Comparative lesion sequencing provides insights into tumor evolution (2008)
Jones, Siân, Chen, Wei-dong, Parmigiana, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, ...
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical...
Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P., Maas, Alex, Wu, Xiaoli, ...
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these...
Daley, Denise, Lewis, Susan, Platzer, Petra, MacMillen, Melissa, Willis, Joseph, Elston, Robert C., ...
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in Americans and is the second leading cause of cancer mortality. Only a minority ( approximately 5%) of familial CRC can be...
Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...
An improved method for staining cell colonies in clonogenic assays. (2007)
Guda, Kishore, Natale, Leanna, Markowitz, Sanford D.
Clonogenic assay is a widely used experimental approach to test for the effects of drugs/genes on the growth and proliferative characteristics of cells in vitro. Accurate quantitation of treatment...
Methods and compositions for categorizing patients (2006)
Background: Colorectal cancer, also referred to herein as colon cancer, is the second leading cause of cancer mortality in the adult American population. An estimated 135,000 new cases of colon...
Methods and compositions for categorizing patients (2006)
Background: Colorectal cancer, also referred to herein as colon cancer, is the second leading cause of cancer mortality in the adult American population. An estimated 135,000 new cases of colon...
Motegi, Akira, Sood, Raman, Moinova, Helen, Markowitz, Sanford D., Liu, Pu Paul, Myung, Kyungjae
Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3)...
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. (2006)
Myung, Seung-Jae, Rerko, Ronald M., Yan, Min, Platzer, Petra, Guda, Kishore, Dotson, Angela, ...
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we...
Detection in Fecal DNA of Colon CancerSpecific Methylation of the Nonexpressed Vimentin Gene (2005)
Chen, Wei-Dong, Han, Z. James, Skoletsky, Joel, Olson, Jeff, Sah, Jerome, Myeroff, Lois, ...
Background: Increased DNA methylation is an epigenetic alteration that is common in human cancers and is often associated with transcriptional silencing. Aberrantly methylated DNA has also been...
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter. (2004)
Coady, Michael J, Chang, Min-Hwang, Charron, Francois M, Plata, Consuelo, Wallendorff, Bernadette, Sah, Jerome Frank, ...
The orphan cotransport protein expressed by the SLC5A8 gene has been shown to play a role in controlling the growth of colon cancers, and the silencing of this gene is a common and early event in...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2003)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2003)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2. (2003)
Wiesner, Georgia L., Daley, Denise, Lewis, Susan, Ticknor, Christine, Platzer, Petra, Lutterbaugh, James, ...
Colorectal cancer is the second most leading cause of cancer death among adult Americans. Two autosomal dominant hereditary forms of the disease, familial adenomatous polyposis and hereditary...
HLTF gene silencing in human colon cancer. (2002)
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2001)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Cancer diagnosis and therapy based on mutations in TGF-.beta. receptors (2001)
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Mechanisms underlying losses of heterozygosity in human colorectal cancers. (2001)
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
Testing for Colon Neoplasia Susceptibility Variants at the Human COX2 Locus (2001)
Wiesner, Georgia L., Platzer, Petra, Buxbaum, Sarah, Lewis, Susan, MacMillen, Mellissa, Olechnowicz, Joseph, ...
Background: Siblings and other first-degree relatives of patients with “sporadic” (i.e., apparently nonfamilial) colorectal cancer or precursor adenomatous colon polyps have an increased risk of...
Chen, Wei-Dong, Eshleman, James R., Aminoshariae, M. Reza, Ma, Ai-Hong, Veloso, Neil, Markowitz, Sanford D., ...
BACKGROUND: Deficiency of DNA mismatch repair is a common feature of cancers exhibiting instability of microsatellite DNA sequences. Cancers with microsatellite instability are recognizable by their...
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Markowitz, Sanford D., Brattain, Michael G., Willson, James K. V.
Background of the invention: 1. Field of the Invention This invention is concerned with diagnostic methods which assist in classification of tumors by phenotype and with therapeutic intervention...
Veigl, Martina L., Kasturi, Lakshmi, Olechnowicz, Joseph, Ma, AiHong, Lutterbaugh, James D., Periyasamy, Sumudra, ...
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA...
Myeroff, Lois L., Markowitz, Sanford D.
Background The murine nm23 gene suppresses the metastatic behavior of malignant rodent tumor lines, and reduced nm23 expression correlates with increased likelihood of lymph node metastases in human...
Haut, Mitchell, Steeg, Patricia S., Willson, James K. V., Markowitz, Sanford D.
Levels of expression of the murine nm23 gene inversely correlate with metastatic potential in several rodent tumor model systems. Expression of the human nm23 homologue also is lower in human breast...
Veigl, Martina L., Kasturi, Lakshmi, Olechnowicz, Joseph, Ma, AiHong, Lutterbaugh, James D., Periyasamy, Sumudra, ...
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA...
Mechanisms underlying losses of heterozygosity in human colorectal cancers
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
Wiesner, Georgia L., Daley, Denise, Lewis, Susan, Ticknor, Christine, Platzer, Petra, Lutterbaugh, James, ...
Colorectal cancer is the second most leading cause of cancer death among adult Americans. Two autosomal dominant hereditary forms of the disease, familial adenomatous polyposis and hereditary...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
The human tumour suppressor gene SLC5A8 expresses a Na+–monocarboxylate cotransporter
Coady, Michael J, Chang, Min-Hwang, Charron, Francois M, Plata, Consuelo, Wallendorff, Bernadette, Sah, Jerome Frank, ...
The orphan cotransport protein expressed by the SLC5A8 gene has been shown to play a role in controlling the growth of colon cancers, and the silencing of this gene is a common and early event in...
Veigl, Martina L., Kasturi, Lakshmi, Olechnowicz, Joseph, Ma, AiHong, Lutterbaugh, James D., Periyasamy, Sumudra, ...
Mutations of DNA mismatch repair genes, including the hMLH1 gene, have been linked to human colon and other cancers in which defective DNA repair is evidenced by the associated instability of DNA...
Mechanisms underlying losses of heterozygosity in human colorectal cancers
Thiagalingam, Sam, Laken, Steve, Willson, James K. V., Markowitz, Sanford D., Kinzler, Kenneth W., Vogelstein, Bert, ...
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for...
HLTF gene silencing in human colon cancer
Moinova, Helen R., Chen, Wei-Dong, Shen, Lanlan, Smiraglia, Dominic, Olechnowicz, Joseph, Ravi, Lakshmeswari, ...
Chromatin remodeling enzymes are increasingly implicated in a variety of important cellular functions. Various components of chromatin remodeling complexes, including several members of the SWI/SNF...
Li, Hui, Myeroff, Lois, Smiraglia, Dominic, Romero, Michael F., Pretlow, Theresa P., Kasturi, Lakshmi, ...
We identify a gene, SLC5A8, and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has...
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
Wiesner, Georgia L., Daley, Denise, Lewis, Susan, Ticknor, Christine, Platzer, Petra, Lutterbaugh, James, ...
Colorectal cancer is the second most leading cause of cancer death among adult Americans. Two autosomal dominant hereditary forms of the disease, familial adenomatous polyposis and hereditary...
Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, ...
Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic...
The human tumour suppressor gene SLC5A8 expresses a Na+–monocarboxylate cotransporter
Coady, Michael J, Chang, Min-Hwang, Charron, Francois M, Plata, Consuelo, Wallendorff, Bernadette, Sah, Jerome Frank, ...
The orphan cotransport protein expressed by the SLC5A8 gene has been shown to play a role in controlling the growth of colon cancers, and the silencing of this gene is a common and early event in...
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
Myung, Seung-Jae, Rerko, Ronald M., Yan, Min, Platzer, Petra, Guda, Kishore, Dotson, Angela, ...
15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we...
Motegi, Akira, Sood, Raman, Moinova, Helen, Markowitz, Sanford D., Liu, Pu Paul, Myung, Kyungjae
Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3)...
Comparative lesion sequencing provides insights into tumor evolution
Jones, Siân, Chen, Wei-dong, Parmigiani, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, ...
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical...
An improved method for staining cell colonies in clonogenic assays
Guda, Kishore, Natale, Leanna, Markowitz, Sanford D.
Clonogenic assay is a widely used experimental approach to test for the effects of drugs/genes on the growth and proliferative characteristics of cells in vitro. Accurate quantitation of treatment...
Motegi, Akira, Liaw, Hung-Jiun, Lee, Kyoo-Young, Roest, Henk P., Maas, Alex, Wu, Xiaoli, ...
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these...
Daley, Denise, Lewis, Susan, Platzer, Petra, MacMillen, Melissa, Willis, Joseph, Elston, Robert C., ...
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in Americans and is the second leading cause of cancer mortality. Only a minority (∼5%) of familial CRC can be explained by known...
Leary, Rebecca J., Lin, Jimmy C., Cummins, Jordan, Boca, Simina, Wood, Laura D., Parsons, D. Williams, ...
We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the...