Dennison, Elaine M., Syddall, Holly E., Jameson, Karen A., Sayer, Avan Aihie, Gaunt, Tom R., Rodriguez, Santiago, ...
Objective: we sought evidence of association of candidate single nucleotide polymorphisms (SNP) within the growth hormone-insulin-like growth factor 1 (IGF1) axis, largely selected on the basis of...
Rodriguez, Santiago, Gaunt, Tom R., Day, Ian N. M.
Mendelian randomization (MR) permits causal inference between exposures and a disease. It can be compared with randomized controlled trials. Whereas in a randomized controlled trial the randomization...
E. Nichols, Pablo Rubinstein, John Barnwell, Santiago Rodriguez, De Cordoba, Richard E. Rosenfield
The Duffy bloodgroup system of human erythrocytes comprises a membrane glycoprotein recently characterized by immunoprecipitation techniques (1). It is a polymorphic system that includes determinants...
Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V.E., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...
The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...
Abdollahi, Mohammad R., Lewis, Rohan M., Gaunt, Tom R., Cumming, Debbie V., Rodriguez, Santiago, Rose-Zerilli, Matthew, ...
The angiotensin II type 1 receptor (AGTR1) is the main target through which angiotensin II influences cardiovascular tone, cell growth, and fluid and electrolyte balance. AGTR1 polymorphism has been...
Lips, Mirjam A., Syddall, Holly E., Gaunt, Tom R., Rodriguez, Santiago, Day, Ian N.M., Cooper, Cyrus, ...
OBJECTIVE: We sought evidence of interaction between single-nucleotide polymorphisms (SNP) in the calcium-sensing receptor (CASR) gene and early life in determination of bone mineral density (BMD)...
Rodriguez, Santiago, Gaunt, Tom R., Vorechovsky, Igor, Kralovicova, Jana, Wood, Peter J., Day, Ian N.M.
Day, Ian N.M., Rodriguez, Santiago, Kralovicova, Jana, Wood, Peter J., Vorechovsky, Igor, Gaunt, Tom R.
Gaunt, Tom R, Rodriguez, Santiago, Zapata, Carlos, Day, Ian NM
Abstract Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these...
Gaunt, Tom R., Rodriguez, Santiago, Zapata, Carlos, Day, Ian N.M.
Background Various software tools are available for the display of pairwise linkage disequilibrium across multiple single nucleotide polymorphisms. The HapMap project also presents these graphics...
Královiová, Jana, Gaunt, Tom R., Rodriguez, Santiago, Wood, Peter J., Day, Ian N.M., Voechovsky, Igor
Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS). Although the risk conferred by IDDM2 has been attributed...
Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...
OBJECTIVES: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...
Rodriguez, Santiago, Huang, Shuwen, Chen, Xiao-he, Gaunt, Tom R., Syddall, Holly E., Gilg, Julie A., ...
Objectives: Recent studies suggest an association between a microsatellite locus (TH01) located in intron 1 of the tyrosine hydroxylase gene (TH) and nicotine dependence. We aimed here to study...
Kralovicova, Jana, Gaunt, Tom R., Rodriguez, Santiago, Wood, Peter J., Day, Ian N.M., Vorechovsky, Igor
Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS). Although the risk conferred by IDDM2 has been attributed...
Rodriguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, Davide I.W., ...
Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by...
Rodriguez, Santiago, Chen, Xiao-he, Miller, George J., Day, Ian N.
Evidence from rodents and association analyses in humans suggest the presence on chromosome Y of one or more genes affecting blood pressure (BP). The HindIII centromeric alphoid polymorphism has been...
Yang, Ian A., Holz, Olaf, Jörres, Rudolf A., Magnussen, Helgo, Barton, Sheila J., Rodriguez, Santiago, ...
Ozone is a major air pollutant with adverse health effects which exhibit marked inter-individual variability. In mice, regions of genetic linkage with ozone-induced lung injury include the tumor...
Day, Ian N. M., Chen, Xiao-He, Gaunt, Tom R., King, Tabitha H. T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Chen, Xiao-He, Rodriguez, Santiago, Hawe, Emma, Talmud, Philippa J., Miller, George J., Underhill, Peter, ...
OBJECTIVE: Cohort and case-control genetic association studies offer the greatest power to detect small genotypic influences on disease phenotypes, relative to family-based designs. However, genetic...
Rodriguez, Santiago, Chen, Xiao-he, Day, Ian N.M.
Polymorphic dinucleotide repeat loci (microsatellite markers) are found in varying abundance throughout the genomes of most organisms. They have been extensively used for genetic studies, but...
Day, Ian N., Chen, Xiao-he, Gaunt, Tom R., King, Tabitha H.T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...
Detection of errors in dinucleotide repeat typing by nondenaturing electrophoresis (2001)
Rodriguez, Santiago, Visedo, Guillermo, Zapata, Carlos
This study shows that consideration of minor bands (heteroduplex, shadow, and faint bands) associated with allele bands in nondenaturing polyacrylamide gel electrophoresis (PAGE) after polymerase...
Spectrum of nonrandom associations between microsatellite loci on human chromosome 11p15 (2001)
Zapata, Carlos, Rodriguez, Santiago, Visedo, Guillermo, Sacristan, Felipe
Most evidence about nonrandom association of alleles at different loci, or gametic disequilibrium, across extensive anonymous regions of the human genome is based on the analysis of overall...
Determination of the chemical composition of Alzheimer's disease paired helical filaments (1994)
Alzheimer's disease is a devastating disease that destroys the memory of the patient, affecting mainly the elderly population. One of the main lesions that characterize the disease is the presence of...
Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies
Rodriguez, Santiago, Gaunt, Tom R., Day, Ian N. M.
Mendelian randomization (MR) permits causal inference between exposures and a disease. It can be compared with randomized controlled trials. Whereas in a randomized controlled trial the randomization...