in high-throughput pyrosequencing (HTPS) technology now allow a thorough analysis of RNA bound to cellular proteins, and, therefore, of post-transcriptional regulons. We used HTPS to...