Satoru Takahashi

Frequently increased epidermal growth factor receptor (EGFR) copy numbers and decreased BRCA1 mRNA expression in Japanese triple-negative breast cancers (2008)

Toyama, Tatsuya, Yamashita, Hiroko, Kondo, Naoto, Okuda, Katsuhiro, Takahashi, Satoru, Sasaki, Hidefumi, ...

Abstract Background Triple-negative breast cancer (estrogen receptor-, progesterone receptor-, and HER2-negative) (TNBC) is a high risk breast cancer that lacks specific therapy targeting these...

Monotone methods for equilibrium selection under perfect foresight dynamics (2008)

Daisuke Oyama; Graduate School Of Economics, Hitotsubashi University, Satoru Takahashi; Department Of Economics, Princeton University, Josef Hofbauer; Department Of Mathematics, University Of Vienna

This paper studies a dynamic adjustment process in a large society of forward-looking agents where payoffs are given by a normal form supermodular game. The stationary states of the dynamics...

Monotone methods for equilibrium selection under perfect foresight dynamics (2008)

Daisuke Oyama; Graduate School Of Economics, Hitotsubashi University, Satoru Takahashi; Department Of Economics, Princeton University, Josef Hofbauer; Department Of Mathematics, University Of Vienna

[This item is a preserved copy. To view the original, visit http://econtheory.org/] This paper studies a dynamic adjustment process in a large society of forward-looking agents where payoffs are...

Primary choriocarcinoma of the urinary bladder (2008)

Minei, Sadatsugu, Matsui, Tsuyoshi, Obinata, Daisuke, Yamaguchi, Kenya, Hirano, Daisaku, Takahashi, Satoru

A 72-year-old woman with asymptomatic macrohematuria was referred to our hospital. Cystoscopy revealed a 7 cm sessile tumor on the left lateral wall of the bladder. Subsequently an intravenous...

Multi-sender cheap talk with restricted state spaces (2008)

Attila Ambrus; Harvard University, Satoru Takahashi; Princeton University

This paper analyzes multi-sender cheap talk when the state space might be restricted, either because the policy space is restricted, or the set of rationalizable policies of the receiver is not the...

Multi-sender cheap talk with restricted state spaces (2008)

Attila Ambrus; Harvard University, Satoru Takahashi; Princeton University

[This item is a preserved copy. To view the original, visit http://econtheory.org/] This paper analyzes multi-sender cheap talk when the state space might be restricted, either because the policy...

Multi-sender cheap talk with restricted state spaces (2008)

Attila Ambrus; Harvard University, Satoru Takahashi; Princeton University

[This item is a preserved copy. To view the original, visit http://econtheory.org/] This paper analyzes multi-sender cheap talk when the state space might be restricted, either because the policy...

2006] “Perfect Public Equilibrium when Players are Patient,” forthcoming (2008)

Drew Fudenberg, David K. Levine, Satoru Takahashi

ABSTRACT. The limit set of perfect public equilibrium payoffs of a repeated game as the discount factor goes to one is characterized, with examples, even when the full-dimensionality condition fails.

Be Passive Or Not? (2008)

Ananyzing Passive Investment, Takao Tarano, Hiroshi Takahashi, Satoru Takahashi

Techniques in financial engineering applied to decision making of investment management. However, they sometimes fail because of unpredictable phenomena in financial markets [1], [2], [6]. We are...

A novel class of advanced glycation inhibitors ameliorates renal and cardiovascular damage in experimental rat models (2008)

Izuhara, Yuko, Nangaku, Masaomi, Takizawa, Shunya, Takahashi, Satoru, Shao, Jing, Oishi, Hisashi, ...

Background. The reno- and cardiovascular-protective effects of angiotensin II receptor blockers (ARBs), have been ascribed, at least in part, to their ability to inhibit the formation of advanced...

Effect of Chinese herbal medicine on overactive bladder (2007)

Ogushi, Tetsuo, Takahashi, Satoru

Gosha-jinki-gan (GJG), a traditional Chinese medicine, is known to be potentially effective for urinary disturbance. For the clinical evaluation of Gosha-jinki-gan, we administered GJG for 6 weeks to...

Selective loss of GABAB receptors in orexin/hypocretin-producing neurons results in disrupted sleep/wakefulness architecture (2007)

Takeshi Sakurai, Taizo Matsuki, Hitomi Takahira, Noriko Hirashima, Thomas Kilduff, Satoshi Kunita, ...

We generated mice with a selective loss of GABAB receptors in orexin neurons. Orexin neurons in these GABAB1<sup>-/-(orexin)</sup> mice showed reduced responsiveness to...

Chronic contained rupture of an abdominal aortic aneurysm mimicking a retroperitoneal tumor (2007)

Obinata, Daisuke, Takenobu, Yasuhiro, Sakuma, Takahiro, Sugimoto, Shuji, Yamaguchi, Kenya, Hirano, Daisuke, ...

Chronic contained rupture of an abdominal aortic aneurysm (AAA) is a rare event that is difficult to diagnose due to the atypical and chronic symptoms. We report a case of chronic contained rupture...

Association of TP53codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients (2007)

Toyama, Tatsuya, Zhang, Zhenhuan, Nishio, Mariko, Hamaguchi, Maho, Kondo, Naoto, Iwase, Hirotaka, ...

Abstract Introduction Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 (also known as p53 ) gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been...

Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors (2007)

Kudo, Takashi, Fujii, Takashi, Ikegami, Shiro, Inokuchi, Kaoru, Takayama, Yuko, Ikehara, Yuzuru, ...

The 3-fucosyl-N-acetyllactosamine [Lewis x (Lex), CD15, SSEA-1] carbohydrate structure is expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and has been...

EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts (2006)

Li, Ying Ji, Azuma, Arata, Usuki, Jiro, Abe, Shinji, Matsuda, Kuniko, Sunazuka, Toshiaki, ...

Abstract Background Fourteen-membered ring macrolides have been effective in reducing chronic airway inflammation and also preventing lung injury and fibrosis in bleomycin-challenged mice via...

Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors (2006)

Kudo, Takashi, Fujii, Takashi, Ikegami, Shiro, Inokuchi, Kaoru, Takayama, Yuko, Ikehara, Yuzuru, ...

The 3-fucosyl-N-acetyllactosamine (Lewis x (Lex), CD15, SSEA-1) carbohydrate structure is expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and has been...

Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors (2006)

Kudo, Takashi, Fujii, Takashi, Ikegami, Shiro, Inokuchi, Kaoru, Takayama, Yuko, Ikehara, Yuzuru, ...

The 3-fucosyl-N-acetyllactosamine (Lewis x (Lex), CD15, SSEA-1) carbohydrate structure is expressed on several glycolipids, glycoproteins, and proteoglycans of the nervous system and has been...

Combination Chemotherapy of Docetaxel, Ifosfamide and Cisplatin (DIP) in Patients with Metastatic Urothelial Cancer: a Preliminary Report (2005)

Takahashi, Satoru, Suzuki, Makoto, Kume, Haruki, Matsumoto, Shinya, Okamoto, Naohiko, Nishimatsu, Hiroaki, ...

Objective: The aim of this study was to evaluate the efficacy and toxicity of a new combination chemotherapy of docetaxel, ifosfamide and cisplatin (DIP) in the treatment of metastatic urothelial...

Monotone Methods for Equilibrium Selection under Perfect Foresight Dynamics (2003)

Oyama, Daisuke, Takahashi, Satoru, Hofbauer, Josef

This paper studies a dynamic adjustment process in a large society of forward-looking agents where payoffs are given by a normal form supermodular game. The stationary states of the dynamics...

The Mouse mafB 5'-Upstream Fragment Directs Gene Expression in Myelomonocytic Cells, Differentiated Macrophages and the Ventral Spinal Cord in Transgenic Mice (2003)

Hamada, Michito, Moriguchi, Takashi, Yokomizo, Tomomasa, Morito, Naoki, Zhang, Chuan, Takahashi, Satoru

The b-Zip transcription factor MafB is an essential determinant of neural development and an inducer of monocytic differentiation. The MafB protein is expressed in a variety of tissues including the...

Doubly coprime representation of linear systems and its application to simultaneous stabilization (2003)

Inaba, Hiroshi, Abdursul, Rixat, Takahashi, Satoru

This paper develops a new representation theory of multivariable time‐invariant linear systems based on the well‐known coprime factorizations of their transfer matrices. This...

デューイ実験学校と特別な教育的配慮の実践 : 算数学習における子どもの困難・ニーズへの対応 (2002)

千賀, 愛, 高橋, 智, センガ, アイ, タカハシ, サトル, Senga, Ai, Takahashi, Satoru, ...

I. はじめに/1.1 問題の所在/1.2 「特別な教育的配慮」とは何か/1.3 本稿の目的と分析視点/II. グループVIIの算数学習と特別な教育的配慮/2.1...

Isolation, Characterization, and Expression Analysis of Zebrafish Large Mafs (2001)

Kajihara, Miwako, Kawauchi, Shimako, Kobayashi, Makoto, Ogino, Hajime, Takahashi, Satoru, Yasuda, Kunio

Large Maf proteins, which are members of the basic leucine zipper (b-Zip) superfamily, are involved in the determination and control of cellular differentiation. The expression patterns of various...

Induction of murine intestinal and hepatic peroxiredoxin MSP23 by dietary butylated hydroxyanisole (2000)

Ishii, Tetsuro, Itoh, Ken, Akasaka, Junetsu, Yanagawa, Toru, Takahashi, Satoru, Yoshida, Hiroshi, ...

Feeding mice with 2(3)-t-butyl-4-hydroxyanisole (BHA) induces phase II detoxifying enzymes that inhibit the action of carcinogens. We have found that dietary BHA induces intestinal and hepatic MSP23...

Aberrant expression of p27Kip1 is associated with malignant transformation of the rat urinary bladder epithelium (2000)

Ogawa, Kumiko, Kimoto, Naoya, Asamoto, Makoto, Nakanishi, Makoto, Takahashi, Satoru, Shirai, Tomoyuki

Alteration in cell cycle regulators is considered to play an important role in carcinogenesis. In order to cast light on changes in reversible hyperplastic and irreversible tumorigenic lesions in the...

Ablation of Nrf2 Function Does Not Increase the Erythroid or Megakaryocytic Cell Lineage Dysfunction Caused by p45 NF-E2 Gene Disruption (1998)

Kuroha, Takashi, Takahashi, Satoru, Komeno, Takuya, Itoh, Ken, Nagasawa, Toshiro, Yamamoto, Masayuki

Maf recognition elements (MAREs or NF-E2 binding sites) have been shown to be vital for erythroid- and megakaryocyte-specific gene expression. Transcription factor NF-E2 is composed of p45, a large...

Conserved Structure, Regulatory Elements, and Transcriptional Regulation from the GATA-1 Gene Testis Promoter (1997)

Onodera, Ko, Yomogida, Kentaro, Suwabe, Naruyoshi, Takahashi, Satoru, Muraosa, Yasushi, Hayashi, Norio, ...

Transcription factor GATA-1 was first identified in erythroid cells, but was later shown to also be expressed in Sertoli cells of the mouse testis. GATA-1 transcription in testis initiates from a...

Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues (1996)

Totsuka, Yukari, Fukutome, Kazuo, Takahashi, Mami, Takahashi, Satoru, Tada, Akihiro, Sugimura, Takashi, ...

One of the mutagenic and carcinogenic heterocyclic amines (HCAs), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx), is present in cooked foods and we are chronically exposed to this compound in...

Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated rats (1995)

Shirai, Tomoyuki, Shibata, Masa-Aki, Takahashi, Satoru, Tagawa, Yoshiaki, Imaida, Katsumi, Hirose, Masao

Differences between reversible papillomatosis and preneo-plastic lesions of the urinary bladder of rats were investigated in terms of cell proliferation and apoptosis after cessation of uracil...

Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis (1994)

Asamoto, Makoto, Takahashi, Satoru, Imaida, Katsumi, Shirai, Tomoyuki, Fukushima, Shoji

Many reports have suggested that gap junctional intercellular communication or gap junction proteins (connexins) could have tumor suppression characteristics. We investigated gap junctional...

Effects of green tea catechins in a rat multi-organ carcinogenesis model (1993)

Hirose, Masao, Hoshiya, Toru, Akagi, Keisuke, Takahashi, Satoru, Hara, Yukihiko, Ito, Nobuyuki

The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p....

Modification of carcinogenesis by {alpha}-tocopherol, t-butylhydro-quinone, propyl gallate and butylated hydroxytoluene in a rat multi-organ carcinogenesis model (1993)

Hirose, Masao, Yada, Hideaki, Hakoi, Kazuo, Takahashi, Satoru, Ito, Nobuyuki

Effects of the dietary antioxidants α-tocopherol (α-Toc), t-butylhydroquinone (TBHQ), propyl gallate (PG) and butylated hydroxytoluene (BHT) were examined using a multi-organ carcinogenesis model....

Carcinogenicity of catechol in F344 rats and B6C3F1 mice (1993)

Hirose, Masao, Fukushima, Shoji, Tanaka, Hikaru, Asakawa, Emiko, Takahashi, Satoru, Ito, Nobuyuki

Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in...

Enhancing effects of diallyl sulfide on hepatocarcinogenesis and inhibitory actions of the related diallyl disulfide on colon and renal carcinogenesis in rats (1992)

Takahashi, Satoru, Hakoi, Kazuo, Yada, Hideaki, Hirose, Masao, Ito, Nobuyuki, Fukushima, Shoji

It has been reported that diallyl sulfide (DS) and diallyl disulfide (DDS), major volatile compounds in garlic (Alliunt sativum), exert anticarcinogenic activity in several organs in rodents. The...

Suppression of spontaneous hepatocellular carcinoma development in C3H/HeNCrj mice by the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611) (1992)

Kushida, Hiromi, Wakabayashi, Keiji, Suzuki, Mika, Takahashi, Satoru, Imaida, Katsumi, Sugimura, Takashi, ...

The study was performed to examine the effects of the lipophilic ascorbic acid, 2-O-octadecylascorbic acid (CV-3611), with a strong scavenging capacity for active oxygen species, on the spontaneous...

Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N'-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis (1992)

Hirose, Masao, Kawabe, Mayumi, Shibata, M., Takahashi, Satoru, Okazaki, Shuzo, Ito, Nobuyuki

Promotion effects of the o-dihydroxybenzene derivatives, protocatechuic acid (PCA), dopamine hydrochloride (DAH), dl-dopa and caffeic acid on forestomach and glandular stomach carcinogenesis were...

Dose-dependent formation of preneoplastic foci and DNA adducts in rat Liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA{alpha}C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) (1992)

Hasegawa, Ryohei, Takahashi, Satoru, Shirai, Tomoyuki, Iwasaki, Shogo, Kim, Dae Joong, Ochiai, Masako, ...

Dose responses to two heterocyclic amines, 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in induction of glutathione Stransferase...

Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis (1990)

Wada, Shigetsugu, Hirose, Masao, Takahashi, Satoru, Okazaki, Shuzo, Ito, Nobuyuki

The modifying effects of para-methoxyphenol (PMP) second stage treatment on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-initiated rat forestomach carcinogenesis were investigated. Groups of 15 6 week...

Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model (1990)

Shibata, Masa-Aki, Fukushima, Shoji, Takahashi, Satoru, Hasegawa, Ryohei, Ito, Nobuyuki

A wide-spectrum organ carcinogenesis model for detection of cancer modifiers in various organs was assessed in F344 male rats. After sequential treatment with diethylnitrosamine, N-methytaitrosourea,...

Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine (1988)

Masui, Tsuneo, Shirai, Tomoyuki, Takahashi, Satoru, Mutai, Mamoru, Fukushima, Shoji

Uracil is known to cause reversible urolithiasis and to induce papillomatosis in the urinary bladder of F344 rats. We examined whether the marked urothelial cell proliferation caused by uracil, given...

Monotone Methods for Equilibrium Selection under Perfect Foresight Dynamics

Deisuke Oyama, Satoru Takahashi, Josef Hofbauer

This paper studies equilibrium selection in supermodular games based on perfect foresight dynamics. A normal form game is played repeatedly in a large society of rational agents. There are frictions:...

Improvement dynamics in games with strategic complementarities

Nikolai S. Kukushkin, Satoru Takahashi, Tetsuo Yamamori

nash equilibrium, better response dynamics, best response dynamics, game with strategic complementarities,

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis

Onodera, Ko, Takahashi, Satoru, Nishimura, Shigeko, Ohta, Jun, Motohashi, Hozumi, Yomogida, Kentaro, ...

Transcription factor GATA-1 is required for the terminal differentiation of both the primitive and definitive erythroid cell lineages, and yet the regulatory mechanisms of GATA-1 itself are not well...

Regulation of NMDA receptors by cyclin-dependent kinase-5

Li, Bing-Sheng, Sun, Miao-Kun, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Vinade, Lucia, ...

Members of the N-methyl-d-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders...

A GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene

Nishimura, Shigeko, Takahashi, Satoru, Kuroha, Takashi, Suwabe, Naruyoshi, Nagasawa, Toshiro, Trainor, Cecelia, ...

A region located at kbp −3.9 to −2.6 5′ to the first hematopoietic exon of the GATA-1 gene is necessary to recapitulate gene expression in both the primitive and definitive erythroid lineages....

In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

Shimizu, Ritsuko, Takahashi, Satoru, Ohneda, Kinuko, Engel, James Douglas, Yamamoto, Masayuki

GATA-1 is a transcription factor essential for erythroid/megakaryocytic cell differentiation. To investigate the contribution of individual domains of GATA-1 to its activity, transgenic mice...

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3

Li, Bing-Sheng, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Jaffe, Howard, Kulkarni, Ashok B., ...

Cyclin-dependent kinase 5 (cdk5) is a serine/threonine kinase activated by associating with its neuron-specific activators p35 and p39. Analysis of cdk5–/– and p35–/– mice has demonstrated...

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

Sun, Jiying, Hoshino, Hideto, Takaku, Kazuaki, Nakajima, Osamu, Muto, Akihiko, Suzuki, Hiroshi, ...

Heme oxygenase-1 (HO-1) protects cells from various insults including oxidative stress. Transcriptional activators, including the Nrf2/Maf heterodimer, have been the focus of studies on the inducible...

HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin

Morita, Masanobu, Ohneda, Osamu, Yamashita, Toshiharu, Takahashi, Satoru, Suzuki, Norio, Nakajima, Osamu, ...

An HLF (HIF-1α-like factor)/HIF-2α-knockout mouse is embryonic lethal, preventing investigation of HLF function in adult mice. To investigate the role of HLF in adult pathological angiogenesis, we...

Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology

Morita, Masanobu, Kobayashi, Akira, Yamashita, Toshiharu, Shimanuki, Tomomasa, Nakajima, Osamu, Takahashi, Satoru, ...

Basic transcription element binding protein (BTEB) is a transcription factor with a characteristic zinc finger motif and is most remarkably enhanced by thyroid hormone T3 treatment (R. J. Denver et...

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

Moriguchi, Takashi, Motohashi, Hozumi, Hosoya, Tomonori, Nakajima, Osamu, Takahashi, Satoru, Ohsako, Seiichiroh, ...

There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities. A critical question in risk assessment of dioxin and related compounds is whether humans are...

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects

Hirasawa, Motoyuki, Ohshima, Toshio, Takahashi, Satoru, Longenecker, Glenn, Honjo, Yasuyuki, ...

Cyclin-dependent kinase 5 (Cdk5) is essential for the proper development of the CNS, as is evident from the perinatal lethality of conventional Cdk5 knockout (Cdk5-/-) mice. Cdk5 is also implicated...

Leukemogenesis Caused by Incapacitated GATA-1 Function

Shimizu, Ritsuko, Kuroha, Takashi, Ohneda, Osamu, Pan, Xiaoqing, Ohneda, Kinuko, Takahashi, Satoru, ...

GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a hematopoietic disorder resembling...

Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling

Takahashi, Satoru, Ohshima, Toshio, Cho, Andrew, Sreenath, Taduru, Iadarola, Michael J., Pant, Harish C., ...

Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved...

The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis

Kelly, Vincent P., Suzuki, Takafumi, Nakajima, Osamu, Arai, Tsuyoshi, Tamai, Yoshitaka, Takahashi, Satoru, ...

Appropriate expression of the selenocysteine tRNA (tRNASec) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an...

MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

Zhang, Chuan, Moriguchi, Takashi, Kajihara, Miwako, Esaki, Ritsuko, Harada, Ayako, Shimohata, Homare, ...

MafA is a transcription factor that binds to the promoter in the insulin gene and has been postulated to regulate insulin transcription in response to serum glucose levels, but there is no current in...

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene

Kobayashi-Osaki, Maki, Ohneda, Osamu, Suzuki, Norio, Minegishi, Naoko, Yokomizo, Tomomasa, Takahashi, Satoru, ...

Transcription factor GATA-2 is essential for definitive hematopoiesis, which developmentally emerges from the para-aortic splanchnopleura (P-Sp). The expression of a green fluorescent protein (GFP)...

Uterine sensitization-associated gene–1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, Motoko, Okuda, Tomohiko, Endo, Shuichiro, Tanaka, Mari, Takahashi, Katsu, Sugiyama, Fumihiro, ...

Dialysis dependency is one of the leading causes of morbidity and mortality in the world, and once end-stage renal disease develops, it cannot be reversed by currently available therapy. Although...

Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche

Suzuki, Norio, Ohneda, Osamu, Minegishi, Naoko, Nishikawa, Mitsuo, Ohta, Takayuki, Takahashi, Satoru, ...

The interaction between stem cells and their supportive microenvironment is critical for their maintenance, function, and survival. Whereas hematopoietic stem cells (HSCs) are among the best...

Perfect Public Equilibrium When Players Are Patient

Drew Fudenberg, David K. Levine, Satoru Takahashi

The limit set of perfect public equilibrium payoffs of a repeated game as the discount factor goes to one is characterized, with examples, even when the full-dimensionality condition fails.

MafB Is Essential for Renal Development and F4/80 Expression in Macrophages

Moriguchi, Takashi, Hamada, Michito, Morito, Naoki, Terunuma, Tsumoru, Hasegawa, Kazuteru, Zhang, Chuan, ...

MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains. Although it is well known that...

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis

Onodera, Ko, Takahashi, Satoru, Nishimura, Shigeko, Ohta, Jun, Motohashi, Hozumi, Yomogida, Kentaro, ...

Transcription factor GATA-1 is required for the terminal differentiation of both the primitive and definitive erythroid cell lineages, and yet the regulatory mechanisms of GATA-1 itself are not well...

Regulation of NMDA receptors by cyclin-dependent kinase-5

Li, Bing-Sheng, Sun, Miao-Kun, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Vinade, Lucia, ...

Members of the N-methyl-d-aspartate (NMDA) class of glutamate receptors (NMDARs) are critical for development, synaptic transmission, learning and memory; they are targets of pathological disorders...

A GATA Box in the GATA-1 Gene Hematopoietic Enhancer Is a Critical Element in the Network of GATA Factors and Sites That Regulate This Gene

Nishimura, Shigeko, Takahashi, Satoru, Kuroha, Takashi, Suwabe, Naruyoshi, Nagasawa, Toshiro, Trainor, Cecelia, ...

A region located at kbp −3.9 to −2.6 5′ to the first hematopoietic exon of the GATA-1 gene is necessary to recapitulate gene expression in both the primitive and definitive erythroid lineages....

In vivo requirements for GATA-1 functional domains during primitive and definitive erythropoiesis

Shimizu, Ritsuko, Takahashi, Satoru, Ohneda, Kinuko, Engel, James Douglas, Yamamoto, Masayuki

GATA-1 is a transcription factor essential for erythroid/megakaryocytic cell differentiation. To investigate the contribution of individual domains of GATA-1 to its activity, transgenic mice...

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3

Li, Bing-Sheng, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Jaffe, Howard, Kulkarni, Ashok B., ...

Cyclin-dependent kinase 5 (cdk5) is a serine/threonine kinase activated by associating with its neuron-specific activators p35 and p39. Analysis of cdk5–/– and p35–/– mice has demonstrated...

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene

Sun, Jiying, Hoshino, Hideto, Takaku, Kazuaki, Nakajima, Osamu, Muto, Akihiko, Suzuki, Hiroshi, ...

Heme oxygenase-1 (HO-1) protects cells from various insults including oxidative stress. Transcriptional activators, including the Nrf2/Maf heterodimer, have been the focus of studies on the inducible...

HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin

Morita, Masanobu, Ohneda, Osamu, Yamashita, Toshiharu, Takahashi, Satoru, Suzuki, Norio, Nakajima, Osamu, ...

An HLF (HIF-1α-like factor)/HIF-2α-knockout mouse is embryonic lethal, preventing investigation of HLF function in adult mice. To investigate the role of HLF in adult pathological angiogenesis, we...

Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology

Morita, Masanobu, Kobayashi, Akira, Yamashita, Toshiharu, Shimanuki, Tomomasa, Nakajima, Osamu, Takahashi, Satoru, ...

Basic transcription element binding protein (BTEB) is a transcription factor with a characteristic zinc finger motif and is most remarkably enhanced by thyroid hormone T3 treatment (R. J. Denver et...

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

Moriguchi, Takashi, Motohashi, Hozumi, Hosoya, Tomonori, Nakajima, Osamu, Takahashi, Satoru, Ohsako, Seiichiroh, ...

There are large inter- and intraspecies differences in susceptibility to dioxin-induced toxicities. A critical question in risk assessment of dioxin and related compounds is whether humans are...

Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects

Hirasawa, Motoyuki, Ohshima, Toshio, Takahashi, Satoru, Longenecker, Glenn, Honjo, Yasuyuki, ...

Cyclin-dependent kinase 5 (Cdk5) is essential for the proper development of the CNS, as is evident from the perinatal lethality of conventional Cdk5 knockout (Cdk5-/-) mice. Cdk5 is also implicated...

Leukemogenesis Caused by Incapacitated GATA-1 Function

Shimizu, Ritsuko, Kuroha, Takashi, Ohneda, Osamu, Pan, Xiaoqing, Ohneda, Kinuko, Takahashi, Satoru, ...

GATA-1 is essential for the development of erythroid and megakaryocytic lineages. We found that GATA-1 gene knockdown female (GATA-1.05/X) mice frequently develop a hematopoietic disorder resembling...

Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling

Takahashi, Satoru, Ohshima, Toshio, Cho, Andrew, Sreenath, Taduru, Iadarola, Michael J., Pant, Harish C., ...

Cocaine, a drug of abuse, increases synaptic dopamine levels in the striatum by blocking dopamine reuptake at axon terminals. Cyclin-dependent kinase 5 (Cdk5) and its activator p35, proteins involved...

The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis

Kelly, Vincent P., Suzuki, Takafumi, Nakajima, Osamu, Arai, Tsuyoshi, Tamai, Yoshitaka, Takahashi, Satoru, ...

Appropriate expression of the selenocysteine tRNA (tRNASec) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an...

MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion

Zhang, Chuan, Moriguchi, Takashi, Kajihara, Miwako, Esaki, Ritsuko, Harada, Ayako, Shimohata, Homare, ...

MafA is a transcription factor that binds to the promoter in the insulin gene and has been postulated to regulate insulin transcription in response to serum glucose levels, but there is no current in...

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene

Kobayashi-Osaki, Maki, Ohneda, Osamu, Suzuki, Norio, Minegishi, Naoko, Yokomizo, Tomomasa, Takahashi, Satoru, ...

Transcription factor GATA-2 is essential for definitive hematopoiesis, which developmentally emerges from the para-aortic splanchnopleura (P-Sp). The expression of a green fluorescent protein (GFP)...

Uterine sensitization-associated gene–1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury

Yanagita, Motoko, Okuda, Tomohiko, Endo, Shuichiro, Tanaka, Mari, Takahashi, Katsu, Sugiyama, Fumihiro, ...

Dialysis dependency is one of the leading causes of morbidity and mortality in the world, and once end-stage renal disease develops, it cannot be reversed by currently available therapy. Although...

Combinatorial Gata2 and Sca1 expression defines hematopoietic stem cells in the bone marrow niche

Suzuki, Norio, Ohneda, Osamu, Minegishi, Naoko, Nishikawa, Mitsuo, Ohta, Takayuki, Takahashi, Satoru, ...

The interaction between stem cells and their supportive microenvironment is critical for their maintenance, function, and survival. Whereas hematopoietic stem cells (HSCs) are among the best...

MafB Is Essential for Renal Development and F4/80 Expression in Macrophages

Moriguchi, Takashi, Hamada, Michito, Morito, Naoki, Terunuma, Tsumoru, Hasegawa, Kazuteru, Zhang, Chuan, ...

MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains. Although it is well known that...

ヘドロの利活用 : I.物理的性質

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 武藤, ゆり, ムトウ, ユリ, Mutō, Yuri, ...

ヘドロは場所によって構成成分・性質にかなり大きな差が見られる.ヘドロが堆積すると停滞水の腐敗や流水阻害等種々の問題が生じるため,...

ヘドロの利活用 : II.ヘドロの乾燥特性

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 金, 原台, Kim, Wontae, 玉津, 智広, ...

前報[4]では4種類のヘドロを対象として, 基本的物理性の検討を行い, ヘドロが極めて細粒質の粘性土で,...

ヘドロの利活用に関する研究 : III.ヘドロの乾燥に伴うコンシステンシー及び透水性の変化

金, 原台, Kim, Wontae, 趙, 宰賢, Cho, Jaehyun, 大上, 岳彦, オオガミ, タケヒコ, ...

港湾・湖沼・河川に堆積するヘドロは膨大な量であり, 必要に応じて浚渫を行わねばならない.しかし, 浚渫土の処理もまた重要な課題である.従って,...

保水剤の添加による土壌物理性の変化 : III.保水剤が透水性に与える影響

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 金, 敏洙, KIM, Minsoo, ...

保水剤を土壌に添加・混入し, 給水後の土壌物理性にどのような変化が生じるかを検討した.本報では,...

北海道東北部火山性寒冷地土壌の水分拡散係数と不飽和透水係数

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

植物育成機能のひとつの因子である土壌水分の供給能力を議論するのに土壌の保水性のみに注目することはできない.供給可能な水分が量的にも十分...

保水剤の添加による土壌物理性の変化 : IV.保水剤が土壌構造に与える影響

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

保水剤が土壌に混合し, 吸水後混合土の含水比が増加するに伴って土壌内に分布している保水剤も吸収・膨潤し, 土壌構造が変化するが,...

園芸用土の物理性に関する研究 : 1.鹿沼土の間隙構造と水分特性

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 雨宮, 悠, アメミヤ, ユウ, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性が良好であることは植物の生育にとって重要な条件であり,...

園芸用土の物理性に関する研究 : II.鹿沼土の土壌構造と水分特性について

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 雨宮, 悠, アメミヤ, ユウ, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性・透水性が良好であることは植物の生育にとって重要を条件であり,...

ヘドロの利活用 : I.物理的性質

矢橋, 晨吾, 武藤, ゆり, 玉津, 智広, 金, 原台, 高橋, 悟, 渡邊, 文雄, ...

ヘドロは場所によって構成成分・性質にかなり大きな差が見られる.ヘドロが堆積すると停滞水の腐敗や流水阻害等種々の問題が生じるため,...

ヘドロの利活用 : II.ヘドロの乾燥特性

矢橋, 晨吾, 金, 原台, 玉津, 智広, 阿部, 勢子, 高橋, 悟, ヤバシ, シンゴ, ...

前報[4]では4種類のヘドロを対象として, 基本的物理性の検討を行い, ヘドロが極めて細粒質の粘性土で,...

ヘドロの利活用に関する研究 : III.ヘドロの乾燥に伴うコンシステンシー及び透水性の変化

金, 原台, 趙, 宰賢, 大上, 岳彦, 高橋, 悟, 矢橋, 晨吾, オオガミ, タケヒコ, ...

港湾・湖沼・河川に堆積するヘドロは膨大な量であり, 必要に応じて浚渫を行わねばならない.しかし, 浚渫土の処理もまた重要な課題である.従って,...

保水剤の添加による土壌物理性の変化 : III.保水剤が透水性に与える影響

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 金, 敏洙, 김, 민수, ?, ??, ...

保水剤を土壌に添加・混入し, 給水後の土壌物理性にどのような変化が生じるかを検討した.本報では,...

北海道東北部火山性寒冷地土壌の水分拡散係数と不飽和透水係数

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, 矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, ...

植物育成機能のひとつの因子である土壌水分の供給能力を議論するのに土壌の保水性のみに注目することはできない.供給可能な水分が量的にも十分...

保水剤の添加による土壌物理性の変化 : IV.保水剤が土壌構造に与える影響

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, 矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, ...

保水剤が土壌に混合し, 吸水後混合土の含水比が増加するに伴って土壌内に分布している保水剤も吸収・膨潤し, 土壌構造が変化するが,...

園芸用土の物理性に関する研究 : 1.鹿沼土の間隙構造と水分特性

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性が良好であることは植物の生育にとって重要な条件であり,...

園芸用土の物理性に関する研究 : II.鹿沼土の土壌構造と水分特性について

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性・透水性が良好であることは植物の生育にとって重要を条件であり,...

保水剤の添加による土壌物理性の変化 : III.保水剤が透水性に与える影響

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 金, 敏洙, KIM, Minsoo, ...

保水剤を土壌に添加・混入し, 給水後の土壌物理性にどのような変化が生じるかを検討した.本報では,...

北海道東北部火山性寒冷地土壌の水分拡散係数と不飽和透水係数

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

植物育成機能のひとつの因子である土壌水分の供給能力を議論するのに土壌の保水性のみに注目することはできない.供給可能な水分が量的にも十分...

保水剤の添加による土壌物理性の変化 : IV.保水剤が土壌構造に与える影響

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

保水剤が土壌に混合し, 吸水後混合土の含水比が増加するに伴って土壌内に分布している保水剤も吸収・膨潤し, 土壌構造が変化するが,...

園芸用土の物理性に関する研究 : 1.鹿沼土の間隙構造と水分特性

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 雨宮, 悠, アメミヤ, ユウ, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性が良好であることは植物の生育にとって重要な条件であり,...

園芸用土の物理性に関する研究 : II.鹿沼土の土壌構造と水分特性について

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, YABASHI, Shingo, 雨宮, 悠, アメミヤ, ユウ, ...

以上の結果を総合的にまとめると以下のとおりになる.保水性及び通気性・透水性が良好であることは植物の生育にとって重要を条件であり,...

Monotone Methods for Equilibrium Selection under Perfect Foresight Dynamics

Oyama, Daisuke, Takahashi, Satoru, Hofbauer, Josef

This paper studies a dynamic adjustment process in a large society of forward-looking agents where payoffs are given by a normal form supermodular game. The stationary states of the dynamics...

ヘドロの利活用 : I.物理的性質

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 武藤, ゆり, ムトウ, ユリ, Mutō, Yuri, ...

ヘドロは場所によって構成成分・性質にかなり大きな差が見られる.ヘドロが堆積すると停滞水の腐敗や流水阻害等種々の問題が生じるため,...

ヘドロの利活用 : II.ヘドロの乾燥特性

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 金, 原台, Kim, Wontae, 玉津, 智広, ...

前報[4]では4種類のヘドロを対象として, 基本的物理性の検討を行い, ヘドロが極めて細粒質の粘性土で,...

ヘドロの利活用に関する研究 : III.ヘドロの乾燥に伴うコンシステンシー及び透水性の変化

金, 原台, Kim, Wontae, 趙, 宰賢, Cho, Jaehyun, 大上, 岳彦, オオガミ, タケヒコ, ...

港湾・湖沼・河川に堆積するヘドロは膨大な量であり, 必要に応じて浚渫を行わねばならない.しかし, 浚渫土の処理もまた重要な課題である.従って,...

熱的変化が火山灰土壌の比表面積並びに水分特性に与える影響

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

山灰土壌の初期状態を乾燥温度, 乾燥時間により変化させ, それぞれの比表面積, 水分保持特性を求め,...

緑地潅漑における土の粒径成分と保水特性上の含水比との関係に関する研究

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, ...

本研究は粒度分析より得られる土の粒径成分と保水特性の関係を調べ、粒径成分から特性上の含水比ならびに含水比差を推定する際の問題点を明ら...

熱的変化が火山灰土壌の比表面積並びに水分特性に与える影響

雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, AMEMIYA, Yu, 矢橋, 晨吾, ヤバシ, シンゴ, ...

山灰土壌の初期状態を乾燥温度, 乾燥時間により変化させ, それぞれの比表面積, 水分保持特性を求め,...

緑地潅漑における土の粒径成分と保水特性上の含水比との関係に関する研究

矢橋, 晨吾, ヤバシ, シンゴ, Yabashi, Shingo, 雨宮, 悠, アメミヤ, ユウ, Amemiya, Yū, ...

本研究は粒度分析より得られる土の粒径成分と保水特性の関係を調べ、粒径成分から特性上の含水比ならびに含水比差を推定する際の問題点を明ら...

Cyclin-Dependent Kinase 5 Is a Regulator of Podocyte Differentiation, Proliferation, and Morphology

Griffin, Sīan V., Hiromura, Keiju, Pippin, Jeffrey, Petermann, Arndt T., Blonski, Mary J., Krofft, Ron, ...

Podocytes are highly specialized and terminally differentiated glomerular cells that play a vital role in renal physiology, including the prevention of proteinuria. Cyclin-dependent kinase 5 (CDK5)...

Overexpression of the Transcription Factor GATA-3 Enhances the Development of Pulmonary Fibrosis

Kimura, Toru, Ishii, Yukio, Yoh, Keigyou, Morishima, Yuko, Iizuka, Takashi, Kiwamoto, Takumi, ...

Recent studies have demonstrated that Th2 cytokines, such as interleukin-4 and interleukin-13, enhance fibrotic processes by activating fibroblast proliferation and collagen production, whereas...

Characterization of GATA-1+ hemangioblastic cells in the mouse embryo

Yokomizo, Tomomasa, Takahashi, Satoru, Mochizuki, Naomi, Kuroha, Takashi, Ema, Masatsugu, Wakamatsu, Asami, ...

Hemangioblasts are thought to be one of the sources of hematopoietic progenitors, yet little is known about their localization and fate in the mouse embryo. We show here that a subset of cells...

Essential and Instructive Roles of GATA Factors in Eosinophil Development

Hirasawa, Ryutaro, Shimizu, Ritsuko, Takahashi, Satoru, Osawa, Mitsujiro, Takayanagi, Shu, Kato, Yuko, ...

GATA transcription factors are major regulators of hematopoietic and immune system. Among GATA factors, GATA-1, GATA-2, and GATA-3 play crucial roles in the development of erythroid cells,...

Multi-sender cheap talk with restricted state spaces

Ambrus, Attila, Takahashi, Satoru

This paper analyzes multi-sender cheap talk when the state space might be restricted, either because the policy space is restricted, or the set of rationalizable policies of the receiver is not the...

The pure Nash equilibrium property and the quasi-acyclic condition

Satoru Takahashi, Tetsuo Yamamori

This paper presents a sufficient condition for the quasi-acyclic condition. A game is quasi-acyclic if from any strategy profile, there exists a finite sequence of strict best replies that ends in a...

Monotone methods for equilibrium selection under perfect foresight dynamics

Oyama, Daisuke, Takahashi, Satoru, Hofbauer, Josef

This paper studies a dynamic adjustment process in a large society of forward-looking agents where payoffs are given by a normal form supermodular game. The stationary states of the dynamics...

Monotone Methods for Equilibrium Selection under Perfect Foresight Dynamics

Josef Hofbauer, Daisuke Oyama, Satoru Takahashi

The paper studies equilibrium selection in supermodular games based on a class of perfect foresight dynamics, introduced by Matsui and Matsuyama (JET 1995) and further developed by Hofbauer and...

PEOPLE'S LIFE INDICATORS BY FUZZY OUTRANKING

HIROSHI INOUE, KUNIO OSHIMA, SATORU TAKAHASHI, JIANMING SHI, MICHIHIRO AMAGASA

It is getting a hard task to precisely express people's life today when people's senses of values have diversified in a short span of several years. In this paper, as a first step, we look at the...

ANTI-COORDINATION GAMES AND DYNAMIC STABILITY

FUHITO KOJIMA, SATORU TAKAHASHI

We introduce the class of anti-coordination games. A symmetric two-player game is said to have the anti-coordination property if, for any mixed strategy, any worst response to the mixed strategy is...

The number of pure Nash equilibria in a random game with nondecreasing best responses

Takahashi, Satoru

We randomly draw a game from a distribution on the set of two-player games with a given size. We compute the distribution and the expectation of the number of pure-strategy Nash equilibria of the...

Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance

Yano, Masashi, Kuroda, Noriyuki, Han, Hongwei, Meguro-Horike, Makiko, Nishikawa, Yumiko, Kiyonari, Hiroshi, ...

The roles of autoimmune regulator (Aire) in the expression of the diverse arrays of tissue-restricted antigen (TRA) genes from thymic epithelial cells in the medulla (medullary thymic epithelial...

Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development

Sultana, Dil Afroz, Tomita, Shuhei, Hamada, Michito, Iwanaga, Yasuyuki, Kitahama, Yuki, Van Khang, Nguyen, ...

The thymus provides a microenvironment that induces the differentiation of T-progenitor cells into functional T cells and that establishes a diverse yet self-tolerant T-cell repertoire. However, the...

Enhanced humoral immune responses against T-independent antigens in Fcα/μR-deficient mice

Honda, Shin-ichiro, Kurita, Naoki, Miyamoto, Akitomo, Cho, Yukiko, Usui, Kenta, Takeshita, Kie, ...

IgM is an antibody class common to all vertebrates that plays a primary role in host defenses against infection. Binding of IgM with an antigen initiates the complement cascade, accelerating cellular...

Embryonic Stem Cells Derived from C57BL/6J and C57BL/6N Mice

Tanimoto, Yoko, Iijima, Saori, Hasegawa, Yoshikazu, Suzuki, Yuko, Daitoku, Yoko, Mizuno, Seiya, ...

Mouse embryonic stem (ES) cells with the C57BL/6 genetic background allow the generation of knockout mice without the need to backcross to C57BL/6. However, C57BL/6 ES cells whose pluripotency after...

Selective loss of GABAB receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture

Matsuki, Taizo, Nomiyama, Mika, Takahira, Hitomi, Hirashima, Noriko, Kunita, Satoshi, Takahashi, Satoru, ...

Hypothalamic neurons that contain the neuropeptide orexin (hypocretin) play important roles in the regulation of sleep/wake. Here we analyze the in vivo and in vitro phenotype of mice lacking the...