Sau-Mei Leung

Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer

Leung, Sau-Mei, Senisterra, Guillermo, Ritchie, Kenneth P., Sadis, Seth E., Lepock, James R., Hightower, Lawrence E.

Defferential scanning calorimetry was used to monitor the thermal transitions of the 70 kDa heat shock cognate protein (Hsc70). Hsc70 had endothermic trasitions with midpoints (Tm) at 59°C and 63°C...

Thermal activation of the bovine Hsc70 molecular chaperone at physiological temperatures: physical evidence of a molecular thermometer

Leung, Sau-Mei, Senisterra, Guillermo, Ritchie, Kenneth P., Sadis, Seth E., Lepock, James R., Hightower, Lawrence E.

Defferential scanning calorimetry was used to monitor the thermal transitions of the 70 kDa heat shock cognate protein (Hsc70). Hsc70 had endothermic trasitions with midpoints (Tm) at 59°C and 63°C...

Evaluation of a Novel, Integrated Approach Using Functionalized Magnetic Beads, Bench-Top MALDI-TOF-MS with Prestructured Sample Supports, and Pattern Recognition Software for Profiling Potential Biomarkers in Human Plasma

Zhang, Xinyi, Leung, Sau-Mei, Morris, Claudia R., Shigenaga, Mark K.

The advantage of using proteins and peptides as biomarkers is that they can be found readily in blood, urine, and other biological fluids. Such sample types are easily obtained and represent a...