Sarah Kinston

A novel mode of enhancer evolution: The Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity (2008)

Smith, Aileen M., Sanchez, Maria-Jose, Follows, George A., Kinston, Sarah, Donaldson, Ian J., Green, Anthony R., ...

Altered cis-regulation is thought to underpin much of metazoan evolution, yet the underlying mechanisms remain largely obscure. The stem cell leukemia TAL1 (also known as SCL) transcription factor is...

blood and (2005)

Ian J. Donaldson, Michael Chapman, Sarah Kinston, Josette Renée L, Kathy Knezevic, Ie Piltz, ...

identification of cis-regulatory sequences controlling

Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development (2005)

Donaldson, Ian J., Chapman, Michael, Kinston, Sarah, Landry, Josette Renée, Knezevic, Kathy, Piltz, Sandie, ...

The development of blood has long served as a model for mammalian cell type specification and differentiation, and yet the underlying transcriptional networks remain ill defined. Characterization of...

Genome-wide identification of cis-regulatory sequences controlling blood and endothelial development (2005)

Donaldson, Ian J., Chapman, Michael, Kinston, Sarah, Landry, Josette Renée, Knezevic, Kathy, Piltz, Sandie, ...

The development of blood has long served as a model for mammalian cell type specification and differentiation, and yet the underlying transcriptional networks remain ill defined. Characterisation of...

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors

Göttgens, Berthold, Nastos, Aristotelis, Kinston, Sarah, Piltz, Sandie, Delabesse, Eric C.M., Stanley, Maureen, ...

Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their...

The scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5′ Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1

Göttgens, Berthold, Broccardo, Cyril, Sanchez, Maria-Jose, Deveaux, Sophie, Murphy, George, Göthert, Joachim R., ...

Analysis of cis-regulatory elements is central to understanding the genomic program for development. The scl/tal-1 transcription factor is essential for lineage commitment to blood cell formation and...

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors

Göttgens, Berthold, Nastos, Aristotelis, Kinston, Sarah, Piltz, Sandie, Delabesse, Eric C.M., Stanley, Maureen, ...

Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their...

The scl +18/19 Stem Cell Enhancer Is Not Required for Hematopoiesis: Identification of a 5′ Bifunctional Hematopoietic-Endothelial Enhancer Bound by Fli-1 and Elf-1

Göttgens, Berthold, Broccardo, Cyril, Sanchez, Maria-Jose, Deveaux, Sophie, Murphy, George, Göthert, Joachim R., ...

Analysis of cis-regulatory elements is central to understanding the genomic program for development. The scl/tal-1 transcription factor is essential for lineage commitment to blood cell formation and...

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity

Pimanda, John E., Donaldson, Ian J., Kinston, Sarah, Knezevic, Kathy, Huckle, Liz, ...

Hematopoietic stem cell (HSC) development is regulated by several signaling pathways and a number of key transcription factors, which include Scl/Tal1, Runx1, and members of the Smad family. However,...

Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

Pimanda, John E., Ottersbach, Katrin, Knezevic, Kathy, Kinston, Sarah, Chan, Wan Y. I., Wilson, Nicola K., ...

Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1...

A novel mode of enhancer evolution: The Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity

Smith, Aileen M., Sanchez, Maria-Jose, Follows, George A., Kinston, Sarah, Donaldson, Ian J., Green, Anthony R., ...

Altered cis-regulation is thought to underpin much of metazoan evolution, yet the underlying mechanisms remain largely obscure. The stem cell leukemia TAL1 (also known as SCL) transcription factor is...