Sean F. Landrette

PLAGL2 Cooperates in Leukemia Development by Upregulating MPL Expression: A Dissertation (2006)

Landrette, Sean F.

Chromosomal alterations involving the RUNXI or CBFB genes are specifically and recurrently associated with human acute myeloid leukemia (AML). One such chromosomal alteration, a pericentric inversion...

Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia (2006)

Kuo, Ya-Huei, Landrette, Sean F., Heilman, Susan Ann, Perrat, Paola N., Garrett, Lisa, Liu, Pu P., ...

The acute myeloid leukemia (AML)-associated CBF beta-SMMHC fusion protein impairs hematopoietic differentiation and predisposes to leukemic transformation. The mechanism of leukemia progression,...

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11 (2004)

Landrette, Sean F., Kuo, Ya-Huei, Hensen, Karen, Perrat, Paola N., ...

Recurrent chromosomal rearrangements are associated with the development of acute myeloid leukemia (AML). The frequent inversion of chromosome 16 creates the CBFB-MYH11 fusion gene that encodes the...

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia (2004)

Castilla, Lucio H., Perrat, Paola N., Martinez, Natalia J., Landrette, Sean F., Keys, R., Oikemus, Sarah R., ...

Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not...