Scott A. Beatson

Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli (2009)

Badea, Luminita, Beatson, Scott A, Kaparakis, Maria, Ferrero, Richard L, Hartland, Elizabeth L

Abstract Background Enteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) pathogen that possesses a type III secretion system (T3SS) encoded within the locus of enterocyte...

Identification of Type 3 fimbriae in uropathogenic Escherichia coli reveals a role in biofilm formation (2008)

Ong, Cheryl-Lynn Y., Ulett, Glen Charles, Mabbett, Amada N., Beatson, Scott A., Webb, Richard I., Monaghan, Wayne, ...

Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection in the United States. Uropathogenic Escherichia coli (UPEC), the most common cause of CAUTI, can form...

Identification of Type 3 fimbriae in uropathogenic Escherichia coli reveals a role in biofilm formation (2008)

Ong, Cheryl-Lynn Y., Ulett, Glen Charles, Mabbett, Amada N., Beatson, Scott A., Webb, Richard I., Monaghan, Wayne, ...

Catheter-associated urinary tract infection (CAUTI) is the most common nosocomial infection in the United States. Uropathogenic Escherichia coli (UPEC), the most common cause of CAUTI, can form...

An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination (2006)

Tobe, Toru, Beatson, Scott A., Taniguchi, Hisaaki, Abe, Hiroyuki, Bailey, Christopher M., Fivian, Amanda, ...

Several pathogenic strains of Escherichia coli exploit type III secretion to inject effector proteins into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. We...

Variation in bacterial flagellins: from sequence to structure (2006)

Beatson, Scott A., Minamino, Tohru, Pallen, Mark J.

Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and...

An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination (2006)

Tobe, Toru, Beatson, Scott A., Taniguchi, Hisaaki, Abe, Hiroyuki, Bailey, Christopher M., Fivian, Amanda, ...

Several pathogenic strains of Escherichia coli exploit type III secretion to inject effector proteins into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. We...

Variation in bacterial flagellins: from sequence to structure (2006)

Beatson, Scott A., Minamino, Tohru, Pallen, Mark J.

Bacterial motility relies chiefly on the rotation of a molecular propeller, the flagellar filament, which is constructed from the protein flagellin. Here, flagellin sequence conservation and...

Evolutionary links between FliH/YscL-like proteins from bacterial type III secretion systems and second-stalk components of the FoF1 and vacuolar ATPases (2006)

Pallen, Mark J., Bailey, Christopher M., Beatson, Scott A.

Bacterial type III secretion drives flagellar biosynthesis and mediates bacterial–eukaryotic interactions. Type III secretion is driven by an ATPase that is homologous to the catalytic subunits of...

Evolutionary links between FliH/YscL-like proteins from bacterial type III secretion systems and second-stalk components of the FoF1 and vacuolar ATPases (2006)

Pallen, Mark J., Bailey, Christopher M., Beatson, Scott A.

Bacterial type III secretion drives flagellar biosynthesis and mediates bacterial-eukaryotic interactions. Type III secretion is driven by an ATPase that is homologous to the catalytic subunits of...

Evolutionary links between FliH/YscL-like proteins from bacterial type III secretion systems and second-stalk components of the FoF1 and vacuolar ATPases (2006)

Pallen, Mark J., Bailey, Christopher M., Beatson, Scott A.

Bacterial type III secretion drives flagellar biosynthesis and mediates bacterial–eukaryotic interactions. Type III secretion is driven by an ATPase that is homologous to the catalytic subunits of...

Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli (2005)

Parham, Nick J., Pollard, Samantha J., Chaudhuri, Roy R., Beatson, Scott A., Desvaux, Mickaël, Russell, Michael A., ...

Uropathogenic Escherichia coli is the most common cause of urinary tract infection (UTI). Cystitis in women is by far the most common UTI; pyelonephritis in both sexes and prostatitis in men are more...

Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

Background: Like many other pathogens, enterohaemorrhagic and enteropathogenic strains of Escherichia coli employ a type-III secretion system to translocate bacterial effector proteins into host...

Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perpective (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

We review the biology of non-flagellar type-III secretion systems from a Darwinian perspective, highlighting the themes of evolution, conservation, variation and decay. The presence of these systems...

Protein secretion systems in Fusobacterium nucleatum: Genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis (2005)

Desvaux, Mickaël, Khan, Arshad, Beatson, Scott A., Scott-Tucker, Anthony, Henderson, Ian R.

Recent genomic analyses of the two sequenced strains F nucleatum subsp. nucleatum ATCC 25586 and F nucleatum subsp. vincentii ATCC 49256 suggested that the major protein secretion systems were...

The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli (2005)

Ren, Chuan-Peng, Beatson, Scott A., Parkhill, Julian, Pallen, Mark J.

Escherichia coli K-12 possesses two adjacent, divergent, promoterless flagellar genes, fhiA-mbhA, that are absent from Salmonella enterica. Through bioinformatics analysis, we found that these genes...

Pseudomonas aeruginosa fimL regulates multiple virulence functions by intersecting with Vfr-modulated pathways (2005)

Whitchurch, Cynthia B., Beatson, Scott A., Comolli, James C., Jakobsen, Thania, Sargent, Jennifer L., Bertrand, Jacob J., ...

Virulence of Pseudomonas aeruginosa involves the co-ordinate expression of a range of factors including type IV pili (tfp), the type III secretion system (TTSS) and quorum sensing. Tfp are required...

Bioinformatics, genomics and evolution of non-flagellar type-III secretion systems: a Darwinian perpective (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

We review the biology of non-flagellar type-III secretion systems from a Darwinian perspective, highlighting the themes of evolution, conservation, variation and decay. The presence of these systems...

Protein secretion systems in Fusobacterium nucleatum: Genomic identification of Type 4 piliation and complete Type V pathways brings new insight into mechanisms of pathogenesis (2005)

Desvaux, Mickaël, Khan, Arshad, Beatson, Scott A., Scott-Tucker, Anthony, Henderson, Ian R.

Recent genomic analyses of the two sequenced strains F nucleatum subsp. nucleatum ATCC 25586 and F nucleatum subsp. vincentii ATCC 49256 suggested that the major protein secretion systems were...

The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli (2005)

Ren, Chuan-Peng, Beatson, Scott A., Parkhill, Julian, Pallen, Mark J.

Escherichia coli K-12 possesses two adjacent, divergent, promoterless flagellar genes, fhiA-mbhA, that are absent from Salmonella enterica. Through bioinformatics analysis, we found that these genes...

Prevalence of pathogenicity island IICFT073 genes among extraintestinal clinical isolates of Escherichia coli (2005)

Parham, Nick J., Pollard, Samantha J., Chaudhuri, Roy R., Beatson, Scott A., Desvaux, Mickaël, Russell, Michael A., ...

Uropathogenic Escherichia coli is the most common cause of urinary tract infection (UTI). Cystitis in women is by far the most common UTI; pyelonephritis in both sexes and prostatitis in men are more...

Bioinformatics analysis of the locus for enterocyte effacement provides novel insights into type-III secretion (2005)

Pallen, Mark J., Beatson, Scott A., Bailey, Christopher M.

Background: Like many other pathogens, enterohaemorrhagic and enteropathogenic strains of Escherichia coli employ a type-III secretion system to translocate bacterial effector proteins into host...

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa (2004)

Ghysels, Bart, Dieu, Bui Thi Min, Beatson, Scott A., Pirnay, Jean-Paul, Ochsner, Urs A., Vasil, Michael L., ...

Under conditions of iron limitation, Pseudomonas aeruginosa secretes a high-affinity siderophore pyoverdine to scavenge Fe(III) in the extracellular environment and shuttle it into the cell. Uptake...

Evolution and comparative genomics of odorant-and pheromone-associated genes in rodents (2004)

Emes, Richard D., Beatson, Scott A., Ponting, Chris P., Goodstadt, Leo

Chemical cues influence a range of behavioral responses in rodents. The involvement of protein odorants and odorant receptors in mediating reproductive behavior, foraging, and predator avoidance...

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa (2004)

Whitchurch, Cynthia B., Leech , Andrew J., Young , Michael D., Kennedy , Derek, Sargent , Jennifer L., Bertrand, Jacob J., ...

Virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate expression of a wide range of virulence factors including type IV pili which are required for colonization of...

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa (2004)

Whitchurch, Cynthia B., Leech, Andrew J., Young, Michael D., Kennedy, Derek, Sargent,Jennifer L., Bertrand, Jacob J., ...

Virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate expression of a wide range of virulence factors including type IV pili which are required for colonization of...

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa (2004)

Ghysels, Bart, Dieu, Bui Thi Min, Beatson, Scott A., Pirnay, Jean-Paul, Ochsner, Urs A., Vasil, Michael L., ...

Under conditions of iron limitation, Pseudomonas aeruginosa secretes a high-affinity siderophore pyoverdine to scavenge Fe(III) in the extracellular environment and shuttle it into the cell. Uptake...

Evolution and comparative genomics of odorant-and pheromone-associated genes in rodents (2004)

Emes, Richard D., Beatson, Scott A., Ponting, Chris P., Goodstadt, Leo

Chemical cues influence a range of behavioral responses in rodents. The involvement of protein odorants and odorant receptors in mediating reproductive behavior, foraging, and predator avoidance...

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa (2004)

Whitchurch, Cynthia B., Leech , Andrew J., Young , Michael D., Kennedy , Derek, Sargent , Jennifer L., Bertrand, Jacob J., ...

Virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate expression of a wide range of virulence factors including type IV pili which are required for colonization of...

Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa (2004)

Whitchurch, Cynthia, Leech, Andrew J., Young, Michael, Kennedy, Derek, Sargent, Jennifer L., Bertrand, Jacob J., ...

Virulence of the opportunistic pathogen Pseudomonas aeruginosa involves the coordinate expression of a wide range of virulence factors including type IV pili which are required for colonization of...

Evolution and Comparative Genomics of Odorant- and Pheromone-Associated Genes in Rodents (2004)

Emes, Richard D., Beatson, Scott A., Ponting, Chris P., Goodstadt, Leo

Chemical cues influence a range of behavioral responses in rodents. The involvement of protein odorants and odorant receptors in mediating reproductive behavior, foraging, and predator avoidance...

Proteome analysis of extracellular proteins regulated by the las and rhl quorum sensing systems in Pseudomonas aeruginosa PAO1 (2003)

Nouwens, Amanda S., Beatson, Scott A., Whitchurch, Cynthia B., Walsh, Bradley. J., Schweizer, Herbert P., Mattick, John S., ...

The las and rhl quorum sensing (QS) systems regulate the expression of several genes in response to cell density changes in Pseudomonas aeruginosa. Many of these genes encode surface-associated or...

Identification of type II and type III pyoverdine receptors from Pseudomonas aeruginosa (2003)

De Chial, Magaly, Ghysels, Bart, Beatson, Scott A., Geoffroy, Valérie, Meyer, Jean Marie, Pattery, Theresa, ...

Pseudomonas aeruginosa produces, under conditions of iron limitation, a high-affinity siderophore, pyoverdine (PVD), which is recognized at the level of the outer membrane by a specific...

Proteome Analysis of Extracellular Proteins Regulated by the las and rhl Quorum Sensing Systems in Pseudomonas aeruginosa PAO1 (2003)

Nouwens, Amanda S., Beatson, Scott A., Whitchurch, Cynthia B., Walsh, Bradley J., Schweizer, Herbert P., Mattick, John S., ...

The las and rhl quorum sensing (QS) systems regulate the expression of several genes in response to cell density changes in Pseudomonas aeruginosa. Many of these genes encode surface-associated or...

Proteome analysis of extracellular proteins regulated by the las and rhl quorum sensing systems in Pseudomonas aeruginosa PAO1 (2003)

Nouwens, Amanda S., Beatson, Scott A., Whitchurch, Cynthia B., Walsh, Bradley. J., Schweizer, Herbert P., Mattick, John S., ...

The las and rhl quorum sensing (QS) systems regulate the expression of several genes in response to cell density changes in Pseudomonas aeruginosa. Many of these genes encode surface-associated or...

Identification of type II and type III pyoverdine receptors from Pseudomonas aeruginosa (2003)

De Chial, Magaly, Ghysels, Bart, Beatson, Scott A., Geoffroy, Valérie, Meyer, Jean Marie, Pattery, Theresa, ...

Pseudomonas aeruginosa produces, under conditions of iron limitation, a high-affinity siderophore, pyoverdine (PVD), which is recognized at the level of the outer membrane by a specific...

Proteome Analysis of Extracellular Proteins Regulated by the las and rhl Quorum Sensing Systems in Pseudomonas aeruginosa PAO1 (2003)

Nouwens, Amanda S., Beatson, Scott A., Whitchurch, Cynthia B., Walsh, Bradley J., Schweizer, Herbert P., Mattick, John S., ...

The las and rhl quorum sensing (QS) systems regulate the expression of several genes in response to cell density changes in Pseudomonas aeruginosa. Many of these genes encode surface-associated or...

Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa (2002)

Beatson, Scott A., Whitchurch, Cynthia B., Sargent, Jennifer L., Levesque, Roger C., Mattick, John S.

Vfr, a homolog of Escherichia coli cyclic AMP (cAMP) receptor protein, has been shown to regulate quorum sensing, exotoxin A production, and regA transcription in Pseudomonas aeruginosa. We...

Differential regulation of twitching motility and elastase production by Vfr in Pseudomonas aeruginosa (2002)

Beatson, Scott A., Whitchurch, Cynthia B., Sargent, Jennifer L., Levesque, Roger C., Mattick, John S.

Vfr, a homolog of Escherichia coli cyclic AMP (cAMP) receptor protein, has been shown to regulate quorum sensing, exotoxin A production, and regA transcription in Pseudomonas aeruginosa. We...