Mensah, Afua, Mulligan, Claire, Linehan, Jackie, Ruf, Sandra, O'Doherty, Aideen, Grygalewicz, Beata, ...
Abstract Background Down syndrome (DS), caused by trisomy of human chromosome 21 (HSA21), is the most common genetic cause of mental retardation in humans. Among complex phenotypes, it displays a...
An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes
O’Doherty, Aideen, Ruf, Sandra, Mulligan, Claire, Hildreth, Victoria, Errington, Mick L., Cooke, Sam, ...
Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated...
Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow*[unk]
McCarty, Owen J. T., Larson, Mark K., Auger, Jocelyn M., Kalia, Neena, Atkinson, Ben T., Pearce, Andrew C., ...
The role of Rac family proteins in platelet spreading on matrix proteins under static and flow conditions has been investigated by using Rac-deficient platelets. Murine platelets form filopodia and...
Mensah, Afua, Mulligan, Claire, Linehan, Jackie, Ruf, Sandra, O'Doherty, Aideen, Grygalewicz, Beata, ...
Canzonetta, Claudia, Mulligan, Claire, Deutsch, Samuel, Ruf, Sandra, O'Doherty, Aideen, Lyle, Robert, ...
Down syndrome (DS) is the most common cause of mental retardation. Many neural phenotypes are shared between DS individuals and DS mouse models; however, the common underlying molecular pathogenetic...
Rac GTPases play critical roles in early T-cell development
Dumont, Celine, Corsoni-Tadrzak, Agnieszka, Ruf, Sandra, De Boer, Jasper, Williams, Adam, Turner, Martin, ...
The Rac1 and Rac2 GTPases play important roles in many processes including cytoskeletal reorganization, proliferation, and survival, and are required for B-cell development. Previous studies had...