Chanthamontri, Chamnongsak, Liu, Jian, McLuckey, Scott A.
Ions derived from nano-electrospray ionization (nano-ESI) of α-synuclein, a 14.5 kDa, 140 amino acid residue protein that is a major component of the Lewy bodies associated with Parkinson's disease,...
Hodges, Brittany D. M., Liang, Xiaorong, McLuckey, Scott A.
Gas phase conversion of multiply protonated peptides to alkali di-metalated peptide ions via ion/ion reactions is demonstrated as an alternative strategy to forming alkali di-metalated ions from...
Liang, Xiaorong, Han, Hongling, Xia, Yu, McLuckey, Scott A.
A pulsed triple ionization source, using a common atmosphere/vacuum interface and ion path, has been developed to generate different types of ions for sequential ion/ion reaction experiments in a...
Busch, Kenneth L., Glish, Gary L., McLuckey, Scott A.
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Chrisman, Paul A., Pitteri, Sharon J., McLuckey, Scott A.
Electron-transfer dissociation (ETD) in a tandem mass spectrometer is an analytically useful ion/ion reaction technique for deriving polypeptide sequence information, but its utility can be limited...
Hogan, Jason M., Pitteri, Sharon J., Chrisman, Paul A., McLuckey, Scott A.
Glycosylation is an important post-translational modification. Analysis of glycopeptides is difficult using collision-induced dissociation, as it typically yields only information about the glycan...
Newton, Kelly A., Pitteri, Sharon J., Laskowski, Michael, McLuckey, Scott A.
Expanded understanding of the factors that direct polypeptide ion fragmentation can lead to improved specificity in the use of tandem mass spectrometry for the identification and characterization of...
Pitteri, Sharon J., Chrisman, Paul A., McLuckey, Scott A.
In this study, the electron-transfer dissociation (ETD) behavior of cations derived from 27 different peptides (22 of which are tryptic peptides) has been studied in a 3D quadrupole ion trap mass...
Reagent Anions for Charge Inversion of Polypeptide/Protein Cations in the Gas Phase
He, Min, Emory, Joshua F., McLuckey, Scott A.
Various reagent anions capable of converting polypeptide cations to anions via ion/ion reactions have been investigated. The major charge inversion reaction channels include multiple proton transfer...
SO2−· Electron Transfer Ion/Ion Reactions with Disulfide Linked Polypeptide Ions
Chrisman, Paul A., Pitteri, Sharon J., Hogan, Jason M., McLuckey, Scott A.
Multiply-charged peptide cations comprised of two polypeptide chains (designated A and B) bound via a disulfide linkage have been reacted with SO2−· in an electrodynamic ion trap mass...
Protonated and deprotonated biological molecules in the gas phase play an important role in life sciences research. The structural information accessible from the ions is highly dependent upon their...
Gas-Phase Ion/Ion Reactions of Multiply Protonated Polypeptides with Metal Containing Anions
Newton, Kelly A., Amunugama, Ravi, McLuckey, Scott A.
Gas-phase reactions of multiply protonated polypeptides and metal containing anions represent a new methodology for manipulating the cationizing agent composition of polypeptides. This approach...