Samuel N. Breit

Structure of the Janus protein human CLIC2 (2007)

Cromer, Brett A., Gorman, Michael A., Dulhunty, Angela F, Board, Philip G, Parker, Michael W, Hanson, Guido, ...

Chloride intracellular channel (CLIC) proteins possess the remarkable property of being able to convert from a water-soluble state to a membrane channel state. We determined the three-dimensional...

Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors. (2006)

Agarwal, Mukesh K., Hastak, Kedar, Jackson, Mark W., Breit, Samuel N., Stark, George R., Agarwal, Munna L.

p53 is essential for the cellular responses to DNA damage that help to maintain genomic stability. Protective p53-dependent cell-cycle checkpoints are activated in response to a wide variety of...

Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4 (2005)

Littler, Dene R, Assaad, Nagi. N, Curmi, Paul M. G, Harrop, Stephen J, Brown, Louis J, Pankhurst, Greg J, ...

The structure of CLIC4, a member of the CLIC family of putative intracellular chloride ion channel proteins, has been determined at 1.8 Å resolution by X-ray crystallography. The protein is...

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes (2003)

Keelan, Jeffrey A., Wang, Kaye, Chaiworapongsa, Tinnakorn, Romero, Roberto, Mitchell, Murray D., Sato, Timothy A., ...

The placenta and fetal membranes are the site of expression of macrophage inhibitory cytokine (MIC‐1), a member of the transforming growth factor (TGF)‐β superfamily. We hypothesized that...

Comparative effects of azimilide and ambasilide on the human ether-a-go-go-related gene (HERG) potassium channel (2000)

Walker, Bruce D, Singleton, Cameron B, Tie, Hui, Bursill, Jane A, Wyse, Ken R, Valenzuela, Stella M, ...

Objective: To evaluate the effects of azimilide and ambasilide on the biophysical properties of the human-ether-a-go-go-related (HERG) channel. Methods: HERG was stably transfected into Chinese...

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Bootcov, Michelle R., Bauskin, Asne R., Valenzuela, Stella M., Moore, Anthony G., Bansal, Mohinder, He, Xiao Yan, ...

Macrophages play a key role in both normal and pathological processes involving immune and inflammatory responses, to a large extent through their capacity to secrete a wide range of biologically...

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1

Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., ...

Macrophage inhibitory cytokine (MIC-1), a divergent member of the transforming growth factor-β (TGF-β) superfamily and activation associated cytokine, is secreted as a 28 kDa dimer. To understand...

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

Bootcov, Michelle R., Bauskin, Asne R., Valenzuela, Stella M., Moore, Anthony G., Bansal, Mohinder, He, Xiao Yan, ...

Macrophages play a key role in both normal and pathological processes involving immune and inflammatory responses, to a large extent through their capacity to secrete a wide range of biologically...

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1

Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., ...

Macrophage inhibitory cytokine (MIC-1), a divergent member of the transforming growth factor-β (TGF-β) superfamily and activation associated cytokine, is secreted as a 28 kDa dimer. To understand...

Macrophage inhibitory cytokine 1 mediates a p53-dependent protective arrest in S phase in response to starvation for DNA precursors

Agarwal, Mukesh K., Hastak, Kedar, Jackson, Mark W., Breit, Samuel N., Stark, George R., Agarwal, Munna L.

p53 is essential for the cellular responses to DNA damage that help to maintain genomic stability. Protective p53-dependent cell-cycle checkpoints are activated in response to a wide variety of...

The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle

Valenzuela, Stella M, Mazzanti, Michele, Tonini, Raffaella, Qiu, Min Ru, Warton, Kristina, Musgrove, Elizabeth A, ...

NCC27 is a nuclear chloride ion channel, identified in the PMA-activated U937 human monocyte cell line. NCC27 mRNA is expressed in virtually all cells and tissues and the gene encoding NCC27 is also...