Hwang, Dong-Youn, Hong, Sunghoi, Jeong, Joo-Won, Choi, Sangdun, Kim, Hansoo, Kim , Jangwoo, ...
Midbrain dopamine (mDA) neurons play critical roles in the regulation of voluntary movement and their dysfunction is associated with Parkinson's disease. Pitx3 has been implicated in the proper...
Krishnan, Jayalakshmi, Chen, Jiayan, Shin, Kum-Joo, Hwang, Jong-Ik, Han, Sang-Uk, Lee, Gwang, ...
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin...
Krishnan, Jayalakshmi, Chen, Jiayan, Shin, Kum-Joo, Hwang, Jong-Ik, Han, Sang-Uk, Lee, Gwang, ...
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin...
Jayalakshmi Krishnan, Gwang Lee, Sang-Uk Han, Sangdun Choi
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitated by the identification of genes regulated in the retinas of different mutants under various light...
Jayalakshmi Krishnan, Gwang Lee, Sang-Uk Han, Sangdun Choi
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitated by the identification of genes regulated in the retinas of different mutants under various light...
Cho, Min Kyung, Kim, Won Dong, Ki, Sung Hwan, Hwang, Jong-Ik, Choi, Sangdun, Lee, Chang Ho, ...
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress. This...
Nam, Ju-Suk, Turcotte, Taryn J., Smith, Peter F., Choi, Sangdun, Yoon, Jeon Kyo
Wnt signaling plays critical biological roles during normal embryonic development and homeostasis in adults. In the canonical pathway, binding of Wnt ligands to the Frizzled (Fzd) receptor and the...
Lee, Jamie A., Sinkovits, Robert F., Mock, Dennis, Rab, Eva L., Cai, Jennifer, Yang, Peng, ...
Background: Activation of naive B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccharide (LPS) and CD40 ligand, induces a combination of common and ligand-specific phenotypic changes...
Lee, Jamie A, Sinkovits, Robert S, Mock, Dennis, Rab, Eva L, Cai, Jennifer, Yang, Peng, ...
Abstract Background Activation of naïve B lymphocytes by extracellular ligands, e.g. antigen, lipopolysaccharide (LPS) and CD40 ligand, induces a combination of common and ligand-specific phenotypic...
Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA (2004)
Hwang, Jong-Ik, Fraser, Iain D. C., Choi, Sangdun, Qin, Xiao-Feng, Simon, Melvin I.
Immune cells respond to chemotactic signals by means of G protein-coupled receptors. Attempts to elucidate the function of specific G protein family members in these responses is complicated by...
Highly Coordinated Gene Regulation in Mouse Skeletal Muscle Regeneration (2003)
Yan, Zhen, Choi, Sangdun, Liu, Xuebin, Zhang, Mei, Schageman, Jeoffrey J., Lee, Sun Young, ...
Mammalian skeletal muscles are capable of regeneration after injury. Quiescent satellite cells are activated to reenter the cell cycle and to differentiate for repair, recapitulating features of...
Choi, Sangdun, Hao, Wenshan, Chen, Ching-Kang, Simon, Melvin I.
To examine the molecular processes that lead to light-induced retinal degeneration, mutant mice deficient in arrestin and rhodopsin kinase were raised in the dark and then subjected to relatively low...
Choi, Sangdun, Begum, Dilara, Koshinsky, Heather, Ow, David W., Wing, Rod A.
With current plant transformation methods (Agrobacterium, biolistics and protoplast fusion), insertion of DNA into the genome occurs randomly and in many instances at multiple sites. Associated...
Choi, Sangdun, Hao, Wenshan, Chen, Ching-Kang, Simon, Melvin I.
To examine the molecular processes that lead to light-induced retinal degeneration, mutant mice deficient in arrestin and rhodopsin kinase were raised in the dark and then subjected to relatively low...
Choi, Sangdun, Begum, Dilara, Koshinsky, Heather, Ow, David W., Wing, Rod A.
With current plant transformation methods (Agrobacterium, biolistics and protoplast fusion), insertion of DNA into the genome occurs randomly and in many instances at multiple sites. Associated...
Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA
Hwang, Jong-Ik, Fraser, Iain D. C., Choi, Sangdun, Qin, Xiao-Feng, Simon, Melvin I.
Immune cells respond to chemotactic signals by means of G protein-coupled receptors. Attempts to elucidate the function of specific G protein family members in these responses is complicated by...
Hwang, Jong-Ik, Choi, Sangdun, Fraser, Iain D. C., Chang, Mi Sook, Simon, Melvin I.
The Gβγ-subunit complex derived from heterotrimeric G proteins can act to regulate the function of a variety of protein targets. We established lentiviral-based RNA interference in J774A.1 mouse...
Choi, Sangdun, Hao, Wenshan, Chen, Ching-Kang, Simon, Melvin I.
To examine the molecular processes that lead to light-induced retinal degeneration, mutant mice deficient in arrestin and rhodopsin kinase were raised in the dark and then subjected to relatively low...
Choi, Sangdun, Begum, Dilara, Koshinsky, Heather, Ow, David W., Wing, Rod A.
With current plant transformation methods (Agrobacterium, biolistics and protoplast fusion), insertion of DNA into the genome occurs randomly and in many instances at multiple sites. Associated...
Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA
Hwang, Jong-Ik, Fraser, Iain D. C., Choi, Sangdun, Qin, Xiao-Feng, Simon, Melvin I.
Immune cells respond to chemotactic signals by means of G protein-coupled receptors. Attempts to elucidate the function of specific G protein family members in these responses is complicated by...
Hwang, Jong-Ik, Choi, Sangdun, Fraser, Iain D. C., Chang, Mi Sook, Simon, Melvin I.
The Gβγ-subunit complex derived from heterotrimeric G proteins can act to regulate the function of a variety of protein targets. We established lentiviral-based RNA interference in J774A.1 mouse...
Cho, Min Kyung, Kim, Won Dong, Ki, Sung Hwan, Hwang, Jong-Ik, Choi, Sangdun, Lee, Chang Ho, ...
Gα12 and Gα13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress. This study...
Krishnan, Jayalakshmi, Lee, Gwang, Han, Sang-Uk, Choi, Sangdun
Understanding the molecular pathways mediating neuronal function in retinas can be greatly facilitated by the identification of genes regulated in the retinas of different mutants under various light...
RNAi Methodologies for the Functional Study of Signaling Molecules
Lee, Gwang, Santat, Leah A., Chang, Mi Sook, Choi, Sangdun
RNA interference (RNAi) was investigated with the aim of achieving gene silencing with diverse RNAi platforms that include small interfering RNA (siRNA), short hairpin RNA (shRNA) and antisense...
Tsuchiya, Masa, Piras, Vincent, Choi, Sangdun, Akira, Shizuo, Tomita, Masaru, Giuliani, Alessandro, ...
Large-scale gene expression studies have mainly focused on highly expressed and ‘discriminatory’ genes to decipher key regulatory processes. Biological responses are consequence of the concerted...
Krishnan, Jayalakshmi, Chen, Jiayan, Shin, Kum-Joo, Hwang, Jong-Ik, Han, Sang-Uk, Lee, Gwang, ...
Exposure to light can induce photoreceptor cell death and exacerbate retinal degeneration. In this study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin...