Scientific Commons: Sean P. McDonough

Primary Hyperoxaluria in Cats Is Caused by a Mutation in the Feline GRHPR Gene (2009)

Goldstein, Richard E., Narala, Saisindhu, Sabet, Nevin, Goldstein, Orly, McDonough, Sean P.

Primary hyperoxaluria (PH) is a rare, inherited disease in humans resulting from mutations in the alanine:glyoxylate aminotransferase gene (PH1) or in the glyoxylate reductase (GRHPR) gene (PH2). A...

Human Granulocytic Ehrlichiosis Agent Infection in a Pony Vaccinated with a Borrelia burgdorferi Recombinant OspA Vaccine and Challenged by Exposure to Naturally Infected Ticks

Chang, Yung-Fu, McDonough, Sean P., Chang, Chao-Fu, Shin, Kwang-Soon, Yen, William, Divers, Thomas

A pony was vaccinated with recombinant OspA vaccine (rOspA) and then exposed 3 months later to Borrelia burgdorferi-infected ticks (Ixodes scapularis) collected in Westchester County, N.Y. At 2 weeks...

Cloning and Molecular Characterization of an Immunogenic LigA Protein of Leptospira interrogans

Palaniappan, Raghavan U. M., Chang, Yung-Fu, Jusuf, S. S. D., Artiushin, S., Timoney, John F., McDonough, Sean P., ...

A clone expressing a novel immunoreactive leptospiral immunoglobulin-like protein A of 130 kDa (LigA) from Leptospira interrogans serovar pomona type kennewicki was isolated by screening a genomic...

Quantitative Evaluation of Inflammatory and Immune Responses in the Early Stages of Chronic Helicobacter pylori Infection

Straubinger, Reinhard K., Greiter, Andrea, McDonough, Sean P., Gerold, Alexander, Scanziani, Eugenio, Soldati, Sabina, ...

The early consequences of Helicobacter pylori infection and the role of bacterial virulence determinants in disease outcome remain to be established. The present study sought to measure the...

In Vitro Cellular Immune Responses to Recombinant Antigens of Mycobacterium avium subsp. paratuberculosis

Shin, Sung Jae, Chang, Chao-Fu, Chang, Ching-Dong, McDonough, Sean P., Thompson, Belinda, Yoo, Han Sang, ...

Five recombinant antigens (Ags; 85A, 85B, 85C, superoxide dismutase [SOD], and 35-kDa protein) were purified from Mycobacterium avium subsp. paratuberculosis and evaluated for their ability to...

Novel Attenuated Salmonella enterica Serovar Choleraesuis Strains as Live Vaccine Candidates Generated by Signature-Tagged Mutagenesis

Ku, Yu-We, McDonough, Sean P., Palaniappan, Raghavan U. M., Chang, Chao-Fu, Chang, Yung-Fu

Salmonella enterica serovar Choleraesuis is a host-adapted pathogen that causes swine paratyphoid. Signature-tagged mutagenesis (STM) was used to understand the pathogenicity of S. enterica serovar...

Immunoprotection of Recombinant Leptospiral Immunoglobulin-Like Protein A against Leptospira interrogans Serovar Pomona Infection

Palaniappan, Raghavan U. M., McDonough, Sean P., Divers, Thomas J., Chen, Chia-Sui, Pan, Ming-Jeng, Matsumoto, Mitsuharu, ...

We previously reported the cloning and characterization of leptospiral immunoglobulin-like proteins LigA and LigB of Leptospira interrogans. LigA and LigB are conserved at the amino-terminal region...

Adherent and Invasive Escherichia coli Is Associated with Granulomatous Colitis in Boxer Dogs

Simpson, Kenneth W., Dogan, Belgin, Rishniw, Mark, Goldstein, Richard E., Klaessig, Suzanne, McDonough, Patrick L., ...

The mucosa-associated microflora is increasingly considered to play a pivotal role in the pathogenesis of inflammatory bowel disease. This study explored the possibility that an abnormal mucosal...