Grant, Chris M., Luikenhuis, Sandra, Beckhouse, Anthony Gordon, Soderbergh, Malin, Dawes, Ian W.
Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We...
Grant, Chris M., Luikenhuis, Sandra, Beckhouse, Anthony Gordon, Soderbergh, Malin, Dawes, Ian W.
Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We...
Grant, Chris M., Luikenhuis, Sandra, Beckhouse, Anthony Gordon, Soderbergh, Malin, Dawes, Ian W.
Glutaredoxins are small heat-stable proteins that are active as glutathione-dependent oxidoreductases and are encoded by two genes, designated GRX1 and GRX2, in the yeast Saccharomyces cerevisiae. We...
Luikenhuis, Sandra, Perrone, Gabriel, Dawes, Ian W., Grant, Chris M.
Glutaredoxins are small heat-stable proteins that act as glutathione-dependent disulfide oxidoreductases. Two genes, designated GRX1 and GRX2, which share 40–52% identity and 61–76% similarity...
Antisense Transcription through the Xist Locus Mediates Tsix Function in Embryonic Stem Cells
Luikenhuis, Sandra, Wutz, Anton, Jaenisch, Rudolf
Expression of the Xist gene, a key player in mammalian X inactivation, has been proposed to be controlled by the antisense Tsix transcript. Targeted deletion of the Tsix promoter encompassing the...
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
Luikenhuis, Sandra, Giacometti, Emanuela, Beard, Caroline F., Jaenisch, Rudolf
Mutations in MECP2 are the cause of Rett syndrome (RTT) in humans, a neurodevelopmental disorder that affects mainly girls. MeCP2 is a protein that binds CpG dinucleotides and is thought to act as a...
Luikenhuis, Sandra, Perrone, Gabriel, Dawes, Ian W., Grant, Chris M.
Glutaredoxins are small heat-stable proteins that act as glutathione-dependent disulfide oxidoreductases. Two genes, designated GRX1 and GRX2, which share 40–52% identity and 61–76% similarity...
Antisense Transcription through the Xist Locus Mediates Tsix Function in Embryonic Stem Cells
Luikenhuis, Sandra, Wutz, Anton, Jaenisch, Rudolf
Expression of the Xist gene, a key player in mammalian X inactivation, has been proposed to be controlled by the antisense Tsix transcript. Targeted deletion of the Tsix promoter encompassing the...
Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
Luikenhuis, Sandra, Giacometti, Emanuela, Beard, Caroline F., Jaenisch, Rudolf
Mutations in MECP2 are the cause of Rett syndrome (RTT) in humans, a neurodevelopmental disorder that affects mainly girls. MeCP2 is a protein that binds CpG dinucleotides and is thought to act as a...
Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2
Giacometti, Emanuela, Luikenhuis, Sandra, Beard, Caroline, Jaenisch, Rudolf
In humans, mutations in the X-linked MECP2 gene, are the cause of Rett syndrome (RTT), a neurodevelopmental disorder that affects mainly girls. MeCP2 binds to methylated CpGs and is thought to act as...
X chromosome choice occurs independently of asynchronous replication timing
Gribnau, Joost, Luikenhuis, Sandra, Hochedlinger, Konrad, Monkhorst, Kim, Jaenisch, Rudolf
In mammals, dosage compensation is achieved by X chromosome inactivation in female cells. Xist is required and sufficient for X inactivation, and Xist gene deletions result in completely skewed X...
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, ...
Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from...