Primary CMV infection: a co-factor HIV-1 disease progression in African infants? (2008)
Slyker, Jennifer A, Payne, Barbara L, John-Stewart, Grace C, Obimbo, Elizabeth, Emery, Sandy, Richardson, Barbara, ...
No abstract available.
Polyfunctional T cell responses are a hallmark of HIV-2 infection (2008)
Duvall, Melody G., Precopio, Melissa Lynn, Ambrozak, David A., Jaye, Assan, McMichael, Andrew J., Whittle, Hilton C., ...
HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2...
Deep analysis of cellular transcriptomes – LongSAGE versus classic MPSS (2007)
Hene, Lawrence, Sreenu, Vattipally B, Vuong, Mai T, Abidi, S Hussain I, Sutton, Julian K, Rowland-Jones, Sarah L, ...
Abstract Background Deep transcriptome analysis will underpin a large fraction of post-genomic biology. 'Closed' technologies, such as microarray analysis, only detect the set of transcripts chosen...
Ondondo, Beatrice, Yang, Hongbing, Dong, Tao, Gleria, Kati De, Suttill, Annie, Conlon, Christopher, ...
No abstract available.
HIV-1 transmission and acute HIV-1 infection (2001)
Hansasuta, Pokrath, Rowland-Jones, Sarah L
An understanding of the central events in the transmission of HIV-1 infection is critical to the development of effective strategies to prevent infection. Although the main routes of transmission...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Kaul, Rupert, Rowland-Jones, Sarah L., Kimani, Joshua, Dong, Tao, Yang, Hong-Bing, Kiama, Peter, ...
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for...
CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects
Kaul, Rupert, Dong, Tao, Plummer, Francis A., Kimani, Joshua, Rostron, Timothy, Kiama, Peter, ...
HIV-1–specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1–exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
Dyer, Wayne B., Ogg, Graham S., Demoitie, Marie-Ange, Jin, Xia, Geczy, Andrew F., Rowland-Jones, Sarah L., ...
Proposals for the use of live attenuated human immunodeficiency virus (HIV) type 1 (HIV-1) as a vaccine candidate in humans have been based on the protection afforded by attenuated simian...
Dorrell, Lucy, Dong, Tao, Ogg, Graham S., Lister, Simon, McAdam, Steve, Rostron, Tim, ...
We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several...
Mature CD8+ T lymphocyte response to viral infection during fetal life
Marchant, Arnaud, Appay, Victor, Van Der Sande, Marianne, Dulphy, Nicolas, Liesnard, Corinne, Kidd, Michael, ...
Immunization of newborns against viral infections may be hampered by ineffective CD8+ T cell responses. To characterize the function of CD8+ T lymphocytes in early life, we studied newborns with...
Kaul, Rupert, Rowland-Jones, Sarah L., Kimani, Joshua, Dong, Tao, Yang, Hong-Bing, Kiama, Peter, ...
Resistance to HIV infection in a small group of Kenyan sex workers is associated with CD8+-lymphocyte responses to HIV cytotoxic T-lymphocyte (CTL) epitopes. Eleven prostitutes meeting criteria for...
CD8+ lymphocytes respond to different HIV epitopes in seronegative and infected subjects
Kaul, Rupert, Dong, Tao, Plummer, Francis A., Kimani, Joshua, Rostron, Timothy, Kiama, Peter, ...
HIV-1–specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1–exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could...
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
Papagno, Laura, Spina, Celsa A, Marchant, Arnaud, Salio, Mariolina, Rufer, Nathalie, Little, Susan, ...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that...
Thimme, Robert, Appay, Victor, Koschella, Marie, Panther, Elisabeth, Roth, Evelyn, Hislop, Andrew D., ...
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by...
Ondondo, Beatrice, Yang, Hongbing, Dong, Tao, Gleria, Kati De, Suttill, Annie, Conlon, Christopher, ...
Deep analysis of cellular transcriptomes – LongSAGE versus classic MPSS
Hene, Lawrence, Sreenu, Vattipally B, Vuong, Mai T, Abidi, S Hussain I, Sutton, Julian K, Rowland-Jones, Sarah L, ...
HIV-specific Cytotoxic T Cells from Long-Term Survivors Select a Unique T Cell Receptor
Dong, Tao, Stewart-Jones, Guillaume, Chen, Nan, Easterbrook, Philippa, Xu, Xiaoning, Papagno, Laura, ...
HIV-specific cytotoxic T lymphocytes (CTL) are important in controlling HIV replication, but the magnitude of the CTL response does not predict clinical outcome. In four donors with delayed disease...
Duvall, Melody G., Loré, Karin, Blaak, Hetty, Ambrozak, David A., Adams, William C., Santos, Kathlyn, ...
Human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) has been documented in vivo and may be an important contributor to HIV-1 transmission and pathogenesis. HIV-1-specific...
HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function
Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...
The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...
Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific
Wilson, Jamie D.K., Ogg, Graham S., Allen, Rachel L., Goulder, Philip J.R., Kelleher, Anthony, Sewell, Andy K., ...
Acute HIV infection is associated with a vigorous immune response characterized by the proliferation of selected T cell receptor V beta (BV)-expressing CD8+ T cells. These ‘expansions', which are...