Sarah Rowland-Jones

Phenotypic characterization of HIV-specific CD8 T cells during acute infant HIV infection (2009)

Slyker, Jennifer, Dong, Tao, John-Stewart, Grace, Lohman-Payne, Barbara, Reilly, Marie, Atzberger, Ann, ...

No abstract available.

Correction: Resisting Immune Exhaustion in HIV-1 Infection (2008)

Sarah Rowland-Jones, Thushan De Silva

Resisting Immune Exhaustion in HIV-1 Infection (2008)

Sarah Rowland-Jones, Thushan De Silva

Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor (2008)

Voelter, Verena, Rufer, Nathalie, Reynard, Severine, Greub, Gilbert, Brookes, Roger, Guillaume, Philippe, ...

Melan-A specific CD8+ T cells are thought to play an important role against the development of melanoma. Their in vivo expansion is often observed with advanced disease. In recent years, low levels...

Development and evaluation of the oligonucleotide ligation assay (OLA) for the detection of drug resistance mutations in HIV-2 patients on antiretroviral therapy (2006)

Jallow, Sabelle, Kaye, Steve, Brandin, Eleanor, Albert, Jan, Vanham, Guido, Whittle, Hilton, ...

No abstract available.

HIV-2 gene product-specific T cell responses and viraemia control (2006)

Leligdowicz, Aleksandra, Yindom, Louis-Marie, Jaye, Assan, Dong, Tao, Alabi, Abraham, Sarge-N'jie, Ramu, ...

No abstract available.

Anti-Retroviral Therapy (ART) Monitoring and the Development of the Oligonucleotide Ligation Assay for Detecting Critical Drug-resistant Mutations in HIV-2 Patients in Preparation of the Global Fund Initiative in The Gambia (2005)

Jallow, Sabelle, Kaye, Steve, Alabi, Abraham, Aveika, Akum, McConkey, Samuel, Rowland-Jones, Sarah, ...

No abstract available.

Paper Alert: Immunology (2001)

Elliott, Tim, Bonneville, Marc, Kruisbeek, Ada, Walker, Paul R., Glaichenhaus, Nicolas, Rowland-Jones, Sarah, ...

A selection of interesting papers that were published in the two months before our press date in major journals most likely to report significant results in immunology.

RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation (2000)

Appay, Victor, Dunbar, P. Rod, Cerundolo, Vincenzo, McMichael, Andrew, Czaplewski, Lloyd, Rowland-Jones, Sarah

RANTES (regulated upon activation, normal T cell expressed and secreted) is released by cytotoxic T lymphocytes (CTL), and is a potent chemoattractant factor for monocytes and T cells, also known for...

Cytotoxic T Cells from Human Immunodeficiency Virus Type 2-Infected Patients Frequently Cross-React with Different Human Immunodeficiency Virus Type 1 Clades

Bertoletti, Antonio, Cham, Fatim, McAdam, Stephen, Rostron, Tim, Rowland-Jones, Sarah, Sabally, Sehu, ...

Knowledge of immune mechanisms responsible for the cross-protection between highly divergent viruses such as human immunodeficiency virus type 1 (HIV-1) and HIV-2 may contribute to an understanding...

Maternal SDF1 3′A Polymorphism Is Associated with Increased Perinatal Human Immunodeficiency Virus Type 1 Transmission

John, Grace C., Rousseau, Christine, Dong, Tao, Rowland-Jones, Sarah, Nduati, Ruth, Mbori-Ngacha, Dorothy, ...

Genetic polymorphisms in chemokine and chemokine receptor genes influence susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and disease progression, but little is known...

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+ T Lymphocytes in Healthy Seropositive Donors

Gillespie, Geraldine M. A., Wills, Mark R., Appay, Victor, O'Callaghan, Chris, Murphy, Mike, Smith, Neil, ...

Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described...

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

Shiroishi, Mitsunori, Tsumoto, Kouhei, Amano, Kimie, Shirakihara, Yasuo, Colonna, Marco, Braud, Veronique M., ...

Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte...

Early T-Cell Responses to Dengue Virus Epitopes in Vietnamese Adults with Secondary Dengue Virus Infections

Simmons, Cameron P., Dong, Tao, Chau, Nguyen Vinh, Dung, Nguyen Thi Phuong, Chau, Tran Nguyen Bich, Thao, Le Thi Thu, ...

T-cell responses to dengue viruses may be important in both protective immunity and pathogenesis. This study of 48 Vietnamese adults with secondary dengue virus infections defined the breadth and...

Longitudinal Assessment of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon Responses during the First Year of Life in HIV-1-Infected Infants

Lohman, Barbara L., Slyker, Jennifer A., Richardson, Barbra A., Farquhar, Carey, Mabuka, Jenniffer M., Crudder, Christopher, ...

Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in...

Natural Killer Cell Function Is Well Preserved in Asymptomatic Human Immunodeficiency Virus Type 2 (HIV-2) Infection but Similar to That of HIV-1 Infection When CD4 T-Cell Counts Fall

Nuvor, Samuel Victor, Van Der Sande, Marianne, Rowland-Jones, Sarah, Whittle, Hilton, Jaye, Assan

Natural killer (NK) cells are potent effectors of natural immunity and their activity prevents human immunodeficiency virus type 1 (HIV-1) viral entry and viral replication. We sought to determine...

Expansion and Diversification of Virus-Specific T Cells following Immunization of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals with a Recombinant Modified Vaccinia Virus Ankara/HIV-1 Gag Vaccine

Dorrell, Lucy, Yang, Hongbing, Ondondo, Beatrice, Dong, Tao, Di Gleria, Kati, Suttill, Annie, ...

Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. Since CD8+ and...

Cytotoxic T Cells from Human Immunodeficiency Virus Type 2-Infected Patients Frequently Cross-React with Different Human Immunodeficiency Virus Type 1 Clades

Bertoletti, Antonio, Cham, Fatim, McAdam, Stephen, Rostron, Tim, Rowland-Jones, Sarah, Sabally, Sehu, ...

Knowledge of immune mechanisms responsible for the cross-protection between highly divergent viruses such as human immunodeficiency virus type 1 (HIV-1) and HIV-2 may contribute to an understanding...

Maternal SDF1 3′A Polymorphism Is Associated with Increased Perinatal Human Immunodeficiency Virus Type 1 Transmission

John, Grace C., Rousseau, Christine, Dong, Tao, Rowland-Jones, Sarah, Nduati, Ruth, Mbori-Ngacha, Dorothy, ...

Genetic polymorphisms in chemokine and chemokine receptor genes influence susceptibility to human immunodeficiency virus type 1 (HIV-1) infection and disease progression, but little is known...

Functional Heterogeneity and High Frequencies of Cytomegalovirus-Specific CD8+ T Lymphocytes in Healthy Seropositive Donors

Gillespie, Geraldine M. A., Wills, Mark R., Appay, Victor, O'Callaghan, Chris, Murphy, Mike, Smith, Neil, ...

Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent host, but remains a major cause of morbidity in immunosuppressed individuals. Using the recently described...

Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G

Shiroishi, Mitsunori, Tsumoto, Kouhei, Amano, Kimie, Shirakihara, Yasuo, Colonna, Marco, Braud, Veronique M., ...

Ig-like transcript 4 (ILT4) (also known as leukocyte Ig-like receptor 2, CD85d, and LILRB2) is a cell surface receptor expressed mainly on myelomonocytic cells, whereas ILT2 (also known as leukocyte...

Early T-Cell Responses to Dengue Virus Epitopes in Vietnamese Adults with Secondary Dengue Virus Infections

Simmons, Cameron P., Dong, Tao, Chau, Nguyen Vinh, Dung, Nguyen Thi Phuong, Chau, Tran Nguyen Bich, Thao, Le Thi Thu, ...

T-cell responses to dengue viruses may be important in both protective immunity and pathogenesis. This study of 48 Vietnamese adults with secondary dengue virus infections defined the breadth and...

Longitudinal Assessment of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Gamma Interferon Responses during the First Year of Life in HIV-1-Infected Infants

Lohman, Barbara L., Slyker, Jennifer A., Richardson, Barbra A., Farquhar, Carey, Mabuka, Jenniffer M., Crudder, Christopher, ...

Human immunodeficiency virus type 1 (HIV-1) infection results in different patterns of viral replication in pediatric compared to adult populations. The role of early HIV-1-specific responses in...

Natural Killer Cell Function Is Well Preserved in Asymptomatic Human Immunodeficiency Virus Type 2 (HIV-2) Infection but Similar to That of HIV-1 Infection When CD4 T-Cell Counts Fall

Nuvor, Samuel Victor, Van Der Sande, Marianne, Rowland-Jones, Sarah, Whittle, Hilton, Jaye, Assan

Natural killer (NK) cells are potent effectors of natural immunity and their activity prevents human immunodeficiency virus type 1 (HIV-1) viral entry and viral replication. We sought to determine...

Expansion and Diversification of Virus-Specific T Cells following Immunization of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals with a Recombinant Modified Vaccinia Virus Ankara/HIV-1 Gag Vaccine

Dorrell, Lucy, Yang, Hongbing, Ondondo, Beatrice, Dong, Tao, Di Gleria, Kati, Suttill, Annie, ...

Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. Since CD8+ and...

Development and evaluation of the oligonucleotide ligation assay (OLA) for the detection of drug resistance mutations in HIV-2 patients on antiretroviral therapy

Jallow, Sabelle, Kaye, Steve, Brandin, Eleanor, Albert, Jan, Vanham, Guido, Whittle, Hilton, ...

HIV-2 gene product-specific T cell responses and viraemia control

Leligdowicz, Aleksandra, Yindom, Louis-Marie, Jaye, Assan, Dong, Tao, Alabi, Abraham, Sarge-N'jie, Ramu, ...

Risk Factors for and Clinical Outcome of Congenital Cytomegalovirus Infection in a Peri-Urban West-African Birth Cohort

Kaye, Steve, Miles, David J.C., Waight, Pauline, Jeffries, David J., Ojuola, Olubukola O., ...

Development and Evaluation of an Oligonucleotide Ligation Assay for Detection of Drug Resistance-Associated Mutations in the Human Immunodeficiency Virus Type 2 pol Gene▿

Jallow, Sabelle, Kaye, Steve, Schutten, Martin, Brandin, Eleonor, Albert, Jan, McConkey, Samuel J., ...

Human immunodeficiency virus type 2 (HIV-2) is naturally resistant to several antiretroviral drugs, including all of the non-nucleoside reverse transcriptase inhibitors and the entry inhibitor T-20,...

Cytomegalovirus Infection in Gambian Infants Leads to Profound CD8 T-Cell Differentiation▿

Miles, David J. C., Van Der Sande, Marianne, Jeffries, David, Kaye, Steve, Ismaili, Jamila, Ojuola, Olubukola, ...

Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary...

Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection

Leligdowicz, Aleksandra, Yindom, Louis-Marie, Onyango, Clayton, Sarge-Njie, Ramu, Alabi, Abraham, Cotten, Matthew, ...

HIV-2 infection in the majority of infected subjects follows an attenuated disease course that distinguishes it from infection with HIV-1. Antigen-specific T cells are pivotal in the management of...

High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-Reactive Cytotoxic T-Cells during the Course of Secondary Dengue Virus Infection

Dong, Tao, Moran, Edward, Vinh Chau, Nguyen, Simmons, Cameron, Luhn, Kerstin, Peng, Yanchun, ...

Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection

Lühn, Kerstin, Simmons, Cameron P., Moran, Edward, Dung, Nguyen Thi Phuong, Chau, Tran Nguyen Bich, Quyen, Nguyen Than Ha, ...

Dengue virus infection is an increasingly important tropical disease, causing 100 million cases each year. Symptoms range from mild febrile illness to severe hemorrhagic fever. The pathogenesis is...

Clustered Mutations in HIV-1 Gag Are Consistently Required for Escape from Hla-B27–Restricted Cytotoxic T Lymphocyte Responses

Kelleher, Anthony D., Long, Chad, Holmes, Edward C., Allen, Rachel L., Wilson, Jamie, Conlon, Christopher, ...

The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263–272,...

Maintenance of Large Subpopulations of Differentiated CD8 T-Cells Two Years after Cytomegalovirus Infection in Gambian Infants

Miles, David J. C., Van Der Sande, Marianne, Jeffries, David, Kaye, Steve, Ojuola, Olubukola, Sanneh, Mariama, ...

Correction: Resisting Immune Exhaustion in HIV-1 Infection

Rowland-Jones, Sarah, De Silva, Thushan

Effects of Antenatal and Postnatal Environments on CD4 T-Cell Responses to Mycobacterium bovis BCG in Healthy Infants in The Gambia▿

Miles, David J. C., Van Der Sande, Marianne, Crozier, Sarah, Ojuola, Olubukola, Palmero, Melba S., Sanneh, Mariama, ...

The Mycobacterium bovis BCG vaccine has a poor record of efficacy in low-income tropical settings. Against this background, we evaluated the immune response of infants to mycobacterial antigens over...

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

Lee, Laurel Yong-Hwa, Ha, Do Lien Anh, Simmons, Cameron, De Jong, Menno D., Chau, Nguyen Van Vinh, Schumacher, Reto, ...

The threat of avian influenza A (H5N1) infection in humans remains a global health concern. Current influenza vaccines stimulate antibody responses against the surface glycoproteins but are...

Resisting Immune Exhaustion in HIV-1 Infection

Rowland-Jones, Sarah, De Silva, Thushan

Sarah Rowland-Jones and Thushan de Silva discuss a new study describing the fate of cytotoxic T lymphocytes responding to HIV-1 from very early through to chronic infection.

Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants

Miles, David J C, Sanneh, Mariama, Holder, Beth, Crozier, Sarah, Nyamweya, Samuel, Touray, Ebrima S, ...

Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and...