Scott W. Eastman

HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane (2006)

Scott W. Eastman, Nolwenn Jouvenet, Paul D. Bieniasz

The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the release of diverse retroviruses from human, but not monkey, cells and is thought to do so by ablating a...

Identification of a Conserved Residue of Foamy Virus Gag Required for Intracellular Capsid Assembly

Eastman, Scott W., Linial, Maxine L.

In contrast to all retroviruses but similar to the hepatitis B virus, foamy viruses (FV) require expression of the envelope protein for budding of intracellular capsids from the cell, suggesting a...

Prototype Foamy Virus Envelope Glycoprotein Leader Peptide Processing Is Mediated by a Furin-Like Cellular Protease, but Cleavage Is Not Essential for Viral Infectivity

Duda, Anja, Stange, Annett, Lüftenegger, Daniel, Stanke, Nicole, Westphal, Dana, Pietschmann, Thomas, ...

Analogous to cellular glycoproteins, viral envelope proteins contain N-terminal signal sequences responsible for targeting them to the secretory pathway. The prototype foamy virus (PFV) envelope...

HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane

Neil, Stuart J. D, Eastman, Scott W, Jouvenet, Nolwenn, Bieniasz, Paul D

The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the release of diverse retroviruses from human, but not monkey, cells and is thought to do so by ablating a...

Identification of a Conserved Residue of Foamy Virus Gag Required for Intracellular Capsid Assembly

Eastman, Scott W., Linial, Maxine L.

In contrast to all retroviruses but similar to the hepatitis B virus, foamy viruses (FV) require expression of the envelope protein for budding of intracellular capsids from the cell, suggesting a...

Prototype Foamy Virus Envelope Glycoprotein Leader Peptide Processing Is Mediated by a Furin-Like Cellular Protease, but Cleavage Is Not Essential for Viral Infectivity

Duda, Anja, Stange, Annett, Lüftenegger, Daniel, Stanke, Nicole, Westphal, Dana, Pietschmann, Thomas, ...

Analogous to cellular glycoproteins, viral envelope proteins contain N-terminal signal sequences responsible for targeting them to the secretory pathway. The prototype foamy virus (PFV) envelope...

HIV-1 Vpu Promotes Release and Prevents Endocytosis of Nascent Retrovirus Particles from the Plasma Membrane

Neil, Stuart J. D, Eastman, Scott W, Jouvenet, Nolwenn, Bieniasz, Paul D

The human immunodeficiency virus (HIV) type-1 viral protein U (Vpu) protein enhances the release of diverse retroviruses from human, but not monkey, cells and is thought to do so by ablating a...

HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway

Martin-Serrano, Juan, Eastman, Scott W., Chung, Wayne, Bieniasz, Paul D.

Many enveloped viruses exploit the class E vacuolar protein-sorting (VPS) pathway to bud from cells, and use peptide motifs to recruit specific class E VPS factors. Homologous to E6AP COOH terminus...

Mutations in the Amino Terminus of Foamy Virus Gag Disrupt Morphology and Infectivity but Do Not Target Assembly▿

Life, Rachel B., Lee, Eun-Gyung, Eastman, Scott W., Linial, Maxine L.

Foamy viruses (FVs) assemble using pathways distinct from those of orthoretroviruses. FV capsid assembly takes place near the host microtubule-organizing center (MTOC). Assembled capsids then migrate...

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

Eastman, Scott W., Yassaee, Mina, Bieniasz, Paul D.

HECT (homologous to the E6AP C terminus) ubiquitin ligases have diverse functions in eukaryotic cells. In screens for proteins that bind to the HECT ubiquitin ligase WWP1, we identified Spartin,...