Sandy C. Marks

Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene (2002)

Odgren, Paul R., Kim, Nacksung, Van Wesenbeeck, Liesbeth, MacKay, Carole A., Mason-Savas, April, Safadi, Fayez F., ...

The toothless (tl) osteopetrotic mutation in the rat affects an osteoblast-derived factor that is required for normal osteoclast differentiation. Although the genetic locus remains unknown, the...

Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression (2000)

Marks, Sandy C., Lundmark, Carin, Christersson, Cecilia, Wurtz, Tilmann, Odgren, Paul R., Seifert, Mark F., ...

The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental stages of chondrocytes, characterized by the expression of collagen types II and X, are...

Colony-stimulating factor-1 (CSF-1) rescues osteoblast attachment, survival and sorting of beta-actin mRNA in the toothless (tl-osteopetrotic) mutation in the rat (2000)

Watanabe, Hiroki, MacKay, Carole A., Mason-Savas, April, Kislauskis, Edward H., Marks, Sandy C.

We have shown that in the osteopetrotic rat mutation toothless (tl) osteoblasts are absent from older bone surfaces in mutants and that mutant osteoblasts in vivo lack the prominent stress fiber...

Facial development and type III collagen RNA expression: concurrent repression in the osteopetrotic (Toothless,tl) rat and rescue after treatment with colony-stimulating factor-1 (1999)

Marks, Sandy C., Lundmark, Carin, Wurtz, Tilmann, Odgren, Paul R., MacKay, Carole A., Mason-Savas, April, ...

The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior facial skeleton. Growth of the anterior face in rats occurs at the premaxillary-maxillary...

The effects of colony-stimulating factor-1 on the number and ultrastructure of osteoclasts in toothless (tl) rats and osteopetrotic (op) mice (1997)

Marks, Sandy C., Iizuka, T., MacKay, Carole A., Mason-Savas, April, Cielinski, Matthew Joseph

The role of colony-stimulating factor-1 (CSF-1 or M-CSF) in osteoclast development is illustrated by observations that administration of exogenous CSF-1 increases osteoclast number and improves the...

Rib fractures in 31 abused infants: postmortem radiologic-histopathologic study (1996)

Kleinman, Paul K., Marks, Sandy C., Nimkin, Katherine, Rayder, Shawn M., Kessler, Stanton C.

PURPOSE: To examine the morphologic alterations of fractures of the lateral and anterior rib arcs and costochondral junction (CCJ) to better understand the factors that influence radiographic...

Bone surface morphology reflects local skeletal metabolism (1996)

Marks, Sandy C., Cielinski, Matthew Joseph, Sundquist, Kai T.

The metabolic activity of bone cells is faithfully reflected in the surface topography of mineralized bone surfaces, and this can be easily detected by scanning electron microscopy (SEM). Forming...

Bone metabolism in the osteopetrotic rat mutation microphthalmia blanc (1995)

Cielinski, Matthew J., Marks, Sandy C.

We have examined parameters of bone metabolism in a new mutation, microphthalmia blanc (mib), in the rat exhibiting a skeletal sclerosis at birth that improves with age. There were no significant...

The mechanisms and mediators of tooth eruption--models for developmental biologists (1995)

Marks, Sandy C., Gorski, Jeffrey P., Wise, Gary E.

Tooth eruption is a localized process in the jaws which exhibits precise timing and bilateral symmetry. It involves resorption and formation of bone on opposite sides of the erupting tooth and these...

The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat (1995)

Cielinski, Matthew J., Jolie, M., Wise, Gary E., Marks, Sandy C.

Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1...

Dental abnormalities in the osteopetrotic rat mutation microphthalmia blanc (1994)

Cielinski, Matthew J., Iizuka, T., Marks, Sandy C.

Dental manifestations of the mild, transient osteopetrosis in the rat mutation microphthalmia blanc (mib) were examined. Eruption of all teeth was delayed in mib rats compared to normal littermates....

Understanding bone cell biology requires an integrated approach: reliable opportunities to study osteoclast biology in vivo (1994)

Cielinski, Matthew J., Marks, Sandy C.

The relative simplicity of all in vitro methods to study bone cell biology will at best result in oversimplification of the development and functional capacity of the skeleton in vivo. We have shown...

Neonatal reductions in osteoclast number and function account for the transient nature of osteopetrosis in the rat mutation microphthalmia blanc (mib) (1994)

Cielinski, Matthew J., Marks, Sandy C.

We have examined the general and skeletal manifestations of osteopetrosis in a new, mild osteopetrotic mutation in the rat, microphalmia blanc (mib). Newborn mutant (mib) rats exhibit the typical...

Experimental studies of osteopetrosis in laboratory animals (1993)

Seifert, Mark F., Popoff, Steven N., Jackson, Mary E., MacKay, Carole A., Cielinski, Matthew Joseph, Marks, Sandy C.

Osteopetrosis is a metabolic bone disease characterized by a systemic increase in skeletal mass. It results from a defect in the production or function of osteoclasts and is inherited in nine...

The skeletal effects of colony-stimulating factor-1 in toothless (osteopetrotic) rats: persistent metaphyseal sclerosis and the failure to restore subepiphyseal osteoclasts (1993)

Marks, Sandy C., MacKay, Carole A., Jackson, Mary E., Larson, Erik K., Cielinski, Matthew Joseph, Stanley, E. Richard, ...

Toothless (tl), one of four osteopetrotic mutations in the rat, is characterized by few osteoclasts, undetectable bone resorption, and failure of correction by bone marrow transplantation. We...

Fractures of the rib head in abused infants (1992)

Kleinman, Paul K., Marks, Sandy C., Spevak, Melissa R., Richmond, Joann M.

Fractures of the posterior ribs are well-recognized sequelae of infant abuse. Previous reports have indicated a predilection for fracture near the costotransverse process. This study expands the...

The effects of colony-stimulating factor-1 on tooth eruption in the toothless (osteopetrotic) rat in relation to the critical periods for bone resorption during tooth eruption (1992)

Iizuka, Tateyuki, Cielinski, Matthew Joseph, Aukerman, Sharon Lea, Marks, Sandy C.

The toothless (tl) rat is an osteopetrotic mutation characterized by a generalized skeletal sclerosis, reduced bone resorption, few osteoclasts and a total absence of erupted teeth. This mutation is...

Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities (1991)

Shalhoub, Victoria, Jackson, Mary E., Lian, Jane B., Stein, Gary S., Marks, Sandy C.

Osteopetrosis is a group of metabolic bone diseases characterized by reductions in osteoclast development and/or function. These aspects of osteoclast biology are known to be influenced by...

Tartrate-resistant acid phosphatase in mononuclear and multinuclear cells during the bone resorption of tooth eruption (1987)

Marks, Sandy C., Grolman, My-Lan

Tartrate-resistant acid phosphatase (TRAP) has been used as a cytochemical marker for the cell mediators of bone resorption, osteoclasts and their mononuclear precursors. We have applied a...

Osteosclerosis, a recessive skeletal mutation on chromosome 19 in the mouse (1985)

Marks, Sandy C., Seifert, Mark F., Lane, Priscilla W.

Osteosclerosis (oc) is an osteopetrotic mutation in the mouse inherited as an autosomal recessive on chromosome 19. Affected animals (oc/oc) exhibit the characteristic radiologic and histologic...

Osteopetrosis, a New Recessive Skeletal Mutation on Chromosome 12 of the Mouse (1976)

MARKS, SANDY C., LANE, PRISCILLA W.

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

Kim, Nacksung, Odgren, Paul R., Kim, Dong-Ku, Marks, Sandy C., Choi, Yongwon

Tumor necrosis factor-related, activation-induced cytokine (TRANCE), a tumor necrosis factor family member, mediates survival of dendritic cells in the immune system and is required for osteoclast...

The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

Van Wesenbeeck, Liesbeth, Odgren, Paul R., MacKay, Carole A., D'Angelo, Marina, Safadi, Fayez F., Popoff, Steven N., ...

The toothless (tl) mutation in the rat is a naturally occurring, autosomal recessive mutation resulting in a profound deficiency of bone-resorbing osteoclasts and peritoneal macrophages. The failure...

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

Kim, Nacksung, Odgren, Paul R., Kim, Dong-Ku, Marks, Sandy C., Choi, Yongwon

Tumor necrosis factor-related, activation-induced cytokine (TRANCE), a tumor necrosis factor family member, mediates survival of dendritic cells in the immune system and is required for osteoclast...

The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

Van Wesenbeeck, Liesbeth, Odgren, Paul R., MacKay, Carole A., D'Angelo, Marina, Safadi, Fayez F., Popoff, Steven N., ...

The toothless (tl) mutation in the rat is a naturally occurring, autosomal recessive mutation resulting in a profound deficiency of bone-resorbing osteoclasts and peritoneal macrophages. The failure...