Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Teresa A. Evans, Sandra L. Siedlak, Liang Lu, Xiaoming Fu, Zeneng Wang, Woody R. McGinnis, ...
Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and...
Wang, Xinglong, Su, Bo, Siedlak, Sandra L., Moreira, Paula I., Fujioka, Hisashi, Wang, Yang, ...
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease (2007)
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
Abstract Background Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. (2007)
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
BACKGROUND: Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly...
The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response (2007)
David J. Bonda, Kate M. Webber, Sandra L. Siedlak, George Perry, Robert P. Friedland, Mark A. Smith
The mechanism(s) responsible for the loss of neurons that characterizes Alzheimer disease is incompletely understood. Nonetheless, there is considerable evidence suggestive of immuneabnormalities...
LRRK2 in Parkinson's disease and dementia with Lewy bodies (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Abstract Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD)....
LRRK2 in Parkinson's disease and dementia with Lewy bodies. (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
BACKGROUND: Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To...
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
LRRK2 in Parkinson's disease and dementia with Lewy bodies
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
Microtubule Reduction in Alzheimer’s Disease and Aging Is Independent of τ Filament Formation
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated τ, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Wang, Xinglong, Su, Bo, Siedlak, Sandra L., Moreira, Paula I., Fujioka, Hisashi, Wang, Yang, ...
Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...
Lee, Hyoung-gon, Chen, Qun, Wolfram, Julie A., Richardson, Sandy L., Liner, Anna, Siedlak, Sandra L., ...
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a “fetal re-expression” pattern, the functional role of Myc in...