Measuring the Effects of an Ever-Changing Environment on Malaria Control (2006)
McCutchan, Thomas F., Grim, K. C., Li, Jun, Weiss, Walter, Rathore, Darmendar, Sullivan, Margery, ...
The effectiveness of malaria control measures depends not only on the potency of the control measures themselves but also upon the influence of variables associated with the environment....
Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...
Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...
Joshi, Manju B., Gam, Albert A., Boykins, Robert A., Kumar, Sanjai, Sacci, John
Given the emerging difficulties with malaria drug resistance and vector control, as well as the persistent lack of an effective vaccine, new malaria vaccine development strategies are needed. We used...
Kinetics and inhibition of class C [beta]-lactamases / (2002)
Thesis (Ph. D.)--Wesleyan University, 2002.
Kumar, Sanjai, Collins, William, Egan, Andrea, Yadava, Anjali, Garraud, Olivier, Blackman, Michael J., ...
The immunogenicity and protective efficacy of four versions of recombinant C-terminal 19-kDa epidermal growth factor-like region of the major surface protein 1 (rMSP119) of Plasmodium falciparum was...
Kumar, Anita, Kumar, Sanjai, Le, Thong P., Southwood, Scott, Sidney, John, Cohen, Joe, ...
Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted...
Joshi, Manju B., Gam, Albert A., Boykins, Robert A., Kumar, Sanjai, Sacci, John, Hoffman, Stephen L., ...
Given the emerging difficulties with malaria drug resistance and vector control, as well as the persistent lack of an effective vaccine, new malaria vaccine development strategies are needed. We used...
Rogers, William O., Baird, J. Kevin, Kumar, Anita, Tine, John A., Weiss, Walter, Aguiar, João C., ...
A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a...
Narum, David L., Kumar, Sanjai, Rogers, William O., Fuhrmann, Steven R., Liang, Hong, Oakley, Miranda, ...
In contrast to conventional vaccines, DNA and other subunit vaccines exclusively utilize host cell molecules for transcription and translation of proteins. The adenine plus thymine content of...
Rogers, William O., Weiss, Walter R., Kumar, Anita, Aguiar, João C., Tine, John A., Gwadz, Robert, ...
We tested a cytokine-enhanced, multiantigen, DNA priming and poxvirus boosting vaccine regimen for prevention of malaria in the Plasmodium knowlesi-rhesus macaque model system. Animals were primed...
Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...
Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...
Measuring the Effects of an Ever-Changing Environment on Malaria Control
McCutchan, Thomas F., Grim, K. Christiana, Li, Jun, Weiss, Walter, Rathore, Darmendar, Sullivan, Margery, ...
The effectiveness of malaria control measures depends not only on the potency of the control measures themselves but also upon the influence of variables associated with the environment....
Activity-based probes for protein tyrosine phosphatases
Kumar, Sanjai, Zhou, Bo, Liang, Fubo, Wang, Wei-Qing, Huang, Zhonghui, Zhang, Zhong-Yin
Protein tyrosine phosphatases (PTPs) are involved in the regulation of many aspects of cellular activity including proliferation, differentiation, metabolism, migration, and survival. Given the large...
Schaecher, Kurt, Kumar, Sanjai, Yadava, Anjali, Vahey, Maryanne, Ockenhouse, Christian F.
High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of...
Mahajan, Babita, Jani, Dewal, Chattopadhyay, Rana, Nagarkatti, Rana, Zheng, Hong, Majam, Victoria, ...
Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the...
Kumar, Sanjai, Collins, William, Egan, Andrea, Yadava, Anjali, Garraud, Olivier, Blackman, Michael J., ...
The immunogenicity and protective efficacy of four versions of recombinant C-terminal 19-kDa epidermal growth factor-like region of the major surface protein 1 (rMSP119) of Plasmodium falciparum was...
Kumar, Anita, Kumar, Sanjai, Le, Thong P., Southwood, Scott, Sidney, John, Cohen, Joe, ...
Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted...
Joshi, Manju B., Gam, Albert A., Boykins, Robert A., Kumar, Sanjai, Sacci, John, Hoffman, Stephen L., ...
Given the emerging difficulties with malaria drug resistance and vector control, as well as the persistent lack of an effective vaccine, new malaria vaccine development strategies are needed. We used...
Rogers, William O., Baird, J. Kevin, Kumar, Anita, Tine, John A., Weiss, Walter, Aguiar, João C., ...
A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a...
Narum, David L., Kumar, Sanjai, Rogers, William O., Fuhrmann, Steven R., Liang, Hong, Oakley, Miranda, ...
In contrast to conventional vaccines, DNA and other subunit vaccines exclusively utilize host cell molecules for transcription and translation of proteins. The adenine plus thymine content of...
Rogers, William O., Weiss, Walter R., Kumar, Anita, Aguiar, João C., Tine, John A., Gwadz, Robert, ...
We tested a cytokine-enhanced, multiantigen, DNA priming and poxvirus boosting vaccine regimen for prevention of malaria in the Plasmodium knowlesi-rhesus macaque model system. Animals were primed...
Kumar, Sanjai, Jones, Trevor R., Oakley, Miranda S., Zheng, Hong, Kuppusamy, Shanmuga P., Taye, Alem, ...
Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the...
Measuring the Effects of an Ever-Changing Environment on Malaria Control
McCutchan, Thomas F., Grim, K. Christiana, Li, Jun, Weiss, Walter, Rathore, Darmendar, Sullivan, Margery, ...
The effectiveness of malaria control measures depends not only on the potency of the control measures themselves but also upon the influence of variables associated with the environment....
Activity-based probes for protein tyrosine phosphatases
Kumar, Sanjai, Zhou, Bo, Liang, Fubo, Wang, Wei-Qing, Huang, Zhonghui, Zhang, Zhong-Yin
Protein tyrosine phosphatases (PTPs) are involved in the regulation of many aspects of cellular activity including proliferation, differentiation, metabolism, migration, and survival. Given the large...
Schaecher, Kurt, Kumar, Sanjai, Yadava, Anjali, Vahey, Maryanne, Ockenhouse, Christian F.
High-density oligonucleotide microarrays are widely used to study gene expression in cells exposed to a variety of pathogens. This study addressed the global genome-wide transcriptional activation of...
Mahajan, Babita, Jani, Dewal, Chattopadhyay, Rana, Nagarkatti, Rana, Zheng, Hong, Majam, Victoria, ...
Proteins present on the surface of malaria parasites that participate in the process of invasion and adhesion to host cells are considered attractive vaccine targets. Aided by the availability of the...
Yadava, Anjali, Sattabongkot, Jetsumon, Washington, Michael A., Ware, Lisa A., Majam, Victoria, Zheng, Hong, ...
A successful vaccine against Plasmodium vivax malaria would significantly improve the health and quality of the lives of more than 1 billion people around the world. A subunit vaccine is the only...
Oakley, Miranda S. M., Kumar, Sanjai, Anantharaman, Vivek, Zheng, Hong, Mahajan, Babita, Haynes, J. David, ...
Intermittent episodes of febrile illness are the most benign and recognized symptom of infection with malaria parasites, although the effects on parasite survival and virulence remain unclear. In...
HDP—A Novel Heme Detoxification Protein from the Malaria Parasite
Jani, Dewal, Nagarkatti, Rana, Beatty, Wandy, Angel, Ross, Slebodnick, Carla, Andersen, John, ...
When malaria parasites infect host red blood cells (RBC) and proteolyze hemoglobin, a unique, albeit poorly understood parasite-specific mechanism, detoxifies released heme into hemozoin (Hz). Here,...
Oakley, Miranda S., McCutchan, Thomas F., Anantharaman, Vivek, Ward, Jerrold M., Faucette, Laurence, Erexson, Cindy, ...
Cerebral malaria (CM) is a primary cause of malaria-associated deaths among young African children. Yet no diagnostic tools are available that could be used to predict which of the children infected...
Pathogenic Roles of CD14, Galectin-3, and OX40 during Experimental Cerebral Malaria in Mice
Oakley, Miranda S., Majam, Victoria, Mahajan, Babita, Gerald, Noel, Anantharaman, Vivek, Ward, Jerrold M., ...
An in-depth knowledge of the host molecules and biological pathways that contribute towards the pathogenesis of cerebral malaria would help guide the development of novel prognostics and...