Sean M. Donahoe

Human Immunodeficiency Virus Type 1- and Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Persist at High Frequency for Prolonged Periods in the Absence of Circulating Peripheral CD4+ T Cells

Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...

CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...

HIV-1–specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy

Ortiz, Gabriel M., Nixon, Douglas F., Trkola, Alexandra, Binley, James, Jin, Xia, Bonhoeffer, Sebastian, ...

Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex...

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells

Dhodapkar, Madhav V., Steinman, Ralph M., Sapp, Mark, Desai, Hema, Fossella, Coraleen, Krasovsky, Joseph, ...

Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously...

Human Immunodeficiency Virus Type 1- and Cytomegalovirus-Specific Cytotoxic T Lymphocytes Can Persist at High Frequency for Prolonged Periods in the Absence of Circulating Peripheral CD4+ T Cells

Spiegel, Hans M. L., Ogg, Graham S., DeFalcon, Elizabeth, Sheehy, Megan E., Monard, Simon, Haslett, Patrick A. J., ...

CD4+ T cells are thought to be critical in the maintenance of virus-specific CD8+ cytotoxic T-cell (CTL) responses. In human immunodeficiency virus type 1 (HIV-1) infection, a selective decline in...

HIV-1–specific immune responses in subjects who temporarily contain virus replication after discontinuation of highly active antiretroviral therapy

Ortiz, Gabriel M., Nixon, Douglas F., Trkola, Alexandra, Binley, James, Jin, Xia, Bonhoeffer, Sebastian, ...

Therapeutic intervention with highly active antiretroviral therapy (HAART) can lead to suppression of HIV-1 plasma viremia to undetectable levels for 3 or more years. However, adherence to complex...

Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells

Dhodapkar, Madhav V., Steinman, Ralph M., Sapp, Mark, Desai, Hema, Fossella, Coraleen, Krasovsky, Joseph, ...

Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects subcutaneously...

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

Appay, Victor, Nixon, Douglas F., Donahoe, Sean M., Gillespie, Geraldine M.A., Dong, Tao, King, Abigail, ...

The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8+ T cells has provided a major development in our understanding of...