Sarah K. Volkman

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum (2009)

Dharia, Neekesh V, Sidhu, Amar, Cassera, María, Westenberger, Scott J, Bopp, Selina ER, Eastman, Rich T, ...

Abstract Background The identification of genetic changes that confer drug resistance or other phenotypic changes in pathogens can help optimize treatment strategies, support the development of new...

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparumpopulation divergence (2008)

Neafsey, Daniel E, Schaffner, Stephen F, Volkman, Sarah K, Park, Daniel, Montgomery, Philip, Milner, Danny A, ...

Abstract Background The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity...

A general SNP-based molecular barcode for Plasmodium falciparumidentification and tracking (2008)

Daniels, Rachel, Volkman, Sarah K, Milner, Danny A, Mahesh, Nira, Neafsey, Daniel E, Park, Daniel J, ...

Abstract Background Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite...

A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking (2008)

Daniels, Rachel, Volkman, Sarah K., Milner, Danny A., Mahesh, Nira, Neafsey, Daniel E., Park, Daniel J., ...

Background: Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a...

A Systematic Map of Genetic Variation in Plasmodium falciparum (2006)

Claire Kidgell, Sarah K. Volkman, Johanna Daily, Justin O. Borevitz, David Plouffe, Yingyao Zhou, ...

Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...

Gene Conversion as a Source of Nucleotide Diversity in Plasmodium falciparum (2003)

Nielsen, Kaare M., Kasper, Jacob, Choi, Mehee, Bedford, Trevor, Kristiansen, Kurt, Wirth, Dyann F., ...

Examination of polymorphisms in the P. falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in chromosome 11. We designate the annotated gene denoted...

Gene Conversion as a Source of Nucleotide Diversity in Plasmodium falciparum (2003)

Nielsen, Kaare M., Kasper, Jacob, Choi, Mehee, Bedford, Trevor, Kristiansen, Kurt, Wirth, Dyann F., ...

Examination of polymorphisms in the Plasmodium falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in chromosome 11. We designate the annotated gene...

Gene Conversion as a Source of Nucleotide Diversity in Plasmodium falciparum (2003)

Nielsen, Kaare M., Kasper, Jacob, Choi, Mehee, Bedford, Trevor, Kristiansen, Kurt, Wirth, Dyann F., ...

Examination of polymorphisms in the P. falciparum gene for falcipain 2 revealed that this gene is one of two paralogs separated by 10.8 kb in chromosome 11. We designate the annotated gene denoted...

A Systematic Map of Genetic Variation in Plasmodium falciparum

Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...

Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...

A Systematic Map of Genetic Variation in Plasmodium falciparum

Kidgell, Claire, Volkman, Sarah K, Daily, Johanna, Borevitz, Justin O, Plouffe, David, Zhou, Yingyao, ...

Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in...

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

Neafsey, Daniel E, Schaffner, Stephen F, Volkman, Sarah K, Park, Daniel, Montgomery, Philip, Milner, Danny A, ...

An array-based SNP genotyping platform for Plasmodium falciparum is reported together with an analysis of SNP diversity in global population samples.

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

Dharia, Neekesh V, Sidhu, Amar Bir Singh, Cassera, María Belén, Westenberger, Scott J, Bopp, Selina ER, Eastman, Rich T, ...

Using tiling microarrays, a mechanism by which Plasmodium falciparum parasites acquire resistance to the antimalarial fosmidomycin has been elucidated