Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents (2004)
Espinosa, Avelina, Clark, David, Stanley, Samuel L.
Objectives: The current use of metronidazole as an anti-amoebic agent causes significant side-effects. The purpose of this study was to identify alternative compounds with which to treat amoebiasis....
Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents (2004)
Espinosa, Avelina, Clark, David, Stanley, Samuel L.
Objectives: The current use of metronidazole as an anti-amoebic agent causes significant side-effects. The purpose of this study was to identify alternative compounds with which to treat amoebiasis....
Seydel, Karl B., Smith, Sara J., Stanley, Samuel L.
Evidence from in vitro studies suggests that gamma interferon (IFN-γ) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with...
Zhang, Zhi, Jin, Lingling, Champion, Gretchen, Seydel, Karl B., Stanley, Samuel L.
Shigellae infect human intestine and cause intense inflammation and destruction of colonic and rectal mucosa. To model the interactions of shigella with human intestine in vivo, we have studied...
Amebic Infection in the Human Colon Induces Cyclooxygenase-2
Stenson, William F., Zhang, Zhi, Riehl, Terrence, Stanley, Samuel L.
We sought to determine if infection of the colon with Entamoeba histolytica induces the expression of cyclooxygenase-2 and, if it does, to determine the contribution of prostaglandins produced...
Lotter, Hannelore, Khajawa, Fareed, Stanley, Samuel L., Tannich, Egbert
The protozoan parasite Entamoeba histolytica causes extensive morbidity and mortality through intestinal infection and amebic liver abscess. Here we show that immunization of gerbils with a single...
Blockade of Caspases Inhibits Amebic Liver Abscess Formation in a Mouse Model of Disease
We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone...
Sultan, Faisal, Jin, Ling-ling, Jobling, Michael G., Holmes, Randall K., Stanley, Samuel L.
One strategy for the induction of mucosal immune responses by oral immunization is to administer the antigen in conjunction with cholera toxin. Cholera toxin consists of one A polypeptide (CTA) which...
Seydel, Karl B., Zhang, Tonghai, Champion, Gretchen A., Fichtenbaum, Carl, Swanson, Paul E., Tzipori, Saul, ...
The protozoan parasite Cryptosporidium parvum invades intestinal epithelial cells and can cause life-threatening diarrhea in immunocompromised individuals. Despite the clinical importance of this...
Seydel, Karl B., Stanley, Samuel L.
Amebic liver abscess is characterized by extensive areas of dead hepatocytes that form cavities surrounded by a thin rim of inflammatory cells and few Entamoeba histolytica trophozoites. E....
Zhang, Zhi, Duchêne, Michael, Stanley, Samuel L.
Entamoeba histolytica trophozoites are covered by lipophosphoglycan-peptidoglycan molecules which may be key virulence factors. We found that pretreatment of severe combined immunodeficient mice...
Zhang, Zhi, Mahajan, Sajan, Zhang, Xiaochung, Stanley, Samuel L.
We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in the pathogenesis of amebic colitis. We found...
Zhang, Xiaochun, Zhang, Zhi, Alexander, Diane, Bracha, Rivka, Mirelman, David, Stanley, Samuel L.
Entamoeba histolytica trophozoites produce amoebapores, a family of small amphipathic peptides capable of insertion into bacterial or eukaryotic membranes and causing cellular lysis. Recently, E....
Davis, Paul H., Zhang, Zhi, Chen, Minghe, Zhang, Xiaochun, Chakraborty, Subhra, Stanley, Samuel L.
Leucine rich repeats serve as recognition motifs for surface proteins from bacteria and eukaryotes. The BspA protein from Bacteroides forsythus mediates bacterial binding to fibronectin and contains...
Seydel, Karl B., Smith, Sara J., Stanley, Samuel L.
Evidence from in vitro studies suggests that gamma interferon (IFN-γ) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with...
Zhang, Zhi, Jin, Lingling, Champion, Gretchen, Seydel, Karl B., Stanley, Samuel L.
Shigellae infect human intestine and cause intense inflammation and destruction of colonic and rectal mucosa. To model the interactions of shigella with human intestine in vivo, we have studied...
Amebic Infection in the Human Colon Induces Cyclooxygenase-2
Stenson, William F., Zhang, Zhi, Riehl, Terrence, Stanley, Samuel L.
We sought to determine if infection of the colon with Entamoeba histolytica induces the expression of cyclooxygenase-2 and, if it does, to determine the contribution of prostaglandins produced...
Lotter, Hannelore, Khajawa, Fareed, Stanley, Samuel L., Tannich, Egbert
The protozoan parasite Entamoeba histolytica causes extensive morbidity and mortality through intestinal infection and amebic liver abscess. Here we show that immunization of gerbils with a single...
Blockade of Caspases Inhibits Amebic Liver Abscess Formation in a Mouse Model of Disease
We looked at the effect of inhibiting caspases on amebic liver abscess in the mouse model of infection. A dose of the pan-caspase inhibitor benzyloxycarbonyl-V-A-D-O-methyl fluoromethyl ketone...
Sultan, Faisal, Jin, Ling-ling, Jobling, Michael G., Holmes, Randall K., Stanley, Samuel L.
One strategy for the induction of mucosal immune responses by oral immunization is to administer the antigen in conjunction with cholera toxin. Cholera toxin consists of one A polypeptide (CTA) which...
Seydel, Karl B., Zhang, Tonghai, Champion, Gretchen A., Fichtenbaum, Carl, Swanson, Paul E., Tzipori, Saul, ...
The protozoan parasite Cryptosporidium parvum invades intestinal epithelial cells and can cause life-threatening diarrhea in immunocompromised individuals. Despite the clinical importance of this...
Seydel, Karl B., Stanley, Samuel L.
Amebic liver abscess is characterized by extensive areas of dead hepatocytes that form cavities surrounded by a thin rim of inflammatory cells and few Entamoeba histolytica trophozoites. E....
Zhang, Zhi, Duchêne, Michael, Stanley, Samuel L.
Entamoeba histolytica trophozoites are covered by lipophosphoglycan-peptidoglycan molecules which may be key virulence factors. We found that pretreatment of severe combined immunodeficient mice...
Zhang, Zhi, Mahajan, Sajan, Zhang, Xiaochung, Stanley, Samuel L.
We used Entamoeba histolytica infection in human intestinal xenografts to study the roles interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α) in the pathogenesis of amebic colitis. We found...
Zhang, Xiaochun, Zhang, Zhi, Alexander, Diane, Bracha, Rivka, Mirelman, David, Stanley, Samuel L.
Entamoeba histolytica trophozoites produce amoebapores, a family of small amphipathic peptides capable of insertion into bacterial or eukaryotic membranes and causing cellular lysis. Recently, E....
Meléndez-López, Samuel G., Herdman, Scott, Hirata, Ken, Choi, Min-Ho, Choe, Youngchool, Craik, Charles, ...
Cysteine proteinases are key virulence factors of the protozoan parasite Entamoeba histolytica. We have shown that cysteine proteinases play a central role in tissue invasion and disruption of host...
Lotter, Hannelore, Zhang, Tonghai, Seydel, Karl B., Stanley, Samuel L., Tannich, Egbert
The emergence of multidrug-resistant organisms and the failure to eradicate infection by a number of important pathogens has led to increased efforts to develop vaccines to prevent infectious...
Marinets, Alexandra, Zhang, Tonghai, Guillén, Nancy, Gounon, Pierre, Bohle, Barbara, Vollmann, Ute, ...
A panel of monoclonal antibodies was raised from mice immunized with a membrane preparation from Entamoeba histolytica, the pathogenic species causing invasive amebiasis in humans. Antibody EH5 gave...
Sperandio, Brice, Regnault, Béatrice, Guo, Jianhua, Zhang, Zhi, Stanley, Samuel L., Sansonetti, Philippe J., ...
Antimicrobial factors are efficient defense components of the innate immunity, playing a crucial role in the intestinal homeostasis and protection against pathogens. In this study, we report that...
Davis, Paul H., Chen, Minghe, Zhang, Xiaochun, Clark, C. Graham, Townsend, R. Reid, Stanley, Samuel L.
The protozoan intestinal parasite Entamoeba histolytica infects millions of people worldwide and is capable of causing amebic dysentery and amebic liver abscess. The closely related species Entamoeba...